Curcuminoids enhance memory in an amyloid-infused rat model of Alzheimer’s disease
Abstract
Alzheimer's disease (AD) is a neurodegenerative disease. There are a limited number of therapeutic options available for the treatment of AD. Curcuminoids (a mixture of bisdemethoxycurcumin, demethoxycurcumin and curcumin) is the main chemical constituent found in turmeric, a well known curry spice, having potential in the treatment of AD. The objective of this study was to investigate the effects of curcuminoid mixture and individual constituents on spatial learning and memory in an amyloid-beta (Abeta) peptide-infused rat model of AD and on the expression of PSD-95, synaptophysin and camkIV. Curcuminoid mixture showed a memory-enhancing effect in rats displaying AD-like neuronal loss only at 30 mg/kg, whereas individual components were effective at 3-30 mg/kg. A shorter duration treatment with test compounds showed that the curcuminoid mixture and bisdemethoxycurcumin increased PSD-95 expression in the hippocampus at 3-30 mg/kg, with maximum effect at a lower dose (3 mg/kg) with respective values of 470.5 and 587.9%. However, after a longer duration treatment, two other compounds (demethoxycurcumin and curcumin) also increased PSD-95 to 331.7 and 226.2% respectively at 30 mg/kg. When studied for their effect on synaptophysin in the hippocampus after the longer duration treatment, the curcuminoid mixture and all three individual constituents increased synaptophysin expression. Of these, demethoxycurcumin was the most effective showing a 350.1% increase (P<0.01) at 30 mg/kg compared to the neurotoxin group. When studied for their effect on camkIV expression after longer treatment in the hippocampus, only demethoxycurcumin at 30 mg/kg increased levels to 421.2%. These compounds salvaged PSD-95, synaptophysin and camkIV expression levels in the hippocampus in the rat AD model, which suggests multiple target sites with the potential of curcuminoids in spatial memory enhancing and disease modifying in AD.
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A curcuminoids mixture treatment improved memory function in amyloid fragment induced Alzheimer's disease-like conditions in rats.
“Additionally, Ahmed and colleagues also reported that a curcuminoids mixture (bisdemethoxycurcumin, demethoxycurcumin and curcumin) treatment improved memory function in amyloid fragment induced AD-like conditions in rats [129].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [129]
Cites
1 retracted
Li, Y., Qin, H., Chen, Q.-S., et al. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.05.039 · Cited by 21 · see citing works
RetractedThe rat brain in stereotaxic coordinates
Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,959 · see citing works
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
Guide for the Care and Use of Laboratory Animals: Eighth Edition
(2011) · doi:10.17226/12910 · Cited by 16,199 · see citing works
Alzheimer's Disease: Genes, Proteins, and Therapy
Selkoe, D. J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.741 · Cited by 6,063 · see citing works
Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397 · see citing works
Blennow, K., de Leon, M. J., & Zetterberg, H. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69113-7 · Cited by 3,134 · see citing works
Yang, F., Lim, G. P., Begum, A. N., Ubeda, O. J., Simmons, M. R., Ambegaokar, S. S., Chen, P. P., Kayed, R., Glabe, C. G., Frautschy, S. A., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m404751200 · Cited by 2,336 · see citing works
Cheng, A., Hsu, C., Lin, J., Hsu, M. M., Ho, Y., Shen, T. S., Ko, J. Y., Lin, J.-T., Lin, B., Ming-Shiang, W., et al. (2001) · PubMed · Cited by 2,071 · see citing works
Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers
Guido, S., Joy, D. C., Joseph, T., Majeed, M. A., Rajendran, R., & Srinivas, P. (1998) · Planta Medica · doi:10.1055/s-2006-957450 · Cited by 1,976 · see citing works
Lim, G. P., Chu, T., Yang, F., Beech, W., Frautschy, S. A., & Cole, G. M. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-21-08370.2001 · Cited by 1,530 · see citing works
Dose escalation of a curcuminoid formulation
Lao, C. D., Ruffin, M. T., Normolle, D. P., Heath, D. D., Murray, S. I., Bailey, J. M., Boggs, M. E., Crowell, J. A., Rock, C. L., & Brenner, D. E. (2006) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-6-10 · Cited by 1,400 · see citing works
Curcumin has potent anti‐amyloidogenic effects for Alzheimer's β‐amyloid fibrils in vitro
Ono, K., Hasegawa, K., Naiki, H., & Yamada, M. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20025 · Cited by 1,254 · see citing works
Migaud, M., Charlesworth, P., Dempster, M., Webster, L. C., Watabe, A. M., Makhinson, M., He, Y., Ramsay, M. F., Morris, R. G. M., Morrison, J. H., et al. (1998) · Nature · doi:10.1038/24790 · Cited by 1,160 · see citing works
Aggarwal, B. B., & Sung, B. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.11.002 · Cited by 1,140 · see citing works
Kim, E., Niethammer, M., Rothschild, A., Jan, Y. N., & Sheng, M. (1995) · Nature · doi:10.1038/378085a0 · Cited by 999 · see citing works
A Placebo-Controlled, Double-blind, Randomized Trial of an Extract of Ginkgo Biloba for Dementia
Le Bars, P. L. (1997) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1997.03550160047037 · Cited by 966 · see citing works
Molecular Understanding and Modern Application of Traditional Medicines: Triumphs and Trials
Corson, T. W., & Crews, C. M. (2007) · Cell · doi:10.1016/j.cell.2007.08.021 · Cited by 656 · see citing works
Gilani, A. H., & Rahman, A. (2005) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2005.06.001 · Cited by 595 · see citing works
Self-citationSZE, C.-I., TRONCOSO, J. C., KAWAS, C., MOUTION, P., PRICE, D. L., & MARTIN, L. J. (1997) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199708000-00011 · Cited by 562 · see citing works
Kim, E., Cho, K.-O., Rothschild, A., & Sheng, M. (1996) · Neuron · doi:10.1016/s0896-6273(00)80284-6 · Cited by 558 · see citing works
Neuroprotective effects of curcumin
Cole, G. M., Teter, B., & Frautschy, S. A. (2007) · ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY · doi:10.1007/978-0-387-46401-5_8 · Cited by 516 · see citing works
Curcuminoids as Potent Inhibitors of Lipid Peroxidation
Sreejayan, & Rao, M. (1994) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1994.tb03258.x · Cited by 461 · see citing works
Revisiting the ancient concept of botanical therapeutics
Schmidt, B. M., Ribnicky, D., Lipsky, P. E., et al. (2007) · Nature Chemical Biology · doi:10.1038/nchembio0707-360 · Cited by 355 · see citing works
Akhondzadeh, S., Noroozıan, M., Mohammadi, M., Ohadinia, S., Jamshidi, A. H., & Khani, M. (2003) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1046/j.1365-2710.2003.00463.x · Cited by 345 · see citing works
Synaptophysin regulates activity-dependent synapse formation in cultured hippocampal neurons
Tarsa, L., & Goda, Y. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.022575999 · Cited by 337 · see citing works
Ahmed, T., & Gilani, A.-H. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.09.010 · Cited by 301 · see citing works
Self-citationEffects of Naturally Occurring Compounds on Fibril Formation and Oxidative Stress of β-Amyloid
Kim, H., Park, B., Lee, K., Choi, C. Y., Jang, S. S., Kim, Y., & Lee, S. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf051985c · Cited by 297 · see citing works
Kang, H., Sun, L. D., Atkins, C. M., Soderling, T. R., Wilson, M. A., & Tonegawa, S. (2001) · Cell · doi:10.1016/s0092-8674(01)00497-4 · Cited by 285 · see citing works
Kim, D. S. H. L., Park, S., & Kim, J.-Y. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01677-9 · Cited by 262 · see citing works
Roncarati, R., Šestan, N., Scheinfeld, M. H., Berechid, B. E., Lopez, P., Meucci, O., McGlade, J. C., RAKIC, P. T., & D'adamio, L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.102192599 · Cited by 196 · see citing works
Curcuminoids enhance amyloid-β uptake by macrophages of Alzheimer's disease patients
Zhang, L., Fiala, M., Cashman, J. R., Sayre, J. W., Monteros, A. E. D. L., Mahanian, M., Zaghi, J., Badmaev, V., Graves, M. C., Bernard, G. W., et al. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-10101 · Cited by 183 · see citing works
Nimmrich, V., & Ebert, U. (2009) · Reviews in the Neurosciences · doi:10.1515/revneuro.2009.20.1.1 · Cited by 138 · see citing works
Withanolides, a new class of natural cholinesterase inhibitors with calcium antagonistic properties
Choudhary, M. I., Nawaz, S. A., Ul‐Haq, Z., Lodhi, M. A., Ghayur, M. N., Jalil, S., Riaz, N., Sammer Yousuf, B., Malik, A. M., Gilani, A. H., et al. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.06.086 · Cited by 121 · see citing works
Self-citationExposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: Blockage by curcumin
Lin, R., Chen, X., Li, W., Han, Y., Liu, P., & Pi, R. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.05.070 · Cited by 114 · see citing works
Shin, R., Ogino, K., Kondo, A., Saido, T. C., Trojanowski, J. Q., Kitamoto, T., & Tateishi, J. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-21-08187.1997 · Cited by 96 · see citing works
Dohare, P., Garg, P., Jain, V., Nath, C., & Ray, M. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.06.012 · Cited by 89 · see citing works
Co-injection of β-amyloid with ibotenic acid induces synergistic loss of rat hippocampal neurons
Morimoto, K., Yoshimi, K., Tonohiro, T., Yamada, N., Oda, T., & Kaneko, I. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00507-1 · Cited by 75 · see citing works
Hu, Y., Xia, Z., Sun, Q., Orsi, A., & Rees, D. D. (2005) · Brain Research · doi:10.1016/j.brainres.2005.08.019 · Cited by 74 · see citing works
Zhang, L. J., Wu, C. F., Meng, X. L., Yuan, D., Cai, X. D., Wang, Q. L., & Yang, J. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.09.067 · Cited by 69 · see citing works
Nakamura, S., Murayama, N., Noshita, T., Katsuragi, R., & Ohno, T. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.07.049 · Cited by 57 · see citing works
Curcumin enhances non-inflammatory phagocytic activity of RAW264.7 cells
Bisht, K., Choi, W. H., Park, S. Y., Chung, M. K., & Koh, W. S. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.12.135 · Cited by 46 · see citing works
Wu, L., Zhang, X., Fukushima, H., Zhang, F.-X., Wang, H., Toyoda, H., Li, B., Kida, S., & Zhuo, M. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06183.x · Cited by 41 · see citing works
Li, Y., Qin, H., CHEN, Q.-S., et al. (2004) · International Journal of Neuroscience · doi:10.1080/00207450490509159 · Cited by 13 · see citing works
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Tiwari, S. K., Agarwal, S., Seth, B., Yadav, A., Nair, S., Bhatnagar, P., Karmakar, M., Kumari, M., Chauhan, L. K. S., Patel, D. K., et al. (2014) · ACS Nano · doi:10.1021/nn405077y · Cited by 558 · see citing works
Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer’s Disease
Reddy, P. H., Manczak, M., Yin, X., Grady, M. C., Mitchell, A., Tonk, S., Kuruva, C. S., Bhatti, J. S., Kandimalla, R., Vijayan, M., et al. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170512 · Cited by 354 · see citing works
Voulgaropoulou, S. D., van Amelsvoort, T. A. M. J., Prickaerts, J., & Vingerhoets, C. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146476 · Cited by 243 · see citing works
Ali, T., Yoon, G. H., Shah, S. A., Lee, H. Y., & Kim, M. O. (2015) · Scientific Reports · doi:10.1038/srep11708 · Cited by 146 · see citing works
Bassani, T. B., Turnes, J. M., Moura, E. L. R., Bonato, J. M., Cóppola-Segovia, V., Zanata, S. M., Oliveira, R. M. M. W., & Vital, M. A. B. F. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.08.014 · Cited by 134 · see citing works
Mehla, J., Gupta, P., Pahuja, M., Diwan, D., & Diksha, D. (2020) · Brain Sciences · doi:10.3390/brainsci10120964 · Cited by 108 · see citing works
Amato, A., Terzo, S., & Mulè, F. (2019) · Antioxidants · doi:10.3390/antiox8120608 · Cited by 107 · see citing works
Go, M. J., Kim, J. M., Kang, J. Y., Park, S. K., Lee, C. J., Kim, M. J., Lee, H. R., Kim, T. Y., Joo, S. G., Kim, D.-O., et al. (2022) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2207.07015 · Cited by 9 · see citing works
- Authors
- Ahmed, T., Enam, S. A., & Gilani, A. H.
- Affiliations
- Aga Khan University (PK)
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2010-09
- Volume
- 169
- Issue
- 3
- Pages
- 1296-1306
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2028832776
- Cited by
- 156
- References
- 44
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 7 · 2023: 8 · 2022: 8 · 2021: 13 · 2020: 14 · 2019: 15 · 2018: 12 · 2017: 10 · 2016: 13 · 2015: 10 · 2014: 9 · 2013: 10 · 2012: 12
- FWCI
- 4.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- eCommons - AKU (Aga Khan University) (submittedVersion)
- Funders
- Aga Khan University Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- curcuminoids, Alzheimer's disease, amyloid-beta, spatial memory, spatial learning, bisdemethoxycurcumin, demethoxycurcumin, curcumin, PSD-95, synaptophysin, CaMKIV, hippocampus, neuroprotection, rat model
- MeSH terms
- Disks Large Homolog 4 Protein, Alzheimer Disease, Animals, Cell Count, Curcumin, Hippocampus, Male, Membrane Proteins, Memory, Neuronal Plasticity, Neurons, Peptide Fragments, Time Factors, Amyloid beta-Peptides, Synaptophysin, Rats, Sprague-Dawley, Gene Expression Profiling, Diarylheptanoids, Intracellular Signaling Peptides and Proteins, Rats, Calcium-Calmodulin-Dependent Protein Kinase Type 4
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