The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory
Open accessAbstract
MicroRNAs are small non-coding RNAs that mediate post-transcriptional gene silencing. Fear-extinction learning in C57/Bl6J mice led to increased expression of the brain-specific microRNA miR-128b, which disrupted stability of several plasticity-related target genes and regulated formation of fear-extinction memory. Increased miR-128b activity may therefore facilitate the transition from retrieval of the original fear memory toward the formation of a new fear-extinction memory.
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Specific for the PFC, the non-coding microRNAs mir-128b and mir-30a-5p have shown to be involved in prefrontal-dependent cognitive maturation by affecting epigenetic mechanisms.
“Specific for the PFC, the non-coding microRNAs mir-128b and mir-30a-5p have shown to be involved in prefrontal-dependent cognitive maturation by affecting epigenetic mechanisms [251, 252].”
From Development of prefrontal cortex (2022) · cites this paper as [251]
The section on fear-extinction learning reports that miR-128b is highly expressed in the frontal cortex, and the Discussion says it is activated in the infralimbic PFC and involved in forming fear-extinction memory. The paper does not establish a role in prefrontal-dependent cognitive maturation; it studies fear extinction in mice and notes that miR-128b levels peak in adulthood. Its reported regulation of plasticity-related genes does not establish the claimed effect on epigenetic mechanisms. The paper also does not address miR-30a-5p, though the sentence has a second citation that may be offered for that microRNA. (LLM, conf=0.84)
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Cites
Mammalian microRNAs predominantly act to decrease target mRNA levels
Guo, H., Ingolia, N. T., Weissman, J. S., & Bartel, D. P. (2010) · Nature · doi:10.1038/nature09267 · Cited by 3,886 · see citing works
Neural Mechanisms of Extinction Learning and Retrieval
Quirk, G. J., & Mueller, D. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301555 · Cited by 1,645 · see citing works
Lai, E. C. (2002) · Nature Genetics · doi:10.1038/ng865 · Cited by 1,478 · see citing works
A novel pathway regulates memory and plasticity via SIRT1 and miR-134
Gao, J., Wang, W.-Y., Mao, Y.-W., Gräff, J., Guan, J.-S., Pan, L., Mak, G., Kim, D., Su, S. C., & Tsai, L.-H. (2010) · Nature · doi:10.1038/nature09271 · Cited by 975 · see citing works
Dopamine controls persistence of long-term memory storage
Rossato, J. I., Bevilaqua, L. R. M., Izquierdo, I., Medina, J. H., & Cammarota, M. (2009) · Science · doi:10.1126/science.1172545 · Cited by 486 · see citing works
Rajasethupathy, P., Fiumara, F., Sheridan, R., Betel, D., Puthanveettil, S. V., Russo, J. J., Sander, C., Tuschl, T., & Kandel, E. (2009) · Neuron · doi:10.1016/j.neuron.2009.05.029 · Cited by 406 · see citing works
Striatal microRNA controls cocaine intake through CREB signalling
Hollander, J. A., Im, H., Amelio, A. L., Kocerha, J., Bali, P., Lu, Q., Willoughby, D., Wahlestedt, C., Conkright, M. D., & Kenny, P. J. (2010) · Nature · doi:10.1038/nature09202 · Cited by 387 · see citing works
Structure and activity of putative intronic miRNA promoters
Monteys, A. M., Spengler, R. M., Wan, J., Tecedor, L., Lennox, K. A., Xing, Y., & Davidson, B. L. (2010) · RNA · doi:10.1261/rna.1731910 · Cited by 379 · see citing works
microRNAs miR-124, let-7d and miR-181a regulate Cocaine-induced Plasticity
Chandrasekar, V., & Dreyer, J. (2009) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2009.08.009 · Cited by 280 · see citing works
Identification of Calcineurin as a Key Signal in the Extinction of Fear Memory
Lin, C.-H., Yeh, S.-H., Leu, T.-H., Chang, W.-C., Wang, S.-S., & Gean, P. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-05-01574.2003 · Cited by 174 · see citing works
Argonaute 2 in dopamine 2 receptor–expressing neurons regulates cocaine addiction
Schaefer, A., Im, H., Venø, M. T., Fowler, C. D., Min, A. K., Intrator, A., Kjems, J., Kenny, P. J., O’Carroll, D., & Greengard, P. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20100451 · Cited by 146 · see citing works
Infralimbic D2 Receptors Are Necessary for Fear Extinction and Extinction-Related Tone Responses
Mueller, D. T., Bravo-Rivera, C., & Quirk, G. J. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.08.014 · Cited by 136 · see citing works
Control of the establishment of aversive memory by calcineurin and Zif268
Baumgärtel, K., Genoux, D., Welzl, H., Tweedie‐Cullen, R. Y., Koshibu, K., Livingstone-Zatchej, M., Mamie, C., & Mansuy, I. M. (2008) · Nature Neuroscience · doi:10.1038/nn.2113 · Cited by 130 · see citing works
A Network of Control Mediated by Regulator of Calcium/Calmodulin-Dependent Signaling
Rakhilin, S., Olson, P. A., Nishi, A., Starkova, N. N., Fienberg, A. A., Nairn, A. C., Surmeier, D. J., & Greengard, P. (2004) · Science · doi:10.1126/science.1099961 · Cited by 103 · see citing works
Lauzon, N. M., Bishop, S. F., & Laviolette, S. R. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0178-09.2009 · Cited by 66 · see citing works
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Singewald, N., Schmuckermair, C., Whittle, N., Holmes, A., & Ressler, K. J. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.12.004 · Cited by 390 · see citing works
“&Bouton, 2001;McNally &Westbrook, 2006)], but it also contains other elements including habituation and desensitization some also say erasure/destabilization (Lin et al., 2011).”
BackgroundInfluentialDevelopment of prefrontal cortex
Kolk, S. M., & Rakic, P. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01137-9 · Cited by 378 · see citing works
“Specific for the PFC, the non-coding microRNAs mir-128b and mir-30a-5p have shown to be involved in prefrontal-dependent cognitive maturation by affecting epigenetic mechanisms [251, 252].”
BackgroundMicroRNAs shape the neuronal landscape
McNeill, E., & Van Vactor, D. (2012) · Neuron · doi:10.1016/j.neuron.2012.07.005 · Cited by 274 · see citing works
General Principals of miRNA Biogenesis and Regulation in the Brain
O'Carroll, D., & Schaefer, A. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.87 · Cited by 205 · see citing works
Epigenetic mechanisms underlying learning and the inheritance of learned behaviors
Dias, B. G., Maddox, S. A., Klengel, T., & Ressler, K. J. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2014.12.003 · Cited by 125 · see citing works
The emerging role of microRNAs in schizophrenia and autism spectrum disorders
Mellios, N., & Sur, M. (2012) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2012.00039 · Cited by 120 · see citing works
Epigenetic memory: The Lamarckian brain
Fischer, A. (2014) · The EMBO Journal · doi:10.1002/embj.201387637 · Cited by 107 · see citing works
GABAergic mechanisms regulated by miR-33 encode state-dependent fear
Jovasevic, V., Corcoran, K. A., Leaderbrand, K., Yamawaki, N., Guedea, A. L., Chen, H. J., Shepherd, G. M. G., & Radulovic, J. (2015) · Nature Neuroscience · doi:10.1038/nn.4084 · Cited by 88 · see citing works
New pharmacological strategies for augmenting extinction learning in anxiety disorders
Sartori, S. B., & Singewald, N. (2017) · e-Neuroforum · doi:10.1515/nf-2017-a011 · Cited by 3 · see citing works
“During extinction learning, regulatory mechanisms, e. g. via microRNAs miR128b (Lin et al., 2011) or miR144 [(Murphy et al., 2017); for review see (Singewald et al., 2015)] and also modifications of DNA and DNA-associated proteins, the histones, play a role.”
Background
- Authors
- Lin, Q., Wei, W., Coelho, C. M., Li, X., Baker-Andresen, D., Dudley, K., Ratnu, V. S., Boskovic, Z., Kobor, M. S., Sun, Y. E., & Bredy, T. W.
- Affiliations
- University of California, Los Angeles (US)
- The University of Queensland (AU)
- University of British Columbia (CA)
- Corresponding author
- Bredy, Timothy W
- ORCID
- Venue
- Nature Neuroscience
- Published
- 2011-08-14
- Volume
- 14
- Issue
- 9
- Pages
- 1115-1117
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W1602077729
- Cited by
- 200
- References
- 15
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 6 · 2023: 7 · 2022: 14 · 2021: 13 · 2020: 10 · 2019: 16 · 2018: 19 · 2017: 21 · 2016: 18 · 2015: 15 · 2014: 21 · 2013: 13 · 2012: 12
- FWCI
- 7.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- QUT ePrints (Queensland University of Technology) (submittedVersion)
- Institute for Future Environments; Science & Engineering Faculty
- Funders
- Michael Smith Health Research BC
- National Institutes of Health
- Canadian Institutes of Health Research
- Australian Research Council (DP1096148)
- National Institute of Mental Health (R01MH084095)
- National Institute on Drug Abuse (K99DA026503)
- Eurostars
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- microRNA, fear extinction, fear memory, memory consolidation, post-transcriptional gene silencing, synaptic plasticity, memory retrieval
- MeSH terms
- Reelin Protein, Animals, Behavior, Animal, Brain, Cell Line, Transformed, Conditioning, Classical, Extinction, Psychological, Fear, Gene Expression Regulation, Humans, Male, Memory, Mice, Inbred C57BL, Nerve Tissue Proteins, Potassium Chloride, Serine Endopeptidases, Transduction, Genetic, Transfection, Trans-Activators, Cell Adhesion Molecules, Neuronal, Extracellular Matrix Proteins, Cyclic AMP Response Element-Binding Protein, RNA, Small Interfering, MicroRNAs, Mice, Protein Phosphatase 1
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