Marine Natural Products: A New Wave of Drugs?

Natural products as sources of new drugs over the last 25 years

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Target identification using drug affinity responsive target stability (DARTS)

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Salinosporamide A: A Highly Cytotoxic Proteasome Inhibitor from a Novel Microbial Source, a Marine Bacterium of the New Genus Salinospora

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The Sorcerer II Global Ocean Sampling Expedition: Expanding the Universe of Protein Families

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Developing a new resource for drug discovery: marine actinomycete bacteria

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The odyssey of marine pharmaceuticals: a current pipeline perspective

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Ziconotide: Neuronal Calcium Channel Blocker for Treating Severe Chronic Pain

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Marine natural products as anticancer drugs

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Patellamide A and C biosynthesis by a microcin-like pathway in Prochloron didemni , the cyanobacterial symbiont of Lissoclinum patella

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Strategies for discovering drugs from previously unexplored natural products

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Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica

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Halichondrins-antitumor polyether macrolides from a marine sponge

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A Review of Trabectedin (ET-743): A Unique Mechanism of Action

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Structure and Activity of Largazole, a Potent Antiproliferative Agent from the Floridian Marine Cyanobacterium Symploca sp.

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Antagonistic Interactions among Marine Pelagic Bacteria

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Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data

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Total Structure Determination of Apratoxin A, a Potent Novel Cytotoxin from the Marine Cyanobacterium Lyngbya majuscula

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The discovery and development of marine compounds with pharmaceutical potential

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Organic structure determination using atomic-resolution scanning probe microscopy

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Natural products and combinatorial chemistry: back to the future

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Eribulin Binds at Microtubule Ends to a Single Site on Tubulin To Suppress Dynamic Instability

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The Taxol Supply Crisis. New NCI Policies for Handling the Large-Scale Production of Novel Natural Product Anticancer and Anti-HIV Agents

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Identification of Direct Protein Targets of Small Molecules

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Pharmaceutically Active Natural Product Synthesis and Supply via Plant Cell Culture Technology

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Discovery and development of the anticancer agent salinosporamide A (NPI-0052)

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Phorboxazoles A and B: potent cytostatic macrolides from marine sponge Phorbas species

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Induced Production of Emericellamides A and B from the Marine-Derived Fungus Emericella sp. in Competing Co-culture

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Synthesis of Ecteinascidin ET-743 and Phthalascidin Pt-650 from Cyanosafracin B

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Automated genome mining for natural products

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Evidence for the Biosynthesis of Bryostatins by the Bacterial Symbiont “ Candidatus Endobugula sertula” of the Bryozoan Bugula neritina

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Marine pharmacology in 2007–8: Marine compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral activities; affecting the immune and nervous system, and other miscellaneous mechanisms of action

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Antiviral Lead Compounds from Marine Sponges

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Genome Mining for Novel Natural Product Discovery

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Total Synthesis and Molecular Target of Largazole, a Histone Deacetylase Inhibitor

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Mixed fermentation for natural product drug discovery

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Libertellenones A–D: Induction of cytotoxic diterpenoid biosynthesis by marine microbial competition

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Antineoplastic cyclic peptides from the marine tunicate Lissoclinum patella

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Marine pharmacology in 2001–2: antitumour and cytotoxic compounds

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Palmerolide A, a Cytotoxic Macrolide from the Antarctic Tunicate Synoicum adareanum

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Biosynthetic Characterization and Chemoenzymatic Assembly of the Cryptophycins. Potent Anticancer Agents from Nostoc Cyanobionts

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A functional genomics approach to the mode of action of apratoxin A

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Theonellamide F. A novel antifungal bicyclic peptide from a marine sponge Theonella sp

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Arenastatin A, a potent cytotoxic depsipeptide from the Okinawan marine sponge Dysidea arenaria

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Deep-Sea Hydrothermal Vents: Potential Hot Spots for Natural Products Discovery?

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Sporolides A and B: Structurally Unprecedented Halogenated Macrolides from the Marine Actinomycete Salinispora t ropica

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Apratoxin A Reversibly Inhibits the Secretory Pathway by Preventing Cotranslational Translocation

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Clinical status of anti-cancer agents derived from marine sources

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GTP-dependent binding of the antiproliferative agent didemnin to elongation factor 1 alpha.

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Chasing the treasures of the sea — bacterial marine natural products

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Engineering Fluorometabolite Production: Fluorinase Expression in Salinispora tropica Yields Fluorosalinosporamide

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Targeting N-type and T-type calcium channels for the treatment of pain

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Finding the target after screening the phenotype

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Marine natural products as sources of novel scaffolds: achievement and concern

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Recent advances and method development for drug target identification

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Marine pharmacology in 2005–2006: Antitumour and cytotoxic compounds

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Bryostatins: biological context and biotechnological prospects

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Marine antifungal theonellamides target 3β-hydroxysterol to activate Rho1 signaling

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The Spongistatins, Potently Cytotoxic Inhibitors of Tubulin Polymerization, Bind in a Distinct Region of the Vinca Domain

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A sea of biosynthesis: marine natural products meet the molecular age

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Total Synthesis of Apratoxin A

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Ammosamides A and B Target Myosin

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Trading molecules and tracking targets in symbiotic interactions

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Loihichelins A−F, a Suite of Amphiphilic Siderophores Produced by the Marine Bacterium Halomonas LOB-5

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Didemnin B

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Pyocyanin Isolated from a Marine Microbial Population: Synergistic Production between Two Distinct Bacterial Species and Mode of Action

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Eribulin mesylate

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Cyclodepsipeptide toxin promotes the degradation of Hsp90 client proteins through chaperone-mediated autophagy

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A Tetrachloro Polyketide Hexahydro-1 H -isoindolone, Muironolide A, from the Marine Sponge Phorbas sp. Natural Products at the Nanomole Scale

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Marinamide, a novel alkaloid and its methyl ester produced by the application of mixed fermentation technique to two mangrove endophytic fungi from the South China Sea

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ω-Conotoxin MVIIA: From Marine Snail Venom to Analgesic Drug

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Spongistatin 1: a new chemosensitizing marine compound that degrades XIAP

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Unusual Antimicrotubule Activity of the Antifungal Agent Spongistatin 1

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PHARMA OVERVIEW

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Marine natural products

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Luteolin, a flavonoid, as an anticancer agent: A review

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Marketed Marine Natural Products in the Pharmaceutical and Cosmeceutical Industries: Tips for Success

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Marine natural products

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Promising bioactive compounds from the marine environment and their potential effects on various diseases

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