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Cited by 572Bone health and osteoporosis researchNutrition and Health in AgingHip and Femur Fractures

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Protein Supplements Increase Serum Insulin-Like Growth Factor-I Levels and Attenuate Proximal Femur Bone Loss in Patients with Recent Hip Fracture: A Randomized, Double-Blind, Placebo-Controlled Trial

Schurch, Marc-Andre, Rizzoli, Rene, Slosman, Daniel, Vadas, Laszlo, Vergnaud, Philippe, Bonjour, Jean-Philippe·1998·Annals of Internal Medicine
DOI 10.7326/0003-4819-128-10-199805150-00002
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Abstract

BACKGROUND: Elderly persons who have osteoporotic hip fracture are often undernourished, particularly with respect to protein. Protein malnutrition may contribute to the occurrence and outcome of hip fracture. OBJECTIVE: To investigate whether oral protein supplements benefit bone metabolism in patients with recent hip fracture. DESIGN: 6-month, randomized, double-blind, placebo-controlled trial with a 6-month post-treatment follow-up. SETTING: University orthopedic ward. PATIENTS: 82 patients (mean age, 80.7 +/- 7.4 years) with recent osteoporotic hip fracture. Patients received calcium supplementation, 550 mg/d, and one dose of vitamin D, 200,000 IU (at baseline). INTERVENTION: Protein supplementation, 20 g/d, or isocaloric placebo (among controls). MEASUREMENTS: Bone mineral density, biochemical markers of bone remodeling, calciotropic hormone levels, biochemically evaluated nutritional and immunologic status, and muscle strength were measured every 6 months. RESULTS: Compared with controls, patients who received protein supplements had significantly greater increases in serum levels of insulin-like growth factor-I (85.6% +/- 14.8% and 34.1% +/- 7.2% at 6 months; difference, 51.5 percentage points [95% CI, 18.6 to 84.4 percentage points]; P = 0.003) and an attenuation of the decrease in proximal femur bone mineral density (-2.29% +/- 0.75% and -4.71% +/- 0.77% at 12 months; difference, 2.42 percentage points [CI, 0.26 to 4.59 percentage points]; P = 0.029). Seven and 13 new vertebral deformities were found among patients who received protein supplements and controls, respectively (P > 0.2). Median stay in rehabilitation wards was shorter for patients who received protein supplements than for controls (33 days [CI, 29 to 56 days] and 54 days [CI, 44 to 62 days]; difference, 21 days [CI, 4 to 25 days]; P = 0.018). CONCLUSION: Protein repletion after hip fracture was associated with increased serum levels of insulin-like growth factor-I, attenuation of proximal femur bone loss, and shorter stay in rehabilitation hospitals.

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Crossref · 10.7326/0003-4819-128-10-199805150-00002

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Authors
Schurch, M.-A., Rizzoli, R., Slosman, D., Vadas, L., Vergnaud, P., & Bonjour, J.-P.
Affiliations
For author affiliations and current author addresses, see end of text.
Venue
Annals of Internal Medicine
Publisher
American College of Physicians
Published
1998-05-15
Volume
128
Issue
10
Pages
801-809
ISSN
  • 0003-4819 (ISSN-L)
  • 1539-3704
DOI
10.7326/0003-4819-128-10-199805150-00002
OpenAlex
W2082655867
Cited by
572
References
1
Citations by year
2026: 5 · 2025: 4 · 2024: 7 · 2023: 13 · 2022: 12 · 2021: 17 · 2020: 10 · 2019: 17 · 2018: 27 · 2017: 15 · 2016: 20 · 2015: 16 · 2014: 33 · 2013: 24 · 2012: 20
FWCI
19.05
Type
journal article
Language
en
Open access
closed
Licence
www.acpjournals.org/journal/aim/text-and-data-mining (tdm)
Locations
  • Annals of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
  • Health Sciences › Medicine › Surgery › Hip and Femur Fractures
Keywords
protein supplementation, osteoporotic hip fracture, insulin-like growth factor I, bone loss, protein malnutrition, older adults, bone metabolism, vertebral deformity, rehabilitation length of stay, calcium and vitamin D supplementation, muscle strength, nutritional status, bone turnover markers, fracture healing, protein repletion, fracture rehabilitation
MeSH terms
Activities of Daily Living, Aged, Aged, 80 and over, Dietary Proteins, Double-Blind Method, Female, Femur, Follow-Up Studies, Hip Fractures, Humans, Immunoglobulin M, Insulin-Like Growth Factor I, Length of Stay, Male, Osteoporosis, Placebos, Prealbumin, Protein Deficiency, Serum Albumin, Bone Density, Dietary Supplements

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