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Cited by 408

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Osteoporosis in Men with Idiopathic Hypogonadotropic Hypogonadism

FINKELSTEIN, JOEL S., KLIBANSKI, ANNE, NEER, ROBERT M., GREENSPAN, SUSAN L., ROSENTHAL, DANIEL I., CROWLEY, WILLIAM F.·1987·Annals of Internal Medicine
DOI 10.7326/0003-4819-106-3-
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Abstract

To assess the effect of testosterone deficiency on skeletal integrity in men, we determined bone density in 23 hypogonadal men with isolated gonadotropin-releasing hormone deficiency and compared those values with ones from controls. Cortical bone density, as assessed by single-photon absorptiometry of the nondominant radius, ranged from 0.57 to 0.86 g/cm2 (mean +/- SE, 0.71 +/- 0.02) in patients with fused epiphyses and from 0.57 to 0.67 g/cm2 (mean, 0.61 +/- 0.01) in patients with open epiphyses, both of which were significantly (p less than 0.001) lower than normal. Spinal trabecular bone density, as assessed by computed tomography, was similarly decreased (p less than 0.0001) and ranged from 42 to 177 mg K2HPO4/cm3 (mean, 112 +/- 7). Cortical bone density was at least 2 SD below normal in 16 of 23 men, and 8 men had spinal bone densities below the fracture threshold of 80 to 100 mg K2HPO4/cm3. Osteopenia was equally severe in men with immature and mature bone ages, suggesting that abnormal bone development plays an important role in the osteopenia of men with idiopathic hypogonadotropic hypogonadism.

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Authors
FINKELSTEIN, J. S., KLIBANSKI, A., NEER, R. M., GREENSPAN, S. L., ROSENTHAL, D. I., & CROWLEY, W. F.
Venue
Annals of Internal Medicine
Publisher
American College of Physicians
Published
1987-03-01
Volume
106
Issue
3
Pages
354-361
ISSN
  • 0003-4819 (ISSN-L)
  • 1539-3704
DOI
10.7326/0003-4819-106-3-
OpenAlex
W2025079080
Cited by
408
References
0
FWCI
16.46
Type
journal article
Language
en
Open access
closed

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