The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Stat3 Activation Is Responsible for IL-6-Dependent T Cell Proliferation Through Preventing Apoptosis: Generation and Characterization of T Cell-Specific Stat3-Deficient Mice
Open accessAbstract
Stat3, a member of STAT, is activated by a variety of cytokines such as IL-6 family of cytokines, granulocyte CSF, epidermal growth factor, and leptin. A recent study with mice genetically deficient in the Stat3 gene has revealed its important role in the early embryogenesis. To assess the function of Stat3 in adult tissues, we disrupted the Stat3 gene specifically in T cells by conditional gene targeting using Cre-loxP system. In Stat3-deficient T cells, IL-6-induced proliferation was severely impaired. IL-6 did not enhance cell cycle progression, but prevented apoptosis of normal T cells. In contrast, IL-6 did not prevent apoptosis of Stat3-deficient T cells. Antiapoptotic protein, Bcl-2, was normally up-regulated in response to IL-6 even in Stat3-deficient T cells. These results demonstrate that Stat3 activation is involved in IL-6-dependent T cell proliferation through prevention of apoptosis independently of Bcl-2.
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“Increased apoptosis and impaired Th17 development”
From Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution (2020) · cites this paper as Takeda et al., 1998b
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“Specific disruption of STAT3 in T cells revealed that STAT3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis (13”
From STAT3 Contributes to the Mitogenic Response of Hepatocytes during Liver Regeneration (2002) · cites this paper as [13]
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“T lymphocyte lineage-specific STAT3-KO mice studies revealed the crucial role of IL-6/STAT3-mediated T cell survival, independent of Bcl-2”
From Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution (2020) · cites this paper as Takeda et al., 1998
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Darnell, J. E. (1997) · Science · doi:10.1126/science.277.5332.1630 · Cited by 3,979
bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death
Boise, L., González‐García, M., Postema, C. E., Ding, L., Lindsten, T., Turka, L. A., Mao, X., Núñez, G., & Thompson, C. B. (1993) · Cell · doi:10.1016/0092-8674(93)90508-n · Cited by 3,089
Zhong, Z., Wen, Z., & Darnell, J. E. (1994) · Science · doi:10.1126/science.8140422 · Cited by 2,070
TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway
Schindler, C., & Darnell, J. E. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.003201 · Cited by 1,808
Impaired immune and acute-phase responses in interleukin-6-deficient mice
Kopf, M., Baumann, H., Freer, G., Freudenberg, M., Lamers, M., Kishimoto, T., Zinkernagel, R., Bluethmann, H., & Köhler, G. (1994) · Nature · doi:10.1038/368339a0 · Cited by 1,768
Self-citationMeraz, M. A., White, J. M., Sheehan, K. C. F., Bach, E. A., Rodig, S. J., Dighe, A. S., Kaplan, D. H., Riley, J. K., Greenlund, A. C., Campbell, D., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81288-x · Cited by 1,656
Novack, D. V., Sorenson, C. M., Shutter, J. R., & Korsmeyer, S. J. (1993) · Cell · doi:10.1016/0092-8674(93)80065-m · Cited by 1,637
Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells
Kaplan, M. H., Schindler, U., Smiley, S. T., & Grusby, M. J. (1996) · Immunity · doi:10.1016/s1074-7613(00)80439-2 · Cited by 1,629
Essential role of Stat6 in IL-4 signalling
Takeda, K., Tanaka, T., Shi, W., Matsumoto, M., Minami, M., Kashiwamura, S.-I., Nakanishi, K., Yoshida, N., Kishimoto, T., & Akira, S. (1996) · Nature · doi:10.1038/380627a0 · Cited by 1,557
Self-citationTargeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease
Durbin, J. E., Hackenmiller, R., Simon, M. C., & Levy, D. E. (1996) · Cell · doi:10.1016/s0092-8674(00)81289-1 · Cited by 1,539
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Research works printed but not linked: 51
- 1995, Annu. Rev. Biochem., 621
- 1997, Science, 1630
- 1996, Cell, 331
- 1997, Immunity, 1
- 1996, Cell, 443
- 1996, Cell, 431
- 1996, Nature, 630
- 1996, Nature, 627
- 1996, Immunity, 313
- 1996, Nature, 174
- 1996, Nature, 171
- 1997, Genes Dev., 179
- 1997, Proc. Natl. Acad. Sci. USA, 7239
- 1995, Mol. Cell. Biol., 3336
- 1995, EMBO J., 5557
- 1996, EMBO J., 2434
- 1996, EMBO J., 2425
- 1997, Immunity, 691
- 1996, Science, 719
- 1998, Mol. Cell. Biol., 1996
- 1995, Science, 81
- 1997, Mol. Cell. Biol., 3295
- 1994, Cell, 63
- 1994, Science, 95
- 1998, Int. J. Biochem. Cell Biol., 1401
- 1995, Science, 79
- 1996, Proc. Natl. Acad. Sci. USA, 9148
- 1997, Proc. Natl. Acad. Sci. USA, 6764
- 1997, Proc. Natl. Acad. Sci. USA, 13897
- 1997, J. Immunol., 5206
- 1997, Proc. Natl. Acad. Sci. USA, 3801
- 1993, Cell, 1155
- 1994, Science, 103
- 1996, J. Clin. Invest., 600
- 1997, Science, 412
- 1998, Blood, 3308
- 1996, Proc. Natl. Acad. Sci. USA, 3963
- 1997, J. Cell Biol., 1207
- 1994, Proc. Natl. Acad. Sci. USA, 3700
- 1993, Cell, 597
- 1995, Science, 1506
- 1995, Cell, 279
- 1994, Immunity, 725
- 1994, Nature, 339
- 1988, J. Exp. Med., 1253
- 1997, J. Immunol., 5791
- 1993, J. Immunol., 83
- 1994, Proc. Natl. Acad. Sci. USA, 10685
- 1993, Science, 1584
- 1993, Cell, 229
- 1997, Cell, 1033
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Schroder, K., Hertzog, P. J., Ravasi, T., & Hume, D. A. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0603252 · Cited by 4,120
STATs: transcriptional control and biological impact
Levy, D. E., & Darnell, J. E. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm909 · Cited by 3,201
Bromberg, J. F., Wrzeszczynska, M. H., Devgan, G., Zhao, Y., Pestell, R. G., Albanese, C., & Darnell, J. E. (1999) · Cell · doi:10.1016/s0092-8674(00)81959-5 · Cited by 2,790
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease
Turner, M. D., Nedjai, B., Hurst, T. P., & Pennington, D. J. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2014.05.014 · Cited by 2,289
Astrocyte scar formation aids central nervous system axon regeneration
Anderson, M. A., Burda, J. E., Ren, Y., Ao, Y., O’Shea, T. M., Kawaguchi, R., Coppola, G., Khakh, B. S., Deming, T. J., & Sofroniew, M. V. (2016) · Nature · doi:10.1038/nature17623 · Cited by 1,851
Metadata
- Authors
- Takeda, K., Kaisho, T., Yoshida, N., Takeda, J., Kishimoto, T., & Akira, S.
- Affiliations
- Hyogo Medical University (JP)
- Research Institute, Osaka Maternal and Child Health Center , Izumi, Osaka ,
- The University of Osaka (JP)
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-11-01
- Volume
- 161
- Issue
- 9
- Pages
- 4652-4660
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W4313347835
- Cited by
- 584
- References
- 52
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 13 · 2023: 11 · 2022: 14 · 2021: 19 · 2020: 19 · 2019: 19 · 2018: 21 · 2017: 20 · 2016: 34 · 2015: 28 · 2014: 27 · 2013: 34 · 2012: 25
- FWCI
- 10.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Immunology (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- STAT3, interleukin-6, T cell proliferation, apoptosis, Bcl-2, conditional gene targeting, Cre-loxP system, STAT family, cell cycle progression, anti-apoptotic signaling
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