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CLOCK genetic variation and metabolic syndrome risk: modulation by monounsaturated fatty acids
Open accessAbstract
Background Disruption of the circadian system may be causal for manifestations of the metabolic syndrome (MetS).Objective The objective was to study the associations of 5 CLOCK polymorphisms with MetS features by analyzing fatty acid (FA) composition from dietary and red blood cell (RBC) membrane sources.Design Participants (n = 1100) in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study were included. Dietary intake was estimated with a validated questionnaire. Anthropometric and biochemical measurements and genotypes were determined. Postprandial lipids and the FA composition of RBC membranes were analyzed.Results CLOCK single nucleotide polymorphisms were significantly associated with obesity and individual components of MetS. For single nucleotide polymorphism rs4580704, minor allele carriers had a 46% lower risk of hypertension than did noncarriers. The monounsaturated fatty acid (MUFA) content of RBC membranes, particularly oleic acid, changed according to CLOCK genetic variants (P < 0.05). We identified significant gene-diet interactions associated with MetS at the CLOCK locus. By dichotomizing MUFA intake, we found different effects across rs4580704 genotypes for glucose (P = 0.020) and insulin resistance (P = 0.026). The protective effect of the minor allele on insulin sensitivity was only present when MUFA intake was >13.2% of energy. We also found different effects across CLOCK 3111T-->C genotypes for saturated fatty acid intake (% of energy) (P = 0.017). The deleterious effect of gene variants on waist circumference was only found with high saturated fatty acid intakes (>11.8%).Conclusions CLOCK polymorphisms interact with FAs to modulate MetS traits. The dietary source and membrane content of MUFAs are implicated in the relations between alterations in the circadian system and MetS.
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“However, when we investigated further the potential modulating effect of diet, we observed that the protective effect of the minor allele on insulin sensitivity was only present when MUFA intake was above the median (>13.2% of energy in this population).”
From Circadian rhythms, metabolism, and chrononutrition in rodents and humans (2016) · cites this paper as [53]
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“Finally, we also observed significant associations with markers of chronic inflammation (i.e., IL-6).”
From Circadian rhythms, metabolism, and chrononutrition in rodents and humans (2016) · cites this paper as [53]
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“Another finding came from the analysis of the MUFA content of red blood cell membranes, particularly oleic acid, which was significantly different according to CLOCK genetic variants.”
From Circadian rhythms, metabolism, and chrononutrition in rodents and humans (2016) · cites this paper as [53]
In the citing paper
“We investigated 5 selected CLOCK single-nucleotide polymorphisms (SNPs) (rs 4864548, rs4580704, rs1464490, rs1801260, and rs3749474), of which 3 (rs4580704, rs1801260, and rs3749474) yielded statistically significant associations with BMI (in kg/m 2 ), blood pressure, glycemic traits, and markers of dietary intake (red blood cell membrane fatty acids).”
From Circadian rhythms, metabolism, and chrononutrition in rodents and humans (2016) · cites this paper as [53]
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“Conversely, the detrimental effect of the minor allele at the rs1801260 SNP on waist circumference was only found with SFA intakes above the median (>11.8% of energy in GOLDN).”
From Circadian rhythms, metabolism, and chrononutrition in rodents and humans (2016) · cites this paper as [53]
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“One of these SNPs, rs4580704, appeared to be protective; minor allele carriers had a 46% lower risk of hypertension than did noncarriers.”
From Circadian rhythms, metabolism, and chrononutrition in rodents and humans (2016) · cites this paper as [53]
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Citations
Cites
Littell, R. C. (1996) · Medical Entomology and Zoology · Cited by 10,345
Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride–methanol
Morrison, W. R., & Smith, L. M. (1964) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40190-7 · Cited by 6,005
Gruber, A. R., Lorenz, R., Bernhart, S. H., Neuböck, R., & Hofacker, I. L. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn188 · Cited by 2,717
Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice
Turek, F. W., Joshu, C., Kohsaka, A., Lin, E., Ivanova, G., McDearmon, E., Laposky, A., Losee-Olson, S., Easton, A., Jensen, D. R., et al. (2005) · Science · doi:10.1126/science.1108750 · Cited by 2,485
Taheri, S., Lin, L., Austin, D., Young, T., & Mignot, E. (2004) · PLoS Medicine · doi:10.1371/journal.pmed.0010062 · Cited by 2,477
Efficiency and power in genetic association studies
de Bakker, P. I. W., Yelensky, R., Pe’er, I., Gabriel, S., Daly, M. J., & Altshuler, D. (2005) · Nature Genetics · doi:10.1038/ng1669 · Cited by 1,678
Subar, A. F., Thompson, F. E., Kipnis, V., Midthune, D., Hurwitz, P. E., McNutt, S., McIntosh, A., & Rosenfeld, S. (2001) · American Journal of Epidemiology · doi:10.1093/aje/154.12.1089 · Cited by 1,401
Allelic discrimination using fluorogenic probes and the 5' nuclease assay.
Livak, K. (1999) · Genetic Analysis, Techniques and Applications (GATA) · doi:10.1016/s1050-3862(98)00019-9 · Cited by 1,352
Relation of triglyceride metabolism and coronary artery disease. Studies in the postprandial state
Patsch, J. R., Miesenböck, G., Hopferwieser, T., Mühlberger, V, Knapp, E., Dunn, J. K., Gotto, A. M., & Patsch, W. (1992) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.12.11.1336 · Cited by 1,122
Rudic, R. D., McNamara, P., Curtis, A.-M., Boston, R. C., Panda, S., Hogenesch, J. B., & FitzGerald, G. A. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020377 · Cited by 1,059
Nuclear Receptor Expression Links the Circadian Clock to Metabolism
Yang, X., Downes, M., Yu, R. T., Bookout, A. L., He, W., Straume, M., Mangelsdorf, D. J., & Evans, R. M. (2006) · Cell · doi:10.1016/j.cell.2006.06.050 · Cited by 946
Allelic discrimination using fluorogenic probes and the 5' nuclease assay
Foitzi, T. (1999) · Medical Entomology and Zoology · Cited by 783
Harmonics of Circadian Gene Transcription in Mammals
Hughes, M. E., DiTacchio, L., Hayes, K. R., Vollmers, C., Pulivarthy, S. R., Baggs, J. E., Panda, S., & Hogenesch, J. B. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000442 · Cited by 689
Sleep Duration and Biomarkers of Inflammation
Patel, S. R., Zhu, X., Storfer-Isser, A., Mehra, R., Jenny, N. S., Tracy, R., & Redline, S. (2009) · Sleep · doi:10.1093/sleep/32.2.200 · Cited by 615
Dietary fats and membrane function: implications for metabolism and disease
Hulbert, A. J., Turner, N. A., Storlien, L. H., & Else, P. L. (2005) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1017/s1464793104006578 · Cited by 410
Canaple, L., Rambaud, J., Dkhissi‐Benyahya, O., Rayet, B., Tan, N. S., Michalik, L., Delaunay, F., Wahli, W., & Laudet, V. (2006) · Molecular Endocrinology · doi:10.1210/me.2006-0052 · Cited by 359
Association between polymorphisms in the Clock gene, obesity and the metabolic syndrome in man
SCOTT, E. M., Carter, A. M., & Grant, P. J. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803778 · Cited by 347
IL-6 and its circadian secretion in humans
Vgontzas, A. N., Bixler, E. O., Lin, H.-M., Prolo, P., Trakada, G., & Chrousos, G. P. (2005) · Neuroimmunomodulation · doi:10.1159/000084844 · Cited by 338
A Daily Rhythm in Glucose Tolerance
la Fleur, S. E., Kalsbeek, A., Wortel, J., Fekkes, M. L., & Buijs, R. M. (2001) · Diabetes · doi:10.2337/diabetes.50.6.1237 · Cited by 337
Biochemical regulation of non-rapid-eye-movement sleep
Krueger, J. M. (2003) · Frontiers in Bioscience · doi:10.2741/1033 · Cited by 329
Lemberger, T., Saladin, R., Vázquez‐Carrera, M., Assimacopoulos, F., Staels, B., Desvergne, B., Wahli, W., & Auwerx, J. H. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.3.1764 · Cited by 326
The relationship between nutrition and circadian rhythms in mammals
Froy, O. (2007) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2007.03.001 · Cited by 295
Thompson, F. E., Subar, A. F., Brown, C., Smith, A. F., Sharbaugh, C., Jobe, J. B., Mittl, B., Gibson, J. T., & Ziegler, R. G. (2002) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(02)90050-7 · Cited by 282
Reed, C. F., Swisher, S. N., Marinetti, G. V., & Enen, E. G. (1960) · PubMed · Cited by 281
NHLBI Family Heart Study: Objectives and Design
HIGGINS, M. W., Province, M. A., HEISS, G. M., Eckfeldt, J. H., Ellison, R. C., Folsom, A. R., Rao, D. C., Sprafka, J. M., & Williams, R. (1996) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a008709 · Cited by 269
Sookoian, S. C., Gemma, C., Gianotti, T. F., Burgueño, A. L., Castaño, G. O., & Pirola, C. J. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.6.1606 · Cited by 262
Differential Rescue of Light- and Food-Entrainable Circadian Rhythms
Fuller, P. M., Lü, J., & Saper, C. B. (2008) · Science · doi:10.1126/science.1153277 · Cited by 260
Warensjö, E., Öhrvall, M., & Vessby, B. O. (2005) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2005.06.001 · Cited by 260
A sense of time: how molecular clocks organize metabolism
Kohsaka, A., & Bass, J. T. (2006) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2006.11.005 · Cited by 233
High-fat feeding alters the clock synchronization to light
Mendoza, J., Pévet, P., & Challet, E. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.159566 · Cited by 213
Garaulet, M., Pérez‐Llamas, F., Perez‐Ayala, M., Martı́nez, P., de Medina, F. S., Tébar, F. J., & Zamora, S. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/74.5.585 · Cited by 211
Self-citationMarinescu, V. D., Kohane, I. S., & Riva, A. (2005) · BMC Bioinformatics · doi:10.1186/1471-2105-6-79 · Cited by 194
Lai, C.-Q., Demissie, S., Cupples, L. A., Zhu, Y., Adiconis, X., Parnell, L. D., Corella, D., & Ordovas, J. M. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m400192-jlr200 · Cited by 163
Self-citationClock genes are implicated in the human metabolic syndrome
Gómez-Abellán, P., Morante, J. J. H., Luján, J., Madrid, J. A., & Garaulet, M. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803689 · Cited by 161
Self-citationChronobiology, genetics and metabolic syndrome
Garaulet, M., & Madrid, J. A. (2009) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3283292399 · Cited by 157
Self-citationMutation screening of the human Clock gene in circadian rhythm sleep disorders
Iwase, T., Kajimura, N., Uchiyama, M., Ebisawa, T., Yoshimura, K., Kamei, Y., Shibui, K., Kim, K., Kudo, Y., Katoh, M., et al. (2002) · Psychiatry Research · doi:10.1016/s0165-1781(02)00006-9 · Cited by 149
Sickness behavior, its mechanisms and significance
Tizard, I. R. (2008) · Animal Health Research Reviews · doi:10.1017/s1466252308001448 · Cited by 141
Barnea, M., Madar, Z., & Froy, O. (2009) · Endocrinology · doi:10.1210/en.2008-0944 · Cited by 138
Young, M. E., & Bray, M. S. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2006.12.010 · Cited by 129
Corella, D., Arnett, D. K., Tsai, M. Y., Kabagambe, E. K., Peacock, J. M., Hixson, J. E., Straka, R. J., Province, M. A., Lai, C., Parnell, L. D., et al. (2007) · Clinical Chemistry · doi:10.1373/clinchem.2006.084863 · Cited by 121
Self-citationPrather, A. A., Marsland, A. L., Hall, M., Neumann, S. A., Muldoon, M. F., & Manuck, S. B. (2009) · Biological Psychology · doi:10.1016/j.biopsycho.2009.04.008 · Cited by 106
Lavialle, M., Champeil‐Potokar, G., Alessandri, J. M. J. M., Balasse, L., Guesnet, P., Papillon, C., Pévet, P., Vancassel, S., VIVIEN‐ROELS, B., & Denis, I. (2008) · Journal of Nutrition · doi:10.1093/jn/138.9.1719 · Cited by 99
Effect of influenza vaccine on markers of inflammation and lipid profile
Tsai, M. Y., Hanson, N. Q., Straka, R. J., Hoke, T. R., Ordovas, J. M., Peacock, J. M., Arends, V. L., & Arnett, D. K. (2005) · Journal of Laboratory and Clinical Medicine · doi:10.1016/j.lab.2005.03.009 · Cited by 93
Self-citationPoppitt, S. D., Kilmartin, P. A., Butler, P. A. G., & Keogh, G. F. (2005) · Lipids in Health and Disease · doi:10.1186/1476-511x-4-30 · Cited by 93
Adiponectin, the controversial hormone
Garaulet, M., Morante, J. J. H., de Heredia, F. P., & Tébar, F. J. (2007) · Public Health Nutrition · doi:10.1017/s1368980007000638 · Cited by 91
Self-citationSleep and energy balance: interactive homeostatic systems
VanItallie, T. B. (2006) · Metabolism · doi:10.1016/j.metabol.2006.07.010 · Cited by 89
Sleep–wake behavior and responses of interleukin-6-deficient mice to sleep deprivation
Morrow, J. D., & Opp, M. R. (2004) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2004.02.003 · Cited by 85
Monteleone, P., Tortorella, A. A. V., Docimo, L., Maldonato, M. N., Canestrelli, B., Luca, L. D., & Maj, M. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.02.003 · Cited by 77
Shen, J., Arnett, D. K., Peacock, J. M., Parnell, L. D., Kraja, A. T., Hixson, J. E., Tsai, M. Y., Lai, C., Kabagambe, E. K., Straka, R. J., et al. (2007) · Journal of Nutrition · doi:10.1093/jn/137.8.1846 · Cited by 69
Self-citationBakan, E., Yıldırım, A., Kurtul, N., Polat, M., Dursun, H., & Cayir, K. (2006) · Acta Diabetologica · doi:10.1007/s00592-007-0224-4 · Cited by 63
Kabagambe, E. K., Tsai, M. Y., Hopkins, P. N., Ordovás, J. M., Peacock, J. M., Borecki, I. B., & Arnett, D. K. (2007) · Clinical Chemistry · doi:10.1373/clinchem.2007.095059 · Cited by 63
Self-citationCircadian variation of postprandial lipemia
Romon, M., Fur, C. L., Lebel, P., Edmé, J.-L., Fruchart, J., & Dallongeville, J. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/65.4.934 · Cited by 63
Pérez‐Martínez, P., Ordovás, J. M., López‐Miranda, J., Gómez, P., Marı́n, C., Moreno, J. A., Fuentes, F. J., de la Puebla, R. Á. F., & Pérez‐Jiménez, F. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.4.809 · Cited by 58
Prediabetes is associated with abnormal circadian blood pressure variability
Gupta, A., Greenway, F. L., Cornélissen, G., Pan, W., & Franz Halberg, A. (2008) · Journal of Human Hypertension · doi:10.1038/jhh.2008.32 · Cited by 50
Nakamura, K.-I., Inoue, I., Takahashi, S., Komoda, T., & Katayama, S. (2008) · PPAR Research · doi:10.1155/2008/348610 · Cited by 33
Food entrainment of circadian gene expression altered in PPARα−/− brown fat and heart
Goh, B. C. K., Wu, X., Evans, A. E., Johnson, M. L., Hill, M., & Gimble, J. M. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.06.136 · Cited by 27
Hamada, T., Murata, T., Narita, K., Takahashi, T., Wada, Y., Kimura, H., & Yoshida, H. (2008) · Blood Pressure · doi:10.1080/08037050802162839 · Cited by 16
N‐6 From Different Sources Protect From Metabolic Alterations to Obese Patients: A Factor Analysis
Morante, J. J. H., Larqué, E., Luján, J., Zamora, S., & Garaulet, M. (2008) · Obesity · doi:10.1038/oby.2008.466 · Cited by 15
Self-citationAdiposity and dietary intake in cardiovascular risk in an obese population from a Mediterranean area
Garaulet, M., Marín, C. R., Pérez‐Llamas, F., Canteras, M., Tébar, F. J., & Zamora, S. (2004) · Journal of Physiology and Biochemistry · doi:10.1007/bf03168219 · Cited by 15
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Metadata
- Authors
- Garaulet, M., Lee, Y.-C., Shen, J., Parnell, L. D., Arnett, D. K., Tsai, M. Y., Lai, C.-Q., & Ordovas, J. M.
- Affiliations
- Tufts University (US)
- Corresponding author
- Garaulet, Marta
- ORCID
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2009-12
- Volume
- 90
- Issue
- 6
- Pages
- 1466-1475
- ISSN
- 0002-9165 (ISSN-L)
- PMC
- PMC2777463
- OpenAlex
- W2119294761
- Cited by
- 172
- References
- 59
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 9 · 2023: 15 · 2022: 8 · 2021: 6 · 2020: 12 · 2019: 3 · 2018: 5 · 2017: 9 · 2016: 15 · 2015: 14 · 2014: 16 · 2013: 16 · 2012: 12
- FWCI
- 6.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Seneca Foundation (02934/PI/05)
- NIH (1R21AR055228-01A1, U01 HL72524, HL54776, DK075030)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- clock genes, circadian rhythm, metabolic syndrome, monounsaturated fatty acids, oleic acid, red blood cell membrane fatty acids, dietary fatty acid intake, saturated fatty acids, insulin resistance, hypertension, obesity, gene-diet interaction
- MeSH terms
- Adult, Aged, Erythrocyte Membrane, Fatty Acids, Monounsaturated, Female, Genotype, Haplotypes, Humans, Insulin Resistance, Male, Middle Aged, Risk, Body Mass Index, Polymorphism, Single Nucleotide, Metabolic Syndrome, CLOCK Proteins
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