CoChat
Sign Up
Cited by 59Malaria Research and ControlBird parasitology and diseasesDigital Imaging for Blood Diseases

Diagnosis of gestational, congenital, and placental malaria in Colombia: Comparison of the efficacy of microscopy, nested polymerase chain reaction, and histopathology

Open access
Campos, Ivón M., Uribe, Mary L., Cuesta, Carolina, Franco-Gallego, Alexander, Carmona-Fonseca, Jaime, Maestre, Amanda·2011·The American Society of Tropical Medicine and Hygiene
DOI 10.4269/ajtmh.2011.10-0507PMC PMC3110370
Open this paper in CoChat — free account

Abstract

The technical capability of different methods to diagnose Plasmodium in maternal peripheral blood, placenta, and umbilical cord blood has not been assessed in Colombia and seldom explored in other malaria-endemic regions. We designed a study to compare the technical and the operational-economical performances of light microscopy (LM), nested polymerase chain reaction (nPCR), and histopathology (HP). In maternal blood, LM had 41% sensitivity and 100% specificity and in placental blood, 35% and 100%, respectively, compared with nPCR. In placental tissue, LM had 33% sensitivity and 95% specificity; and nPCR 47% and 77%, respectively; compared with HP. Light microscopy had the best operational-economical qualification. We concluded that nPCR and HP performed better compared with LM, but field implementation of these two techniques remains a problem. Therefore, LM is recommended as the gold standard for diagnosis of gestational malaria and placental blood infection in the field.

Integrity signals

Registry

Crossref · 10.4269/ajtmh.2011.10-0507

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

The text we found for this paper looks like another document, so its claims and self-check weren’t run. The registry and citation checks still apply.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The text we found for this paper looks like another document, so the self-check wasn’t run.

Cites

Flagged first, then by citations

Research works printed but not linked: 21

  1. [1]Cardona-Arias, Jaiberth Antonio and Carmona-Fonseca, Jaime, 2022, "Frequency of gestational malaria and maternal–neonatal outcomes, in Northwestern Colombia 2009–2020" Scientific Reports Vol. 12, No. 1, 2045-2322
  2. [2]Cardona-Arias, Jaiberth Antonio, Higuita Gutiérrez, Luis Felipe, and Carmona-Fonseca, Jaime, 2023, "Diagnostic Accuracy of a Thick Blood Smear Compared to qPCR for Malaria Associated with Pregnancy in Colombia" Tropical Medicine and Infectious Disease Vol. 8, No. 2, pp 119, 2414-6366
  3. [3]Cardona-Arias, Jaiberth Antonio, Carmona-Fonseca, Jaime, and Carvalho, Luzia Helena, 2022, "Congenital malaria: Frequency and epidemiology in Colombia, 2009-2020" PLOS ONE Vol. 17, No. 2, pp e0263451, 1932-6203
  4. [4]Recht, Judith, Siqueira, André M., Monteiro, Wuelton M., Herrera, Sonia M., Herrera, Sócrates, and Lacerda, Marcus V. G., 2017, "Malaria in Brazil, Colombia, Peru and Venezuela: current challenges in malaria control and elimination" Malaria Journal Vol. 16, No. 1, 1475-2875
  5. [5]Vásquez, Ana María, Zuluaga, Lina, Tobón, Alberto, Posada, Maritza, Vélez, Gabriel, González, Iveth J., Campillo, Ana, and Ding, Xavier, 2018, "Diagnostic accuracy of loop-mediated isothermal amplification (LAMP) for screening malaria in peripheral and placental blood samples from pregnant women in Colombia" Malaria Journal Vol. 17, No. 1, 1475-2875
  6. [6]Vásquez, Ana María, Medina, Ana Catalina, Tobón-Castaño, Alberto, Posada, Maritza, Vélez, Gabriel Jaime, Campillo, Ana, González, Iveth J., Ding, Xavier, and Snounou, Georges, 2018, "Performance of a highly sensitive rapid diagnostic test (HS-RDT) for detecting malaria in peripheral and placental blood samples from pregnant women in Colombia" PLOS ONE Vol. 13, No. 8, pp e0201769, 1932-6203
  7. [7]Gnidehou, Sedami, Doritchamou, Justin, Arango, Eliana M., Cabrera, Ana, Arroyo, Maria Isabel, Kain, Kevin C., Ndam, Nicaise Tuikue, Maestre, Amanda, Yanow, Stephanie K., and Adams, J. H., 2014, "Functional Antibodies against VAR2CSA in Nonpregnant Populations from Colombia Exposed to Plasmodium falciparum and Plasmodium vivax" Infection and Immunity Vol. 82, No. 6, pp 2565, 1098-5522
  8. [10]Omer, Samia A., Noureldein, Ali N., Eisa, Hadeel, Abdelrahim, Mutasim, Idress, Hagir E., Abdelrazig, Abdelrahim M., and Adam, Ishag, 2019, "Impact of Submicroscopic Plasmodium falciparum Parasitaemia on Maternal Anaemia and Low Birth Weight in Blue Nile State, Sudan" Journal of Tropical Medicine Vol. 2019, pp 1, 1687-9694
  9. [11]Vásquez, A. M., Vélez, G., Medina, A., Serra-Casas, E., Campillo, A., Gonzalez, I. J., Murphy, S. C., Seilie, A. M., Ding, X. C., and Tobón Castaño, A., 2020, "Evaluation of highly sensitive diagnostic tools for the detection of P. falciparum in pregnant women attending antenatal care visits in Colombia" BMC Pregnancy and Childbirth Vol. 20, No. 1, 1471-2393
  10. [12]Omer, Samia A. and Sulaiman, Suad M., 2020, "The Placenta and Plasmodium Infections: a Case Study from Blue Nile State, Sudan" Current Tropical Medicine Reports Vol. 7, No. 4, pp 153, 2196-3045
  11. [13]Sant, Candice, Mohammed, Nisha, Oura, Christopher, Sanford, Bryan, Kirk, Shawn, Ibeleme, David, Nicholls, Soren, and Georges, Karla, 2026, "Imported malaria in Trinidad, West Indies: Detection of multiple non-endemic Plasmodium species" Parasitology International Vol. 115, pp 103305, 13835769
  12. [15]Costa, Fabio T.M., Lopes, Stefanie C.P., Albrecht, Letusa, Ataíde, Ricardo, Siqueira, André M., Souza, Rodrigo M., Russell, Bruce, Renia, Laurent, Marinho, Claudio R.F., and Lacerda, Marcus V.G., 2012, "On the pathogenesis of Plasmodium vivax malaria: Perspectives from the Brazilian field" International Journal for Parasitology Vol. 42, No. 12, pp 1099, 00207519
  13. [16]Sanabria, Alvaro, Gomez, Ximena, Vega, Valentin, Dominguez, Luis Carlos, and Osorio, Camilo, 2013, "Prediction of prolonged mechanical ventilation for intensive care unit patients: A cohort study" Colombia Medica Vol. 44, No. 3, pp 184, 1657-9534
  14. [17]Chávez González, Elibet, González Rodríguez, Emilio F., and Llanes Camacho, María del Carmen, 2013, "Dependence of P-wave dispersion on mean arterial pressure as an independent hemodynamic variable in school children" Colombia Medica Vol. 44, No. 3, pp 178, 1657-9534
  15. [18]Yasnot, Maria Fernanda, Perkins, Douglas Jay, Corredor, Mauricio, Yanow, Stephanie, Carmona-Fonseca, Jaime, and Maestre, Amanda Elena, 2013, "The effects of Plasmodium vivax gestational malaria on the clinical and immune status of pregnant women in Northwestern Colombia" Colombia Medica Vol. 44, No. 3, pp 172, 1657-9534
  16. [19]Agudelo, Olga, Arango, Eliana, Maestre, Amanda, and Carmona-Fonseca, Jaime, 2013, "Prevalence of gestational, placental and congenital malaria in north-west Colombia" Malaria Journal Vol. 12, No. 1, 1475-2875
  17. [20]Elbashir, Haggar M, Salih, Magdi M, Elhassan, Elhassan M, Mohmmed, Ahmed A, Elbashir, Mustafa I, and Adam, Ishag, 2011, "Polymerase chain reaction and histology in diagnosis of placental malaria in an area of unstable malaria transmission in Central Sudan" Diagnostic Pathology Vol. 6, No. 1, 1746-1596
  18. [21]Castellanos, María Eugenia, Bardají, Azucena, Menegon, Michela, Mayor, Alfredo, Desai, Meghna, Severini, Carlo, Menéndez, Clara, and Padilla, Norma, 2012, "Plasmodium vivax congenital malaria in an area of very low endemicity in Guatemala: implications for clinical and epidemiological surveillance in a malaria elimination context" Malaria Journal Vol. 11, No. 1, 1475-2875
  19. [22]Arango, Eliana M, Samuel, Roshini, Agudelo, Olga M, Carmona-Fonseca, Jaime, Maestre, Amanda, and Yanow, Stephanie K, 2012, "Genotype comparison of Plasmodium vivax and Plasmodium falciparum clones from pregnant and non-pregnant populations in North-west Colombia" Malaria Journal Vol. 11, No. 1, 1475-2875
  20. [23]Agudelo, Olga M, Aristizabal, Beatriz H, Yanow, Stephanie K, Arango, Eliana, Carmona-Fonseca, Jaime, and Maestre, Amanda, 2014, "Submicroscopic infection of placenta by Plasmodium produces Th1/Th2 cytokine imbalance, inflammation and hypoxia in women from north-west Colombia" Malaria Journal Vol. 13, No. 1, 1475-2875
  21. [24]Cardona-Arias, Jaiberth Antonio, Carmona-Fonseca, Jaime, and Carvalho, Luzia Helena, 2021, "Meta-analysis of the prevalence of malaria associated with pregnancy in Colombia 2000–2020" PLOS ONE Vol. 16, No. 7, pp e0255028, 1932-6203

Cited by

Sorted by citations

Related

Authors
Campos, I. M., Uribe, M. L., Cuesta, C., Franco-Gallego, A., Carmona-Fonseca, J., & Maestre, A.
Affiliations
Universidad de Antioquia (CO)
ORCID
Uribe, Mary L.
Venue
The American Society of Tropical Medicine and Hygiene
Publisher
American Society of Tropical Medicine and Hygiene
Published
2011-06-01
Volume
84
Issue
6
Pages
929-935
ISSN
  • 0002-9637 (ISSN-L)
  • 1476-1645
DOI
10.4269/ajtmh.2011.10-0507
PMC
PMC3110370
OpenAlex
W2098115629
Cited by
59
References
41
Citations by year
2026: 1 · 2023: 2 · 2022: 5 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 2 · 2015: 4 · 2014: 6 · 2013: 15 · 2012: 8
FWCI
10.38
Type
journal article
Language
en
Open access
Locations
  • American Journal of Tropical Medicine and Hygiene (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Repository University of Antioquia (University of Antioquia) (submittedVersion, cc-by)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
  • Life Sciences › Immunology and Microbiology › Parasitology › Bird parasitology and diseases
  • Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Digital Imaging for Blood Diseases
Keywords
malaria in pregnancy, congenital malaria, placental malaria, Plasmodium, malaria diagnosis, optical microscopy, nested PCR, histopathology, sensitivity and specificity, operating costs, maternal blood, placental blood, umbilical cord blood, Colombia
MeSH terms
Adult, Colombia, Female, Fetal Blood, Humans, Microscopy, Placenta, Plasmodium falciparum, Pregnancy, Prospective Studies, Sensitivity and Specificity, Pregnancy Complications, Parasitic, DNA, Protozoan, Polymerase Chain Reaction, Malaria, Falciparum, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review