Mitochondrial Dysfunction in Skeletal Muscle Pathologies

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Autophagy is required to maintain muscle mass.

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Skeletal muscle metabolism is a major determinant of resting energy expenditure.

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Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice

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Transcriptional integration of mitochondrial biogenesis

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Mitochondria, oxidative stress and neurodegeneration

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The Interplay Between Mitochondrial Dynamics and Mitophagy

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<i>Drosophila</i> Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin

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Invited Review: Contractile activity-induced mitochondrial biogenesis in skeletal muscle

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Protein breakdown in muscle wasting: Role of autophagy-lysosome and ubiquitin-proteasome

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MiD49 and MiD51, new components of the mitochondrial fission machinery

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Mitochondrial fission and remodelling contributes to muscle atrophy

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Autophagy is defective in collagen VI muscular dystrophies, and its reactivation rescues myofiber degeneration

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High-fat diets cause insulin resistance despite an increase in muscle mitochondria

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Skeletal Muscle Is a Primary Target of SOD1G93A-Mediated Toxicity

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Physiological and Pathological Roles of the Mitochondrial Permeability Transition Pore in the Heart

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Mitochondrial DNA–Deletion Mutations Accumulate Intracellularly to Detrimental Levels in Aged Human Skeletal Muscle Fibers

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Mitochondrial function and apoptotic susceptibility in aging skeletal muscle

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Muscle wasting and cachexia in heart failure: mechanisms and therapies

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OPA1 processing in cell death and disease – the long and short of it

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Disuse-induced muscle wasting

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Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia

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Apoptosis in skeletal muscle with aging

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Molecular and cellular mechanisms of skeletal muscle atrophy: an update

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Targeting Mitochondrial Dysfunction: Role for PINK1 and Parkin in Mitochondrial Quality Control

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Denervation-Induced Skeletal Muscle Atrophy Is Associated with Increased Mitochondrial Ros Production

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Skeletal Muscle Apoptosis and Weight Loss in Chronic Obstructive Pulmonary Disease

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Regulation of Muscle Protein Degradation

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Aging of skeletal muscle fibers

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Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour-bearing mice

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Skeletal muscle insulin resistance: role of mitochondria and other ROS sources

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Role of PGC-1α during acute exercise-induced autophagy and mitophagy in skeletal muscle

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Fueling the Cell Division Cycle

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Mitochondrial signaling contributes to disuse muscle atrophy

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Impaired PGC-1α function in muscle in Huntington's disease

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Peroxisome Proliferator-activated Receptor γ Coactivator 1α or 1β Overexpression Inhibits Muscle Protein Degradation, Induction of Ubiquitin Ligases, and Disuse Atrophy

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IL-6 regulation on skeletal muscle mitochondrial remodeling during cancer cachexia in the ApcMin/+ mouse

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Apoptosis in muscle atrophy: Relevance to sarcopenia

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The Melatonin MT1 Receptor Axis Modulates Mutant Huntingtin-Mediated Toxicity

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Mitochondrial impairment in patients and asymptomatic mutation carriers of Huntington's disease

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Disrupted Skeletal Muscle Mitochondrial Dynamics, Mitophagy, and Biogenesis during Cancer Cachexia: A Role for Inflammation

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PGC-1α modulates denervation-induced mitophagy in skeletal muscle

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Mitochondrial quality control by the ubiquitin–proteasome system

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Structures of human mitofusin 1 provide insight into mitochondrial tethering

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Reduced mitochondrial density in the vastus lateralis muscle of patients with COPD

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Abnormal Mitochondrial Function in Locomotor and Respiratory Muscles of COPD Patients

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Mitochondrial fragmentation in apoptosis

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Mitochondrial DNA deletion mutations are concomitant with ragged red regions of individual, aged muscle fibers: Analysis by laser-capture microdissection

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Expression of mitochondrial fission and fusion regulatory proteins in skeletal muscle during chronic use and disuse

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Adaptive plasticity of autophagic proteins to denervation in aging skeletal muscle

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Diet-induced obesity alters signalling pathways and induces atrophy and apoptosis in skeletal muscle in a prediabetic rat model: Diet-induced obesity and skeletal muscle

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Molecular Genetics of Huntington's Disease

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The Ubiquitin-Proteasome System Regulates Mitochondrial Intermembrane Space Proteins

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Skeletal muscle denervation causes skeletal muscle atrophy through a pathway that involves both Gadd45a and HDAC4

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Mitochondrial Dysfunction in COPD Patients with Low Body Mass Index

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Defects in Mitochondrial ATP Synthesis in Dystrophin-Deficient Mdx Skeletal Muscles May Be Caused by Complex I Insufficiency

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Role of Creatine Supplementation in Conditions Involving Mitochondrial Dysfunction: A Narrative Review

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The Role of Mitochondria in Mediation of Skeletal Muscle Repair

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IL‐6 Deficiency Attenuates Skeletal Muscle Atrophy by Inhibiting Mitochondrial ROS Production through the Upregulation of PGC‐1α in Septic Mice

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Angiotensin (1-7) Decreases Myostatin-Induced NF-κB Signaling and Skeletal Muscle Atrophy

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Is Upregulation of Sarcolipin Beneficial or Detrimental to Muscle Function?

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Therapeutic Targets for Regulating Oxidative Damage Induced by Ischemia‐Reperfusion Injury: A Study from a Pharmacological Perspective

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Requirements for successful mitochondrial transplantation

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Glycyl‐ l ‐histidyl‐ l ‐lysine‐Cu2+ rescues cigarette smoking‐induced skeletal muscle dysfunction via a sirtuin 1‐dependent pathway

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Sarcopenia in the Aging Process: Pathophysiological Mechanisms, Clinical Implications, and Emerging Therapeutic Approaches

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Serum Retinol Binding Protein 4 as a Potential Biomarker for Sarcopenia in Older Adults

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A High-Fat Diet Induces Muscle Mitochondrial Dysfunction and Impairs Swimming Capacity in Zebrafish: A New Model of Sarcopenic Obesity

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Bufei Jianpi Formula Improves Mitochondrial Function and Suppresses Mitophagy in Skeletal Muscle via the Adenosine Monophosphate-Activated Protein Kinase Pathway in Chronic Obstructive Pulmonary Disease

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Mechanisms Underlying the Effects of the Green Tea Polyphenol EGCG in Sarcopenia Prevention and Management

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Protection of Oxidative Stress-induced DNA Damage and Apoptosis by Rosmarinic Acid in Murine Myoblast C2C12 Cells

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Gastric Cancer with Sarcopenia: an Area Worth Focusing On

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Identifying Acss1, Mtfp1 and Oxct1 as key regulators and promising biomarkers of sarcopenia in various models

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Porous Se@Sio 2 Nanoparticles Improve Oxidative Injury to Promote Muscle Regeneration Via Modulating Mitochondria

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5-Heptadecylresorcinol Ameliorates Obesity-Associated Skeletal Muscle Mitochondrial Dysfunction through SIRT3-Mediated Mitophagy

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Analyzing super-enhancer temporal dynamics reveals potential critical enhancers and their gene regulatory networks underlying skeletal muscle developmentPreprint

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The Effects of Calcium-β-Hydroxy-β-Methylbutyrate on Aging-Associated Apoptotic Signaling and Muscle Mass and Function in Unloaded but Nonatrophied Extensor Digitorum Longus Muscles of Aged Rats

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Fuzhuan brick tea extract ameliorates obesity-induced skeletal muscle atrophy by alleviating mitochondrial dysfunction in mice

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Loss of zebrafish atp6v1e1b, encoding a subunit of vacuolar ATPase, recapitulates human ARCL type 2C syndrome and identifies multiple pathobiological signatures

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Adrenalectomy attenuates hyperalgesia but does not regulate muscle wasting in a female rat model of fibromyalgia

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Elevated mir-145-5p is associated with skeletal muscle dysfunction and triggers apoptotic cell death in C2C12 myotubes

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Specialized, Pro-Resolving Mediators as Potential Therapeutic Agents for Alleviating Fibromyalgia Symptomatology

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Repairing muscle with broccoli-derived sulforaphane: A preclinical evaluation for the treatment of mitochondrial myopathies

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Engineering Targeted Gene Delivery Systems for Primary Hereditary Skeletal Myopathies: Current Strategies and Future Perspectives

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Exercise-induced mitochondrial protection in skeletal muscle of ovariectomized mice: A myogenic E2 synthesis-independent mechanism

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Electroacupuncture alleviates multifidus muscle injury by modulating mitochondrial function and Ca2+ uptake

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Kcnma1 is involved in mitochondrial homeostasis in diabetes‐related skeletal muscle atrophy

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HS-1793 protects C2C12 cells from oxidative stress via mitochondrial function regulation

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A Scoping Review Investigating the “Gene-Dosage Theory” of Mitochondrial DNA in the Healthy Skeletal Muscle

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Secreted protein acidic and rich in cysteine-guided biomimetic delivery of nano-antioxidants reverses muscle atrophy in a mouse model of sarcopenia

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Inhibition of NOX4 attenuates muscle damage and mitochondrial dysfunction in inflammatory myopathy

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The Impact of H1–H4 Receptor Antagonists on the Levels of Selected Oxidative Stress Markers in Liver and Muscle Tissue in an Animal Model of Colitis

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Mapping sarcopenia’s causal proteome reveals a leptin-driven inflammatory-mitochondrial axis for early prediction

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Elevated miR-145-5p is Associated with Chronic Obstructive Pulmonary Disease (COPD) Associated Skeletal Muscle Dysfunction and Triggers Apoptotic Cell Death in C2C12 MyotubesPreprint

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Methanol extract of Myelophycus caespitosus ameliorates oxidative stress-induced cytotoxicity in C2C12 murine myoblasts via activation of heme oxygenase-1

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Keemilise sideme energia tootmisest ja ülekande regulatsioonist mitokondrites patoloogiate korral

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DBP, a key characteristic molecule associated with skeletal muscle dysfunction in COPDPreprint

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Serum metabolomics reveals shared biomarkers and potential common mechanisms of sarcopenia and cognitive impairment

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Additional file 3 of Cholic and deoxycholic acids induce mitochondrial dysfunction, impaired biogenesis and autophagic flux in skeletal muscle cells

Ábrigo, J., Olguín, H. C., Tacchi, F., Orozco-Aguilar, J., Valero‐Breton, M., Soto, J., Castro‐Sepúlveda, M., Elorza, Á. A., Simon, F., & Cabello‐Verrugio, C. (2024) · Figshare · doi:10.6084/m9.figshare.26595605

Additional file 2 of Cholic and deoxycholic acids induce mitochondrial dysfunction, impaired biogenesis and autophagic flux in skeletal muscle cells

Ábrigo, J., Olguín, H. C., Tacchi, F., Orozco-Aguilar, J., Valero‐Breton, M., Soto, J., Castro‐Sepúlveda, M., Elorza, Á. A., Simon, F., & Cabello‐Verrugio, C. (2024) · Figshare · doi:10.6084/m9.figshare.26595602

Additional file 1 of Cholic and deoxycholic acids induce mitochondrial dysfunction, impaired biogenesis and autophagic flux in skeletal muscle cells

Ábrigo, J., Olguín, H. C., Tacchi, F., Orozco-Aguilar, J., Valero‐Breton, M., Soto, J., Castro‐Sepúlveda, M., Elorza, Á. A., Simon, F., & Cabello‐Verrugio, C. (2024) · Figshare · doi:10.6084/m9.figshare.26595599

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Chen, X., Ji, Y., Liu, R., Zhu, X., Wang, K., Yang, X., Liu, B., Gao, Z., Huang, Y. H., Shen, Y., et al. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04369-z · Cited by 340 · see citing works

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