Cited by 1,205Wound Healing and TreatmentsImmune cells in cancerLiver physiology and pathology

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Differential Roles of Macrophages in Diverse Phases of Skin Repair

Lucas, Tina, Waisman, Ari, Ranjan, Rajeev, Roes, Jürgen, Krieg, Thomas, Müller, Werner, Roers, Axel, Eming, Sabine A·2010·The Journal of Immunology

DOI 10.4049/jimmunol.0903356

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Abstract

Influx of macrophages plays a crucial role in tissue repair. However, the precise function of macrophages during the healing response has remained a subject of debate due to their functional dichotomy as effectors of both tissue injury and repair. We tested the hypothesis that macrophages recruited during the diverse phases of skin repair after mechanical injury exert specific functions to restore tissue integrity. For this purpose, we developed a mouse model that allows conditional depletion of macrophages during the sequential stages of the repair response. Depletion of macrophages restricted to the early stage of the repair response (inflammatory phase) significantly reduced the formation of vascularized granulation tissue, impaired epithelialization, and resulted in minimized scar formation. In contrast, depletion of macrophages restricted to the consecutive mid-stage of the repair response (phase of tissue formation) resulted in severe hemorrhage in the wound tissue. Under these conditions, transition into the subsequent phase of tissue maturation and wound closure did not occur. Finally, macrophage depletion restricted to the late stage of repair (phase of tissue maturation) did not significantly impact the outcome of the repair response. These results demonstrate that macrophages exert distinct functions during the diverse phases of skin repair, which are crucial to control the natural sequence of repair events.

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Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144
Wound repair and regeneration
Gurtner, G. C., Werner, S., Barrandon, Y., & Longaker, M. T. (2008) · Nature · doi:10.1038/nature07039 · Cited by 6,542
Alternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189
Monocyte and macrophage heterogeneity
Gordon, S., & Taylor, P. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1733 · Cited by 5,190
Myofibroblasts and mechano-regulation of connective tissue remodelling
Tomasek, J. J., Gabbiani, G., Hinz, B., Chaponnier, C., & Brown, R. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm809 · Cited by 4,290
VEGF receptor signalling ? in control of vascular function
Olsson, A.-K., Dimberg, A., Kreuger, J., & Claesson-Welsh, L. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1911 · Cited by 3,122
Inflammation in Wound Repair: Molecular and Cellular Mechanisms
Eming, S. A., Krieg, T., & Davidson, J. M. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700701 · Cited by 2,429
Self-citation
The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions
Nahrendorf, M., Swirski, F. K., Aikawa, E., Stangenberg, L., Wurdinger, T., Figueiredo, J.-L., Libby, P., Weissleder, R., & Pittet, M. J. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070885 · Cited by 2,300
Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis
Arnold, L., Henry, A., Poron, F., Baba-Amer, Y., van Rooijen, N., Plonquet, A., Gherardi, R. K., & Chazaud, B. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070075 · Cited by 2,002
Inflammatory cells during wound repair: the good, the bad and the ugly
Martin, P., & Leibovich, S. J. (2005) · Trends in Cell Biology · doi:10.1016/j.tcb.2005.09.002 · Cited by 1,340 · cited 1×
“Their number increases during the phase of inflammation, peaks during the phase of tissue formation, and gradually declines during the maturation phase (9).”
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Show all 0 references

Research works printed but not linked: 32

Babcock, 2008, Circulating blood cells function as a surveillance system for damaged tissue in Drosophila larvae., Proc. Natl. Acad. Sci. USA, 105, 10017, 10.1073/pnas.0709951105 · DOI
Niethammer, 2009, A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish., Nature, 459, 996, 10.1038/nature08119 · DOI · Paper page
Chen, 2009, C/EBPalpha initiates primitive myelopoiesis in pluripotent embryonic cells., Blood, 114, 40, 10.1182/blood-2008-11-189159 · DOI
Werner, 2007, Keratinocyte-fibroblast interactions in wound healing., J. Invest. Dermatol., 127, 998, 10.1038/sj.jid.5700786 · DOI
Eming, 2009, Interrelation of immunity and tissue repair or regeneration., Semin. Cell Dev. Biol., 20, 517, 10.1016/j.semcdb.2009.04.009 · DOI · Paper page
Loots, 1998, Differences in cellular infiltrate and extracellular matrix of chronic diabetic and venous ulcers versus acute wounds., J. Invest. Dermatol., 111, 850, 10.1046/j.1523-1747.1998.00381.x · DOI · Paper page
Simpson, 1972, The neutrophilic leukocyte in wound repair a study with antineutrophil serum., J. Clin. Invest., 51, 2009, 10.1172/JCI107007 · DOI · Paper page
Leibovich, 1975, The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum., Am. J. Pathol., 78, 71
Martin, 2003, Wound healing in the PU.1 null mouse—tissue repair is not dependent on inflammatory cells., Curr. Biol., 13, 1122, 10.1016/S0960-9822(03)00396-8 · DOI
Werner, 2003, Regulation of wound healing by growth factors and cytokines., Physiol. Rev., 83, 835, 10.1152/physrev.2003.83.3.835 · DOI · Paper page
Eming, 2007, Accelerated wound closure in mice deficient for interleukin-10., Am. J. Pathol., 170, 188, 10.2353/ajpath.2007.060370 · DOI
Ishida, 2008, Chemokine receptor CX3CR1 mediates skin wound healing by promoting macrophage and fibroblast accumulation and function., J. Immunol., 180, 569, 10.4049/jimmunol.180.1.569 · DOI · Paper page
Han, 2008, Development and regeneration of the neonatal digit tip in mice., Dev. Biol., 315, 125, 10.1016/j.ydbio.2007.12.025 · DOI
Buch, 2005, A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration., Nat. Methods, 2, 419, 10.1038/nmeth762 · DOI
Clausen, 1999, Conditional gene targeting in macrophages and granulocytes using LysMcre mice., Transgenic Res., 8, 265, 10.1023/A:1008942828960 · DOI · Paper page
Cazac, 2000, TGF-beta receptor controls B cell responsiveness and induction of IgA in vivo., Immunity, 13, 443, 10.1016/S1074-7613(00)00044-3 · DOI
Raes, 2002, Differential expression of FIZZ1 and Ym1 in alternatively versus classically activated macrophages., J. Leukoc. Biol., 71, 597, 10.1189/jlb.71.4.597 · DOI
Nair, 2003, Macrophages in chronic type 2 inflammation have a novel phenotype characterized by the abundant expression of Ym1 and Fizz1 that can be partly replicated in vitro., Immunol. Lett., 85, 173, 10.1016/S0165-2478(02)00225-0 · DOI
Benjamin, 1998, A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF., Development, 125, 1591, 10.1242/dev.125.9.1591 · DOI
Roth, 2006, Plasmin modulates vascular endothelial growth factor-A-mediated angiogenesis during wound repair., Am. J. Pathol., 168, 670, 10.2353/ajpath.2006.050372 · DOI · Paper page
Alon, 1995, Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity., Nat. Med., 1, 1024, 10.1038/nm1095-1024 · DOI
Carvalho, 2007, Compensatory signalling induced in the yolk sac vasculature by deletion of TGFbeta receptors in mice., J. Cell Sci., 120, 4269, 10.1242/jcs.013169 · DOI
McCartney-Francis, 1990, TGF-beta regulates production of growth factors and TGF-beta by human peripheral blood monocytes., Growth Factors, 4, 27, 10.3109/08977199009011007 · DOI
Duffield, 2003, The inflammatory macrophage: a story of Jekyll and Hyde., Clin. Sci. (Lond.), 104, 27, 10.1042/cs1040027 · DOI
Duffield, 2005, Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair., J. Clin. Invest., 115, 56, 10.1172/JCI200522675 · DOI · Paper page
Kim, 2008, Dynamics of neutrophil infiltration during cutaneous wound healing and infection using fluorescence imaging., J. Invest. Dermatol., 128, 1812, 10.1038/sj.jid.5701223 · DOI
Mirza, 2009, Selective and specific macrophage ablation is detrimental to wound healing in mice., Am. J. Pathol., 175, 2454, 10.2353/ajpath.2009.090248 · DOI · Paper page
Martinez, 2009, Alternative activation of macrophages: an immunologic functional perspective., Annu. Rev. Immunol., 27, 451, 10.1146/annurev.immunol.021908.132532 · DOI · Paper page
Pull, 2005, Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury., Proc. Natl. Acad. Sci. USA, 102, 99, 10.1073/pnas.0405979102 · DOI
ten Dijke, 2007, Extracellular control of TGFbeta signalling in vascular development and disease., Nat. Rev. Mol. Cell Biol., 8, 857, 10.1038/nrm2262 · DOI
Li, 2006, Transforming growth factor-beta regulation of immune responses., Annu. Rev. Immunol., 24, 99, 10.1146/annurev.immunol.24.021605.090737 · DOI
Kümin, 2007, Peroxiredoxin 6 is required for blood vessel integrity in wounded skin., J. Cell Biol., 179, 747, 10.1083/jcb.200706090 · DOI

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Pang, J., Santoro, E., Roberts, R. E., Purcell, J., Fortman, J. D., & Koh, T. J. (2025) · Wound Repair and Regeneration · doi:10.1111/wrr.70009 · Cited by 2
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Prevention of complications during implantation of devices in arrhythmology, past, present and future
Eshmatov, O. R., Batalov, R., Krivolapov, S., Khynin, M. S., Sitkova, E., Pokrovskaya, L. A., Berezina, E., & Botvin, V. (2024) · Rational Pharmacotherapy in Cardiology · doi:10.20996/1819-6446-2024-3000 · Cited by 2
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Background
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Makarov, V., Pominova, D., Ryabova, A., Saveleva, T. A., Игнатьева, И. В., Reshetov, I. V., & Loschenov, V. (2018) · Photonics Europe · doi:10.1117/12.2309783 · Cited by 2
Clinical and Pathological Assessment of Aloe Vera and Propolis for Wound Healing in Normal and Diabetic Albino Rats
El-Din, M. M. M., & Allaam, A. A. A. (2017) · Zagazig Veterinary Journal/Zagazig Veterinary Journal (Online) · doi:10.21608/zvjz.2017.7862 · Cited by 2
“Whereas, depletion of macrophages during the inflammatory wound, induced delay of healing wound in a mouse [8].”
Background
Dysregulated inflammation in diabetic wounds
denDekker, A. D., & Gallagher, K. A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816413-6.00005-8 · Cited by 5
Chronological changes in rat heel skin following depressurization of pressure ulcer-like dermal lesions.
Haba, D., & Arakawa, T. (2019) · Acta Histochemica · doi:10.1016/j.acthis.2019.151459 · Cited by 2
Nanomaterials for Wound Healing
Uzunallı, G. (2019) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-030-31202-2_3 · Cited by 4
Updates in Fetal Wound Healing and Scar Prevention
Khatib, L., Cass, D., & Adzick, N. (2018) · Springer eBooks · doi:10.1007/978-3-319-60814-3_3 · Cited by 2
Neuropeptides, Inflammation, and Diabetic Wound Healing: Lessons from Experimental Models and Human Subjects
Tellechea, A., Pradhan‐Nabzdyk, L., LoGerfo, F. W., & Veves, A. (2018) · Contemporary diabetes · doi:10.1007/978-3-319-89869-8_8 · Cited by 6
Cells in the Skin
Wang, X., Gao, X.-H., Zhang, X., Zhou, L., Mi, Q., Hong, Y., Song, B., McGovern, N. N., Lim, S. H., Tang, M. B. Y., et al. (2016) · Springer eBooks · doi:10.1007/978-94-024-0902-4_6
Tissue Remodeling and Repair During Type 2 Inflammation
Chan, A. J., Jang, J. C., & Nair, M. G. (2015) · Springer eBooks · doi:10.1007/978-1-4939-2911-5_7 · Cited by 3
Stem Cell and Stem Cell-Derived Molecular Therapies to Enhance Dermal Wound Healing
Antonyshyn, J. A., & Fitzpatrick, L. E. (2015) · Springer eBooks · doi:10.1007/978-3-319-20726-1_6 · Cited by 2
Innovations in Molecular Mechanisms and Tissue Engineering
Wilson-Rawls, J., & Kusumi, K. (2016) · Stem Cell Biology and Regenerative Medicine · doi:10.1007/978-3-319-44996-8 · Cited by 2
The ROS Gatekeeper Hypothesis: A Conceptual Framework for Gasotransmitter Signaling in Pressure Ulcers
Shinkai, R., Tsukase, N., Nishizawa, Y., Nomura, A., & Tomita, T. (2026) · Oxygen · doi:10.3390/oxygen6030024 · Cited by 1
“In addition, impaired macrophage polarization, characterized by persistence of pro-inflammatory M1-like phenotypes and insufficient transition toward reparative M2-like phenotypes, interferes with the resolution of inflammation and subsequent tissue remodeling [10,38–40].”
A Roadmap to Perfused Skin: Defining the Next Generation of Research Questions in Cutaneous Tissue Engineering
Kızılkurtlu, A. A., & Yılmaz, Ö. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27125350 · Cited by 3
“Still, unresolved inflammation can produce a hostile environment characterized by excessive protease activity, oxidative stress, endothelial dysfunction, leaky vessels, fibrosis, and impaired re-epithelialization [97,98,120,124].”
Influential
Emerging Nanomaterials Can Even Treat Chronic Wounds: A Review of Evidence on Magnesium-Based Systems
Shou, Y., Zhao, X., Yang, F., Bai, X., Gao, F., Li, Z., Liu, Y., & Wang, Y.-C. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s592359 · Cited by 1
Cellular gatekeepers of infected wounds: the dual role of adipocytes in coordinating immunity and regeneration
Yan, H., Wang, Y., He, X., Li, Y., Yang, L., Yang, J., Meng, X., Peng, C., Zhang, X., Yakupu, A., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1793958 · Cited by 1
DcR3 reprograms macrophage plasticity to promote wound healing and hair regeneration.
Ou, S.-H., Chen, Y.-C., Hsieh, S.-L., & Chen, C.-C. (2026) · Journal of dermatological science (Amsterdam) · doi:10.1016/j.jdermsci.2026.01.002 · Cited by 1
Immunomodulatory Potential of a Composite Amniotic Membrane Hydrogel for Wound Healing: Effects on Macrophage Cytokine Secretion
Wang, T., Zhu, Z., Hua, W., & Xue, S. (2025) · Biomedicines · doi:10.3390/biomedicines13102574 · Cited by 1
“Initially, pro-inflammatory M1-type macrophages dominate the early phase of wound healing, with up to 85% of macrophages exhibiting the M1 phenotype [15].”
Temporal dynamics of macrophages transcriptional profiles during zebrafish wound healing
Begon-Pescia, C., Ozbilgic, R., Boireau, S., Louis, A., Georges, S., Manchon, L., & Nguyen-Chi, M. E. (2025) · bioRxiv · doi:10.1101/2025.09.12.675595 · Cited by 1
“In addition, these cells facilitate the resolution of inflammation and mediate reparative processes including angiogenesis, granulation tissue formation, re-epithelialization, and extracellular matrix remodeling through the release of matrix metalloproteases 12,13 .”
l-cysteine rescues radiation induced ferroptosis and boosts wound healing through fibroblasts proliferation and migration.
Yang, M., Huang, C.-L., Luo, W., Gong, P., Huang, B., & Yao, Y. (2025) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2025.152599 · Cited by 1
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Dou, S., Ling, S., Nong, W., Wei, B., Huang, Y., Li, G., Wang, R., & Qin, H. (2025) · Functional & Integrative Genomics · doi:10.1007/s10142-025-01631-z · Cited by 2
“Studies have shown that M1 macrophages have a role in the initial phases of wound healing (Shaw and Martin 2009), whereas M2 macrophages are implicated in subsequent stages of the wound healing process (Lucas et al. 1950).”
Enhanced scar mitigation via hyperbaric oxygen therapy and immune modulation using nanoparticle-orchestrated photosynthetic chlorella in polysaccharide hydrogels
Huang, W.-Y., Pan, W.-Y., Wu, S.-H., Nguyen, H. T., & Chuang, A. E.-Y. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.160666 · Cited by 1
A systematic in vitro study of the effect of normoglycaemic and hyperglycaemic conditions on the biochemical and cellular interactions of clinically-available wound dressings with different physicochemical properties
Saberianpour, S., Melotto, G., Forss, R., Redhead, L., Sandeman, S., Terrazzini, N., Sarker, D., & Santin, M. (2025) · PLoS ONE · doi:10.1371/journal.pone.0317258 · Cited by 1
IGF1 and CXCR4 Respectively Related With Inhibited M1 Macrophage Polarization in Keloids
Liu, Y., Han, B., Tan, L., Ji, D., & Chen, X. (2024) · Journal of Craniofacial Surgery · doi:10.1097/scs.0000000000010479 · Cited by 2
“6 – 8 In particular, M2 macrophages are associated with ﬁ brosis and scarring and persist in keloids.”
Background
Molecular evidence of sterile tissue damage during pathogenesis of the pododermatitis aseptica hemorrhagica circumscripta is associated with disturbed epidermal-dermal homeostasis
Reeder, T. L., Zarlenga, D. S., & Dyer, R. M. (2024) · Journal of Dairy Science · doi:10.3168/jds.2023-24577 · Cited by 1
FADD- and RIPK3-mediated cell death ensures timely clearance of wound macrophages and promotes wound healingPreprint
Injarabian, L., Willenborg, S., Welcker, D., Pasparakis, M., Kashkar, H., & Eming, S. (2023) · bioRxiv · doi:10.1101/2023.03.29.534669 · Cited by 1
Self-citation
A helminth mimic of TGF-β, TGM, enhances regenerative cutaneous wound healing and modulates immune cell recruitment and activationPreprint
Lothstein, K. E., Chen, F., Mishra, P., Smyth, D., Wu, W.-H., Lemenze, A., Kumamoto, Y., Maizels, R., & Gause, W. (2022) · bioRxiv · doi:10.1101/2022.09.24.509317 · Cited by 1
“This process initiates re-epithelialization (50-52).”
BackgroundMethod
Chlorite-Oxidized Oxyamylose (COAM) Has Antibacterial Activity and Positively Affects Skin Wound Healing
Pereira, R. V. S., Ugarte-Berzal, E., Vandooren, J., Nylander, K., Martens, E., Mellaert, L. V., Damme, J. V., Vranckx, J., Matthys, P., Alamae, T., et al. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s375487 · Cited by 1
“…an anti-inflammatory profile contributes to the resolution of the inflammatory phase and consequently the transition into the proliferative phase.38 Lucas et al (2010) clearly showed through conditionally macrophage-depleted mice that the role of these inflammatory cells differs according to the…”
Background
Space-Time Mapping Identifies Concerted Multicellular Patterns and Gene Programs in Healing Wounds and their Conservation in Cancers
Hu, K., Kuhn, N. F., Courau, T., & Krummel, M. (2022) · bioRxiv · doi:10.1101/2022.05.25.493500 · Cited by 1
Epidermal Protein C Levels Correspond to Local Injury Severity and Increased Clinical Support in Burn Patients
Zhao, R., Wang, D., Lang, T. C., Kim, A., Wijewardana, A., Vandervord, J., McGrath, R., Fulcher, G., Lin, H.-Y., Xue, M., et al. (2021) · European Burn Journal · doi:10.3390/ebj2040017 · Cited by 1
Hypoxia-Inducible Factor Drives Vascularization of Modularly Assembled Engineered Tissue
Lam, G. C., & Sefton, M. (2019) · Tissue Engineering. Part A · doi:10.1089/ten.tea.2018.0294 · Cited by 1
“24,25 Notably, effects on recruitment were most pronounced at day 3, corresponding to a peak in HIF-1 activation in control implants.”
Genetics and Regeneration in Vertebrates
Hutchins, E. D., & Kusumi, K. (2016) · Springer eBooks · doi:10.1007/978-3-319-27583-3_11 · Cited by 1
Characterization of Inflammatory Gene Expression and Chemotaxis of Macrophages Expressing Guanylin and Guanylyl Cyclase-C
Hasegawa, K. (2015) · American Journal of Life Sciences · doi:10.11648/j.ajls.s.2015030302.18 · Cited by 1
“In contrast, mannose receptor CD206–positive M2 macrophages are characterized by high expression of anti-inflammatory cytokines such as IL-10 [13,14] and arginase (Arg) 1 [15,16], which are involved in the repair or remodeling of tissues [4,9,17].”
Background
Ключевые слова: микроорганизмы из многолетнемерзлых пород, кожные раны, репарация, скорость репа- рации, реактивность иммунной системы. EFFECTS OF METABOLITES OF BACTERIA BACILLUS SP. FROM PERMAFROST ON SPEED REPAIR OF SKIN WOUND
Bazhin, A., Kalenova, L., & Novikova, M. (2014) · doi:10.12737/7269 · Cited by 1
Rôle pro-inflammatoire et immunomodulateur de la proteinase 3 membranaire exprimée au cours de l'apoptose : implications dans la granulomatose avec polyangéite
Millet, A. (2014) · theses.fr (ABES) · doi:10.70675/177eeb36z2faez449fz9cb7z368c2bf63218
“Les macrophages décrits comme alternativement activés (type M2) ont été démontrés comme fondamentaux dans la réparation cutanée après une atteinte mécanique (Lucas et al. 2010) ou bien dans la régénération musculaire (Saclier et al. 2013).”
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Rosenthal, K., Drakovac, S., & Stone, S. (2012) · doi:10.1097/ipc.0b013e318255d58a · Cited by 1
Live Biotherapeutics : importance of formulation and lyophilization parametersand an example of a clinical application
Tyagi, N. (2023) · doi:10.54612/a.4g1r1pvjb4 · Cited by 1
FOXO1 has a Dual Function to Promote Normal but Inhibit Diabetic Wound Healing
Graves, D. T. (2017) · Recent clinical techniques, results, and research in wounds · doi:10.1007/15695_2017_45 · Cited by 1
The Wound Macrophage
Crane, M. J., & Albina, J. E. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1311-4_12 · Cited by 1
Macrophage ferroptosis in diabetic foot ulcers: current evidence, mechanisms, and therapeutic implications
Lang, J., Zhao, H., Zhou, N., Zhao, Y., Tie, Y., Yang, C., & Zhao, G. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1952662
A spatiotemporally programmed bioactive scaffold for orbital reconstruction
Shen, W., Chen, M., Peng, Y., Wang, J., Zhong, H., Xie, J., Zhou, Y., Gao, Q., Huang, X., Gou, Z., et al. (2026) · Bioactive Materials · doi:10.1016/j.bioactmat.2026.09.044
“As inflammation transitions toward resolution, macrophage-mediated reparative signaling can overlap with endothelial-cell recruitment and early angiogenic activation [108,109].”
Immunohistochemical Insights into Enhanced Burn Wound Healing by Poly(vinyl alcohol)/Gentamicin and Poly(vinyl alcohol)/Chitosan/Gentamicin Hydrogels
Nikolić, A., Milošević, I., Janković, A., Prokić, B., Nićković, E., Stevanović, M., Majstorović, M., Mirilović, M., Mišković-Stanković, V., & Božinovski, T. L. (2026) · Gels · doi:10.3390/gels12100925
“Macrophage-derived cytokines and growth factors stimulate fibroblast proliferation, and the newly established vasculature supplies oxygen and nutrients for active tissue regeneration [41,44].”
Influential
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Godeshala, S., Pallod, S., Fu, L., Yaron, J. R., & Rege, K. (2026) · Advanced Therapeutics · doi:10.1002/adtp.202500588
Embracing macrophage complexity for research and translation
Ginhoux, F., Mulder, K., Arcila-Barrera, S., & Amit, I. (2026) · Immunity · doi:10.1016/j.immuni.2026.09.015
Decoding cutaneous injury-induced inflammation through single-cell RNA sequencing
Batzli, G. F., Kleb, S. S., Droll, S. H., & Shook, B. A. (2026) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2026.103703
The cutaneous vasculature: Development, repair, and disease
Wang, K., Quintana, J., Yang, V., Kawasumi, K., & Kam, C. Y. (2026) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2026.103704
Histone post-translational modifications in diabetic foot ulcer healing: linking immune dysregulation to tissue repair
Hou, J., Chen, J., Chen, Y., Luo, Z., Yuan, S., 邓呈亮, & 肖顺娥 (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1957976
Coenzyme A activates TLR4 and enhances alternative macrophage activation in line with MyD88 agonism
Jones, A. E., Rios, A., Ibrahimovic, N., Ball, A. B., Chávez, C., Bayley, N. A., Falta, N. A., Mekkittikul, M., Carrillo, C., Hsieh, W. Y., et al. (2026) · EMBO Reports · doi:10.1038/s44319-026-00925-y · Cited by 4
“For example, inhibition of the initial pro-in ﬂ ammatory response dampens the future expression of alternative activation markers and decreases wound healing (Lucas et al, 2010).”
Cathepsin D as a central regulator of extracellular matrix remodeling in wound healing and chronic tissue pathologies
Rangappa, S., Gowda, S., Hanumesh, P., Prashantha, K., & Manjula, R. V. (2026) · Tissue Barriers · doi:10.1080/21688370.2026.2730865
A dual-crosslinked silk fibroin hydrogel with aldehyde-functionalized glycyrrhizic acid as a structural–pharmacological crosslinker for diabetic wound healing
Ouyang, Y., Xing, J., Dai, M., Wang, K., & Yu, B. (2026) · Biomaterials Advances · doi:10.1016/j.bioadv.2026.215216
Cell-Free Regenerative Therapies for Wound Healing and Skin Repair: The Emerging Role of Adipose-Derived Stem Cell Extracellular Vesicles.
Zhang, Y., Guo, X.-X., Chen, Y., Peng, Y., Cheong, S., Hu, X., Liu, X.-R., Lu, F., & He, Y.-F. (2026) · Advances in wound care · doi:10.1177/21621918261479710
Repair and regeneration across the lifespan: an ontogenetic perspective
Barrera-saldaña, H. A., Fernández-Garza, L. E., Guillen-Silva, F., Fajardo‐Ramírez, Ó. R., Pavlovich, R. I., Gómez-Gallardo, F. V., Rodríguez-Fuentes, D. E., Avila-Villalobos, A. Y., Barrera‐Barrera, S. A., & Somoza, R. A. (2026) · Frontiers in Aging · doi:10.3389/fragi.2026.1888854
“Selective ablation experiments confirm that failure to execute this macrophage transition causes uncontrolled inflammation, delayed wound closure, and severe tissue damage (Lucas et al., 2010; Mirza et al., 2009).”
D-mannose blocks S-adenosylmethionine generation to suppress macrophage IL-1β expression
Chen, Y., Xu, J., Fu, J.-F., Du, J., Feng, Z.-Q., Wang, M., Liu, Y., & Liu, Y.-T. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1895029

Authors: Lucas, T., Waisman, A., Ranjan, R., Roes, J., Krieg, T., Müller, W., Roers, A., & Eming, S. A.
Affiliations: Department of Dermatology
Johannes Gutenberg University Mainz (DE)
University College London (GB)
University of Cologne (DE)
University of Manchester (GB)
Technische Universität Dresden (DE)
ORCID: Waisman, Ari
Ranjan, Rajeev
Roes, Jürgen
Krieg, Thomas
Müller, Werner
Roers, Axel
Eming, Sabine A
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 2010-04-01
Volume: 184
Issue: 7
Pages: 3964-3977
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.0903356
OpenAlex: W2118654016
Cited by: 1,205
References: 0
Citations by year: 2026: 47 · 2025: 71 · 2024: 84 · 2023: 86 · 2022: 110 · 2021: 102 · 2020: 90 · 2019: 76 · 2018: 87 · 2017: 83 · 2016: 73 · 2015: 78 · 2014: 73 · 2013: 66 · 2012: 41
FWCI: 47.25
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Research Explorer (The University of Manchester) (submittedVersion)
Funders: University College London
Deutsche Forschungsgemeinschaft (SFB829)
Topics: Health Sciences › Medicine › Surgery › Wound Healing and Treatments
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Keywords: macrophages, skin repair, wound healing, mechanical damage, granulation tissue, re-epithelialization, scar formation, hemorrhage, tissue maturation, wound closure, tissue formation
MeSH terms: Animals, Cell Separation, Flow Cytometry, Immunohistochemistry, Macrophages, Mice, Inbred C57BL, Mice, Transgenic, Skin, Skin Physiological Phenomena, Wound Healing, Reverse Transcriptase Polymerase Chain Reaction, Mice

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Differential Roles of Macrophages in Diverse Phases of Skin Repair

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