The DOI matches its Crossref record; 120 of the 120 references it cites were found in a registry or an index.
Current Status of Therapeutic Approaches against Peripheral Nerve Injuries: A Detailed Story from Injury to Recovery
Open accessAbstract
Peripheral nerve injury is a complex condition with a variety of signs and symptoms such as numbness, tingling, jabbing, throbbing, burning or sharp pain. Peripheral nerves are fragile in nature and can easily get damaged due to acute compression or trauma which may lead to the sensory and motor functions deficits and even lifelong disability. After lesion, the neuronal cell body becomes disconnected from the axon's distal portion to the injury site leading to the axonal degeneration and dismantlement of neuromuscular junctions of targeted muscles. In spite of extensive research on this aspect, complete functional recovery still remains a challenge to be resolved. This review highlights detailed pathophysiological events after an injury to a peripheral nerve and the associated factors that can either hinder or promote the regenerative machinery. In addition, it throws light on the available therapeutic strategies including supporting therapies, surgical and non-surgical interventions to ameliorate the axonal regeneration, neuronal survival, and reinnervation of peripheral targets. Despite the availability of various treatment options, we are still lacking the optimal treatments for a perfect and complete functional regain. The need for the present age is to discover or design such potent compounds that would be able to execute the complete functional retrieval. In this regard, plant-derived compounds are getting more attention and several recent reports validate their remedial effects. A plethora of plants and plant-derived phytochemicals have been suggested with curative effects against a number of diseases in general and neuronal injury in particular. They can be a ray of hope for the suffering individuals.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
An overview of tissue and whole organ decellularization processes
Crapo, P. M., Gilbert, T. W., & Badylak, S. F. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.01.057 · Cited by 3,591
Curcumin: A Review of Its Effects on Human Health
Hewlings, S., & Kalman, D. (2017) · Foods · doi:10.3390/foods6100092 · Cited by 2,720
Biomedical applications of biodegradable polymers
Ulery, B. D., Nair, L. S., & Laurencin, C. T. (2011) · Journal of Polymer Science Part B: Polymer Physics · doi:10.1002/polb.22259 · Cited by 2,206
Quercetin, Inflammation and Immunity
Li, Y., Yao, J., Han, C., Yang, J., Chaudhry, M., Wang, S., Liu, H., & Yin, Y. (2016) · Nutrients · doi:10.3390/nu8030167 · Cited by 1,999
Phiel, C. J., Zhang, F., Huang, E. Y., Guenther, M. G., Lazar, M. A., & Klein, P. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101287200 · Cited by 1,758
SEDDON, H. J. (1943) · Brain · doi:10.1093/brain/66.4.237 · Cited by 1,434
Calixto, J. B. (2000) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2000000200004 · Cited by 1,282
The repair Schwann cell and its function in regenerating nerves
Jessen, K. R., & Mirsky, R. (2016) · The Journal of Physiology · doi:10.1113/jp270874 · Cited by 1,176
Advancing biomaterials of human origin for tissue engineering
Chen, F.-M., & Liu, X. (2016) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2015.02.004 · Cited by 1,158
Peripheral Nerve Reconstruction after Injury: A Review of Clinical and Experimental Therapies
Grinsell, D., & Keating, C. P. (2014) · BioMed Research International · doi:10.1155/2014/698256 · Cited by 1,048
Cited by
Peripheral Nerve Injury Treatments and Advances: One Health Perspective
Lopes, B., Sousa, P., Alvites, R., Branquinho, M., Sousa, A. C., Mendonça, C., Atayde, L. M., Luís, A. L., Varejão, A. S. P., & Maurício, A. C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020918 · Cited by 381
Choi, Y. S., Hsueh, Y.-Y., Koo, J., Yang, Q., Avila, R., Hu, B., Xie, Z., Lee, G., Ning, Z., Liu, C., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19660-6 · Cited by 292
Zhang, Z., Yang, J., Wang, H., Wang, C., Gu, Y., Xu, Y., Lee, S., Yokota, T., Haick, H., Someya, T., et al. (2024) · Science Advances · doi:10.1126/sciadv.adj5389 · Cited by 292
Basic mechanisms of peripheral nerve injury and treatment via electrical stimulation
Chu, X.-L., Song, X.-Z., Li, Q., Li, Y.-R., He, F., Gu, X.-S., & Ming, D. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.335823 · Cited by 164
Neurological Complications following Surgical Treatments of the Lower Molars
Mancini, A., Inchingolo, A. M., Blasio, M. D., Ruvo, E. D., Noia, A. D., Ferrante, L., Vecchio, G. D., Palermo, A., Inchingolo, F., Inchingolo, A. D., et al. (2024) · International Journal of Dentistry · doi:10.1155/2024/5415597 · Cited by 17
The Ambivalent Role of miRNA-21 in Trauma and Acute Organ Injury
Ritter, A., Han, J., Bianconi, S., Henrich, D., Marzi, I., Leppik, L., & Weber, B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252011282 · Cited by 6
Metadata
- Authors
- Hussain, G., Wang, J., Rasul, A., Anwar, H., Qasim, M., Zafar, S., Aziz, N., Razzaq, A., Hussain, R., de Aguilar, J.-L. G., & Sun, T.
- Venue
- International Journal of Biological Sciences
- Publisher
- Ivyspring International Publisher
- Published
- 2020
- Volume
- 16
- Issue
- 1
- Pages
- 116-134
- ISSN
- 1449-2288 (ISSN-L)
- OpenAlex
- W2992510019
- Cited by
- 323
- References
- 120
- FWCI
- 8.57
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
