Cited by 222Muscle metabolism and nutritionNutrition and Health in AgingMuscle Physiology and Disorders

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Ingestion of Wheat Protein Increases In Vivo Muscle Protein Synthesis Rates in Healthy Older Men in a Randomized Trial

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Gorissen, Stefan HM, Horstman, Astrid MH, Franssen, Rinske, Crombag, Julie JR, Langer, Henning, Bierau, Jörgen, Respondek, Frederique, van Loon, Luc JC·2016·The Journal of Nutrition

DOI 10.3945/jn.116.231340

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Abstract

Background Muscle mass maintenance is largely regulated by basal muscle protein synthesis and the capacity to stimulate muscle protein synthesis after food intake. The postprandial muscle protein synthetic response is modulated by the amount, source, and type of protein consumed. It has been suggested that plant-based proteins are less potent in stimulating postprandial muscle protein synthesis than animal-derived proteins. However, few data support this contention.Objective We aimed to assess postprandial plasma amino acid concentrations and muscle protein synthesis rates after the ingestion of a substantial 35-g bolus of wheat protein hydrolysate compared with casein and whey protein.Methods Sixty healthy older men [mean ± SEM age: 71 ± 1 y; body mass index (in kg/m(2)): 25.3 ± 0.3] received a primed continuous infusion of l-[ring-(13)C6]-phenylalanine and ingested 35 g wheat protein (n = 12), 35 g wheat protein hydrolysate (WPH-35; n = 12), 35 g micellar casein (MCas-35; n = 12), 35 g whey protein (Whey-35; n = 12), or 60 g wheat protein hydrolysate (WPH-60; n = 12). Plasma and muscle samples were collected at regular intervals.Results The postprandial increase in plasma essential amino acid concentrations was greater after ingesting Whey-35 (2.23 ± 0.07 mM) than after MCas-35 (1.53 ± 0.08 mM) and WPH-35 (1.50 ± 0.04 mM) (P < 0.01). Myofibrillar protein synthesis rates increased after ingesting MCas-35 (P < 0.01) and were higher after ingesting MCas-35 (0.050% ± 0.005%/h) than after WPH-35 (0.032% ± 0.004%/h) (P = 0.03). The postprandial increase in plasma leucine concentrations was greater after ingesting Whey-35 than after WPH-60 (peak value: 580 ± 18 compared with 378 ± 10 μM, respectively; P < 0.01), despite similar leucine contents (4.4 g leucine). Nevertheless, the ingestion of WPH-60 increased myofibrillar protein synthesis rates above basal rates (0.049% ± 0.007%/h; P = 0.02).Conclusions The myofibrillar protein synthetic response to the ingestion of 35 g casein is greater than after an equal amount of wheat protein. Ingesting a larger amount of wheat protein (i.e., 60 g) substantially increases myofibrillar protein synthesis rates in healthy older men. This trial was registered at clinicaltrials.gov as NCT01952639.

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Authors: Gorissen, S. H., Horstman, A. M., Franssen, R., Crombag, J. J., Langer, H., Bierau, J., Respondek, F., & van Loon, L. J.
Affiliations: Maastricht University Medical Centre (NL)
ORCID: Gorissen, Stefan HM
Horstman, Astrid MH
Langer, Henning
Bierau, Jörgen
Respondek, Frederique
Venue: The Journal of Nutrition
Publisher: Elsevier BV
Published: 2016-09
Volume: 146
Issue: 9
Pages: 1651-1659
ISSN: 0022-3166 (ISSN-L)
DOI: 10.3945/jn.116.231340
OpenAlex: W2495419802
Cited by: 221
References: 38
Citations by year: 2026: 27 · 2025: 22 · 2024: 26 · 2023: 27 · 2022: 26 · 2021: 26 · 2020: 29 · 2019: 13 · 2018: 17 · 2017: 6 · 2016: 1
FWCI: 8.49
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2342 d)
Locations: Journal of Nutrition (publishedVersion)
PubMed (publishedVersion)
Research Publications (Maastricht University) (publishedVersion, other-oa)
Research Bank (Australian Catholic University) (submittedVersion)
Research Publications (Maastricht University) (submittedVersion, other-oa)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords: muscle protein synthesis, older men, plant proteins, whey protein, casein, leucine, myofibrillar protein synthesis, muscle mass preservation, plasma amino acids, sarcopenia prevention
MeSH terms: Whey Proteins, Aged, Aged, 80 and over, Amino Acids, Essential, Blood Glucose, Blood Pressure, Body Weight, Caseins, Diet, Double-Blind Method, Humans, Leucine, Male, Muscle Proteins, Myofibrils, Phenylalanine, Plant Proteins, Protein Hydrolysates, Protein Biosynthesis, Triticum, Exercise, Body Mass Index, Muscle, Skeletal, Postprandial Period

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Ingestion of Wheat Protein Increases In Vivo Muscle Protein Synthesis Rates in Healthy Older Men in a Randomized Trial

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