Tip60: Connecting chromatin to DNA damage signaling

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High-Resolution Profiling of Histone Methylations in the Human Genome

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ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage

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The Mammalian Epigenome

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A Chromatin Landmark and Transcription Initiation at Most Promoters in Human Cells

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Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

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Loss of the Suv39h Histone Methyltransferases Impairs Mammalian Heterochromatin and Genome Stability

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γH2AX and cancer

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How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers

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ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex

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Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

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MDC1 Directly Binds Phosphorylated Histone H2AX to Regulate Cellular Responses to DNA Double-Strand Breaks

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Requirement of the MRN complex for ATM activation by DNA damage

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Reversal of Histone Lysine Trimethylation by the JMJD2 Family of Histone Demethylases

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RNF8 Transduces the DNA-Damage Signal via Histone Ubiquitylation and Checkpoint Protein Assembly

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Involvement of the TIP60 Histone Acetylase Complex in DNA Repair and Apoptosis

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Orchestration of the DNA-Damage Response by the RNF8 Ubiquitin Ligase

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Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer

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Structure of HP1 Chromodomain Bound to a Lysine 9-Methylated Histone H3 Tail

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ATM Signaling Facilitates Repair of DNA Double-Strand Breaks Associated with Heterochromatin

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Direct Activation of the ATM Protein Kinase by the Mre11/Rad50/Nbs1 Complex

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Acetylation of the p53 DNA-binding domain regulates apoptosis induction.

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Tip60-Dependent Acetylation of p53 Modulates the Decision between Cell-Cycle Arrest and Apoptosis

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A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM

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Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway

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Dynamic Regulation of Histone Lysine Methylation by Demethylases

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Covalent modifications of histones during development and disease pathogenesis

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RAP80 Targets BRCA1 to Specific Ubiquitin Structures at DNA Damage Sites

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Acetylation by Tip60 Is Required for Selective Histone Variant Exchange at DNA Lesions

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Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9

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Maintenance of Stable Heterochromatin Domains by Dynamic HP1 Binding

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Histone acetylation by Trrap–Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks

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Structural and Functional Conservation of the NuA4 Histone Acetyltransferase Complex from Yeast to Humans

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Binding of Chromatin-Modifying Activities to Phosphorylated Histone H2A at DNA Damage Sites

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Acetylation of histone H4 by Esa1 is required for DNA double-strand break repair

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Activation and regulation of ATM kinase activity in response to DNA double-strand breaks

Lee, J.-H., & Paull, T. T. (2007) · Oncogene · doi:10.1038/sj.onc.1210872 · Cited by 545

Crosstalk between histone modifications during the DNA damage response

van Attikum, H., & Gasser, S. M. (2009) · Trends in Cell Biology · doi:10.1016/j.tcb.2009.03.001 · Cited by 542

Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways

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Tudor, MBT and chromo domains gauge the degree of lysine methylation

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The diverse functions of histone acetyltransferase complexes

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Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60

Sun, Y., Jiang, X., Xu, Y., Ayrapetov, M. K., Moreau, L. A., Whetstine, J. R., & Price, B. D. (2009) · Nature Cell Biology · doi:10.1038/ncb1982 · Cited by 454

An RNAi Screen of Chromatin Proteins Identifies Tip60-p400 as a Regulator of Embryonic Stem Cell Identity

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ATM Activation and Its Recruitment to Damaged DNA Require Binding to the C Terminus of Nbs1

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Profile of Histone Lysine Methylation across Transcribed Mammalian Chromatin

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The PHD finger, a nuclear protein-interaction domain

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HP1-β mobilization promotes chromatin changes that initiate the DNA damage response

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Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma

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γH2AX and MDC1: Anchoring the DNA-damage-response machinery to broken chromosomes

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TopBP1 activates ATR through ATRIP and a PIKK regulatory domainPreprint

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The highly conserved and multifunctional NuA4 HAT complex

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DNA Damage-Dependent Acetylation and Ubiquitination of H2AX Enhances Chromatin Dynamics

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Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response

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Screen for DNA‐damage‐responsive histone modifications identifies H3K9Ac and H3K56Ac in human cells

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DNA Damage-Induced Acetylation of Lysine 3016 of ATM Activates ATM Kinase Activity

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Tip60 in DNA damage response and growth control: many tricks in one HAT

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Emerging common themes in regulation of PIKKs and PI3Ks

Lempiäinen, H., & Halazonetis, T. D. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.281 · Cited by 312

Tip60 and Histone Deacetylase 1 Regulate Androgen Receptor Activity through Changes to the Acetylation Status of the Receptor

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Protein Acetylation Microarray Reveals that NuA4 Controls Key Metabolic Target Regulating Gluconeogenesis

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Involvement of novel autophosphorylation sites in ATM activation

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Role of Dot1-Dependent Histone H3 Methylation in G1 and S Phase DNA Damage Checkpoint Functions of Rad9

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The DNA Damage Checkpoint Response Requires Histone H2B Ubiquitination by Rad6-Bre1 and H3 Methylation by Dot1

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Autophosphorylation of ataxia‐telangiectasia mutated is regulated by protein phosphatase 2A

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Heterochromatin protein 1 is recruited to various types of DNA damage

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Two-step activation of ATM by DNA and the Mre11–Rad50–Nbs1 complex

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Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation

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Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models

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Expression of Tip60, an androgen receptor coactivator, and its role in prostate cancer development

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Tip60 acetylates six lysines of a specific class in core histones in vitro

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Epigenetic regulation of heterochromatic DNA stability

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Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo

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ATM signaling and genomic stability in response to DNA damage

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The Global Histone Modification Pattern Correlates with Cancer Recurrence and Overall Survival in Gastric Adenocarcinoma

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Ataxia‐telangiectasia, cancer and the pathobiology of the ATM gene

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PR-Set7–dependent lysine methylation ensures genome replication and stability through S phase

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Human Rvb1/Tip49 Is Required for the Histone Acetyltransferase Activity of Tip60/NuA4 and for the Downregulation of Phosphorylation on H2AX after DNA Damage

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Active and Repressive Chromatin Are Interspersed without Spreading in an Imprinted Gene Cluster in the Mammalian Genome

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Structure of histone acetyltransferases 1 1Edited by P. W. Wright

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The FATC Domains of PIKK Proteins Are Functionally Equivalent and Participate in the Tip60-dependent Activation of DNA-PKcs and ATM

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Activation of ATM depends on chromatin interactions occurring before induction of DNA damage

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Homozygous disruption of the tip60 gene causes early embryonic lethality

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Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo

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p14 ARF Activates a Tip60-Dependent and p53-Independent ATM/ATR/CHK Pathway in Response to Genotoxic Stress

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Histone modifications in response to DNA damage

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The p400/Tip60 ratio is critical for colorectal cancer cell proliferation through DNA damage response pathways

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New p53 related genes in human tumors: significant downregulation in colon and lung carcinomas

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Active Role for Nibrin in the Kinetics of Atm Activation

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Carboxyl‐terminal region conserved among phosphoinositide‐kinase‐related kinases is indispensable for mTOR function in vivo and in vitro

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Activation of ATR and related PIKKs

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