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Aspirin for the Prevention of Cardiovascular Disease: U.S. Preventive Services Task Force Recommendation Statement
Abstract
DESCRIPTION: Update of the 2002 U.S. Preventive Services Task Force (USPSTF) recommendation about the use of aspirin for the prevention of coronary heart disease. METHODS: Review of the literature since 2002, focusing on new evidence on the benefits and harms of aspirin for the primary prevention of cardiovascular disease, including myocardial infarction and stroke. The new evidence was reviewed and synthesized according to sex. RECOMMENDATIONS: Encourage men age 45 to 79 years to use aspirin when the potential benefit of a reduction in myocardial infarctions outweighs the potential harm of an increase in gastrointestinal hemorrhage. (A recommendation) Encourage women age 55 to 79 years to use aspirin when the potential benefit of a reduction in ischemic strokes outweighs the potential harm of an increase in gastrointestinal hemorrhage. (A recommendation) Evidence is insufficient to assess the balance of benefits and harms of aspirin for cardiovascular disease prevention in men and women 80 years or older. (I statement) Do not encourage aspirin use for cardiovascular disease prevention in women younger than 55 years and in men younger than 45 years. (D recommendation).
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“The Framingham risk score is a global index of CHD risk used in clinical settings (8, 17, 30).”
From Effects of Low-Carbohydrate and Low-Fat Diets: A Randomized Trial (2014) · cites this paper as [30]
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Metadata
- Authors
- U.S. Preventive Services Task Force*
- Corresponding author
- U.S. Preventive Services Task Force*
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 2009-03-17
- Volume
- 150
- Issue
- 6
- Pages
- 396-404
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2599856343
- Cited by
- 533
- References
- 11
- Citations by year
- 2025: 4 · 2024: 4 · 2023: 9 · 2022: 10 · 2021: 10 · 2020: 21 · 2019: 23 · 2018: 20 · 2017: 24 · 2016: 32 · 2015: 46 · 2014: 58 · 2013: 61 · 2012: 71
- FWCI
- 45.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Antiplatelet Therapy and Cardiovascular Diseases
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Health Promotion and Cardiovascular Prevention
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Keywords
- aspirin, cardiovascular disease prevention, primary prevention, coronary artery disease, myocardial infarction, ischemic stroke, gastrointestinal bleeding, sex differences, benefit-harm balance, USPSTF recommendations
- MeSH terms
- Age Factors, Aged, Aspirin, Cardiovascular Diseases, Brain Ischemia, Female, Gastrointestinal Hemorrhage, Humans, Male, Middle Aged, Myocardial Infarction, Platelet Aggregation Inhibitors, Primary Prevention, Cost of Illness, Risk Assessment
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