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Cited by 323

The DOI matches its Crossref record; 120 of the 120 references it cites were found in a registry or an index.

Current Status of Therapeutic Approaches against Peripheral Nerve Injuries: A Detailed Story from Injury to Recovery

Open access
Hussain, Ghulam, Wang, Jing, Rasul, Azhar, Anwar, Haseeb, Qasim, Muhammad, Zafar, Shamaila, Aziz, Nimra, Razzaq, Aroona, Hussain, Rashad, de Aguilar, Jose-Luis Gonzalez, Sun, Tao·2020·International Journal of Biological Sciences
DOI 10.7150/ijbs.35653
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Abstract

Peripheral nerve injury is a complex condition with a variety of signs and symptoms such as numbness, tingling, jabbing, throbbing, burning or sharp pain. Peripheral nerves are fragile in nature and can easily get damaged due to acute compression or trauma which may lead to the sensory and motor functions deficits and even lifelong disability. After lesion, the neuronal cell body becomes disconnected from the axon's distal portion to the injury site leading to the axonal degeneration and dismantlement of neuromuscular junctions of targeted muscles. In spite of extensive research on this aspect, complete functional recovery still remains a challenge to be resolved. This review highlights detailed pathophysiological events after an injury to a peripheral nerve and the associated factors that can either hinder or promote the regenerative machinery. In addition, it throws light on the available therapeutic strategies including supporting therapies, surgical and non-surgical interventions to ameliorate the axonal regeneration, neuronal survival, and reinnervation of peripheral targets. Despite the availability of various treatment options, we are still lacking the optimal treatments for a perfect and complete functional regain. The need for the present age is to discover or design such potent compounds that would be able to execute the complete functional retrieval. In this regard, plant-derived compounds are getting more attention and several recent reports validate their remedial effects. A plethora of plants and plant-derived phytochemicals have been suggested with curative effects against a number of diseases in general and neuronal injury in particular. They can be a ray of hope for the suffering individuals.

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Metadata

Authors
Hussain, G., Wang, J., Rasul, A., Anwar, H., Qasim, M., Zafar, S., Aziz, N., Razzaq, A., Hussain, R., de Aguilar, J.-L. G., & Sun, T.
Venue
International Journal of Biological Sciences
Publisher
Ivyspring International Publisher
Published
2020
Volume
16
Issue
1
Pages
116-134
ISSN
1449-2288 (ISSN-L)
DOI
10.7150/ijbs.35653
OpenAlex
W2992510019
Cited by
323
References
120
FWCI
8.57
Type
journal article
Language
en
Open access
gold

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

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