Meal frequency patterns determine the phase of mouse peripheral circadian clocks
Open accessAbstract
Peripheral circadian clocks in mammals are strongly entrained by light-dark and eating cycles. Their physiological functions are maintained by the synchronization of the phase of organs via clock gene expression patterns. However, little is known about the adaptation of peripheral clocks to the timing of multiple daily meals. Here, we investigated the effect of irregular eating patterns, in terms of timing and volume, on their peripheral clocks in vivo. We found that the phase of the peripheral clocks was altered by the amount of food and the interval between feeding time points but was unaffected by the frequency of feeding, as long as the interval remained fixed. Moreover, our results suggest that a late dinner should be separated into 2 half-dinners in order to alleviate the effect of irregular phases of peripheral clocks.
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The liver clock is affected by the balance between food intake and starvation intervals.
“The liver clock is affected by the balance between food intake and starvation intervals [267,268,269].”
From Effects of diet, lifestyle, Chrononutrition and alternative dietary interventions on postprandial Glycemia and insulin resistance (2022) · cites this paper as [268]
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- Authors
- Kuroda, H., Tahara, Y., Saito, K., Ohnishi, N., Kubo, Y., Seo, Y., Otsuka, M., Fuse, Y., Ohura, Y., Hirao, A., & Shibata, S.
- Affiliations
- Waseda University (JP)
- Corresponding author
- Shibata, Shigenobu
- Venue
- Scientific Reports
- Published
- 2012-10-05
- Volume
- 2
- Issue
- 1
- Pages
- 711-711
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC3464454
- OpenAlex
- W1972334269
- Cited by
- 105
- References
- 36
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2023: 8 · 2022: 8 · 2021: 7 · 2020: 6 · 2019: 9 · 2018: 10 · 2017: 8 · 2016: 11 · 2015: 11 · 2014: 11 · 2013: 5 · 2012: 1
- FWCI
- 3.96
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Scientific Reports (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- Fuji Foundation for Protein Research
- Ministry of Education, Culture, Sports, Science and Technology
- Waseda University
- Japan Society for the Promotion of Science (23659126, 23300278)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- meal frequency, peripheral circadian clock, clock phase, irregular eating, feeding interval, clock gene expression, circadian entrainment, late dinner, meal timing
- MeSH terms
- Animals, Animal Feed, Animal Nutritional Physiological Phenomena, Circadian Rhythm, Eating, Feeding Behavior, Kidney, Light, Liver, Luciferases, Mice, Transgenic, Submandibular Gland, Time Factors, Gene Expression, Photoperiod, Genes, Reporter, Mice, Gene Knock-In Techniques, Period Circadian Proteins, Circadian Clocks
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