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CD28- T lymphocytes. Antigenic and functional properties
Abstract
A subset of CD8+ alpha beta-TCR/CD3+ T lymphocytes in adult human peripheral blood lacks expression of CD28, a membrane receptor for the B7/BB1 B cell differentiation Ag that is involved in T cell activation. CD28-8+ T cells were not observed in the thymus and were present at only low frequency in cord blood, suggesting that these cells may represent a type of “memory” population. Consistent with this interpretation, CD28-8+ T cells were morphologically large, granular lymphocytes and expressed CD54 (intercellular adhesion molecule-1), CD58 (lymphocyte function-associated Ag-3 (LFA)), and high levels of CD11a (LFA-1), but did not express Ag associated with acute activation (e.g., HLA-DR, CD25, CD69). Freshly isolated CD28-8+ T lymphocytes mediated potent anti-CD3 redirected cytotoxicity against FcR-bearing targets, demonstrating that the CD3/TCR complex is functional and that these cells possess cytolytic activity. However, the anti-CD3-induced proliferative response of CD28-8+ T cells was substantially less than CD28+8+ T cells and this deficiency could not be overcome by addition of exogenous IL-2. A large panel of T cell clones were produced from the CD28+8+ and CD28-8+ T cell populations by single cell sorting using a flow cytometer. CD28 expression was stable on clones derived from CD28+8+ T lymphocytes, whereas CD28 expression was quite variable and apparently reexpressed on some clones generated from the CD28-8+ T cell population. As with the freshly isolated cells, CD28-8+ T cell clones were cytotoxic, but anergic to anti-CD3- induced proliferation and could not be costimulated using B7 or CD58 (LFA-3) murine L cell transfectants. These results indicate that CD28- and CD28+ T cells may play different roles in an immune response.
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Hamann, D., Baars, P. A., Rep, M. H. G., Hooibrink, B., Kerkhof-Garde, S. R., Klein, M. R., & Lier, R. A. W. V. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.9.1407 · Cited by 1,366
Callan, M. F. C., Tan, L., Annels, N., Ogg, G. S., Wilson, J. D. K., O'Callaghan, C. A., Steven, N., McMichael, A. J., & Rickinson, A. B. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.9.1395 · Cited by 892
The aging of the immune system
Weiskopf, D., Weinberger, B., & Grubeck-Loebenstein, B. (2009) · Transplant International · doi:10.1111/j.1432-2277.2009.00927.x · Cited by 908
Khan, N., Shariff, N., Cobbold, M., Bruton, R., Ainsworth, J. A., Sinclair, A. J., Nayak, L., & Moss, P. A. H. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.4.1984 · Cited by 754
Schmidt, D., Goronzy, J. J., & Weyand, C. M. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118638 · Cited by 482
Mackall, C. L., Fleisher, T. A., Brown, M. R., Andrich, M. P., Chen, C. C., Feuerstein, I. M., Magrath, I. T., Wexler, L. H., Dimitrov, D. S., & Gress, R. E. (1997) · Blood · doi:10.1182/blood.v89.10.3700 · Cited by 400
Effros, R. B., Boucher, N., Porter, V., Zhu, X., Spaulding, C., Walford, R. L., Kronenberg, M., Cohen, D., & Schächter, F. (1994) · Experimental Gerontology · doi:10.1016/0531-5565(94)90073-6 · Cited by 377
Expansion of cytotoxic CD8 + CD28 − T cells in healthy ageing people, including centenarians
FAGNONI, F. F., VESCOVINI, R., MAZZOLA, M., BOLOGNA, G., NIGRO, E., LAVAGETTO, G., FRANCESCHI, C., PASSERI, M., & SANSONI, P. (1996) · Immunology · doi:10.1046/j.1365-2567.1996.d01-689.x · Cited by 362
Voehringer, D., Koschella, M., & Pircher, H. (2002) · Blood · doi:10.1182/blood-2002-02-0657 · Cited by 352
Inflammaging as a prodrome to Alzheimer's disease
Giunta, B., Fernandez, F., Nikolic, W. V., Obregon, D., Rrapo, E., Town, T., & Tan, J. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-51 · Cited by 327
Human CD8+ T-cell differentiation in response to viruses
van Lier, R. A. W., ten Berge, I. J. M., & Gamadia, L. E. (2003) · Nature Reviews Immunology · doi:10.1038/nri1254 · Cited by 297
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Fearon, D. T., Manders, P., & Wagner, S. D. (2001) · Science · doi:10.1126/science.1062589 · Cited by 265
Posnett, D. N., Edinger, J. W., Manavalan, J. S., Irwin, C., & Marodon, G. (1999) · International Immunology · doi:10.1093/intimm/11.2.229 · Cited by 202
Son, N. H., Murray, S., Yanovski, J., Hodes, R. J., & Weng, N.-P. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.3.1191 · Cited by 200
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Boucher, N., Dufeu-Duchesne, T., Vicaut, E., Farge, D., Effros, R. B., & Schächter, F. (1998) · Experimental Gerontology · doi:10.1016/s0531-5565(97)00132-0 · Cited by 194
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Effros, R. B. (1997) · Developmental & Comparative Immunology · doi:10.1016/s0145-305x(97)00027-x · Cited by 175
Filaci, G., Fravega, M., Negrini, S., Procopio, F., Fenoglio, D., Rizzi, M., Brenci, S., Contini, P., Olive, D., Ghio, M., et al. (2004) · Human Immunology · doi:10.1016/j.humimm.2003.12.001 · Cited by 163
Tsukishiro, T., Donnenberg, A. D., & Whiteside, T. L. (2003) · Cancer Immunology, Immunotherapy · doi:10.1007/s00262-003-0395-6 · Cited by 158
Role of T lymphocyte replicative senescence in vaccine efficacy
Effros, R. B. (2007) · Vaccine · doi:10.1016/j.vaccine.2006.08.032 · Cited by 152
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Effros, R. B. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2003.09.024 · Cited by 127
Metabolic reprogramming of human CD8+ memory T cells through loss of SIRT1
Jeng, M. Y., Hull, P. A., Fei, M., Kwon, H.-S., Tsou, C.-L., Kasler, H., Ng, C.-P., Gordon, D. E., Johnson, J., Krogan, N., et al. (2018) · Journal of Experimental Medicine · doi:10.1084/jem.20161066 · Cited by 121
Effros, R. B. (1998) · The American Journal of Human Genetics · doi:10.1086/301845 · Cited by 105
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Leitner, J., Herndler-Brandstetter, D., Zlabinger, G. J., Grubeck-Loebenstein, B., & Steinberger, P. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1401917 · Cited by 104
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Chou, J. P., Ramirez, C. M., Wu, J. E., & Effros, R. B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064702 · Cited by 78
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Metadata
- Authors
- Azuma, M., Phillips, J. H., & Lanier, L. L.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1993-02
- Volume
- 150
- Issue
- 4
- Pages
- 1147-1159
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2101881039
- Cited by
- 387
- References
- 0
- FWCI
- 6.56
- Type
- journal article
- Language
- en
- Open access
- closed
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