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Cited by 1,381Diabetes Management and ResearchDiabetes, Cardiovascular Risks, and LipoproteinsAdvanced Glycation End Products research

Significance of HbA1c Test in Diagnosis and Prognosis of Diabetic Patients

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Sherwani, Shariq I., Khan, Haseeb A., Ekhzaimy, Aishah, Masood, Afshan, Sakharkar, Meena K.·2016·Biomarker Insights
DOI 10.4137/bmi.s38440PMC PMC4933534
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Abstract

Diabetes is a global endemic with rapidly increasing prevalence in both developing and developed countries. The American Diabetes Association has recommended glycated hemoglobin (HbA1c) as a possible substitute to fasting blood glucose for diagnosis of diabetes. HbA1c is an important indicator of long-term glycemic control with the ability to reflect the cumulative glycemic history of the preceding two to three months. HbA1c not only provides a reliable measure of chronic hyperglycemia but also correlates well with the risk of long-term diabetes complications. Elevated HbA1c has also been regarded as an independent risk factor for coronary heart disease and stroke in subjects with or without diabetes. The valuable information provided by a single HbA1c test has rendered it as a reliable biomarker for the diagnosis and prognosis of diabetes. This review highlights the role of HbA1c in diagnosis and prognosis of diabetes patients.

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  • Blood glucose concentration and HbA1c are still the major biomarkers for both diagnosis and patient monitoring.

    “Even though a variety of predictive, diagnostic, and prognostic biomarkers (and related technologies) are continuously proposed, blood glucose concentration and HbA1c are still the major biomarkers for both diagnosis and patient monitoring 36,37.”

    From Glucose biosensors in clinical practice: principles, limits and perspectives of currently used devices (2022) · cites this paper as [37]

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Authors
Sherwani, S. I., Khan, H. A., Ekhzaimy, A., Masood, A., & Sakharkar, M. K.
Affiliations
  • The Ohio State University (US)
  • King Saud University (SA)
  • King Khalid University Hospital (SA)
  • University of Saskatchewan (CA)
Corresponding author
Khan, Haseeb A.
ORCID
Venue
Biomarker Insights
Publisher
SAGE Publications
Published
2016-01
Volume
11
Pages
BMI.S38440
ISSN
1177-2719 (ISSN-L)
DOI
10.4137/bmi.s38440
PMC
PMC4933534
OpenAlex
W2470838351
Cited by
1,381
References
4
Citations by year
2026: 130 · 2025: 201 · 2024: 237 · 2023: 242 · 2022: 181 · 2021: 134 · 2020: 120 · 2019: 78 · 2018: 39 · 2017: 15 · 2016: 1 · 2014: 1
FWCI
6.52
Type
journal article
Language
en
Open access
Licence
Locations
  • Biomarker Insights (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
Keywords
HbA1c, diabetes diagnosis, diabetes prognosis, glycemic control, chronic hyperglycemia, diabetes complications, coronary heart disease risk, stroke risk, biomarkers

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