Cited by 53Nutrition, Genetics, and DiseaseGenetics and Physical PerformanceDietary Effects on Health

Lunch eating predicts weight-loss effectiveness in carriers of the common allele at PERILIPIN1: the ONTIME (Obesity, Nutrigenetics, Timing, Mediterranean) study

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Garaulet, Marta, Vera, Beatriz, Bonnet-Rubio, Gemma, Gómez-Abellán, Purificación, Lee, Yu-Chi, Ordovás, José M·2016·The American Journal of Clinical Nutrition

Abstract

Background We propose that eating lunch late impairs the mobilization of fat from adipose tissue, particularly in carriers of PERILIPIN1 (PLIN1) variants.Objective The aim was to test the hypothesis that PLIN1, a circadian lipid-stabilizing protein in the adipocyte, interacts with the timing of food intake to affect weight loss.Design A total of 1287 overweight and obese subjects [229 men and 1058 women; mean ± SD body mass index (in kg/m 2): 31 ± 5] who attended outpatient obesity clinics were enrolled in the ONTIME (Obesity, Nutrigenetics, Timing, Mediterranean) study. Timing of food intake was estimated with a validated questionnaire. Anthropometric variables and PLIN1 genotypes were analyzed, including 6209T>C (rs2289487), 11482G>A (rs894160), 13041A>G (rs2304795), and 14995A>T (rs1052700). The main outcomes were effectiveness of the program and weight-loss progression during 28 wk of treatment.Results The PLIN1 locus was associated with variability in response to a weight-loss program. Specifically, carrying the minor C allele at the PLIN1 6209T>C was associated with better weight-loss response (P = 0.035). The probability of being a better responder [percentage of weight loss ≥7.5% (median)] was 33% higher among C than among TT carriers (OR: 1.32; 95% CI: 1.05, 1.67; P = 0.017). We found an interaction of PLIN1 × food timing between the 14995A>T variant and timing of lunch eating for total weight loss (P = 0.035). Among AA carriers, eating late was associated with less weight loss (P < 0.001), whereas time of eating did not influence weight loss among TT carriers (P = 0.326).Conclusions Variability at the PLIN1 locus is associated with variability in weight loss. Moreover, eating late is related to lower weight-loss effectiveness among carriers of the AA genotype at the PLIN1 14995A>T variant. These results contribute to our ability to implement more precise and successful obesity treatments. The ONTIME study was registered at clinicaltrials.gov as NCT02829619.

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  • People with rs1052700 AA in PLIN1 show less weight loss when eating late compared to TT carriers, where eating late does not influence weight loss at all.

    “people with rs1052700 amino acid (AA) show less weight loss when eating late compared to TT carriers, where eating late does not influence weight loss at all (146).”

    From Meal timing and its role in obesity and associated diseases (2024) · cites this paper as [146]

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  1. Garaulet M, Smith CE, Gomez-Abellan P, Ordovas-Montanes M, Lee YC, Parnell LD, Arnett DK, Ordovas JM. REV-ERB-alpha circadian gene variant associates with obesity in two independent populations: Mediterranean and North American. Mol Nutr Food Res 2014;58:821-9.

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Authors
Garaulet, M., Vera, B., Bonnet-Rubio, G., Gómez-Abellán, P., Lee, Y.-C., & Ordovás, J. M.
Affiliations
  • Instituto Murciano de Investigación Biosanitaria (ES)
  • Tufts University (US)
Corresponding author
Garaulet, Marta
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
2016-10
Volume
104
Issue
4
Pages
1160-1166
ISSN
0002-9165 (ISSN-L)
OpenAlex
W2519322291
Cited by
53
References
48
Citations by year
2026: 2 · 2025: 6 · 2024: 7 · 2023: 9 · 2022: 7 · 2021: 5 · 2020: 8 · 2019: 5 · 2018: 2 · 2017: 2
FWCI
2.42
Type
journal article
Language
en
Open access
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Spanish Government of Economy and Competitiveness (SAF2014-52480-R)
  • European Regional Development Fund (SAF2014-52480-R)
  • USDA–Agricultural Research Service (58-1950-4-003)
  • Centro Nacional Investigaciones Cardiovasculares (CNIC)
  • Spanish Ministry of Economy and Competitiveness (MINECO)
  • Pro-CNIC Foundation
  • Severo Ochoa Center of Excellence (SEV-2015-0505)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Physical Performance
  • Health Sciences › Medicine › Physiology › Dietary Effects on Health
Keywords
PLIN1, gene-diet interaction, meal timing, weight loss response, obesity, adipose tissue lipolysis, circadian rhythm, nutrigenetics
MeSH terms
Perilipin-1, Adult, Alleles, Circadian Rhythm, Diet Surveys, Diet, Reducing, Eating, Feeding Behavior, Female, Genotype, Humans, Male, Middle Aged, Obesity, Program Evaluation, Weight Loss, Body Mass Index, Polymorphism, Single Nucleotide, Overweight, Nutrigenomics, Gene-Environment Interaction, Weight Reduction Programs, Lunch

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