The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Cutting Edge: Vitamin D-Mediated Human Antimicrobial Activity against Mycobacterium tuberculosis Is Dependent on the Induction of Cathelicidin
Abstract
Host defense against intracellular pathogens depends upon innate and adaptive antimicrobial effector pathways. TLR2/1-activation of monocytes leads to the vitamin D-dependent production of cathelicidin and, at the same time, an antimicrobial activity against intracellular Mycobacterium tuberculosis. To determine whether induction of cathelicidin was required for the vitamin D-triggered antimicrobial activity, the human monocytic cell line THP-1 was infected with M. tuberculosis H37Ra and then activated with the active vitamin D hormone 1,25-dihydroxyvitamin D3 (1,25D3). 1,25D3 stimulation resulted in antimicrobial activity against intracellular M. tuberculosis and expression of cathelicidin mRNA and protein. Using small interfering RNA (siRNA) specific for cathelicidin, 1,25D3-induced cathelicidin mRNA and protein expressions were efficiently knocked down, whereas a nonspecific siRNA control had little effect. Finally, 1,25D3-induced antimicrobial activity was completely inhibited in the presence of siRNA against cathelicidin, instead leading to enhanced intracellular growth of mycobacteria. These data demonstrate that cathelicidin is required for the 1,25D3-triggered antimicrobial activity against intracellular M. tuberculosis.
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Cites
Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response
Liu, P. T., Stenger, S., Li, H., Wenzel, L., Tan, B. H., Krutzik, S. R., Ochoa, M. T., Schauber, J., Wu, K., Meinken, C., et al. (2006) · Science · doi:10.1126/science.1123933 · Cited by 3,924
Self-citationVitamin D in the treatment of pulmonary tuberculosis
Martineau, A. R., Honecker, F. U., Wilkinson, R. J., & Griffiths, C. J. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2006.12.052 · Cited by 216
Cited by
Pludowski, P., Holick, M. F., Pilz, S., Wagner, C. L., Hollis, B. W., Grant, W. B., Shoenfeld, Y., Lerchbaum, E., Llewellyn, D. J., Kienreich, K., et al. (2013) · Autoimmunity Reviews · doi:10.1016/j.autrev.2013.02.004 · Cited by 836
Vitamin D3: a helpful immuno-modulator: Vitamin D3 as immuno-modulator
Di Rosa, M., Malaguarnera, M., Nicoletti, F., & Malaguarnera, L. (2011) · Immunology · doi:10.1111/j.1365-2567.2011.03482.x · Cited by 447
Bergman, P., Lindh, Å. U., Björkhem-Bergman, L., & Lindh, J. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065835 · Cited by 429
Sonawane, A., Santos, J. C., Mishra, B. B., Jena, P., Progida, C., Sorensen, O. E., Gallo, R., Appelberg, R., & Griffiths, G. (2011) · Cellular Microbiology · doi:10.1111/j.1462-5822.2011.01644.x · Cited by 165
Host Defense Peptide LL-37 Selectively Reduces Proinflammatory Macrophage Responses
Brown, K. L., Poon, G. F. T., Birkenhead, D., Pena, O. M., Falsafi, R., Dahlgren, C., Karlsson, A., Bylund, J., Hancock, R. E. W., & Johnson, P. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002508 · Cited by 163
Hamilton, S. A., McNeil, R., Hollis, B. W., Davis, D. J., Winkler, J., Cook, C., Warner, G., Bivens, B., McShane, P., & Wagner, C. L. (2010) · International Journal of Endocrinology · doi:10.1155/2010/917428 · Cited by 105
Innate immunity to mycobacteria: vitamin D and autophagy
Jo, E.-K. (2010) · Cellular Microbiology · doi:10.1111/j.1462-5822.2010.01491.x · Cited by 98
Lee, H.-M., Shin, D.-M., Choi, D.-K., Lee, Z.-W., Kim, K.-H., Yuk, J.-M., Kim, C. D., Lee, J.-H., & Jo, E.-K. (2009) · Cellular Microbiology · doi:10.1111/j.1462-5822.2009.01285.x · Cited by 69
New Insights into the Interaction of Mycobacterium Tuberculosis and Human Macrophages
Bruns, H., & Stenger, S. (2014) · Future Microbiology · doi:10.2217/fmb.13.164 · Cited by 47
Self-citationLopez-Lopez, N., Gonzalez-Curiel, I., Castañeda-Delgado, J., Montoya-Rosales, A., Gandara-Jasso, B., Enciso-Moreno, J. A., & Rivas-Santiago, B. (2014) · Microbes and Infection · doi:10.1016/j.micinf.2014.06.010 · Cited by 25
Metadata
- Authors
- Liu, P. T., Stenger, S., Tang, D. H., & Modlin, R. L.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-08
- Volume
- 179
- Issue
- 4
- Pages
- 2060-2063
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1927671826
- Cited by
- 773
- References
- 2
- FWCI
- 39.75
- Type
- journal article
- Language
- en
- Open access
- closed
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