Cited by 264interferon and immune responsesImmune Response and InflammationImmunotherapy and Immune Responses

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The IRF family of transcription factors: Inception, impact and implications in oncogenesis

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Yanai, Hideyuki, Negishi, Hideo, Taniguchi, Tadatsugu·2012·OncoImmunology

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Abstract

Members of the interferon-regulatory factor (IRF) proteins family were originally identified as transcriptional regulators of the Type I interferon system. Thanks to consistent advances made in our understanding of the immunobiology of innate receptors, it is now clear that several IRFs are critical for the elicitation of innate pattern recognition receptors, and-as a consequence-for adaptive immunity. In addition, IRFs have attracted great attentions as they modulate cellular responses that are involved in tumorigenesis. The regulation of oncogenesis by IRFs has important implications for understanding the host susceptibility to several Types of cancers, their progression, as well as the potential for therapeutic interventions.

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Authors: Yanai, H., Negishi, H., & Taniguchi, T.
Affiliations: Japan Science and Technology Agency (JP)
Corresponding author: Taniguchi, Tadatsugu
ORCID: Yanai, Hideyuki
Negishi, Hideo
Taniguchi, Tadatsugu
Venue: OncoImmunology
Publisher: Informa UK Limited
Published: 2012-11
Volume: 1
Issue: 8
Pages: 1376-1386
ISSN: 2162-4011 (ISSN-L)
2162-402X
DOI: 10.4161/onci.22475
PMC: PMC3518510
OpenAlex: W2031904443
Cited by: 261
References: 140
Citations by year: 2026: 15 · 2025: 18 · 2024: 24 · 2023: 22 · 2022: 32 · 2021: 29 · 2020: 25 · 2019: 26 · 2018: 21 · 2017: 14 · 2016: 8 · 2015: 9 · 2014: 12 · 2013: 6
FWCI: 3.78
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc
Locations: OncoImmunology (publishedVersion, cc-by-nc)
Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
Funders: Core Research for Evolutional Science and Technology
Topics: Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: interferon regulatory factors, transcription factors, type I interferon, innate immunity, pattern recognition receptors, adaptive immunity, carcinogenesis, cancer susceptibility, tumor progression, cancer therapy

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The IRF family of transcription factors: Inception, impact and implications in oncogenesis

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