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The IRF family of transcription factors: Inception, impact and implications in oncogenesis
Open accessAbstract
Members of the interferon-regulatory factor (IRF) proteins family were originally identified as transcriptional regulators of the Type I interferon system. Thanks to consistent advances made in our understanding of the immunobiology of innate receptors, it is now clear that several IRFs are critical for the elicitation of innate pattern recognition receptors, and-as a consequence-for adaptive immunity. In addition, IRFs have attracted great attentions as they modulate cellular responses that are involved in tumorigenesis. The regulation of oncogenesis by IRFs has important implications for understanding the host susceptibility to several Types of cancers, their progression, as well as the potential for therapeutic interventions.
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“Borzoi correctly predicts the upregulation of SHTN1 expression owing to the creation of a CEBP binding motif69–72 (see Supplementary Fig. 9a and Extended Data Fig. 6a,b for additional examples).”
From Predicting RNA-seq coverage from DNA sequence as a unifying model of gene regulation (2025) · cites this paper as [71]
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Metadata
- Authors
- Yanai, H., Negishi, H., & Taniguchi, T.
- Affiliations
- Japan Science and Technology Agency (JP)
- Corresponding author
- Taniguchi, Tadatsugu
- Venue
- OncoImmunology
- Publisher
- Informa UK Limited
- Published
- 2012-11
- Volume
- 1
- Issue
- 8
- Pages
- 1376-1386
- ISSN
- 2162-4011 (ISSN-L)
- 2162-402X
- PMC
- PMC3518510
- OpenAlex
- W2031904443
- Cited by
- 261
- References
- 140
- Citations by year
- 2026: 15 · 2025: 18 · 2024: 24 · 2023: 22 · 2022: 32 · 2021: 29 · 2020: 25 · 2019: 26 · 2018: 21 · 2017: 14 · 2016: 8 · 2015: 9 · 2014: 12 · 2013: 6
- FWCI
- 3.78
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- OncoImmunology (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- Core Research for Evolutional Science and Technology
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- interferon regulatory factors, transcription factors, type I interferon, innate immunity, pattern recognition receptors, adaptive immunity, carcinogenesis, cancer susceptibility, tumor progression, cancer therapy
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