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miR-128 regulates neuronal migration, outgrowth and intrinsic excitability via the intellectual disability gene Phf6

Franzoni, Eleonora, Booker, Sam A, Parthasarathy, Srinivas, Rehfeld, Frederick, Grosser, Sabine, Srivatsa, Swathi, Fuchs, Heiko R, Tarabykin, Victor, Vida, Imre, Wulczyn, F Gregory·2015·eLife
DOI 10.7554/elife.04263PMC PMC4337614
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Abstract

miR-128, a brain-enriched microRNA, has been implicated in the control of neurogenesis and synaptogenesis but its potential roles in intervening processes have not been addressed. We show that post-transcriptional mechanisms restrict miR-128 accumulation to post-mitotic neurons during mouse corticogenesis and in adult stem cell niches. Whereas premature miR-128 expression in progenitors for upper layer neurons leads to impaired neuronal migration and inappropriate branching, sponge-mediated inhibition results in overmigration. Within the upper layers, premature miR-128 expression reduces the complexity of dendritic arborization, associated with altered electrophysiological properties. We show that Phf6, a gene mutated in the cognitive disorder Börjeson-Forssman-Lehmann syndrome, is an important regulatory target for miR-128. Restoring PHF6 expression counteracts the deleterious effect of miR-128 on neuronal migration, outgrowth and intrinsic physiological properties. Our results place miR-128 upstream of PHF6 in a pathway vital for cortical lamination as well as for the development of neuronal morphology and intrinsic excitability.

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Research works printed but not linked: 44

  1. Arlotta, 2005, Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo, Neuron, 45, 207, 10.1016/j.neuron.2004.12.036 · DOI
  2. Bicker, 2013, The DEAH-box helicase DHX36 mediates dendritic localization of the neuronal precursor-microRNA-134, Genes & Development, 27, 991, 10.1101/gad.211243.112 · DOI
  3. Bruno, 2011, Identification of a microRNA that activates gene expression by repressing nonsense-mediated RNA decay, Molecular Cell, 42, 500, 10.1016/j.molcel.2011.04.018 · DOI
  4. Cheng, 2009, miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche, Nature Neuroscience, 12, 399, 10.1038/nn.2294 · DOI · Paper page
  5. Clovis, 2012, Convergent repression of Foxp2 3'UTR by miR-9 and miR-132 in embryonic mouse neocortex: implications for radial migration of neurons, Development, 139, 3332, 10.1242/dev.078063 · DOI
  6. Cochella, 2012, Diverse functions of MicroRNAs in nervous system development, Current Topics in Developmental Biology, 99, 115, 10.1016/B978-0-12-387038-4.00005-7 · DOI
  7. Coolen, 2012, miR-9 controls the timing of neurogenesis through the direct inhibition of antagonistic factors, Developmental Cell, 22, 1052, 10.1016/j.devcel.2012.03.003 · DOI
  8. Cooper, 2013, Cell biology in neuroscience: mechanisms of cell migration in the nervous system, The Journal of Cell Biology, 202, 725, 10.1083/jcb.201305021 · DOI
  9. Davis, 2012, Regulator of calmodulin signaling knockout mice display anxiety-like behavior and motivational deficits, The European Journal of Neuroscience, 35, 300, 10.1111/j.1460-9568.2011.07956.x · DOI
  10. Englund, 2005, Pax6, Tbr2, and Tbr1 are expressed sequentially by radial glia, intermediate progenitor cells, and postmitotic neurons in developing neocortex, The Journal of Neuroscience, 25, 247, 10.1523/JNEUROSCI.2899-04.2005 · DOI · Paper page
  11. Evsyukova, 2013, Integrative mechanisms of oriented neuronal migration in the developing brain, Annual Review of Cell and Developmental Biology, 29, 299, 10.1146/annurev-cellbio-101512-122400 · DOI
  12. Friedman, 2008, Most mammalian mRNAs are conserved targets of microRNAs, Genome Research, 19, 92, 10.1101/gr.082701.108 · DOI · Paper page
  13. Guerrier, 2009, The F-bar domain of srGAP2 Induces membrane protrusions required for neuronal migration and morphogenesis, Cell, 138, 990, 10.1016/j.cell.2009.06.047 · DOI
  14. Heng, 2010, Molecular layers underlying cytoskeletal remodelling during cortical development, Trends in Neurosciences, 33, 38, 10.1016/j.tins.2009.09.003 · DOI
  15. Jaehning, 2010, The Paf1 complex: platform or player in RNA polymerase II transcription?, Biochimica Et Biophysica Acta, 1799, 379, 10.1016/j.bbagrm.2010.01.001 · DOI
  16. Krek, 2005, Combinatorial microRNA target predictions, Nature Genetics, 37, 495, 10.1038/ng1536 · DOI · Paper page
  17. La Torre, 2013, Conserved microRNA pathway regulates developmental timing of retinal neurogenesis, Proceedings of the National Academy of Sciences of USA, 110, E2362, 10.1073/pnas.1301837110 · DOI
  18. Lin, 2011, The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory, Nature Neuroscience, 14, 1115, 10.1038/nn.2891 · DOI · Paper page
  19. Lower, 2002, Mutations in PHF6 are associated with Börjeson-Forssman-Lehmann syndrome, Nature Genetics, 32, 661, 10.1038/ng1040 · DOI
  20. Makeyev, 2007, The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing, Molecular Cell, 27, 435, 10.1016/j.molcel.2007.07.015 · DOI · Paper page
  21. Maragkakis, 2009, DIANA-microT web server: elucidating microRNA functions through target prediction, Nucleic Acids Research, 37, W273, 10.1093/nar/gkp292 · DOI
  22. McNeill, 2012, MicroRNAs Shape the neuronal Landscape, Neuron, 75, 363, 10.1016/j.neuron.2012.07.005 · DOI · Paper page
  23. Nieto, 2004, Expression of Cux-1 and Cux-2 in the subventricular zone and upper layers II-IV of the cerebral cortex, The Journal of Comparative Neurology, 479, 168, 10.1002/cne.20322 · DOI
  24. Nowak, 2014, Lin28a regulates neuronal differentiation and controls miR-9 production, Nature Communications, 5, 3687, 10.1038/ncomms4687 · DOI
  25. Rakhilin, 2004, A network of control mediated by regulator of calcium/calmodulin-dependent signaling, Science, 306, 698, 10.1126/science.1099961 · DOI
  26. Rehfeld, 2015, Lin28 and let-7: ancient milestones on the road from pluripotencyto neurogenesis, Cell and Tissue Research, 359, 145, 10.1007/s00441-014-1872-2 · DOI
  27. Rosário, 2012, Neocortical dendritic complexity is controlled during development by NOMA-GAP-dependent inhibition of Cdc42 and activation of cofilin, Genes & Development, 26, 1743, 10.1101/gad.191593.112 · DOI
  28. Rybak, 2008, A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment, Nature Cell Biology, 10, 987, 10.1038/ncb1759 · DOI
  29. Rybak, 2009, The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2, Nature Cell Biology, 11, 1411, 10.1038/ncb1987 · DOI
  30. Saito, 2006, In vivo electroporation in the embryonic mouse central nervous system, Nature Protocols, 1, 1552, 10.1038/nprot.2006.276 · DOI
  31. Shibata, 2011, MicroRNA-9 regulates neurogenesis in mouse telencephalon by targeting multiple transcription factors, The Journal of Neuroscience, 31, 3407, 10.1523/JNEUROSCI.5085-10.2011 · DOI · Paper page
  32. Siegel, 2011, microRNAs in neurons: manifold regulatory roles at the synapse, Current Opinion in Genetics & Development, 21, 491, 10.1016/j.gde.2011.04.008 · DOI
  33. Silahtaroglu, 2007, Detection of microRNAs in frozen tissue sections by fluorescence in situ hybridization using locked nucleic acid probes and tyramide signal amplification, Nature Protocols, 2, 2520, 10.1038/nprot.2007.313 · DOI
  34. Siomi, 2010, Posttranscriptional regulation of microRNA biogenesis in animals, Molecular Cell, 38, 323, 10.1016/j.molcel.2010.03.013 · DOI
  35. Sun, 2013, MicroRNAs: regulators of neuronal fate, Current Opinion in cell Biology, 25, 215, 10.1016/j.ceb.2012.12.007 · DOI
  36. Sun, 2011, miR-137 forms a regulatory loop with nuclear receptor TLX and LSD1 in neural stem cells, Nature Communications, 2, 529, 10.1038/ncomms1532 · DOI
  37. Tan, 2013, MicroRNA-128 governs neuronal excitability and motor behavior in mice, Science, 342, 1254, 10.1126/science.1244193 · DOI · Paper page
  38. Todd, 2012, PHF6 interacts with the nucleosome remodeling and deacetylation (NuRD) complex, Journal of Proteome Research, 11, 4326, 10.1021/pr3004369 · DOI
  39. Tsurusaki, 2012, Mutations affecting components of the SWI/SNF complex cause Coffin-Siris syndrome, Nature Genetics, 44, 376, 10.1038/ng.2219 · DOI
  40. Visvanathan, 2007, The microRNA miR-124 antagonizes the anti-neural REST/SCP1 pathway during embryonic CNS development, Genes & Development, 21, 744, 10.1101/gad.1519107 · DOI · Paper page
  41. Voss, 2007, Protein and gene expression analysis of Phf6, the gene mutated in the Börjeson-Forssman-Lehmann Syndrome of intellectual disability and obesity, Brain Research Gene Expression Patterns, 7, 858, 10.1016/j.modgep.2007.06.007 · DOI
  42. Wieczorek, 2013, A comprehensive molecular study on Coffin-Siris and Nicolaides-Baraitser syndromes identifies a broad molecular and clinical spectrum converging on altered chromatin remodeling, Human Molecular Genetics, 22, 5121, 10.1093/hmg/ddt366 · DOI
  43. Yoo, 2009, MicroRNA-mediated switching of chromatin-remodelling complexes in neural development, Nature, 460, 642, 10.1038/nature08139 · DOI · Paper page
  44. Zhang, 2013, The x-linked intellectual disability protein PHF6 Associates with the PAF1 complex and regulates neuronal migration in the mammalian brain, Neuron, 78, 986, 10.1016/j.neuron.2013.04.021 · DOI

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Metadata

Authors
Franzoni, E., Booker, S. A., Parthasarathy, S., Rehfeld, F., Grosser, S., Srivatsa, S., Fuchs, H. R., Tarabykin, V., Vida, I., & Wulczyn, F. G.
Affiliations
  • Institute for Cell and Neurobiology, Charité-Universitätsmedizin Berlin, Berlin, Germany
  • Institute for Integrative Neuroanatomy, Charité-Universitätsmedizin Berlin, Berlin, Germany
  • Institute for Stem Cell Research and Regenerative Medicine, Heinrich Heine University, Düsseldorf, Germany
Venue
eLife
Publisher
eLife Sciences Publications, Ltd
Published
2015-01-03
Volume
4
ISSN
2050-084X
DOI
10.7554/elife.04263
PMC
PMC4337614
Cited by
94
References
8
Language
en
Licence
Funders
Deutsche Forschungsgemeinschaft (Graduate School 1123, Collaborative Research Program 665, Excellence Initiative 257)

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