A Higher Adherence to a Mediterranean-Style Diet Is Inversely Associated with the Development of Frailty in Community-Dwelling Elderly Men and Women,
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Adherence to a Mediterranean-style diet is associated with a lower risk for mortality, cognitive decline, and dementia. Whether adherence to a Mediterranean-style diet protects against age-related frailty is unclear. Therefore, our objective was to examine the association between a Mediterranean-style diet with the risk of frailty in community-dwelling older persons. We conducted longitudinal analyses using data from 690 community-living persons (≥65 y) who were randomly selected from a population registry in Tuscany, Italy. Participants of the Invecchiare in Chianti study of aging completed the baseline examination in 1998-2000 and were re-examined at least once over 6 y. Adherence to a Mediterranean-style diet (scored 0-9, modeled categorically as ≤3, 4-5, and ≥6) was computed from the European Prospective Investigation into Cancer and nutrition FFQ previously validated in this cohort. Frailty was defined as having at least 2 of the following criteria: poor muscle strength, feeling of exhaustion, low walking speed, and low physical activity. After a 6-y follow-up, higher adherence (score ≥6) to a Mediterranean-style diet was associated with lower odds of developing frailty [OR = 0.30 (95% CI: 0.14, 0.66)] compared with those with lower adherence (score ≤3). A higher adherence to a Mediterranean-style diet at baseline was also associated with a lower risk of low physical activity (OR = 0.62; 95% CI: 0.40, 0.96) and low walking speed [OR = 0.48 (95% CI: 0.27, 0.86)] but not with feelings of exhaustion and poor muscle strength. In community-dwelling older adults, higher adherence to a Mediterranean-style diet was inversely associated with the development of frailty.
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Adherence to the Mediterranean diet is the only behavioural factor consistently associated with a lower risk of frailty.
“adherence to the Mediterranean diet was the only behavioural factor consistently associated with a lower risk of frailty”
From Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty (2018) · cites this paper as [248]
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- Authors
- Talegawkar, S. A., Bandinelli, S., Bandeen-Roche, K., Chen, P., Milaneschi, Y., Tanaka, T., Semba, R. D., Guralnik, J. M., & Ferrucci, L.
- Affiliations
- Johns Hopkins University (US)
- Azienda Sanitaria di Firenze (IT)
- National Institute on Aging (US)
- University of Maryland, Baltimore (US)
- Corresponding author
- Talegawkar, Sameera A.
- ORCID
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2012-12
- Volume
- 142
- Issue
- 12
- Pages
- 2161-2166
- ISSN
- 0022-3166 (ISSN-L)
- PMC
- PMC3497964
- OpenAlex
- W2139664878
- Cited by
- 265
- References
- 44
- Citations by year
- 2026: 11 · 2025: 10 · 2024: 6 · 2023: 22 · 2022: 19 · 2021: 34 · 2020: 17 · 2019: 26 · 2018: 33 · 2017: 31 · 2016: 20 · 2015: 16 · 2014: 11 · 2013: 8 · 2012: 1
- FWCI
- 11.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- VU Research Portal (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Johns Hopkins University (P30AG021334)
- Ministero della Salute (N01-AG-5-0002, N.1-AG-1-2111, ICS 110.1/RF97.71, 263 MD 821336, 263 MD 9164, N.1-AG-1-1, R01 AG027012)
- National Institutes of Health (263MD9164, N.1-AG-1-2111, N.1-AG-1-1, N01-AG-5-0002, 263 MD 821336, AG027012)
- National Institute on Aging (N.1‐AG‐1‐2111, 263 MD 9164, 821336, ICS 110.1/RF97.71, N.1-AG-1-1, 263MD821336, 1-AG-1-2111, R01AG027012, AG027012, P30AG021334, N01 AG-5-0002)
- National Institute on Minority Health and Health Disparities (263MD9164, 263MD 821336)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- Mediterranean diet, dietary adherence, frailty, community-dwelling older adults, physical inactivity, muscle strength, exhaustion, aging
- MeSH terms
- Aged, Aged, 80 and over, Female, Humans, Longitudinal Studies, Male, Walking, Frail Elderly, Diet, Mediterranean, Muscle Strength
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