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Cited by 512

The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.

Diagnosis and Treatment of Extrapulmonary Tuberculosis

Open access
Lee, Ji Yeon·2015·Tuberculosis and Respiratory Diseases
DOI 10.4046/trd.2015.78.2.47
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Abstract

Extrapulmonary tuberculosis (EPTB) constitutes about 20% of all cases of tuberculosis (TB) in Korea. Diagnosing EPTB remains challenging because clinical samples obtained from relatively inaccessible sites may be paucibacillary, thus decreasing the sensitivity of diagnostic tests. Whenever practical, every effort should be made to obtain appropriate specimens for both mycobacteriologic and histopathologic examinations. The measurement of biochemical markers in TB-affected serosal fluids (adenosine deaminase or gamma interferon) and molecular biology techniques such as polymerase chain reaction may be useful adjuncts in the diagnosis of EPTB. Although the disease usually responds to standard anti-TB drug therapy, the ideal regimen and duration of treatment have not yet been established. A paradoxical response frequently occurs during anti-TB therapy. It should be distinguished from other causes of clinical deterioration. Surgery is required mainly to obtain valid diagnostic specimens and to manage complications. Because smear microscopy or culture is not available to monitor patients with EPTB, clinical monitoring is the usual way to assess the response to treatment.

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Metadata

Authors
Lee, J. Y.
Venue
Tuberculosis and Respiratory Diseases
Publisher
The Korean Academy of Tuberculosis and Respiratory Diseases
Published
2015
Volume
78
Issue
2
Pages
47
ISSN
  • 0378-0066 (ISSN-L)
  • 1738-3536
  • 2005-6184
DOI
10.4046/trd.2015.78.2.47
OpenAlex
W2047943465
Cited by
512
References
62
FWCI
29.69
Type
journal article
Language
en
Open access
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