The IRF family of transcription factors: Inception, impact and implications in oncogenesis

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The IRF Family Transcription Factors in Immunity and Oncogenesis

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Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements

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Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes

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Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes

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Integration of interferon-α/β signalling to p53 responses in tumour suppression and antiviral defence

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IRF4 addiction in multiple myeloma

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Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activityPreprint

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Interferon regulatory factors: the next generation

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Exploiting Synthetic Lethality for the Therapy of ABC Diffuse Large B Cell Lymphoma

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Antiviral innate immunity pathways

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Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1

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Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape

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The growing family of interferon regulatory factors

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Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator.

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Anti-Oncogenic and Oncogenic Potentials of Interferon Regulatory Factors-1 and -2

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An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes

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Deletion of IRF-1 , Mapping to Chromosome 5q31.1, in Human Leukemia and Preleukemic Myelodysplasia

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Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKε‐mediated IRF activation

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An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes

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The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4

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Abnormal skin, limb and craniofacial morphogenesis in mice deficient for interferon regulatory factor 6 (Irf6)

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Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma

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Inactivation of Interferon Regulatory Factor-1 Tumor Suppressor Protein by HPV E7 Oncoprotein

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Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch

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Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage

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Regulation of immunity and oncogenesis by the IRF transcription factor family

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The IRF family, revisited

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The KSHV Immediate-Early Transcription Factor RTA Encodes Ubiquitin E3 Ligase Activity that Targets IRF7 for Proteosome-Mediated Degradation

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Poxvirus Protein N1L Targets the I-κB Kinase Complex, Inhibits Signaling to NF-κB by the Tumor Necrosis Factor Superfamily of Receptors, and Inhibits NF-κB and IRF3 Signaling by Toll-like Receptors

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Crystal structure of an IRF‐DNA complex reveals novel DNA recognition and cooperative binding to a tandem repeat of core sequences

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Role of IFN regulatory factor 5 transcription factor in antiviral immunity and tumor suppression

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Functional Analysis of Human Herpesvirus 8-Encoded Viral Interferon Regulatory Factor 1 and Its Association with Cellular Interferon Regulatory Factors and p300

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Recurrent translocations involving the IRF4 oncogene locus in peripheral T-cell lymphomas

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Rotavirus NSP1 Inhibits Expression of Type I Interferon by Antagonizing the Function of Interferon Regulatory Factors IRF3, IRF5, and IRF7

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A Novel Interferon Regulatory Factor Family Transcription Factor, ICSAT/Pip/LSIRF, That Negatively Regulates the Activity of Interferon-Regulated Genes

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TLR pathways and IFN‐regulatory factors: To each its own

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The Interferon Regulatory Factor Family in Host Defense: Mechanism of Action

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Activation of a cell-cycle-regulated histone gene by the oncogenic transcription factor IRF-2

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The Feedback Phase of Type I Interferon Induction in Dendritic Cells Requires Interferon Regulatory Factor 8

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Identification and characterization of nucleophosmin/B23/numatrin which binds the anti-oncogenic transcription factor IRF-1 and manifests oncogenic activity

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Identification of the interferon regulatory factor 5 gene (IRF-5) as a direct target for p53

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The IRF-3 Transcription Factor Mediates Sendai Virus-Induced Apoptosis

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Dynamic Evolution of Immune System Regulators: The History of the Interferon Regulatory Factor Family

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Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes.

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Interferon regulatory factor family of transcription factors and regulation of oncogenesis

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Protein-Protein and DNA-Protein Interactions Affect the Activity of Lymphoid-Specific IFN Regulatory Factors

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Expression of Interferon Consensus Sequence Binding Protein (ICSBP) Is Downregulated in Bcr-Abl-Induced Murine Chronic Myelogenous Leukemia-Like Disease, and Forced Coexpression of ICSBP Inhibits Bcr-Abl-Induced Myeloproliferative Disorder

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Inhibition of Interferon Regulatory Factor 7 (IRF7)-Mediated Interferon Signal Transduction by the Kaposi's Sarcoma-Associated Herpesvirus Viral IRF Homolog vIRF3

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Inhibition of p300 Histone Acetyltransferase by Viral Interferon Regulatory Factor

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A regulatory feedback loop involving p63 and IRF6 links the pathogenesis of 2 genetically different human ectodermal dysplasias

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IRF-1 Is an Essential Mediator in IFN-γ-Induced Cell Cycle Arrest and Apoptosis of Primary Cultured Hepatocytes

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Interferon regulatory factor-3 is an in vivo target of DNA-PK

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Unique properties of a second human herpesvirus 8-encoded interferon regulatory factor (vIRF-2).

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Loss of transcription factor IRF-1 affects tumor susceptibility in mice carrying the Ha-ras transgene or nullizygosity for p53Preprint

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Signaling through IFN Regulatory Factor-5 Sensitizes p53-Deficient Tumors to DNA Damage–Induced Apoptosis and Cell Death

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IRF6 is a mediator of Notch pro‐differentiation and tumour suppressive function in keratinocytes

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Accelerated exon skipping of IRF-1 mRNA in human myelodysplasia/leukemia; a possible mechanism of tumor suppressor inactivation.

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TRAF6 and the Three C-Terminal Lysine Sites on IRF7 Are Required for Its Ubiquitination-Mediated Activation by the Tumor Necrosis Factor Receptor Family Member Latent Membrane Protein 1

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Interferon Regulatory Factor 3 Is a Cellular Partner of Rotavirus NSP1

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Interferon Regulatory Factor 6 Promotes Cell Cycle Arrest and Is Regulated by the Proteasome in a Cell Cycle-Dependent Manner

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Epstein‐Barr Virus: The First Human Tumor Virus and its Role in Cancer

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Two distinct regions of deletion on the long arm of chromosome 5 in differentiated adenocarcinomas of the stomach.

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Activation of Interferon Regulatory Factor 3 in Response to DNA-damaging Agents

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Interferon consensus sequence binding protein (ICSBP; IRF-8) antagonizes BCR/ABL and down-regulates bcl-2

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Lysyl Oxidase Inhibits Ras-Mediated Transformation by Preventing Activation of NF-κB

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Repression of IFN Regulatory Factor 8 by DNA Methylation Is a Molecular Determinant of Apoptotic Resistance and Metastatic Phenotype in Metastatic Tumor Cells

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