Cited by 1,205Wound Healing and TreatmentsImmune cells in cancerLiver physiology and pathology

The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.

Differential Roles of Macrophages in Diverse Phases of Skin Repair

Lucas, Tina, Waisman, Ari, Ranjan, Rajeev, Roes, Jürgen, Krieg, Thomas, Müller, Werner, Roers, Axel, Eming, Sabine A·2010·The Journal of Immunology

DOI 10.4049/jimmunol.0903356

Open this paper in CoChat — free account

Abstract

Influx of macrophages plays a crucial role in tissue repair. However, the precise function of macrophages during the healing response has remained a subject of debate due to their functional dichotomy as effectors of both tissue injury and repair. We tested the hypothesis that macrophages recruited during the diverse phases of skin repair after mechanical injury exert specific functions to restore tissue integrity. For this purpose, we developed a mouse model that allows conditional depletion of macrophages during the sequential stages of the repair response. Depletion of macrophages restricted to the early stage of the repair response (inflammatory phase) significantly reduced the formation of vascularized granulation tissue, impaired epithelialization, and resulted in minimized scar formation. In contrast, depletion of macrophages restricted to the consecutive mid-stage of the repair response (phase of tissue formation) resulted in severe hemorrhage in the wound tissue. Under these conditions, transition into the subsequent phase of tissue maturation and wound closure did not occur. Finally, macrophage depletion restricted to the late stage of repair (phase of tissue maturation) did not significantly impact the outcome of the repair response. These results demonstrate that macrophages exert distinct functions during the diverse phases of skin repair, which are crucial to control the natural sequence of repair events.

Integrity signals

Registry

Crossref · 10.4049/jimmunol.0903356

Cites

0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144
Wound repair and regeneration
Gurtner, G. C., Werner, S., Barrandon, Y., & Longaker, M. T. (2008) · Nature · doi:10.1038/nature07039 · Cited by 6,542
Alternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189
Monocyte and macrophage heterogeneity
Gordon, S., & Taylor, P. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1733 · Cited by 5,190
Myofibroblasts and mechano-regulation of connective tissue remodelling
Tomasek, J. J., Gabbiani, G., Hinz, B., Chaponnier, C., & Brown, R. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm809 · Cited by 4,290
VEGF receptor signalling ? in control of vascular function
Olsson, A.-K., Dimberg, A., Kreuger, J., & Claesson-Welsh, L. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1911 · Cited by 3,122
Inflammation in Wound Repair: Molecular and Cellular Mechanisms
Eming, S. A., Krieg, T., & Davidson, J. M. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700701 · Cited by 2,429
Self-citation
The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions
Nahrendorf, M., Swirski, F. K., Aikawa, E., Stangenberg, L., Wurdinger, T., Figueiredo, J.-L., Libby, P., Weissleder, R., & Pittet, M. J. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070885 · Cited by 2,300
Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis
Arnold, L., Henry, A., Poron, F., Baba-Amer, Y., van Rooijen, N., Plonquet, A., Gherardi, R. K., & Chazaud, B. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070075 · Cited by 2,002
Inflammatory cells during wound repair: the good, the bad and the ugly
Martin, P., & Leibovich, S. J. (2005) · Trends in Cell Biology · doi:10.1016/j.tcb.2005.09.002 · Cited by 1,340 · cited 1×
“Their number increases during the phase of inflammation, peaks during the phase of tissue formation, and gradually declines during the maturation phase (9).”
Background

Flagged first, then by citations

Show all 0 references

Research works printed but not linked: 32

Babcock, 2008, Circulating blood cells function as a surveillance system for damaged tissue in Drosophila larvae., Proc. Natl. Acad. Sci. USA, 105, 10017, 10.1073/pnas.0709951105 · DOI
Niethammer, 2009, A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish., Nature, 459, 996, 10.1038/nature08119 · DOI · Paper page
Chen, 2009, C/EBPalpha initiates primitive myelopoiesis in pluripotent embryonic cells., Blood, 114, 40, 10.1182/blood-2008-11-189159 · DOI
Werner, 2007, Keratinocyte-fibroblast interactions in wound healing., J. Invest. Dermatol., 127, 998, 10.1038/sj.jid.5700786 · DOI
Eming, 2009, Interrelation of immunity and tissue repair or regeneration., Semin. Cell Dev. Biol., 20, 517, 10.1016/j.semcdb.2009.04.009 · DOI · Paper page
Loots, 1998, Differences in cellular infiltrate and extracellular matrix of chronic diabetic and venous ulcers versus acute wounds., J. Invest. Dermatol., 111, 850, 10.1046/j.1523-1747.1998.00381.x · DOI · Paper page
Simpson, 1972, The neutrophilic leukocyte in wound repair a study with antineutrophil serum., J. Clin. Invest., 51, 2009, 10.1172/JCI107007 · DOI · Paper page
Leibovich, 1975, The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum., Am. J. Pathol., 78, 71
Martin, 2003, Wound healing in the PU.1 null mouse—tissue repair is not dependent on inflammatory cells., Curr. Biol., 13, 1122, 10.1016/S0960-9822(03)00396-8 · DOI
Werner, 2003, Regulation of wound healing by growth factors and cytokines., Physiol. Rev., 83, 835, 10.1152/physrev.2003.83.3.835 · DOI · Paper page
Eming, 2007, Accelerated wound closure in mice deficient for interleukin-10., Am. J. Pathol., 170, 188, 10.2353/ajpath.2007.060370 · DOI
Ishida, 2008, Chemokine receptor CX3CR1 mediates skin wound healing by promoting macrophage and fibroblast accumulation and function., J. Immunol., 180, 569, 10.4049/jimmunol.180.1.569 · DOI · Paper page
Han, 2008, Development and regeneration of the neonatal digit tip in mice., Dev. Biol., 315, 125, 10.1016/j.ydbio.2007.12.025 · DOI
Buch, 2005, A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration., Nat. Methods, 2, 419, 10.1038/nmeth762 · DOI
Clausen, 1999, Conditional gene targeting in macrophages and granulocytes using LysMcre mice., Transgenic Res., 8, 265, 10.1023/A:1008942828960 · DOI · Paper page
Cazac, 2000, TGF-beta receptor controls B cell responsiveness and induction of IgA in vivo., Immunity, 13, 443, 10.1016/S1074-7613(00)00044-3 · DOI
Raes, 2002, Differential expression of FIZZ1 and Ym1 in alternatively versus classically activated macrophages., J. Leukoc. Biol., 71, 597, 10.1189/jlb.71.4.597 · DOI
Nair, 2003, Macrophages in chronic type 2 inflammation have a novel phenotype characterized by the abundant expression of Ym1 and Fizz1 that can be partly replicated in vitro., Immunol. Lett., 85, 173, 10.1016/S0165-2478(02)00225-0 · DOI
Benjamin, 1998, A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF., Development, 125, 1591, 10.1242/dev.125.9.1591 · DOI
Roth, 2006, Plasmin modulates vascular endothelial growth factor-A-mediated angiogenesis during wound repair., Am. J. Pathol., 168, 670, 10.2353/ajpath.2006.050372 · DOI · Paper page
Alon, 1995, Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity., Nat. Med., 1, 1024, 10.1038/nm1095-1024 · DOI
Carvalho, 2007, Compensatory signalling induced in the yolk sac vasculature by deletion of TGFbeta receptors in mice., J. Cell Sci., 120, 4269, 10.1242/jcs.013169 · DOI
McCartney-Francis, 1990, TGF-beta regulates production of growth factors and TGF-beta by human peripheral blood monocytes., Growth Factors, 4, 27, 10.3109/08977199009011007 · DOI
Duffield, 2003, The inflammatory macrophage: a story of Jekyll and Hyde., Clin. Sci. (Lond.), 104, 27, 10.1042/cs1040027 · DOI
Duffield, 2005, Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair., J. Clin. Invest., 115, 56, 10.1172/JCI200522675 · DOI · Paper page
Kim, 2008, Dynamics of neutrophil infiltration during cutaneous wound healing and infection using fluorescence imaging., J. Invest. Dermatol., 128, 1812, 10.1038/sj.jid.5701223 · DOI
Mirza, 2009, Selective and specific macrophage ablation is detrimental to wound healing in mice., Am. J. Pathol., 175, 2454, 10.2353/ajpath.2009.090248 · DOI · Paper page
Martinez, 2009, Alternative activation of macrophages: an immunologic functional perspective., Annu. Rev. Immunol., 27, 451, 10.1146/annurev.immunol.021908.132532 · DOI · Paper page
Pull, 2005, Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury., Proc. Natl. Acad. Sci. USA, 102, 99, 10.1073/pnas.0405979102 · DOI
ten Dijke, 2007, Extracellular control of TGFbeta signalling in vascular development and disease., Nat. Rev. Mol. Cell Biol., 8, 857, 10.1038/nrm2262 · DOI
Li, 2006, Transforming growth factor-beta regulation of immune responses., Annu. Rev. Immunol., 24, 99, 10.1146/annurev.immunol.24.021605.090737 · DOI
Kümin, 2007, Peroxiredoxin 6 is required for blood vessel integrity in wounded skin., J. Cell Biol., 179, 747, 10.1083/jcb.200706090 · DOI

Sorted by citations

Items 801–900 of 1,005

Mechanisms of anastomotic leakage in colorectal cancer surgery: unraveling the roles of inflammation, immunity, and microbiota – a narrative review
Ma, K., Gu, T., Wu, Z., & Li, Z. (2025) · International Journal of Surgery · doi:10.1097/js9.0000000000003151 · Cited by 12
Automated and Enclosed Three-Dimensional Biofabrication System for Mesenchymal Stem Cell Culture to Enhance Diabetic Wound Healing
Chen, Y., Xu, Y., Cai, J., Lauwers, M., Xiang, L., Zheng, Y., Chu, H., Chen, X., Ker, D. F. E., Zhang, C., et al. (2025) · Biomaterials Research · doi:10.34133/bmr.0205 · Cited by 12
“The poor healing of diabetic skin wounds remains a significant clinical challenge, with research indicating that this is largely due to underlying pathological mechanisms such as decreased local growth factor secretion, oxidative stress, vascular damage, and chronic inflammatory responses [ 3 ].”
Innate immune cells in vascular lesions: mechanism and significance of diversified immune regulation
Wu, J., Qian, Y.-L., Yang, K.-Y., Zhang, S., Zeng, E.-M., & Luo, D.-Y. (2025) · Annals medicus · doi:10.1080/07853890.2025.2453826 · Cited by 9
Immune cells in Alzheimer’s disease: insights into pathogenesis and potential therapeutic targets
Fu, X., Cai, H., Quan, S., Ren, Z., Xu, Y., & Jia, L. (2024) · Medical Review · doi:10.1515/mr-2024-0064 · Cited by 10
“…microglial recognize pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs) through pattern recognition receptors (PRRs) expressed on their cell surface, subsequently becoming activated into either pro-in ﬂ ammatory or anti-in ﬂ ammatory phenotypes [59, 60].”
Granulocyte colony stimulating factor promotes scarless tissue regeneration
Huang, J., Sati, S., Murphy, C., Spencer, C., Rapp, E., Prouty, S., Korte, S., Ahart, O., Sheng, E., Jones, P., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114742 · Cited by 9
“27 Depletion of early-stage macrophages reduced scar formation, and depletion of mid-stage macrophages prevented wound closure.”
A bioelectronic device for electric field treatment of wounds reduces inflammation in an in vivo mouse model
Hernandez, C., Hsieh, H.-C., Zhu, K., Li, H.-P., Yang, H.-Y., Recendez, C., Asefifeyzabadi, N., Nguyen, T., Tebyani, M., Baniya, P., et al. (2024) · PLoS ONE · doi:10.1371/journal.pone.0303692 · Cited by 9
“Although macrophages comprise a large spectrum of phenotypes, for simplicity here we use the dominant simplified nomenclature in the literature of M1 (pro-inflammatory subtype) and M2 (pro-reparative subtype) [6, 23–25, 34, 35].”
Method
Spatiotemporal orchestration of macrophage activation trajectories by Vγ4 T cells during skin wound healing
Hu, W., Zhang, X., Liu, Z., Yang, J., Sheng, H., Liu, Z., Chen, C., Shang, R., Chen, Y., Lu, Y., et al. (2024) · iScience · doi:10.1016/j.isci.2024.109545 · Cited by 11
“12,13 Subsequently, as healing progresses, alternatively activated M2 macrophages accumulate and become dominant within the wound milieu.”
Background
Exploring the mechanisms behind autologous lipotransfer for radiation-induced fibrosis: A systematic review
Pattani, N., Sanghera, J., Langridge, B. J., Frommer, M., Abu-Hanna, J., & Butler, P. E. M. (2024) · PLoS ONE · doi:10.1371/journal.pone.0292013 · Cited by 9
miR‐186‐5p targets TGFβR2 to inhibit RAW264.7 cell migration and proliferation during mouse skin wound healing
Wang, Y., Li, Y.-F., Ni, D., Wei, Z., Fu, Z., Li, C., Sun, H., Wu, Y., Li, Y., Zhang, Y.-X., et al. (2023) · Environmental Toxicology · doi:10.1002/tox.23914 · Cited by 9
“47 Therefore, we also explored the effects of miR-186-5p on migration and proliferation of mouse macrophages (RAW264.”
Background
FADD- and RIPK3-Mediated Cell Death Ensures Clearance of Ly6Chigh Wound Macrophages from Damaged Tissue
Injarabian, L., Willenborg, S., Welcker, D., Sanin, D. E., Pasparakis, M., Kashkar, H., & Eming, S. A. (2023) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2023.06.203 · Cited by 11
Self-citation
The myeloid mineralocorticoid receptor regulates dermal angiogenesis and inflammation in glucocorticoid‐induced impaired wound healing
Nguyen, V. T., Ngô, Q. T., Palacios, R., Nakamura, T., Farman, N., Aractingi, S., & Jaisser, F. (2022) · British Journal of Pharmacology · doi:10.1111/bph.15932 · Cited by 12
“In various organs, macrophages are also major players of the healing process after tissue damage (Brancato & Albina, 2011; Fraccarollo et al., 2019; Lucas et al., 2010; Rahmani et al., 2018).”
Background
Denervation Affected Skin Wound Healing in a Modified Rat Model
Lu, L., Liu, D., Ying, J., Yao, Z., Hou, Q., Wang, H., Qi, F., Luan, W., & Jiang, H. (2022) · The International Journal of Lower Extremity Wounds · doi:10.1177/15347346221090758 · Cited by 9
“23 Collagen production by ﬁ broblasts is stimulated by various cytokines that mainly produced by macrophages.”
Lentiviral Delivery of Small Hairpin RNA Targeting Connective Tissue Growth Factor Blocks Profibrotic Signaling in Tenon's Capsule Fibroblasts.
Lei, D.-W., Dong, C. G., Wu, W., Dong, A., Li, T., Chan, M., Zhou, X., & Yuan, H.-P. (2016) · Investigative Ophthalmology and Visual Science · doi:10.1167/iovs.16-19480 · Cited by 9
Stem Cell Therapy in Wound Healing and Tissue Regeneration
Meiliana, A., Dewi, N. M., & Wijaya, A. (2016) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v8i2.191 · Cited by 9
“In particular, macrophages appear to play an important role in promoting angiogenesis in the granulation tissue during the early phase of skin repair, and in vascular maturation and stabilization in the subsequent phases.(56) Distinct types of wound healing macrophages”
Background
Development of novel murine mammary imaging windows to examine wound healing effects on leukocyte trafficking in mammary tumors with intravital imaging
Sobolik, T., Su, Y.-J., Ashby, W., Schaffer, D. K., Wells, S., Wikswo, J., Zijlstra, A., & Richmond, A. (2016) · IntraVital · doi:10.1080/21659087.2015.1125562 · Cited by 9
“Tumor associated neutrophils and macrophages play an important role in wound repair and healing and can either promote or inhibit tumor growth.(27-29) Given this information, the wound healing response must be taken into consideration when evaluating early leukocyte recruitment using intravital imaging techniques with…”
Background
In Vivo Remodelling of Vascularizing Engineered Tissues
Chamberlain, M. D., West, M. E. D., Lam, G. C., & Sefton, M. V. (2014) · Annals of Biomedical Engineering · doi:10.1007/s10439-014-1146-x · Cited by 9
Distinct CD11b+-monocyte subsets accelerate endothelial cell recovery after acute and chronic endothelial cell damage.
Becher, U., Möller, L., Tiyerili, V., Vasa-Nicotera, M., Hauptmann, F., Zimmermann, K., Pfeifer, A., Nickenig, G., Wassmann, S., & Werner, N. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.02.004 · Cited by 9
“Evidence on the importance of monocytes/macrophages to the recovery of vascular injuries has been obtained from other experimental studies in macrophage-deficient mice [18–20].”
Result
KDM5A, a H3K4me3 demethylase, regulates skin wound healing by promoting M2 macrophage polarization via suppression of Socs1
Zhang, J.-X., Wang, C., & Dong, X. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1638356 · Cited by 8
“The inflammatory response constitutes a fundamental determinant of cutaneous wound repair, with studies demonstrating markedly impaired tissue regeneration following macrophage depletion in vivo (Kirwin et al., 2024; Lucas et al., 2010).”
Quercetin‑copper nanoparticles loaded sprayed hydrogel with anti-inflammation and re-epithelization effects to dynamically course regulation for scald wound healing
Zhou, X., Zuo, W.-B., Gao, T., Zhu, X.-Z., Zhang, Q.-Q., Ma, L.-L., Cai, Y., Yang, J.-H., & Zhang, X. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.167511 · Cited by 8
Molecular mechanisms of ubiquitination in wound healing
Zhang, Q., Gu, R., Dai, Y., Chen, J., Ye, P., Zhu, H., He, W., & Nie, X. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116670 · Cited by 7
Alpha(α)-mangostin (Xanthone of Garcinia mangostana L.): Augmenting Macrophages Activity for an Effective Diabetic Wound Healing
Patrick, M., Zohdi, W. N. W. M., Muid, S. A., & Omar, E. (2024) · TRENDS IN THE SCIENCES · doi:10.48048/tis.2024.8254 · Cited by 8
“Macrophages play different roles in the different phases of the repair response and coordinate the natural sequence of repair phases in the skin, required to restore homeostasis and integrity of the solid tissue after injury [6].”
Background
Exosomal MiR-381 from M2-polarized macrophages attenuates urethral fibroblasts activation through YAP/GLS1-regulated glutaminolysis
Chen, Y.-H., Xu, Y.-C., Lin, T.-T., Chen, H., Dong, R., Cai, F., Ke, Z.-B., Chen, J.-Y., Wei, Y., Zheng, Q.-S., et al. (2023) · Inflammation Research · doi:10.1007/s00011-023-01735-x · Cited by 8
“M1 macrophages have pro‐inflammatory activity, while M2 macrophages protect against inflammatory responses and promote extracellular matrix reconstruction [37].”
Background
Technological Advances in Accelerated Wound Repair and Regeneration
Sofra, X., & Lampe, N. (2020) · Health · doi:10.4236/health.2020.127053 · Cited by 8
Healing power: The mammalian macrophage in skeletal regeneration, scar formation, and regenerative medicine
Simkin, J., Dawson, L., Simkin, M., & Muneoka, K. (2019) · Journal of Immunology and Regenerative Medicine · doi:10.1016/j.regen.2019.100026 · Cited by 5
Mammalian musculoskeletal regeneration is associated with reduced inflammatory cytokines and an influx of T cellsPreprint
Gawriluk, T. R., Simkin, J., Hacker, C. K., Kimani, J., Kiama, S., Ezenwa, V., & Seifert, A. (2019) · bioRxiv · doi:10.1101/723783 · Cited by 8
“regeneration [22-27].”
5, 7, 2', 4', 5'-Pentamethoxyflavanone regulates M1/M2 macrophage phenotype and protects the septic mice.
Feng, L., Xu, L.-S., Guo, M., Huang, W., Zhu, J., Kong, L., Wu, X.-F., & Xu, Q. (2019) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(19)30042-1 · Cited by 8
Co-culture of human bone marrow mesenchymal stem cells and macrophages attenuates lipopolysaccharide-induced inflammation in human corneal epithelial cells
Jeong, W.-Y., Kim, J.-H., & Kim, C.-W. (2018) · Bioscience, biotechnology and biochemistry · doi:10.1080/09168451.2018.1438167 · Cited by 8
The Role of Myeloid Lineage Cells on Skin Healing and Skin Regeneration
Yousuf, Y., & Amini-Nik, S. (2017) · doi:10.4172/2157-7552.1000202 · Cited by 8
“Another study confirmed that macrophage-depletion reduces TGF-β1 and impairs granulation tissue formation [55].”
Background
Biomimetic polymeric transcatheter heart valve leaflets with low calcification and good regenerative ability
Wang, X., Jiang, H., Zhang, W., Kong, Y., Kong, D., Liu, J., & Wang, Z. (2023) · Journal of Materials Chemistry B · doi:10.1039/d3tb00761h · Cited by 7
Engineered piezoelectric dressings advance cutaneous wound healing
Chen, Z., Liu, H., Zhe, M., Ritz, U., & Xing, F. (2026) · Bioactive Materials · doi:10.1016/j.bioactmat.2026.04.017 · Cited by 4
Macrophage cell therapy enabled by interleukin-4 mRNA-loaded lipid nanoparticles to sustain a pro-reparative phenotype in inflammatory injuries
O'Brien, E. M., Tylek, T., Geisler, H. C., Mukalel, A. J., Whitaker, R. C., Sung, S., Binder‐Markey, B. I., Weissman, D., Mitchell, M. J., & Spiller, K. L. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123869 · Cited by 11
The Effects of M2 Macrophages-Derived Exosomes on Urethral Fibrosis and Stricture in Scar Formation
Ren, X., Wang, Z., Wang, J., Xing, L., Wei, H., Liu, C., Liu, S., Zhu, Y., Feng, C., Yin, Y., et al. (2025) · ImmunoTargets and Therapy · doi:10.2147/itt.s500499 · Cited by 6
Regeneration in Mice of Injured Skin, Heart, and Spinal Cord by α-Gal Nanoparticles Recapitulates Regeneration in Amphibians
Galili, U., Li, J., & Schaer, G. (2024) · Nanomaterials · doi:10.3390/nano14080730 · Cited by 7
“This recruitment is observed within 24 h post-injection (Figure 2A) and is significantly faster than that observed in untreated injuries in mice [34] in which macrophage migration is directed by MCP1, MIP1, and RANTES [58–65].”
Background
Collagenase-based wound debridement agent induces extracellular matrix supporting phenotype in macrophages
Banerjee, P., Das, A., Singh, K., Khanna, S., Sen, C. K., & Roy, S. (2024) · Scientific Reports · doi:10.1038/s41598-024-53424-2 · Cited by 8
Harnessing cytokine-induced killer cells to accelerate diabetic wound healing: an approach to regulating post-traumatic inflammation
Yang, Y.-X., Zhang, C., Jiang, Y., He, Y.-J., Cai, J., Liang, L., Chen, Z., Pan, S., Hua, C., Wu, K., et al. (2024) · Regenerative Biomaterials · doi:10.1093/rb/rbad116 · Cited by 7
“It has been well reported that TGF-b causes extracellular matrix contraction, resulting in wound closure by promoting myofibroblast production from fibroblasts, and that it increases collagen synthesis [46].”
Background
Anastomotic stenosis of bioengineered trachea grafts is driven by transforming growth factor β1-induced signaling, proinflammatory macrophages, and delayed epithelialization
Weber, J., Martins, R. S., Muslim, Z., Baig, M., Poulikidis, K., Shetawi, A. H. A., & Bhora, F. (2023) · JTCVS Open · doi:10.1016/j.xjon.2023.07.016 · Cited by 7
“Persistent M1 macrophages lead to delayed wound healing by providing a sustained source of proinflammatory cytokines.(23,24) In normal healing, M2 macrophages dominate the later phases of wound healing and secrete anti-inflammatory mediators, including the genes IL4 and RPL13 A to curtail the M1-induced inflammation.”
Background
Klotho enhances bone regenerative function of hPDLSCs via modulating immunoregulatory function and cell autophagy
Niu, Q., Chen, H., Ou, Q., Yang, S., Peng, Y., Xie, Y., Yu, L., Cheng, Z., Cao, Y., & Wang, Y. (2023) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-023-03849-8 · Cited by 8
“The macrophages promote the reconstitution of vascular networks during the early, then facilitate collagen synthesis in the wound bed, and eventually form granulation tissue, providing a temporary condition for cells to migrate, communicate, and proliferate [36, 37].”
Background
Bacterial Pyocyanin Inducible Keratin 6A Accelerates Closure of Epithelial Defect under Conditions of Mitochondrial Dysfunction
Ghatak, S., Hemann, C. F., Boslett, J. J., Singh, K., Sharma, A., Masry, M. S. E., Abouhashem, A. S., Ghosh, N., Mathew‐Steiner, S. S., Roy, S., et al. (2023) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2023.03.1671 · Cited by 9
RETRACTED: Centella asiatica extract in carboxymethyl cellulose at its optimal concentration improved wound healing in mice models
Tanga, B. M., Bang, S., Fang, X., Seo, C., Zoysa, M. D., Saadeldin, I. M., Lee, S., Park, S. U., Chung, S., Lee, G., et al. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e12031 · Cited by 9
Retracted
Peroxisome Proliferator-Activated Receptor-γ Agonist Attenuates Vocal Fold Fibrosis in Rats via Regulation of Macrophage Activation
Kaba, S., Kawai, Y., Tanigami, Y., Ohnishi, H., Kita, T., Yoshimatsu, M., Omori, K., & Kishimoto, Y. (2022) · American Journal Of Pathology · doi:10.1016/j.ajpath.2022.02.002 · Cited by 9
Assessment of para‑inflammation in a wound healing model
Wang, G., Shen, G., Jiang, X., Chen, Z., & Yin, T. (2020) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2020.8666 · Cited by 10
The Effect of Microporous Polysaccharide Hemospheres on Wound Healing and Scarring in Wild-Type and db/db Mice
Miller, K. J., Cao, W., Ibrahim, M. M., & Levinson, H. (2017) · Advances in Skin & Wound Care · doi:10.1097/01.asw.0000513149.43488.56 · Cited by 7
Biomaterials from Decellularized Tissues
Londoño, R., & Badylak, S. F. (2016) · Wiley eBooks · doi:10.1002/9781119126218.ch12 · Cited by 7
Ablation of a small subpopulation of diabetes-specific bone marrow-derived cells in mice protects against diabetic neuropathy.
Urabe, H., Terashima, T., Kojima, H., & Chan, L. (2016) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.00381.2015 · Cited by 7
Anticipatory cognitive stress appraisal modulates suppression of wound-induced macrophage activation by acute psychosocial stress.
Kuebler, U., Wirtz, P. H., Sakai, M., Stemmer, A., Meister, R., & Ehlert, U. (2015) · Psychophysiology · doi:10.1111/psyp.12368 · Cited by 7
Kinetics of the angiogenic response in lung endothelium following acute inflammatory injury with bleomycin
Yunt, Z., Mohning, M., Barthel, L., Kearns, M., Tuder, R., Hyde, D., Henson, P., & Janssen, W. (2014) · Experimental Lung Research · doi:10.3109/01902148.2014.938202 · Cited by 7
“Depletion of specific macrophage subpopulations early in the course of skin repair has been shown to abrogate wound angiogenesis [44].”
Background
Amelogenins promote an alternatively activated macrophage phenotype in vitro
Almqvist, S., Werthén, M., Lyngstadaas, S., Ågren, M., & Thomsen, P. (2011) · International Journal of Nano and Biomaterials · doi:10.1504/ijnbm.2011.042134 · Cited by 7
“Macrophages are important cells for tissue repair (Mirza et al., 2009; Lucas et al., 2010).”
Background
Plant-Based Biomaterials as Bio-Instructive Immunomodulators: Design Principles, Mechanisms, and Translational Challenges
Lamponi, S. (2026) · Life · doi:10.3390/life16040538 · Cited by 6
Corneal macrophages and limbal stem cells: emerging roles in ocular surface regeneration
Mao, Y., Ou, S., Si, W., Zhang, Y., Xu, S., Qi, Y., & Zhang, F. (2026) · Annals of Medicine · doi:10.1080/07853890.2026.2616082 · Cited by 8
“…depletion yields markedly different outcomes: early removal impairs granulation tissue formation and re-epithelialization; intermediate-phase depletion reduces neovascularization and increases hemorrhagic risk; and late-stage ablation disrupts matrix organization and scar architecture [80].”
Effects of magnetic responsive GelMA hydrogel with tensile stimulation on proliferation, migration and osteogenic differentiation of periosteum-derived cells.
Dong, G., Chen, Z., Xia, B., Lv, Y., & Chen, G.-B. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.145525 · Cited by 6
Contribution of CARD9 signaling to wound healing in skin promoted by topical administration of heat-killed Enterococcus faecalis strain KH2 and the involvement of Dectin-2
Kurosaka, S., Tanno, H., Hirose, M., Kamada, W., Takayashiki, R., Sone, I., Sato, Y., Watanabe, T., Ishi, S., Shoji, M., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1550934 · Cited by 6
“Lucas and colleagues showed the importance of macrophages at all stages of wound healing, demonstrated by macrophage depletion at different times, indicating that depletion of both pro-in ﬂ ammatory and anti-in ﬂ ammatory macrophages delayed wound healing (38).”
Xanthohumol, a prenylated flavonoid from hops (Humulus lupulus L.) exerts multidirectional pro-healing properties towards damaged zebrafish hair cells by regulating the innate immune response.
Kasica, N., & Kaleczyc, J. (2024) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2024.116809 · Cited by 6
(Not) Home alone: Antigen presenting cell – T Cell communication in barrier tissues
Neuwirth, T., Knapp, K., & Stary, G. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.984356 · Cited by 6
Macrophage-Specific, Mafb-Deficient Mice Showed Delayed Skin Wound Healing
Inoue, Y., Liao, C.-W., Tsunakawa, Y., Tsai, I., Takahashi, S., & Hamada, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169346 · Cited by 10
“reported that macrophage removal during the inflammatory phase decreased angiogenesis and delayed the formation of the granulation tissue [13].”
Background
Transcriptome-targeted analysis of human peripheral blood-derived macrophages when cultured on biomaterial meshes
Mora-Navarro, C., Ozpinar, E., Sze, D., Martin, D. P., & Freytes, D. (2021) · Biomedical Materials · doi:10.1088/1748-605x/abdbdb · Cited by 6
“Mφs are crucial contributors to each of these phases of healing and play important roles in orchestrating the body’s response to an injury or surgical insult [11, 12].”
Background
Tagitinin F has Anti-inflammatory, Anti-nociceptive and Anti-Matrix Metalloproteinase Properties: An in Silico, in Vitro and in Vivo study.
da Silva, L. P., Santos, E. C., Borges, B. A., Veloso, M., Chagas-Paula, D., Gonçalves, R. V., & Novaes, R. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105303 · Cited by 6
Immune Cell Circuits in Mucosal Wound Healing: Clinical Implications
Zundler, S., Tauschek, V., & Neurath, M. F. (2020) · Visceral Medicine · doi:10.1159/000506846 · Cited by 19
The Role of Interplay of Mesenchymal Stromal Cells and Macrophages in Physiological and Reparative Tissue Remodeling
Andreeva, E. R., & Buravkova, L. B. (2018) · Human Physiology · doi:10.1134/s0362119718010036 · Cited by 6
Priming mobilized peripheral blood mononuclear cells with the "activated platelet supernatant" enhances the efficacy of cell therapy for myocardial infarction of rats.
Kang, J., Hur, J., Kang, J.-A., Lee, H.-S., Jung, H., Choi, J.-I., Lee, H., Kim, Y. S., Ahn, Y., & Kim, H.-S. (2016) · Cardiovascular Therapeutics · doi:10.1111/1755-5922.12194 · Cited by 6
Computational Identification of Mechanistic Factors That Determine the Timing and Intensity of the Inflammatory Response
Nagaraja, S., Jaques Reifman, A., & Mitrophanov, A. Y. (2015) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1004460 · Cited by 7
“Moreover, reducing the levels of functional macrophages in wounds can severely delay the wound healing time in mouse models [36, 37, 39].”
BackgroundResult
Correction: In Vivo Imaging Reveals a Pioneer Wave of Monocyte Recruitment into Mouse Skin Wounds
Rodero, M., Licata, F., Poupel, L., Hamon, P., & Khosrotehrani, K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115508 · Cited by 6
Critical Role of the GM-CSF Signaling Pathway in Macrophage Pro-Repair Activities
Bernasconi, E., D'Angelo, F., Michetti, P., & Velin, D. (2014) · Pathobiology (Basel) · doi:10.1159/000365395 · Cited by 6
Emerging Strategies for Biomaterials-Mediated Reprogramming of Macrophages in Tissue Repair and Regeneration
Park, J., Zhang, M., Chen, J.-J., Liu, L., Weiss, A., & Wang, Z. (2026) · Regenerative Medicine and Dentistry · doi:10.53941/rmd.2026.100011 · Cited by 5
“However, depletion studies suggested that macrophages may play a less critical role during this phase, indicating partial redundancy in tissue remodelling [70].”
Local macrophage dynamics-inspired engineering of time-programmed nano-vaccine scaffold for postoperative cancer immunotherapy.
Xu, Z., Chen, Q., Hao, M., Cao, Y., Kuang, X., Li, C., Liu, Z., Xue, J., Zhao, J., Zhao, M., et al. (2026) · Science Bulletin · doi:10.1016/j.scib.2026.02.019 · Cited by 5
The promoting effect of Balanus albicostatus cement protein 19k (Balcp19k) on wound healing by regulating fibroblast migration and relieving early-stage inflammation responses.
Song, J.-Y., Zeng, L., Ye, Z.-J., Lu, P., Jing, C.-Y., Hu, B.-R., & He, H. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.138781 · Cited by 5
Testosterone Promotes Nerve Tethering and Acellular Biomaterial Perineural Fibrosis in a Rat Wound Repair Model
Schuster, C. R., Reiche, E., Keller, P. R., Hu, S., Soares, V. V., Rahmayanti, S., Suresh, V., Harris, T. G. W., Doloff, J. C., TUFFAHA, S. H., et al. (2024) · Advances in Wound Care · doi:10.1089/wound.2024.0043 · Cited by 5
“37,38 Our clinical work has demonstrated that patients receiving exogenous testosterone therapy have worse scarring outcomes after chest mascu-linization surgery and that there is a testosterone dose – response effect.”
Antimycobacterial and healing effects of Pranlukast against MTB infection and pathogenesis in a preclinical mouse model of tuberculosis
Rajmani, R. S., & Surolia, A. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1347045 · Cited by 5
Research on evolution process of full‐layer incision of skin tissue under different laser incidences
Chen, Y., Huang, J., Wang, K.-H., Li, X.-P., Rui, Y.-F., & Fan, W. (2023) · Journal of Biophotonics · doi:10.1002/jbio.202300284 · Cited by 5
Histological evaluation of mouse tongue incisions after Er:YAG laser surgery with different pulse energies versus after conventional scalpel surgery
Ou, M.-M., & Huang, X.-F. (2023) · Lasers in Medical Science · doi:10.1007/s10103-023-03852-9 · Cited by 5
The Specifics of Neovascularization of Wound Defects in the Oral Mucosa during Its Regeneration under a Piezoelectric Polymer Membrane
Konyaeva, A., Varakuta, E., Leiman, A., Bolbasov, E., & Chernova, U. (2023) · Bulletin of experimental biology and medicine · doi:10.1007/s10517-023-05793-3 · Cited by 5
“More pronounced decrease in the VEGF expression level and slight increase in CD34 expression in group 1 in comparison with group 2 were a prerequisite for insufficient blood supply in the healing wound defect [11].”
Background
Human adipose-derived stem cells in fibrin glue carrier modulate wound healing phases in rats
Araújo, S., Sganzella, M. F., Sagiorato, R. N., Leite, M. N., Caetano, G. F., de Aro, A. A., Esquisatto, M. A. M., Frade, M. A. C., de Andrade, T. A. M., & dos Santos, G. M. T. (2022) · Current Research in Biotechnology · doi:10.1016/j.crbiot.2022.10.004 · Cited by 5
Dielectrophoretic characterization of macrophage phenotypes
Soe, M. T. M., Spiller, K., & Noh, M. (2022) · Electrophoresis · doi:10.1002/elps.202200046 · Cited by 5
“For example, in normal wound healing, the vast majority resemble an M1 phenotype in the early phases, but at later phases, they transition into M2-like phenotype(s) [7, 8].”
Background
Evaluation of 4% stabilized Sodium Hypochlorite activity in the repair of cutaneous excisional wounds in mice.
da Costa, M. C., Ferreira, B., de Moura, F. D., de Lima, L. G., Araujo, F. D. A., & Mota, F. C. (2021) · Injury · doi:10.1016/j.injury.2021.05.035 · Cited by 5
Novel leukocyte-depleted platelet-rich plasma-based skin equivalent as an in vitro model of chronic wounds: a preliminary study
Seria, E., Galea, G., Borg, J., Schembri, K., Grech, G., Tagliaferro, S. S., & Felice, A. (2021) · BMC Molecular and Cell Biology · doi:10.1186/s12860-021-00366-6 · Cited by 5
“It is well known that macrophages alter phenotypes from an M1 proinflammatory phenotype to an M2 pro-repair phenotype, leading to a reduction in inflammatory markers and a promotion of a proliferation phase, secreting PDGF, TGF-α, and bFGF [33].”
Background
Macrophage Polarization in Skin Wound Healing: Progress in Biology and Therapeutics
Chen, L., Cheng, L., Chen, T., Zhang, Y., & Zhang, J. (2021) · Journal of Shanghai Jiaotong University (Science) · doi:10.1007/s12204-021-2276-6 · Cited by 5
Bone Marrow-Derived Macrophages Enhance Vessel Stability in Modular Engineered Tissues
West, M. E. D., Sefton, E., & Sefton, M. (2019) · Tissue Engineering. Part A · doi:10.1089/ten.tea.2018.0222 · Cited by 5
“19 Wound healing studies have identiﬁed distinct, nonredundant macrophage populations responsible for sequential phases of tissue repair, 20 and the induction of vascular endothelial growth factor (VEGF)- mediated angiogenesis.”
Introduction to Wound Healing and Tissue Repair
Eming, S. A. (2018) · Springer eBooks · doi:10.1007/978-3-319-98477-3_5 · Cited by 6
Self-citation
Effect of Different Omega-6/Omega-3 Polyunsaturated Fatty Acid Ratios on the Formation of Monohydroxylated Fatty Acids in THP-1 Derived Macrophages
Keeren, K., Huang, D., Smyl, C., Fischer, A., Rothe, M., & Weylandt, K. H. (2015) · Biology · doi:10.3390/biology4020314 · Cited by 2
“Macrophages also play a role in wound healing and organ regeneration via SPMs [6,16].”
Phenotypic Plasticity and the Origins and Progression of Ovarian Cancer
Carter, L. E., Cook, D. P., & Vanderhyden, B. (2019) · The Ovary · doi:10.1016/b978-0-12-813209-8.00033-9 · Cited by 5
Manipulating the healing response
Azzimonti, B., Sabbatini, M., Rimondini, L., & Cannas, M. F. (2016) · Elsevier eBooks · doi:10.1016/b978-1-78242-455-0.00004-5 · Cited by 5
Novel Animal Models for Tracking the Fate and Contributions of Bone Marrow Derived Cells in Diabetic Healing
Caskey, R. C., & Liechty, K. W. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-505-7_6 · Cited by 6
Regenerative Medicine and the Foreign Body Response
Daly, K. A., Brown, B. N., & Badylak, S. F. (2011) · Humana Press eBooks · doi:10.1007/978-1-61779-322-6_19 · Cited by 4
Temporal dynamics of macrophage transcriptional profiles during zebrafish wound healing
Begon-Pescia, C., Manchon, L., Ozbilgic, R., Boireau, S., Louis, A., Georges, S., & Nguyen-Chi, M. E. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1721612 · Cited by 4
Regulation of macrophage transcriptional dynamics during acute and chronic wound repair
Raja, S. R., Sk, M. H., Wajeed, S., Yangdol, R., Yadav, A., Jindal, H., Fatima, A., Siddiquie, A., Pulakat, L., Subramanian, R., et al. (2025) · Inflammation Research · doi:10.1007/s00011-025-02133-1 · Cited by 6
“Among the various cell types involved in inflammation and tissue repair, macrophages play a crucial role in their coordination by incorporating certain signals from the surroundings into the inflammation and healing process [28, 29].”
Single-cell–guided repositioning of Sorafenib enables nano-immunotherapy for scarless burn healing
Tao, Y., Li, H.-X., Xie, J., Ding, R., Zhuang, Z., Yang, X., Zhu, Y., Jie, S., & Chen, X.-L. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.170493 · Cited by 4
Hybrid living electronic skin for proactive scarless wound healing
Ma, Y., Xiong, C., Guo, F., Huang, M., Xie, X., Guo, Q., & Shi, P. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123721 · Cited by 4
The Association of Wagner Classification, Microbial Resistance, Immune Markers, and Glycemic Control With Diabetic Foot Ulcer Severity: A Multi-disciplinary Approach to Predict Severity and Outcome
Saleem, M. N., Mir, A., Ullah, U., Talha, M., Nawaz, H., Rehman, A., & Ullah, R. (2025) · Cureus · doi:10.7759/cureus.90914 · Cited by 4
“The balance between the production and death of these cells is carefully regulated by the body [11].”
Deciphering the Iron Metabolism and Ferroptosis in Diabetic Wound Healing
Feng, Y.-S., Cao, Y.-C., Ouyang, Y., Wang, W.-X., & Feng, S.-L. (2025) · Current Diabetes Reviews · doi:10.2174/0115733998352547250107065356 · Cited by 4
Stromal vascular fraction: Mechanisms and application in reproductive disorders
Liu, Z.-H., Xie, Q., & Huang, J.-L. (2025) · World Journal of Stem Cells · doi:10.4252/wjsc.v17.i1.101097 · Cited by 4
Mechanism of engineered macrophage membrane bionic gene-carrying nanospheres for targeted drug delivery to promote wound repair in deep second-degree burns
Zhu, Z., Zhu, X., Miao, S., Wang, B., Li, Z., Zhang, D., Zou, S., Zhang, Y., Zhang, Q., & Hu, K. (2025) · Scientific Reports · doi:10.1038/s41598-025-86716-2 · Cited by 4
“…wounds or when wounds are oversized, the over-contraction and continued differentiation may lead to scar formation. therefore, the most critical role in preventing scar formation is to appropriately control the inflammatory response and the differentiation of fibroblasts to myofibroblasts 20,24 .”
Mitochondrial DNA mutations attenuate Bleomycin-induced dermal fibrosis by inhibiting differentiation into myofibroblasts.
Reǐter, L., Niehoff, N., Weiland, D., Helbig, D., Eming, S. A., Krieg, T., Etich, J., Brachvogel, B., Wiesner, R., & Knuever, J. (2024) · Matrix Biology · doi:10.1016/j.matbio.2024.07.002 · Cited by 4
Self-citation
A pro‐reparative bioelectronic device for controlled delivery of ions and biomolecules
Asefifeyzabadi, N., Nguyen, T., Li, H.-P., Zhu, K., Yang, H.-Y., Baniya, P., Lopez, A. I. M., Gallegos, A., Hsieh, H.-C., Dechiraju, H., et al. (2024) · Wound Repair and Regeneration · doi:10.1111/wrr.13191 · Cited by 4
“40,65 M1 macrophages secrete cytokines such as IL-1, TNFa, IL-6, IL-12 and matrix metalloproteinases (MMPs), while M2 cells produce arginase, TGFb, CCL18, PGE2, and IL-10 and upregulate scavenger receptors such as CD206 and CD163.”
The metabolic cofactor Coenzyme A enhances alternative macrophage activation via MyD88-linked signalingPreprint
Jones, A. E., Rios, A., Ibrahimovic, N., Chavez, C., Bayley, N. A., Ball, A. B., Hsieh, W. Y., Sammarco, A., Bianchi, A., Cortez, A. A., et al. (2024) · bioRxiv · doi:10.1101/2024.03.28.587096 · Cited by 4
Bacterial Lipoteichoic Acid Induces Capsular Contracture by Activating Innate Immune Response
Ahmad, I., Xuan, T., Wang, Q., Zhang, S., Wang, L., Gu, J., Qi, F., & Luan, W. (2023) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000011054 · Cited by 6
“11,12 Although myofibroblasts are activated by macrophages after injury, certain sub-populations of macrophages have been defined only recently.”
Proximal ear hole injury heals by limited regeneration during the early postnatal phase in mice
Abarca-Buis, R., & Krötzsch, E. (2022) · Journal of Anatomy · doi:10.1111/joa.13782 · Cited by 4
“…vessels in the proximal region in comparsion with distal region could promote the release of blood components, including monocyte- derived macrophages, which are critical for the progression of wound healing (Lucas et al., 2010) and regeneration (Godwin et al., 2013; Simkin et al., 2017).”
Background
Topical Topiramate Improves Wound Healing in an Animal Model of Hyperglycemia
Jara, C. P., do Prado, T. P., Bóbbo, V. C. D., Ramalho, A. D. F. S., Lima, M. H. M., Velloso, L. A., & ARAUJO, E. P. D. (2019) · Biological Research For Nursing · doi:10.1177/1099800419845058 · Cited by 4
Annexin A1 drives macrophage skewing towards a resolving phenotype to accelerate the regeneration of muscle injury through AMPK activation
McArthur, S., Gobbetti, T., Juban, G., Desgeorges, T., Théret, M., Gondin, J., Toller-Kawahisa, J. E., Reutelingsperger, C., Perretti, M., & Mounier, R. (2018) · bioRxiv · doi:10.1101/375709 · Cited by 4
“…effete cells and debris by phagocytosis (Mantovani et al., 2013), serving as antigen presenting cells to recruit the adaptive arm of the immune response (Motwani and Gilroy, 2015), and ultimately enabling processes of tissue repair and resolution (Lucas et al., 2010; Troidl et al., 2009).”
Background
Induced Granulation Tissue but not Artificial Dermis Enhances Early Host–Graft Interactions in Full-Thickness Burn Wounds
Lagus, H., Kankuri, E., Nuutila, K., Juteau, S., Sarlomo-Rikala, M., & Vuola, J. (2018) · World Journal of Surgery · doi:10.1007/s00268-017-4270-6 · Cited by 4
“Macrophages have been shown to play a key role in orchestrating both the quality of the inflammatory response and progression of wound healing to the proliferation phase [21].”
Background
Therapeutic tissue regeneration by a macrophage colony-stimulating factor Fc conjugate.
van den Boorn, J. G., & Hartmann, G. (2014) · Molecular Therapy · doi:10.1038/mt.2014.150 · Cited by 4
BluePort: A Platform to Study the Eosinophilic Response of Mice to the Bite of a Vector of Leishmania Parasites, Lutzomyia longipalpis Sand Flies
Mejia, J. S., Toot-Zimmer, A. L., Schultheiss, P. C., Beaty, B. J., & Titus, R. G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013546 · Cited by 4
“), an indication that the beads were no longer generating danger signals to the innate immune system. In support of this interpretation was the finding of collagen-rich extracellular matrix deposition, a terminal event of the wound healing and tissue regeneration process”
Background

Authors: Lucas, T., Waisman, A., Ranjan, R., Roes, J., Krieg, T., Müller, W., Roers, A., & Eming, S. A.
Affiliations: Department of Dermatology
Johannes Gutenberg University Mainz (DE)
University College London (GB)
University of Cologne (DE)
University of Manchester (GB)
Technische Universität Dresden (DE)
ORCID: Waisman, Ari
Ranjan, Rajeev
Roes, Jürgen
Krieg, Thomas
Müller, Werner
Roers, Axel
Eming, Sabine A
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 2010-04-01
Volume: 184
Issue: 7
Pages: 3964-3977
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.0903356
OpenAlex: W2118654016
Cited by: 1,205
References: 0
Citations by year: 2026: 47 · 2025: 71 · 2024: 84 · 2023: 86 · 2022: 110 · 2021: 102 · 2020: 90 · 2019: 76 · 2018: 87 · 2017: 83 · 2016: 73 · 2015: 78 · 2014: 73 · 2013: 66 · 2012: 41
FWCI: 47.25
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Research Explorer (The University of Manchester) (submittedVersion)
Funders: University College London
Deutsche Forschungsgemeinschaft (SFB829)
Topics: Health Sciences › Medicine › Surgery › Wound Healing and Treatments
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Keywords: macrophages, skin repair, wound healing, mechanical damage, granulation tissue, re-epithelialization, scar formation, hemorrhage, tissue maturation, wound closure, tissue formation
MeSH terms: Animals, Cell Separation, Flow Cytometry, Immunohistochemistry, Macrophages, Mice, Inbred C57BL, Mice, Transgenic, Skin, Skin Physiological Phenomena, Wound Healing, Reverse Transcriptase Polymerase Chain Reaction, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Differential Roles of Macrophages in Diverse Phases of Skin Repair

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Metadata

Record

About these checks