Menopausal hot flashes: a review of physiology and biosociocultural perspective on methods of assessment
Open accessAbstract
Hot flashes continue to be a troublesome problem for menopausal women the world over. After >50 y of research, we still do not understand the etiology and mechanism of hot flashes, nor do we know how estrogen, the major pharmaceutical treatment, works to reduce hot flashes. We are gaining insight into sociocultural complexities that may affect how and whether women report hot flashes. And we are becoming more sophisticated in our research tools (be it questionnaires, physiological monitors, or brain imaging techniques). New aspects of hot flash research, including neuroimaging and the study of genetic polymorphisms, when combined with increasingly nuanced ways of asking questions of culturally distinct populations, provide challenges but rich complexity from which a better understanding will emerge.
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The etiology of hot flushes remains unknown.
“Despite affecting millions of individuals, the etiology of hot flushes remains unknown.”
From Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: A novel hypothesis on the mechanism of hot flushes (2013) · cites this paper as Kronenberg, 2010
It is not the absolute level of estrogens, but the rate of estrogen withdrawal that determines the onset of flushes.
“It is not the absolute level of estrogens, but the rate of estrogen withdrawal that determines the onset of flushes (Kronenberg, 2010; Santoro, 2008).”
From Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: A novel hypothesis on the mechanism of hot flushes (2013) · cites this paper as Kronenberg, 2010
Hot flushes are characterized by a transient and intense sensation of heat accompanied by activation of heat-loss effectors including skin vasodilatation, sweating, and cold-seeking behavior.
“Hot flushes are characterized by a transient and intense sensation of heat accompanied by the activation of heat-loss effectors including skin vasodilatation, sweating, and cold-seeking behavior (Fig. 3) (Freedman, 2001; Kronenberg, 2010).”
From Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: A novel hypothesis on the mechanism of hot flushes (2013) · cites this paper as Kronenberg, 2010
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Flagged first, then by citations
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Cited by
Sorted by citations
Rance, N. E., Dacks, P. A., Mittelman-Smith, M. A., Romanovsky, A. A., & Krajewski-Hall, S. J. (2013) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.07.003 · Cited by 380 · see citing works
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- Authors
- Kronenberg, F.
- Affiliations
- Michelle R. Clayman Institute for Gender Research (US)
- Corresponding author
- Kronenberg, Fredi
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 140
- Issue
- 7
- Pages
- 1380S-1385S
- ISSN
- 0022-3166 (ISSN-L)
- OpenAlex
- W2155545706
- Cited by
- 73
- References
- 36
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 6 · 2023: 6 · 2022: 3 · 2021: 7 · 2020: 1 · 2019: 3 · 2018: 6 · 2017: 10 · 2016: 3 · 2015: 7 · 2014: 3 · 2013: 4 · 2012: 4
- FWCI
- 3.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Keywords
- menopausal hot flashes, estrogen therapy, genetic polymorphism, menopause
- MeSH terms
- Female, Humans, Menopause, Middle Aged, Hot Flashes
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