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Cohabitation in the Intestine: Interactions among Helminth Parasites, Bacterial Microbiota, and Host Immunity

Reynolds, Lisa A, Finlay, B Brett, Maizels, Rick M·2015·The Journal of Immunology
DOI 10.4049/jimmunol.1501432PMC PMC4617609
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Abstract

Both intestinal helminth parasites and certain bacterial microbiota species have been credited with strong immunomodulatory effects. Recent studies reported that the presence of helminth infection alters the composition of the bacterial intestinal microbiota and, conversely, that the presence and composition of the bacterial microbiota affect helminth colonization and persistence within mammalian hosts. This article reviews recent findings on these reciprocal relationships, in both human populations and mouse models, at the level of potential mechanistic pathways and the implications these bear for immunomodulatory effects on allergic and autoimmune disorders. Understanding the multidirectional complex interactions among intestinal microbes, helminth parasites, and the host immune system allows for a more holistic approach when using probiotics, prebiotics, synbiotics, antibiotics, and anthelmintics, as well as when designing treatments for autoimmune and allergic conditions.

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Metadata

Authors
Reynolds, L. A., Finlay, B. B., & Maizels, R. M.
Venue
The Journal of Immunology
Publisher
Oxford University Press (OUP)
Published
2015-11-01
Volume
195
Issue
9
Pages
4059-4066
ISSN
  • 0022-1767
  • 1550-6606
DOI
10.4049/jimmunol.1501432
PMC
PMC4617609
Cited by
167
References
14
Language
en
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)

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