The DOI matches its Crossref record.
Changes in energy balance and body composition at menopause: a controlled longitudinal study.
Abstract
OBJECTIVE: To describe the effects of menopause on resting metabolic rate, body composition, fat distribution, physical activity during leisure time, and fasting insulin levels. DESIGN: A longitudinal comparison of metabolic changes in women who experienced menopause with changes in age-matched women who did not experience menopause. SETTING: General clinical research center. PATIENTS: An initial cohort of 35 sedentary healthy premenopausal women (age range, 44 to 48 years). After 6 years of follow-up, 18 women had spontaneously stopped menstruating for at least 12 months and 17 women remained premenopausal. No women received hormone replacement therapy. RESULTS: Women who experienced menopause lost more fat-free mass than women who remained premenopausal (-3.0 +/- 1.1 kg and -0.5 +/- 0.5 kg, respectively), had greater decreases in resting metabolic rate (-103 +/- 55 kcal/d and -8 +/- 17 kcal/d) and physical activity during leisure time (-127 +/- 79 kcal/d and 64 +/- 60 kcal/d), and had greater increases in fat mass (2.5 +/- 2 kg and 1.0 +/- 1.5 kg), fasting insulin levels (11 +/- 9 pmol/L and -2 +/- 5 pmol/L), and waist-to-hip ratios (0.04 +/- 0.01 and 0.01 +/- 0.01) (P < or = 0.01 for all comparisons). Menopause did not affect energy intake, fasting glucose levels, or peak oxygen consumption. CONCLUSIONS: Natural menopause is associated with reduced energy expenditure during rest and physical activity, an accelerated loss of fat-free mass, and increased central adiposity and fasting insulin levels. These changes may indicate a worsening cardiovascular and metabolic risk profile.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“an age-related loss of muscle mass has been observed in women, this loss being particularly important at menopause (323,324).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [324]
Citations
Cited by
Sorted by citations
The Emergence of the Metabolic Syndrome with Menopause
Carr, M. C. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030242 · Cited by 1,449
“Several groups have shown increased fasting insulin (22, 48) and increased fasting glucose levels (37, 63) in postmenopausal compared with premenopausal women, which would imply worsened insulin resistance with the menopause.”
BackgroundInfluential2016 IMS Recommendations on women’s midlife health and menopause hormone therapy
Baber, R., Panay, N., & Fenton, A. J. (2016) · Climacteric · doi:10.3109/13697137.2015.1129166 · Cited by 968
Changes in Proinflammatory Cytokine Activity after Menopause
Pfeilschifter, J., Köditz, R., Pfohl, M., & Schatz, H. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.1.0456 · Cited by 929
Hughes, V. A., Frontera, W. R., Roubenoff, R., Evans, W. J., & Singh, M. A. F. (2002) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.2.473 · Cited by 804
“Data from cross-sectional and longitudinal studies suggest that the greatest rate of decline in lean tissue may occur in the perimenopausal years, followed by a more gradual decline thereafter (37, 38).”
BackgroundRoubenoff, R., & HUGHES, V. A. (2000) · The Journals of Gerontology Series A · doi:10.1093/gerona/55.12.m716 · Cited by 698
“Acceleration of lean tissue loss is seen during the menopausal years in women (19,20).”
BackgroundUnderstanding weight gain at menopause
Davis, S. R., Castelo‐Branco, C., Chedraui, P. A., Lumsden, M. A., Nappi, R. E., Shah, D., Villaseca, P., & as the Writing Group of the International Menopause Society for World Menopause Day 2012 (2012) · Climacteric · doi:10.3109/13697137.2012.707385 · Cited by 646
Labrie, F., Luu-The, V., Labrie, C., Bélanger, A., Simard, J., Lin, S.-X., & Pelletier, G. (2003) · Endocrine Reviews · doi:10.1210/er.2001-0031 · Cited by 544
“In fact, an age-related loss of muscle mass has been observed in women, this loss being particularly important at menopause (323, 324).”
BackgroundEstrogen Regulation of Growth Hormone Action
Leung, K., Johannsson, G., Leong, G. M., & Ho, K. K. Y. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0035 · Cited by 550
“distribution of body fat toward the abdomen (74, 75, 80).”
BackgroundEstrogen: A master regulator of bioenergetic systems in the brain and body
Rettberg, J. R., Yao, J., & Brinton, R. D. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.08.001 · Cited by 534
“Fasting insulin (Poehlman et al., 1995; Razay et al., 2007) and glucose (Dallongeville et al., 1995; Lynch et al., 2002) levels have been shown to rise as estrogen levels decrease during the menopausal transition, but this is proposed as a secondary response to the change in body fat distribution…”
Menopause-Associated Lipid Metabolic Disorders and Foods Beneficial for Postmenopausal Women
Ko, S., & Kim, H. (2020) · Nutrients · doi:10.3390/nu12010202 · Cited by 561
Sarcopenia, Calf Circumference, and Physical Function of Elderly Women: A Cross‐Sectional Study
Rolland, Y., Lauwers‐Cancès, V., Cournot, M., Nourhashémi, F., Reynish, W., Rivière, D., Vellas, B. J., & Grandjean, H. (2003) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2003.51362.x · Cited by 515
Direct effects of sex steroid hormones on adipose tissues and obesity
Mayes, J., & Watson, G. (2004) · Obesity Reviews · doi:10.1111/j.1467-789x.2004.00152.x · Cited by 509
Effect of menopausal status on body composition and abdominal fat distribution
Toth, M., Tchernof, A., Sites, C., & Poehlman, É. T. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801118 · Cited by 504
Self-citationEndocrine Control of Body Composition in Infancy, Childhood, and Puberty
Veldhuis, J. D., Roemmich, J. N., Richmond, E. J., Rogol, A. D., Lovejoy, J. C., Sheffield-Moore, M., Mauras, N., & Bowers, C. Y. (2005) · Endocrine Reviews · doi:10.1210/er.2003-0038 · Cited by 452
“(540–545) and falls in amenorrheic states (546).”
Brochu, M., Tchernof, A., Dionne, I. J., Sites, C. K., Eltabbakh, G. H., Sims, E. A. H., & Poehlman, E. T. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.3.7365 · Cited by 443
“fatness and decline in energy expenditure (4).”
Aging, body composition, and lifestyle: the Fels Longitudinal Study
Guo, S. S., Zeller, C., Chumlea, W. C., & Siervogel, R. M. (1999) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/70.3.405 · Cited by 408
Long‐Term Weight Development in Women: A 15‐Year Follow‐up of the Effects of Pregnancy
Linne, Y. M., Dye, L., Barkeling, B., & Rössner, S. (2004) · Obesity Research · doi:10.1038/oby.2004.146 · Cited by 370
S ARCOPENIA , W EIGHT L OSS , AND N UTRITIONAL F RAILTY IN THE E LDERLY
Bales, C. W., & Ritchie, C. S. (2002) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.22.010402.102715 · Cited by 350
Hormone Replacement Therapy and Sleep-disordered Breathing
Shahar, E., Redline, S. S., Young, T. B., Boland, L. L., Baldwin, C. M., Nieto, F. J., O’Connor, G. T., Rapoport, D. M., & Robbins, J. A. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200210-1238oc · Cited by 349
Skeletal muscle contractile and noncontractile components in young and older women and men
Kent‐Braun, J. A., Ng, A. V., & Young, K. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.88.2.662 · Cited by 343
“(24) observed that perimenopausal women who had an accelerated loss of fat-free mass reported reduced physical activity.”
BackgroundCentral effects of estradiol in the regulation of food intake, body weight, and adiposity
Brown, L. M., & Clegg, D. J. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2009.12.005 · Cited by 331
Adjuvant Treatment and Onset of Menopause Predict Weight Gain After Breast Cancer Diagnosis
Goodwin, P. J., Ennis, M., Pritchard, K. I., McCready, D. R., Koo, J., Sidlofsky, S., Trudeau, M., Hood, N., & Redwood, S. (1999) · Journal of Clinical Oncology · doi:10.1200/jco.1999.17.1.120 · Cited by 323
Freedland, E. S. (2004) · Nutrition & Metabolism · doi:10.1186/1743-7075-1-12 · Cited by 303
“The abundant presence of peripheral fat mass in generally obese women is associated with increased plasma adiponectin, and the loss of estrogen with menopause is associated with an increase in central fat [132].”
Nicklas, B. J. (2004) · American Journal of Epidemiology · doi:10.1093/aje/kwh281 · Cited by 298
“Thus, men with high levels of visceral adipose tissue may have experienced earlier CHD mortality; for women, the risk associated with visceral adipose tissue may become more apparent in older age, after a menopause-related increase in such tissue (35).”
BackgroundMenopause‐Related Changes in Body Fat Distribution
Toth, M. J., Tchernof, A., Sites, C. K., & Poehlman, É. T. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06506.x · Cited by 297
Self-citationFat and protein redistribution with aging: metabolic considerations
Beaufrère, B., & Morio, B. (2000) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601025 · Cited by 295
Kalantaridou, S. N., Naka, K. K., Papanikolaou, E., Kazakos, N., Kravariti, M., Calis, K. A., Paraskevaidis, E. A., Sideris, D. A., Tsatsoulis, A., Chrousos, G. P., et al. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0015 · Cited by 284
Atkinson, C., Compston, J. E., Day, N., Dowsett, M., & Bingham, S. A. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.2.326 · Cited by 281
HOCKING, S. L., Samocha‐Bonet, D., Milner, K., Greenfield, J. R., & Chisholm, D. J. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1041 · Cited by 294
“, women have less intraabdominal fat than men and better insulin sensitivity; this would seem to be an estrogen effect, rather than a lack of androgen effect, because this benefit is lost after menopause when insulin sensitivity is closely related to intraabdominal fat (224, 225).”
BackgroundEnergy Metabolism Changes and Dysregulated Lipid Metabolism in Postmenopausal Women
Ko, S., & Jung, Y. (2021) · Nutrients · doi:10.3390/nu13124556 · Cited by 302
“In a 6-year follow-up longitudinal study, natural postmenopausal women lost more FFM than age-matched premenopausal women while showing increased central adiposity and reduced energy expenditure during rest and physical activity [25].”
BackgroundSympathetic system activity in obesity and metabolic syndrome
TENTOLOURIS, N., LIATIS, S., & KATSILAMBROS, N. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1367.010 · Cited by 260
Obesity Is Associated with Functional Decline in Community‐Dwelling Rural Older Persons
Jensen, G. L., & Friedmann, J. M. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50220.x · Cited by 261
Trémollieres, F. A., Pouilles, J.-M., & Ribot, C. A. (1996) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(96)70111-4 · Cited by 242
Feng, Y., Hong, X., Wilker, E. H., Li, Z., Zhang, W., Jin, D., Liu, X., Zang, T., Xu, X., & Xu, X. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.06.016 · Cited by 236
“Natural menopause is associated with an increased central adiposity [23–25] and it contributes to the worsening of lipid profile in post-menopausal women [16].”
BackgroundPersky, A. M., Green, P. S., Stubley, L., Howell, C. O., Zaulyanov, L., Brazeau, G. A., & Simpkins, J. W. (2000) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1046/j.1525-1373.2000.22308.x · Cited by 233
Gender Aspects of the Role of the Metabolic Syndrome as a Risk Factor for Cardiovascular Disease
Regitz‐Zagrosek, V., Lehmkuhl, E., & Mahmoodzadeh, S. (2007) · Gender Medicine · doi:10.1016/s1550-8579(07)80056-8 · Cited by 229
Origins and Clinical Relevance of Sarcopenia
Roubenoff, R. (2001) · Canadian Journal of Applied Physiology · doi:10.1139/h01-006 · Cited by 225
Metabolic Syndrome and Menopause
Stefańska, A., Bergmann, K., & Sypniewska, G. (2015) · Advances in clinical chemistry · doi:10.1016/bs.acc.2015.07.001 · Cited by 222
Sox, H. C., & Rennie, D. (2006) · Annals of Internal Medicine · doi:10.7326/0003-4819-144-8-200604180-00123 · Cited by 200
“In its letter, the university referred only to the Annals of Internal Medicine article, a 1995 article on energy expenditure after menopause (1).”
BackgroundWeight development over time in parous women—The SPAWN study—15 years follow-up
Linne, Y. M., Dye, L., Barkeling, B., & Rössner, S. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802441 · Cited by 201
Park, S. H., Kim, B. I., Yun, J. W., Kim, J. W., Park, D. I., Cho, Y. K., Sung, I. K., Park, C. Y., Sohn, C. I., Jeon, W. K., et al. (2004) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2004.03362.x · Cited by 198
The Effect of Menopause on the Metabolic Syndrome Among Korean Women
Kim, H. M., Park, J.-H., Ryu, S. Y., & Kim, J. (2007) · Diabetes Care · doi:10.2337/dc06-1400 · Cited by 195
“Natural menopause is associated with increased central adiposity (19).”
BackgroundMenopause is an independent predictor of metabolic syndrome in Iranian women
Eshtiaghi, R., Esteghamati, A., & Nakhjavani, M. (2010) · Maturitas · doi:10.1016/j.maturitas.2009.11.004 · Cited by 195
Cho, G. J., Lee, J. H., Park, H. T., Shin, J., Hong, S., Kim, T., Hur, J. Y., Lee, K. W., Park, Y. K., & Kim, S. H. (2008) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3181559860 · Cited by 183
Simkin‐Silverman, L. R., Wing, R. R., Boraz, M. A., & Kuller, L. H. (2003) · Annals of Behavioral Medicine · doi:10.1207/s15324796abm2603_06 · Cited by 176
Brochu, M., Starling, R. D., Tchernof, A., Matthews, D. E., Garcı́a-Rubi, E., & Poehlman, É. T. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.7.6685 · Cited by 176
Self-citationDavis, S. R., Walker, K., & Strauss, B. J. (2000) · Menopause The Journal of The North American Menopause Society · doi:10.1097/00042192-200011000-00005 · Cited by 165
Lipedema and the Potential Role of Estrogen in Excessive Adipose Tissue Accumulation
Katzer, K., Hill, J. L., McIver, K. B., & Foster, M. T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111720 · Cited by 187
“Indeed, the loss of estrogen with menopause shifts adipose tissue accumulation away from the lower body towards central/abdominal deposition [26], a distribution commonly seen in males [26,27].”
BackgroundSites, C. K., Toth, M. J., Cushman, M., L’Hommedieu, G. D., Tchernof, A., Tracy, R. P., & Poehlman, É. T. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(01)02934-x · Cited by 164
Self-citationMetabolic impact of sex hormones on obesity
Brown, L. M., Gent, L. M., Davis, K. E., & Clegg, D. J. (2010) · Brain Research · doi:10.1016/j.brainres.2010.04.056 · Cited by 161
“The loss of estrogens with menopause is associated with an increase in intra-abdominal fat accrual (Poehlman et al., 1995; Lee et al., 2009).”
Effects of the Menopause Transition on Body Fatness and Body Fat Distribution
Tchernof, A., & Poehlman, É. T. (1998) · Obesity Research · doi:10.1002/j.1550-8528.1998.tb00344.x · Cited by 167
Self-citationRetractedRachoń, D., & Teede, H. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.09.026 · Cited by 161
“Results from human studies have also demonstrated that women who became postmenopausal had significantly greater reductions in resting metabolic rate and lower physical activity levels compared to their premenopausal controls (Ravussin et al., 1988; Poehlman et al., 1995).”
BackgroundThe Influence of Sex Hormones on Obesity across the Female Life Span
Lovejoy, J. C. (1998) · Journal of Women s Health · doi:10.1089/jwh.1998.7.1247 · Cited by 161
Ma, X., Lee, P., Chisholm, D. J., & James, D. E. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00001 · Cited by 167
Lovejoy, J. C., Champagne, C. M., Smith, S. R., de Jonge, L., & Xie, H. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/74.1.90 · Cited by 155
“Poehlman et al (2) suggested that changes in energy expenditure (EE) and dietary intake patterns may play a role in weight gain during menopause.”
BackgroundGeary, N. (2001) · Peptides · doi:10.1016/s0196-9781(01)00449-1 · Cited by 172
Relation between body composition, fat distribution, and lung function in elderly men
Santana, H., Zoico, E., Turcato, E., Tosoni, P., Bissoli, L., Olivieri, M., Bosello, O., & Zamboni, M. M. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.4.827 · Cited by 153
Body mass index in mid-life women: relative influence of menopause, hormone use, and ethnicity
Matthews, K., Abrams, B. F., Crawford, S. L., Miles, T. P., Neer, R., Powell, L. H., & Wesley, D. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801618 · Cited by 150
Natural course of gestational diabetes mellitus: long term follow up of women in the SPAWN study
Linne, Y. M., Barkeling, B., & Rössner, S. (2002) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1016/s1470-0328(02)01973-0 · Cited by 152
Gender differences in the cardiovascular effects of sex hormones
Vitale, C., Fini, M., Speziale, G., & Chierchia, S. L. (2010) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2010.00817.x · Cited by 152
Energy Balance in Early Breast Cancer Patients Receiving Adjuvant Chemotherapy
Harvie, M., Campbell, I. T., Baildam, A. D., & Howell, A. (2004) · Breast Cancer Research and Treatment · doi:10.1023/b:brea.0000014037.48744.fa · Cited by 145
“5 kg [26] and is unlikely to account for the magnitude of the gains in body fat reported here.”
Menopausal status and hepatic steatosis in a general female population
Völzke, H., Schwarz, S., Baumeister, S., Wallaschofski, H., Schwahn, C., Grabe, H.-J., Kohlmann, T., John, U., & Dören, M. (2007) · Gut · doi:10.1136/gut.2006.115345 · Cited by 141
The role of hormones, cytokines and heat shock proteins during age-related muscle loss
Lee, C. E., McArdle, A., & Griffiths, R. (2007) · Clinical Nutrition · doi:10.1016/j.clnu.2007.05.005 · Cited by 141
Menopause, energy expenditure, and body composition
Poehlman, É. T. (2002) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1034/j.1600-0412.2002.810705.x · Cited by 144
Self-citationRetractedDifferences in Adipose Tissue Metabolism between Postmenopausal and Perimenopausal Women
Ferrara, C. M., Lynch, N. A., Nicklas, B. J., Ryan, A. S., & Berman, D. M. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2001-012034 · Cited by 134
“and a redistribution of fat to the abdominal region (4, 5) also”
BackgroundCan obesity be a risk factor in elderly people?
İnelmen, E., Sergi, G., Coin, A., Miotto, F., Peruzza, S., & Enzi, G. (2003) · Obesity Reviews · doi:10.1046/j.1467-789x.2003.00107.x · Cited by 136
Roles of G protein-coupled estrogen receptor GPER in metabolic regulation
Sharma, G., Mauvais‐Jarvis, F., & Prossnitz, E. R. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2017.02.012 · Cited by 132
“Ovariectomized mice and postmenopausal women share similar metabolic traits resulting from E2 reduction, such as increased adiposity, changes in body fat distribution (specifically central fat), lower energy expenditure, glucose intolerance and reduced insulin sensitivity [16,41].”
Obesity in breast cancer – What is the risk factor?
James, F., Wootton, S. A., Jackson, A. A., Wiseman, M. J., Copson, E., & Cutress, R. (2015) · European Journal of Cancer · doi:10.1016/j.ejca.2015.01.057 · Cited by 133
“There is also evidence that the menopause accelerates the fat mass gain and lean mass loss that occurs in women with ageing [45,46].”
BackgroundImpact of Premature Ovarian Failure on Mortality and Morbidity among Chinese Women
Wu, X., Cai, H., Kallianpur, A. R., Li, H., Yang, G., Gao, J., Xiang, Y., Ji, B., Yutang, Zheng, W., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089597 · Cited by 129
“01) after six years follow-up [34].”
Relative contribution of aging and menopause to changes in lean and fat mass in segmental regions
Douchi, T., Yamamoto, S., Yoshimitsu, N., Andoh, T., Matsuo, T., & Nagata, Y. (2002) · Maturitas · doi:10.1016/s0378-5122(02)00161-5 · Cited by 127
“Third, a longitudinal study demonstrated that natural menopause is associated with reduced energy expenditure during rest and physical activity, accelerating the loss of fat-free mass [12].”
BackgroundMenopausal status and risk factors for cardiovascular disease
Peters, H., Westendorp, I. C. D., Hak, A. E., et al. (1999) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.1999.00547.x · Cited by 126
Lovejoy, J. C. (2003) · Primary Care: Clinics in Office Practice · doi:10.1016/s0095-4543(03)00012-5 · Cited by 128
“It was also suggested that menopausal women have a slightly decreased resting metabolic rate (RMR) [31].”
BackgroundBody fat distribution, the menopause transition, and hormone replacement therapy.
Tchernof, A., Poehlman, É. T., & Després, J. (2000) · PubMed · Cited by 124
RetractedLovejoy, J. C., Smith, S. R., & Rood, J. C. (2001) · Obesity Research · doi:10.1038/oby.2001.2 · Cited by 121
Thyroid stimulating hormone is associated with metabolic syndrome in euthyroid postmenopausal women
Park, H. T., Cho, G. J., Ahn, K. H., Shin, J., Hong, S., Kim, T., Hur, J. Y., Kim, Y. T., Lee, K. W., & Kim, S. H. (2009) · Maturitas · doi:10.1016/j.maturitas.2009.01.007 · Cited by 121
Role of Hormones in the Pathogenesis and Management of Sarcopenia
Kamel, H. K., Maas, D. L., & Duthie, E. H. (2002) · Drugs & Aging · doi:10.2165/00002512-200219110-00004 · Cited by 116
The Metabolic Syndrome in Women
Schneider, J. G., TOMPKINS, C. M., Blumenthal, R. S., & Mora, S. (2006) · Cardiology in Review · doi:10.1097/01.crd.0000233757.15181.67 · Cited by 120
“Alternatively, loss of estrogen is associated with an increase in abdominal obesity, which may increase a woman’s risk for developing insulin resistance.(26) A woman does not have to be clinically obese (body mass index BMI 30 kg/m(2)) to be at risk for metabolic syndrome.”
BackgroundCarr, M. C., Hokanson, J. E., Zambon, A., Deeb, S. S., Barrett, P. H. R., Purnell, J. Q., & Brunzell, J. D. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.6.7586 · Cited by 120
Gender determinants of cardiovascular risk factors and diseases
Mercuro, G. G., Deidda, M., Piras, A., Dessalvi, C. C., Maffei, S., & Rosano, G. M. C. (2010) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0b013e32833178ed · Cited by 114
Kenny, R. A., Dawson, L. M., Kleppinger, A., Iannuzzi-Sucich, M., & Judge, J. O. (2003) · The Journals of Gerontology Series A · doi:10.1093/gerona/58.5.m436 · Cited by 114
“One study found an association between the loss of estrogen at menopause and the loss of lean muscle mass (7), and another study found that muscle strength declined around menopause (11).”
BackgroundChu, M. C., Cosper, P., Orio, F., Carmina, E., & Lobo, R. A. (2006) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2005.06.073 · Cited by 113
Maestá, N., Nahás, E. A. P., Nahás-Neto, J., Orsatti, F. L., Fernandes, C. E., Traiman, P., & Burini, R. C. (2006) · Maturitas · doi:10.1016/j.maturitas.2006.10.001 · Cited by 113
Hormone Replacement Therapy, Insulin Sensitivity, and Abdominal Obesity in Postmenopausal Women
Ryan, A. S., Nicklas, B. J., & Berman, D. M. (2002) · Diabetes Care · doi:10.2337/diacare.25.1.127 · Cited by 112
“The menopause transition is a period of fat mass gain and loss of lean tissue (8).”
BackgroundEstradiol and Tamoxifen Reverse Ovariectomy-Induced Physical Inactivity in Mice
Gorzek, J. F., Hendrickson, K. C., Forstner, J. P., Rixen, J. L., MORAN, A. L., & Lowe, D. A. (2007) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000241649.15006.b8 · Cited by 111
Normal Diaphragmatic Motion and the Effects of Body Composition
Kantarcı, F., Mihmanlı, İ., Demirel, M. K., et al. (2004) · Journal of Ultrasound in Medicine · doi:10.7863/jum.2004.23.2.255 · Cited by 111
Menopause, obesity and inflammation: interactive risk factors for Alzheimer’s disease
Christensen, A., & Pike, C. J. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00130 · Cited by 112
Macdonald, H. M., New, S. A., Campbell, M., & Reid, D. M. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802283 · Cited by 109
Kohrt, W. M., Ehsani, A. A., & Birge, S. J. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.84.5.1506 · Cited by 108
“The notion that sex hormones independently modulate energy balance is supported by the study by Poehlman and colleagues (23), who found that women progressing through menopause gained more total and abdominal fat and lost more lean body mass over a 6-yr period than did age-matched women who remained premenopausal over…”
BackgroundResultTotal daily energy expenditure in free-living older African-Americans and Caucasians
Carpenter, W. H., Fonong, T., Toth, M. J., Ades, P. A., Calles-Escandón, J., Walston, J. D., & Poehlman, É. T. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.274.1.e96 · Cited by 109
Self-citationDeterminants of disability in older coronary patients
Ades, P. A., Savage, P. D., Tischler, M. D., Poehlman, É. T., Dee, J. M., & Niggel, J. B. (2002) · American Heart Journal · doi:10.1067/mhj.2002.119379 · Cited by 103
Self-citationNatural course of gestational diabetes mellitus: long term follow up of women in the SPAWN study
Linne, Y. M., Barkeling, B., & Rössner, S. (2002) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1046/j.1471-0528.2002.01373.x · Cited by 106
Swift, D. L., Earnest, C. P., Blair, S. N., & Church, T. S. (2011) · British Journal of Sports Medicine · doi:10.1136/bjsports-2011-090025 · Cited by 107
Increased urinary cortisol levels during the menopause transition
Woods, N. F., Carr, M. C., Tao, E. Y., Taylor, H. J., & Mitchell, E. S. (2006) · Menopause The Journal of The North American Menopause Society · doi:10.1097/01.gme.0000198490.57242.2e · Cited by 103
“Increased cortisol during the menopausal transition is significant because it may influence the accumulation of central abdominal fat, which contributes to cardiovascular disease risk.(36,37) Several groups have found a strong association between cortisol levels and central abdominal fat depots.”
BackgroundChang, C.-J., Wu, C.-H., Yao, W.-J., Yang, Y.-C., Wu, J.-S., & Lu, F.-H. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801457 · Cited by 101
Carr, M. C., Ayyobi, A. F., Murdoch, S. J., Deeb, S. S., & Brunzell, J. D. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000013284.47317.95 · Cited by 100
Changes in LDL Density across the Menopausal Transition
Carr, M. C., Kim, K. H., Zambon, A., Mitchell, E. S., Woods, N. F., Casazza, C. P., Purnell, J. Q., Hokanson, J. E., Brunzell, J. D., & Schwartz, R. S. (2000) · Journal of Investigative Medicine · doi:10.1177/108155890004800405 · Cited by 100
Hormone Replacement Therapy Is Associated With Better Glycemic Control in Women With Type 2 Diabetes
Ferrara, A. M., Karter, A. J., Ackerson, L., Liu, J. Y., & Selby, J. V. (2001) · Diabetes Care · doi:10.2337/diacare.24.7.1144 · Cited by 98
“I n women with type 2 diabetes, the changes in sex-hormone levels, abdominal fat, and insulin metabolism that accompany menopause (1,2) may represent additional impediments in achieving good glycemic control.”
BackgroundMENOPAUSE, ESTROGENS, AND ENDOTHELIAL DYSFUNCTION: CURRENT CONCEPTS
Maturana, M. A., Irigoyen, M. C., & Spritzer, P. M. (2007) · Clinics · doi:10.1590/s1807-59322007000100012 · Cited by 97
Weight control and the management of obesity after menopause: the role of physical activity
Dubnov‐Raz, G., Brzezinski, A., & Berry, E. M. (2003) · Maturitas · doi:10.1016/s0378-5122(02)00328-6 · Cited by 94
“[47] Poehlman ET, Toth MJ, Gardner AW.”
BackgroundFat Distribution and Insulin Sensitivity in Postmenopausal Women: Influence of Hormone Replacement
Munoz, J., Derstine, A., & Gower, B. A. (2002) · Obesity Research · doi:10.1038/oby.2002.59 · Cited by 94
Metadata
- Authors
- Poehlman, E. T., Toth, M. J., & Gardner, A. W.
- Affiliations
- From the University of Maryland and Baltimore Veterans Affairs Medical Center, Baltimore, Maryland.
- University of Maryland, Baltimore (US)
- Baltimore VA Medical Center (US)
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1995-11-01
- Volume
- 123
- Issue
- 9
- Pages
- 673-675
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2072594041
- Cited by
- 520
- References
- 0
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2023: 8 · 2022: 4 · 2021: 15 · 2020: 10 · 2019: 5 · 2018: 13 · 2017: 13 · 2016: 9 · 2015: 25 · 2014: 20 · 2013: 16 · 2012: 29
- FWCI
- 5.79
- Type
- journal article
- Language
- en
- Status
- Retracted
- Update notices
- retraction (2003-10-21)
- Open access
- closed
- Locations
- Annals of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (7k04ag000564-06)
- National Institute on Aging (AG07857, T32AG00219, T32AG000219, KO4-AG00564)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- menopause, energy balance, body composition, resting metabolic rate, fat-free mass loss, fat mass, abdominal obesity, waist-to-hip ratio, leisure-time physical activity, energy expenditure, fasting insulin, cardiovascular risk, metabolic risk, premenopausal women
- MeSH terms
- Adipose Tissue, Adult, Body Composition, Cardiovascular Diseases, Energy Metabolism, Fasting, Female, Humans, Insulin, Longitudinal Studies, Menopause, Middle Aged, Risk Factors, Exercise
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
