Autophagy activity contributes to programmed cell death in Caenorhabditis elegans
Open accessAbstract
The physiological relationship between autophagy and programmed cell death during C. elegans development is poorly understood. In C. elegans, 131 somatic cells and a large number of germline cells undergo programmed cell death. Autophagy genes function in the removal of somatic cell corpses during embryogenesis. Here we demonstrated that autophagy activity participates in germ-cell death induced by genotoxic stress. Upon γ ray treatment, fewer germline cells execute the death program in autophagy mutants. Autophagy also contributes to physiological germ-cell death and post-embryonic cell death in ventral cord neurons when ced-3 caspase activity is partially compromised. Our study reveals that autophagy activity contributes to programmed cell death during C. elegans development.
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Autophagic machinery precipitates germ cell and ventral cord neuron RCD during C. elegans development.
“The autophagic machinery also precipitates germ cell and ventral cord neuron RCD during C. elegans development [834]”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [834]
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- Authors
- Wang, H., Lu, Q., Cheng, S., Wang, X., & Zhang, H.
- Affiliations
- National Institute of Biological Sciences, Beijing (CN)
- Chinese Academy of Sciences (CN)
- Corresponding author
- Zhang, Hong
- Venue
- Autophagy
- Publisher
- Informa UK Limited
- Published
- 2013-12-05
- Volume
- 9
- Issue
- 12
- Pages
- 1975-1982
- ISSN
- 1554-8627 (ISSN-L)
- 1554-8635
- OpenAlex
- W2172108417
- Cited by
- 39
- References
- 32
- Citations by year
- 2025: 4 · 2024: 4 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 7 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 4 · 2013: 1
- FWCI
- 2.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Autophagy (publishedVersion)
- PubMed (publishedVersion)
- Digital Commons@Becker (Washington University School of Medicine) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Natural Science Foundation of China (31225018)
- National Key Research and Development Program of China (2011CB910100, 2013CB910100)
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- programmed cell death, Caenorhabditis elegans, germ cell death, genotoxic stress, gamma radiation, embryonic development
- MeSH terms
- Animals, Autophagy, Calcium-Binding Proteins, Gamma Rays, Germ Cells, Membrane Proteins, Microtubule-Associated Proteins, Mutation, Caenorhabditis elegans, Apoptosis, Caspases, Caenorhabditis elegans Proteins, Organisms, Genetically Modified
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