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Cited by 246Hyperglycemia and glycemic control in critically ill and hospitalized patientsDiabetes Management and ResearchIntensive Care Unit Cognitive Disorders

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

Prevalence and Predictors of Corticosteroid-Related Hyperglycemia in Hospitalized Patients

Donihi, Amy Calabrese, Raval, Ditina, Saul, Melissa, Korytkowski, Mary T., DeVita, Michael A.·2006·Endocrine Practice
DOI 10.4158/ep.12.4.358
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Abstract

Objective To investigate the prevalence of and risk factors for hyperglycemia in hospitalized patients receiving corticosteroids, which have been identified as an independent predictor of hyperglycemia.Methods We conducted a retrospective review of electronic medical records of patients admitted to the general medicine service at a university hospital during a 1-month period. Pharmacy charges were used to identify patients receiving high doses (> or = 40 mg/day of prednisone or the equivalent) of corticosteroids for at least 2 days. Occurrence of hyperglycemia and the presence of risk factors, including history of diabetes, duration of corticosteroid therapy, concurrent parenteral nutrition, antibiotic therapy, use of medications associated with hyperglycemia, severity of illness scores, and hospital length of stay, were determined. Patients experiencing multiple episodes of hyperglycemia (glucose levels > or = 200 mg/dL) were compared with those who had < or = 1 hyperglycemic episode. Patients without a history of diabetes were assessed separately.Results During the 1-month study period, 66 of 617 patients received high doses of corticosteroids, but only 50 of the 66 had glucose measurements. Hyperglycemia was documented in 32 of these 50 patients (64%), and multiple hyperglycemic episodes occurred in 26 (52%). A history of diabetes was documented in 12 of 26 patients who experienced multiple episodes, in comparison with 4 of 24 patients with < or = 1 episode of hyperglycemia (P = 0.035). Among patients without a history of diabetes, 19 of 34 (56%) had hyperglycemia at least once. Patients with multiple episodes of hyperglycemia had more comorbid diseases, longer duration of corticosteroid therapy, and longer duration of hospital stay.Conclusion Hyperglycemia occurs in a majority of hospitalized patients receiving high doses of corticosteroids. In light of the poor outcomes associated with hyperglycemia, protocols targeting its detection and management should be available for patients who receive corticosteroid therapy.

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  1. Inzucchi, 2003, Risk factors for poor glycemic control in a medical intensive care unit (ICU) [abstract], Diabetes., 52, A96

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Metadata

Authors
Donihi, A. C., Raval, D., Saul, M., Korytkowski, M. T., & DeVita, M. A.
Affiliations
University of Pittsburgh (US)
Corresponding author
Donihi, Amy Calabrese
ORCID
Venue
Endocrine Practice
Publisher
Elsevier BV
Published
2006-07
Volume
12
Issue
4
Pages
358-362
ISSN
1530-891X (ISSN-L)
DOI
10.4158/ep.12.4.358
OpenAlex
W1977503469
Cited by
246
References
13
Citations by year
2026: 4 · 2025: 16 · 2024: 13 · 2023: 16 · 2022: 18 · 2021: 15 · 2020: 15 · 2019: 13 · 2018: 21 · 2017: 14 · 2016: 12 · 2015: 15 · 2014: 15 · 2013: 22 · 2012: 13
FWCI
3.41
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Endocrine Practice (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • American Diabetes Association
  • Eli Lilly and Company
  • Novo Nordisk
  • Medical Center, University of Pittsburgh
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hyperglycemia and glycemic control in critically ill and hospitalized patients
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
Keywords
corticosteroid-induced hyperglycemia, hospitalized patients, prednisone, risk factors, prevalence, history of diabetes, length of hospital stay, comorbidities, medical inpatients
MeSH terms
Adrenal Cortex Hormones, Adult, Aged, Female, Hospitalization, Humans, Hyperglycemia, Male, Middle Aged, Retrospective Studies, Risk Factors, Comorbidity, Prevalence, Diabetes Complications

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