The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
STAT3 Negatively Regulates Type I IFN-Mediated Antiviral Response
Open accessAbstract
Type I IFNs are crucial cytokines of innate immunity for combating viral infections. Signaling through type I IFN receptors triggers the activation of STAT proteins, including STAT1, STAT2, and STAT3. Although an essential role of STAT1 and STAT2 for type I IFN-induced antiviral response has been well established by studies of gene-targeted mice and human mutations, the role of STAT3 for this response remains unclear. Using gain-of-function and loss-of-function approaches, we demonstrated that STAT3 negatively regulates type I IFN-mediated response. STAT3 knockdown or knockout cells displayed enhanced gene expression and antiviral activity in response to IFN-α/β. Restoration of STAT3 to STAT3KO cells resulted in attenuation of the response. Upon viral infection, increased type I IFN production in STAT3KO cells resulted in enhanced STAT activation and ISG expression. One mechanism for the enhanced IFN production and response in the absence of STAT3 might operate through an MDA5-dependent manner. STAT3 also appeared to suppress IFN response directly in a manner dependent on its N-terminal domain and independent of its function as a transcriptional factor. Taken together, these results define STAT3 as a negative regulator of type I IFN response and provide a therapeutic target for viral infections.
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Cites
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Yu, H., Pardoll, D., & Jove, R. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2734 · Cited by 4,383
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
Kato, H., Takeuchi, O., Sato, S., Yoneyama, M., Yamamoto, M., Matsui, K., Uematsu, S., Jung, A., Kawai, T., Ishii, K. J., et al. (2006) · Nature · doi:10.1038/nature04734 · Cited by 3,888
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Self-citationUnderstanding and exploiting the endogenous interleukin-10/STAT3-mediated anti-inflammatory response
MURRAY, P. (2006) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2006.01.010 · Cited by 436
Hematopoietic cytokine receptor signaling
Baker, S. J., Rane, S. G., & Reddy, E. P. (2007) · Oncogene · doi:10.1038/sj.onc.1210757 · Cited by 256
Kortylewski, M., Kujawski, M., Herrmann, A., Yang, C., Wang, L., Liu, Y., Salcedo, R., & Yu, H. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3031 · Cited by 122
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STAT3 positively regulates an early step in B-cell development
Chou, W.-C., Levy, D. E., & Lee, C.-K. (2006) · Blood · doi:10.1182/blood-2006-05-024430 · Cited by 94
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McCauley, M. E., & Baloh, R. H. (2019) · Acta Neuropathologica · doi:10.1007/s00401-018-1933-9 · Cited by 341
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The immunology of influenza virus-associated bacterial pneumonia.
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Metadata
- Authors
- Wang, W.-B., Levy, D. E., & Lee, C.-K.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-09-01
- Volume
- 187
- Issue
- 5
- Pages
- 2578-2585
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2117453887
- Cited by
- 178
- References
- 8
- FWCI
- 2.95
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Wang, W.-B., Levy, D. E., & Lee, C.-K. (2011). STAT3 Negatively Regulates Type I IFN-Mediated Antiviral Response. The Journal of Immunology. https://doi.org/10.4049/jimmunol.1004128
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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