Combined transcriptome and proteome profiling reveals specific molecular brain signatures for sex, maturation and circalunar clock phase
Open accessAbstract
Many marine animals, ranging from corals to fishes, synchronise reproduction to lunar cycles. In the annelid Platynereis dumerilii, this timing is orchestrated by an endogenous monthly (circalunar) clock entrained by moonlight. Whereas daily (circadian) clocks cause extensive transcriptomic and proteomic changes, the quality and quantity of regulations by circalunar clocks have remained largely elusive. By establishing a combined transcriptomic and proteomic profiling approach, we provide first systematic insight into the molecular changes in Platynereis heads between circalunar phases, and across sexual differentiation and maturation. Whereas maturation elicits large transcriptomic and proteomic changes, the circalunar clock exhibits only minor transcriptomic, but strong proteomic regulation. Our study provides a versatile extraction technique and comprehensive resources. It corroborates that circadian and circalunar clock effects are likely distinct and identifies key molecular brain signatures for reproduction, sex and circalunar clock phase. Examples include prepro-whitnin/proctolin and ependymin-related proteins as circalunar clock targets.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Systematic analyses of head-specific transcriptomes identified 3 additional receptors belonging to the GnRH receptor superfamily.
“Systematic analyses of head-specific transcriptomes (57) allowed us to identify 3 additional receptors that belong to the GnRH receptor superfamily.”
From Corazonin signaling integrates energy homeostasis and lunar phase to regulate aspects of growth and sexual maturation in <i>Platynereis</i> (2020) · cites this paper as [57]
Two tobi-like α-glucosidases (tobi-like 1 and 2), as well as homologs of phosphoenolpyruvate carboxykinase (pepck) and glycogen synthase, were identified in Platynereis published transcriptomes.
“Using sequence-similarity and molecular phylogenetic approaches (SI Appendix, Fig. S7), we identified 2 tobi-like α-glucosidases (called hereafter tobi-like 1 and 2), as well as homologs of phosphoenolpyruvate carboxykinase (pepck, one of the key enzymes contributing to gluconeogenesis) and glycogen synthase in Platynereis published transcriptomes (53, 57).”
From Corazonin signaling integrates energy homeostasis and lunar phase to regulate aspects of growth and sexual maturation in <i>Platynereis</i> (2020) · cites this paper as [57]
Circalunar and circasemilunar reproductive rhythms are widespread in marine animals and likely evolutionarily ancient, yet insights about the underlying endocrine effectors are scarce.
“Circalunar and circasemilunar reproductive rhythms are widespread in marine animals (5) and likely evolutionarily ancient, yet insights about the underlying endocrine effectors are scarce (57, 60, 61).”
From Corazonin signaling integrates energy homeostasis and lunar phase to regulate aspects of growth and sexual maturation in <i>Platynereis</i> (2020) · cites this paper as [57]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
R: A Language and Environment for Statistical Computing
R Core Team (2000) · doi:10.32614/r.manuals · Cited by 355,706 · see citing works
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482 · see citing works
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106 · see citing works
MUSCLE: multiple sequence alignment with high accuracy and high throughput
Edgar, R. C. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh340 · Cited by 44,662 · see citing works
Robinson, M. D., McCarthy, D. J., & Smyth, G. K. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btp616 · Cited by 41,364 · see citing works
limma powers differential expression analyses for RNA-sequencing and microarray studies
Ritchie, M. E., Phipson, B., Wu, D., Hu, Y., Law, C. W., Shi, W., & Smyth, G. K. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv007 · Cited by 40,458 · see citing works
Cutadapt removes adapter sequences from high-throughput sequencing reads
Martin, M. (2011) · EMBnet.journal · doi:10.14806/ej.17.1.200 · Cited by 33,889 · see citing works
IQ-TREE: A Fast and Effective Stochastic Algorithm for Estimating Maximum-Likelihood Phylogenies
Nguyen, L.-T., Schmidt, H. A., von Haeseler, A., & Minh, B. Q. (2015) · Molecular Biology and Evolution · doi:10.1093/molbev/msu300 · Cited by 26,046 · see citing works
Self-citationAn analysis of variance test for normality (complete samples)
SHAPIRO, S. S., & WILK, M. B. (1965) · Biometrika · doi:10.1093/biomet/52.3-4.591 · Cited by 23,480 · see citing works
Full-length transcriptome assembly from RNA-Seq data without a reference genome
Grabherr, M. G., Haas, B. J., Yassour, M., Levin, J. Z., Thompson, D. A., Amit, I., Adiconis, X., Fan, L., Raychowdhury, R., Zeng, Q., et al. (2011) · Nature Biotechnology · doi:10.1038/nbt.1883 · Cited by 20,770 · see citing works
ModelFinder: fast model selection for accurate phylogenetic estimates
Kalyaanamoorthy, S., Minh, B. Q., Wong, T. K. F., von Haeseler, A., & Jermiin, L. S. (2017) · Nature Methods · doi:10.1038/nmeth.4285 · Cited by 18,449 · see citing works
Self-citationCox, J., & Mann, M. (2008) · Nature Biotechnology · doi:10.1038/nbt.1511 · Cited by 14,855 · see citing works
A rapid alkaline extraction procedure for screening recombinant plasmid DNA
Birnboim, H. C., & Doly, J. (1979) · Nucleic Acids Research · doi:10.1093/nar/7.6.1513 · Cited by 14,686 · see citing works
Schägger, H., & von Jagow, G. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90587-2 · Cited by 11,420 · see citing works
UFBoot2: Improving the Ultrafast Bootstrap Approximation
Hoang, D. T., Chernomor, O., von Haeseler, A., Minh, B. Q., & Vinh, L. S. (2018) · Molecular Biology and Evolution · doi:10.1093/molbev/msx281 · Cited by 10,881 · see citing works
Self-citationStatistical significance for genomewide studies
Storey, J. D., & Tibshirani, R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1530509100 · Cited by 9,692 · see citing works
Universal sample preparation method for proteome analysis
Wiśniewski, J. R., Zougman, A., Nagaraj, N., & Mann, M. (2009) · Nature Methods · doi:10.1038/nmeth.1322 · Cited by 8,352 · see citing works
McCarthy, D. J., Chen, Y., & Smyth, G. K. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks042 · Cited by 5,195 · see citing works
Ultrafast Approximation for Phylogenetic Bootstrap
Minh, B. Q., Nguyen, M. A. T., & von Haeseler, A. (2013) · Molecular Biology and Evolution · doi:10.1093/molbev/mst024 · Cited by 4,844 · see citing works
Self-citationKraken: ultrafast metagenomic sequence classification using exact alignments
Wood, D. E., & Salzberg, S. L. (2014) · Genome Biology · doi:10.1186/gb-2014-15-3-r46 · Cited by 4,521 · see citing works
THE GENERALIZATION OF ‘STUDENT'S’ PROBLEM WHEN SEVERAL DIFFERENT POPULATION VARLANCES ARE INVOLVED
WELCH, B. L. (1947) · Biometrika · doi:10.1093/biomet/34.1-2.28 · Cited by 4,135 · see citing works
2016 update of the PRIDE database and its related tools
Vizcaíno, J. A., Csordás, A., del‐Toro, N., Dianes, J. A., Griss, J., Lavidas, I., Mayer, G., Pérez‐Riverol, Y., Reisinger, F., Ternent, T., et al. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1145 · Cited by 3,466 · see citing works
A circadian gene expression atlas in mammals: Implications for biology and medicine
Zhang, R., Lahens, N. F., Ballance, H. I., Hughes, M. E., & Hogenesch, J. B. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408886111 · Cited by 2,304 · see citing works
CEGMA: a pipeline to accurately annotate core genes in eukaryotic genomes
Parra, G., Bradnam, K. R., & Korf, I. F. (2007) · Bioinformatics · doi:10.1093/bioinformatics/btm071 · Cited by 2,159 · see citing works
Spatio-temporal transcriptome of the human brain
Kang, H. J., Kawasawa, Y. I., Cheng, F., Zhu, Y., Xu, X., Li, M., Sousa, A. M. M., Pletikos, M., Meyer, K. A., Sedmak, G., et al. (2011) · Nature · doi:10.1038/nature10523 · Cited by 2,084 · see citing works
Using GOstats to test gene lists for GO term association
Falcon, S., & Gentleman, R. C. (2006) · Bioinformatics · doi:10.1093/bioinformatics/btl567 · Cited by 2,019 · see citing works
Mfuzz: A software package for soft clustering of microarray data
Kumar, L., & Futschik, M. E. (2007) · Bioinformation · doi:10.6026/97320630002005 · Cited by 2,000 · see citing works
The Generalization of `Student's' Problem when Several Different Population Variances are Involved
Welch, B. L. (1947) · Biometrika · doi:10.2307/2332510 · Cited by 1,946 · see citing works
A transcription factor response element for gene expression during circadian night
Ueda, H. R., Chen, W., Adachi, A. A., Wakamatsu, H., Hayashi, S., Takasugi, T., Nagano, M., Nakahama, K., Suzuki, Y., Sugano, S., et al. (2002) · Nature · doi:10.1038/nature00906 · Cited by 850 · see citing works
Gene Expression Profiles in the Brain Predict Behavior in Individual Honey Bees
Whitfield, C. W., Cziko, A.-M., & Robinson, G. E. (2003) · Science · doi:10.1126/science.1086807 · Cited by 618 · see citing works
Using MUMmer to Identify Similar Regions in Large Sequence Sets
Delcher, A. L., Salzberg, S. L., & Phillippy, A. M. (2003) · Current Protocols in Bioinformatics · doi:10.1002/0471250953.bi1003s00 · Cited by 544 · see citing works
NOISE-ROBUST SOFT CLUSTERING OF GENE EXPRESSION TIME-COURSE DATA
Futschik, M. E., & Carlisle, B. (2005) · Journal of Bioinformatics and Computational Biology · doi:10.1142/s0219720005001375 · Cited by 543 · see citing works
Ciliary photoreceptors with a vertebrate-type opsin in an invertebrate brain
Arendt, D., Tessmar-Raible, K., Snyman, H., Dorresteijn, A. W., & Wittbrodt, J. (2004) · Science · doi:10.1126/science.1099955 · Cited by 458 · see citing works
Self-citationJust, T., & Hartmann, M. (1937) · The American Midland Naturalist · doi:10.2307/2420591 · Cited by 455 · see citing works
NextGenMap: fast and accurate read mapping in highly polymorphic genomes
Sedlazeck, F. J., Rescheneder, P., & von Haeseler, A. (2013) · Bioinformatics · doi:10.1093/bioinformatics/btt468 · Cited by 442 · see citing works
Self-citationTessmar-Raible, K., Raible, F., Christodoulou, F., Guy, K., Rembold, M., Hausen, H., & Arendt, D. (2007) · Cell · doi:10.1016/j.cell.2007.04.041 · Cited by 384 · see citing works
Self-citationStructure, function, and evolution of ferritins
Andrews, S. C., Harrison, P. M., Yewdall, S. J., Arosio, P., Levi, S., Bottke, W., DARL, M. V., Briat, J., Laulhère, J. P., & Lobréaux, S. (1992) · Journal of Inorganic Biochemistry · doi:10.1016/0162-0134(92)84062-r · Cited by 336 · see citing works
Dmrt genes in the development and evolution of sexual dimorphism
Kopp, A. (2012) · Trends in Genetics · doi:10.1016/j.tig.2012.02.002 · Cited by 329 · see citing works
The genetics of migration on the move
Liedvogel, M., Åkesson, S., & Bensch, S. (2011) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2011.07.009 · Cited by 318 · see citing works
Detecting significant changes in protein abundance
Kammers, K., Cole, R. N., Tiengwe, C., & Ruczinski, I. (2015) · EuPA Open Proteomics · doi:10.1016/j.euprot.2015.02.002 · Cited by 314 · see citing works
Veenstra, J. A. (2010) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2010.02.010 · Cited by 228 · see citing works
Another place, another timer: marine species and the rhythms of life
Tessmar‐Raible, K., Raible, F., & Arboleda, E. (2011) · BioEssays · doi:10.1002/bies.201000096 · Cited by 208 · see citing works
Self-citationOri, A., Toyama, B. H., Harris, M. S., Bock, T., Iskar, M., Bork, P., Ingolia, N. T., Hetzer, M. W., & Beck, M. (2015) · Cell Systems · doi:10.1016/j.cels.2015.08.012 · Cited by 201 · see citing works
The crown-of-thorns starfish genome as a guide for biocontrol of this coral reef pest
Hall, M. R., Kocot, K. M., Baughman, K. W., Fernández-Valverde, S. L., Gauthier, M. E. A., Hatleberg, W. L., Krishnan, A., McDougall, C., Motti, C. A., Shoguchi, E., et al. (2017) · Nature · doi:10.1038/nature22033 · Cited by 199 · see citing works
Arendt, D., Tessmar, K., de Campos-Baptista, M.-I. M., Dorresteijn, A., & Wittbrodt, J. (2002) · Development · doi:10.1242/dev.129.5.1143 · Cited by 192 · see citing works
Deep sequencing the circadian and diurnal transcriptome ofDrosophilabrainPreprint
Hughes, M. E., Grant, G. R., Paquin, C., Qian, J. M., & Nitabach, M. N. (2012) · Genome Research · doi:10.1101/gr.128876.111 · Cited by 170 · see citing works
Immunological properties of oxygen-transport proteins: hemoglobin, hemocyanin and hemerythrin
Coates, C. J., & Decker, H. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2326-7 · Cited by 167 · see citing works
The neuropeptide complement of the marine annelid Platynereis dumerilii
Conzelmann, M., Williams, E. A., Krug, K., Franz-Wachtel, M., Macek, B., & Jékely, G. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-906 · Cited by 165 · see citing works
The developmental proteome of Drosophila melanogasterPreprint
Casas-Vila, N., Bluhm, A., Sayols, S., Dinges, N., Dejung, M., Altenhein, T., Kappei, D., Altenhein, B., Roignant, J., & Butter, F. (2017) · Genome Research · doi:10.1101/gr.213694.116 · Cited by 161 · see citing works
Signaling cascades and the importance of moonlight in coral broadcast mass spawning
Kaniewska, P., Alon, S., Karako‐Lampert, S., Hoegh‐Guldberg, O., & Levy, O. (2015) · eLife · doi:10.7554/elife.09991 · Cited by 153 · see citing works
Walther, D. M., & Mann, M. (2010) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m110.004523 · Cited by 150 · see citing works
Circadian and circalunar clock interactions in a marine annelid
Zantke, J., Ishikawa-Fujiwara, T., Arboleda, E., Lohs, C., Schipany, K., Hallay, N., Straw, A. D., Todo, T., & Tessmar-Raible, K. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.08.031 · Cited by 148 · see citing works
Self-citationFischer, A., & Dorresteijn, A. W. C. (2004) · BioEssays · doi:10.1002/bies.10409 · Cited by 141 · see citing works
Deery, M. J., Maywood, E. S., Chesham, J. E., Sládek, M., Karp, N. A., Green, E. W., Charles, P. D., Reddy, A. B., Kyriacou, C. P., Lilley, K. S., et al. (2009) · Current Biology · doi:10.1016/j.cub.2009.10.024 · Cited by 125 · see citing works
An Overview of Monthly Rhythms and Clocks
Raible, F., Takekata, H., & Tessmar-Raible, K. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00189 · Cited by 121 · see citing works
Self-citationInsect ferritins: Typical or atypical?
Pham, D. Q. ‐., & Winzerling, J. J. (2010) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2010.03.004 · Cited by 120 · see citing works
Conservation of mRNA and protein expression during development of C. elegans.
Grün, D., Kirchner, M., Thierfelder, N., Stoeckius, M., Selbach, M., & Rajewsky, N. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.01.001 · Cited by 113 · see citing works
The lunar cycle: a cue for amphibian reproductive phenology?
Grant, R., Chadwick, E. A., & Halliday, T. R. (2009) · Animal Behaviour · doi:10.1016/j.anbehav.2009.05.007 · Cited by 111 · see citing works
The genomic basis of circadian and circalunar timing adaptations in a midge
Kaiser, T. S., Poehn, B., Szkiba, D., Preussner, M., Sedlazeck, F. J., Zrim, A., Neumann, T., Nguyen, L.-T., Betancourt, A. J., Hummel, T., et al. (2016) · Nature · doi:10.1038/nature20151 · Cited by 109 · see citing works
Self-citationHedgehog Signaling Regulates Segment Formation in the Annelid Platynereis
Dray, N., Tessmar‐Raible, K., Gouar, M. L., Vibert, L., Christodoulou, F., Schipany, K., Guillou, A., Zantke, J., Snyman, H., Béhague, J., et al. (2010) · Science · doi:10.1126/science.1188913 · Cited by 98 · see citing works
Self-citationTessmar‐Raible, K., Steinmetz, P. R. H., Snyman, H., Hassel, M., & Arendt, D. (2005) · BioTechniques · doi:10.2144/000112023 · Cited by 98 · see citing works
Self-citationHauenschild, C. (1966) · General and Comparative Endocrinology · doi:10.1016/0016-6480(66)90108-0 · Cited by 91 · see citing works
Transcriptome assemblies for studying sex-biased gene expression in the guppy, Poecilia reticulata
Sharma, E., Künstner, A., Fraser, B. A., Zipprich, G., Kottler, V. A., Henz, S. R., Weigel, D., & Dreyer, C. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-400 · Cited by 89 · see citing works
Ependymin, a Brain Extracellular Glycoprotein, and CNS Plasticitya
Shashoua, V. E. (1991) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1991.tb25916.x · Cited by 85 · see citing works
Gomulski, L. M., Dimopoulos, G., Xi, Z., Scolari, F., Gabrieli, P., Siciliano, P., Clarke, A. R., Malacrida, A. R., & Gasperi, G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030857 · Cited by 84 · see citing works
The sex-biased brain: sexual dimorphism in gene expression in two species of songbirds
Naurin, S., Hansson, B., Hasselquist, D., Kim, Y., & Bensch, S. (2011) · BMC Genomics · doi:10.1186/1471-2164-12-37 · Cited by 83 · see citing works
MARCHING TO A DIFFERENT DRUMMER: CRABS SYNCHRONIZE REPRODUCTION TO A 14-MONTH LUNAR-TIDAL CYCLE
Skov, M. W., Hartnoll, R. G., Ruwa, R. K., Shunula, J. P., Vannini, M., & Stefano Cannicci, A. (2005) · Ecology · doi:10.1890/04-0917 · Cited by 83 · see citing works
A database of circadian and diel rhythmic gene expression in the yellow fever mosquito Aedes aegypti
Leming, M. T., Rund, S. S. C., Behura, S. K., Duffield, G. E., & O’Tousa, J. E. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-1128 · Cited by 72 · see citing works
Chiang, C.-K., Mehta, N., Patel, A., Zhang, P., Ning, Z., Mayne, J., Sun, W. Y. L., Cheng, H.-Y. M., & Figeys, D. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004695 · Cited by 69 · see citing works
Reproducibility-Optimized Test Statistic for Ranking Genes in Microarray Studies
Elo, L. L., Filén, S., Lahesmaa, R., & Aittokallio, T. A. (2008) · IEEE Transactions on Computational Biology and Bioinformatics · doi:10.1109/tcbb.2007.1078 · Cited by 68 · see citing works
Genetic and Genomic Tools for the Marine AnnelidPlatynereis dumerilii
Zantke, J., Bannister, S. C., Rajan, V. B. V., Raible, F., & Tessmar‐Raible, K. (2014) · Genetics · doi:10.1534/genetics.112.148254 · Cited by 66 · see citing works
Self-citationHormonale Hemmung der Geschlechtsreife und Metamorphose bei dem Polychaeten Platynereis Dumerilii
Hauenschild, C. (1956) · Zeitschrift für Naturforschung B · doi:10.1515/znb-1956-0302 · Cited by 56 · see citing works
Das Auge von Platynereis dumerilii (Polychaeta) Sein Feinbau im ontogenetischen und adaptiven Wandel
Br�kelmann, F., & Br�kelmann, J. (1966) · Cell and Tissue Research · doi:10.1007/bf00335748 · Cited by 55 · see citing works
Lunar periodicities of diadematid echinoids breeding in Fiji
Coppard, S. E., & Campbell, A. (2005) · Coral Reefs · doi:10.1007/s00338-005-0491-5 · Cited by 54 · see citing works
Sex differences in the molecular signature of the developing mouse hippocampus
Bundy, J. L., Vied, C., & Nowakowski, R. S. (2017) · BMC Genomics · doi:10.1186/s12864-017-3608-7 · Cited by 50 · see citing works
Uric Acid: The Sperm-Release Pheromone of the Marine Polychaete Platynereis dumerilii
Zeeck, E., Harder, T., & Beckmann, M. (1998) · Journal of Chemical Ecology · doi:10.1023/a:1022328610423 · Cited by 49 · see citing works
Worker Honeybee Brain Proteome
Hernández, L. G., Lu, B., da Cruz, G. C. N., Calábria, L. K., Martins, N. F., Togawa, R. C., Espíndola, F. S., Yates, J. R., Cunha, R. B., & de Sousa, M. V. (2011) · Journal of Proteome Research · doi:10.1021/pr2007818 · Cited by 49 · see citing works
Brady, A. K., Willis, B. L., Harder, L. D., & Vize, P. D. (2016) · The Biological Bulletin · doi:10.1086/bblv230n2p130 · Cited by 48 · see citing works
Kennedy, B., & Pearse, J. S. (1975) · Journal of Experimental Marine Biology and Ecology · doi:10.1016/0022-0981(75)90007-6 · Cited by 47 · see citing works
Molecular evolution of the ependymin protein family: a necessary update.
Suárez‐Castillo, E. C., & García‐Arrarás, J. E. (2007) · BMC Evolutionary Biology · doi:10.1186/1471-2148-7-23 · Cited by 45 · see citing works
Entrainment of Tidal and Semilunar Rhythms by Artificial Moonlight Cycles
Saigusa, M. (1988) · Biological Bulletin · doi:10.2307/1541779 · Cited by 44 · see citing works
Schenk, S., Krauditsch, C., Frühauf, P., Gerner, C., & Raible, F. (2016) · eLife · doi:10.7554/elife.17126 · Cited by 44 · see citing works
Self-citationA transcriptional blueprint for a spiral-cleaving embryo
Chou, H.-C., Pruitt, M., Bastin, B. R., & Schneider, S. (2016) · BMC Genomics · doi:10.1186/s12864-016-2860-6 · Cited by 43 · see citing works
Hauenschild, C. (1959) · Zeitschrift für Naturforschung B · doi:10.1515/znb-1959-0204 · Cited by 41 · see citing works
Slany, A., Bileck, A., Kreutz, D., Mayer, R. L., Muqaku, B., & Gerner, C. (2016) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m116.058099 · Cited by 41 · see citing works
Self-citationHauenschild, C. (1960) · Zeitschrift für Naturforschung B · doi:10.1515/znb-1960-0111 · Cited by 40 · see citing works
York, P. S., Cummins, S. F., Degnan, S. M., Woodcroft, B. J., & Degnan, B. M. (2012) · Frontiers in Zoology · doi:10.1186/1742-9994-9-9 · Cited by 39 · see citing works
Li, Y., Wang, X., Hou, Y., Zhou, X., Chen, Q., Guo, C., Xia, Q., Zhang, Y., & Zhao, P. (2015) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5b00736 · Cited by 39 · see citing works
Transcriptome dynamics over a lunar month in a broadcast spawning acroporid coral
Oldach, M. J., Workentine, M., Matz, M. V., Fan, T., & Vize, P. D. (2017) · Molecular Ecology · doi:10.1111/mec.14043 · Cited by 39 · see citing works
Mating Changes Sexually Dimorphic Gene Expression in the Seed Beetle Callosobruchus maculatus
Immonen, E., Sayadi, A., Bayram, H. L., & Arnqvist, G. (2017) · Genome Biology and Evolution · doi:10.1093/gbe/evx029 · Cited by 39 · see citing works
Regeneration and endocrinology in the polychaetePlatynereis dumerilii
Hofmann, D. K. (1976) · Development Genes and Evolution · doi:10.1007/bf00848884 · Cited by 30 · see citing works
Elo, L. L., Hiissa, J., Tuimala, J., Kallio, A., Korpelainen, E., & Aittokallio, T. A. (2009) · Briefings in Bioinformatics · doi:10.1093/bib/bbp033 · Cited by 30 · see citing works
Altincicek, B., & Vilcinskas, A. (2007) · Frontiers in Zoology · doi:10.1186/1742-9994-4-18 · Cited by 29 · see citing works
How Reefs Respond to Mass Coral Spawning
Guest, J. R. (2008) · Science · doi:10.1126/science.1155285 · Cited by 24 · see citing works
Zebrafish pituitary gene expression before and after sexual maturation
He, W., Dai, X., Chen, X., He, J., & Yin, Z. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0488 · Cited by 23 · see citing works
Saavedra, M., & Pousão‐Ferreira, P. (2006) · Journal of the Marine Biological Association of the United Kingdom · doi:10.1017/s0025315406013841 · Cited by 22 · see citing works
Notizen: Weitere Versuche zur Frage des Juvenilhormons bei Platynereis
Hauenschild, C. (1956) · Zeitschrift für Naturforschung B · doi:10.1515/znb-1956-9-1026 · Cited by 21 · see citing works
Development of a medium for in vitro culture of oocytes from the polychaeteNereis virens
Heacox, A. E., Fischer, A., & Frangenberg, H. R. (1983) · In Vitro Cellular & Developmental Biology - Plant · doi:10.1007/bf02618162 · Cited by 19 · see citing works
Beckmann, M., Hardege, J. D., & Zeeck, E. (1995) · Marine Environmental Research · doi:10.1016/0141-1136(94)00145-f · Cited by 18 · see citing works
Discovery and evolution of novel hemerythrin genes in annelid worms
Costa-Paiva, E. M., Whelan, N. V., Waits, D. S., Santos, S. R., Schrago, C. G., & Halanych, K. M. (2017) · BMC Evolutionary Biology · doi:10.1186/s12862-017-0933-z · Cited by 18 · see citing works
Tops, B. B. J., Gauci, S., Heck, A. J. R., & Krijgsveld, J. (2009) · Journal of Proteome Research · doi:10.1021/pr900678j · Cited by 17 · see citing works
Metabolite supply in oocytes of Nereis virens: role of nucleosides
Hoeger, U., Rebscher, N., & Geier, G. (1999) · Springer eBooks · doi:10.1007/978-94-017-2887-4_8 · Cited by 14 · see citing works
Sex pheromones in marine polychaetes: Steroids from ripe Nereis succinea
Zeeck, E., Hardege, J. D., Willig, A., Ikekawa, N., & Fujimoto, Y. (1994) · Steroids · doi:10.1016/0039-128x(94)90124-4 · Cited by 14 · see citing works
Lunar cycle in the reproductive activity in the forktail rabbitfish
Rahman, M. S., Takemura, A., Park, Y. J., & Takano, K. (2003) · Fish Physiology and Biochemistry · doi:10.1023/b:fish.0000030623.49948.3c · Cited by 14 · see citing works
Schenk, S., & Hoeger, U. (2010) · Molecular Reproduction and Development · doi:10.1002/mrd.21208 · Cited by 13 · see citing works
Self-citationMetabolite supply in oocytes of Nereis virens: role of nucleosides
Hoeger, U., Rebscher, N., & Geier, G. (1999) · Hydrobiologia · doi:10.1023/a:1003792525942 · Cited by 13 · see citing works
Schulz, G., Ulbrich, K. P., Hauenschild, C., & Pfannenstiel, H. D. (1989) · Development Genes and Evolution · doi:10.1007/bf00376367 · Cited by 10 · see citing works
Hauenschild, C. (1974) · Helgoland Marine Research · doi:10.1007/bf01613305 · Cited by 9 · see citing works
Nunes, A. T., Brito, N. F., Oliveira, D. S., Araujo, G. D. T., Nogueira, F. C. S., Domont, G. B., Moreira, M. F., Moreira, L. M., Soares, M. R., & Melo, A. C. A. (2016) · PROTEOMICS · doi:10.1002/pmic.201600126 · Cited by 8 · see citing works
Zoccola, D., & Tambutté, S. (2015) · eLife · doi:10.7554/elife.12936 · Cited by 3 · see citing works
Flagged first, then by citations
1 of the 111 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Meisel J 1990 Zur Hormonabhängigkeit der Spermatogenese bei Platynereis dumerilii: Licht- und elektronenmikroskopische Befunde sowie experimentelle Untersuchungen in vivo und in vitro. PhD-Thesis Bochum Ruhr-Universität
- Zantke J Oberlerchner H Tessmar-Raible K 2015 Keeping clockscoordinated: Crosstalk between light, circadian and circalunar clocks Hideharu N Helm B Annual, Lunar and Tidal Clocks: Patterns and Mechanisms of Nature’sEnigmatic Rhythms Japan Springer
Cited by
Sorted by citations
Kuehn, E., Clausen, D. S., Null, R. W., Metzger, B. M., Willis, A. D., & Özpolat, B. D. (2021) · Journal of Experimental Zoology Part B Molecular and Developmental Evolution · doi:10.1002/jez.b.23100 · Cited by 196 · see citing works
The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks
Andreatta, G., & Tessmar-Raible, K. (2020) · Journal of Molecular Biology · doi:10.1016/j.jmb.2020.03.009 · Cited by 111 · see citing works
Self-citationThe Nereid on the rise: Platynereis as a model system
Özpolat, B. D., Randel, N., Williams, E. A., Bezares-Calderón, L. A., Andreatta, G., Balavoine, G., Bertucci, P. Y., Ferrier, D. E. K., Gambi, M. C., Gazave, E., et al. (2021) · EvoDevo · doi:10.1186/s13227-021-00180-3 · Cited by 85 · see citing works
Self-citationAbdullah‐Zawawi, M., Afiqah‐Aleng, N., Ikhwanuddin, M., Sung, Y. Y., Tola, S., Fazhan, H., & Waiho, K. (2021) · Reviews in Aquaculture · doi:10.1111/raq.12552 · Cited by 71 · see citing works
ggVolcanoR: A Shiny app for customizable visualization of differential expression datasets
Mullan, K. A., Bramberger, L., Munday, P. R., Gonçalves, G., Revote, J., Mifsud, N. A., Illing, P. T., Anderson, A., Kwan, P., Purcell, A. W., et al. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.10.020 · Cited by 65 · see citing works
Andreatta, G., Broyart, C., Borghgraef, C., Vadiwala, K., Kozin, V., Polo, A., Bileck, A., Beets, I., Schoofs, L., Gerner, C., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1910262116 · Cited by 61 · see citing works
Self-citationRhythms of behavior: are the times changin’?
Häfker, N. S., & Tessmar‐Raible, K. (2019) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2019.10.005 · Cited by 58 · see citing works
Self-citationRajan, V. B. V., Häfker, N. S., Arboleda, E., Poehn, B., Gossenreiter, T., Gerrard, E. J., Hofbauer, M., Mühlestein, C., Bileck, A., Gerner, C., et al. (2021) · Nature Ecology & Evolution · doi:10.1038/s41559-020-01356-1 · Cited by 40 · see citing works
Self-citationZurl, M., Poehn, B., Rieger, D., Krishnan, S., Rokvić, D., Rajan, V. B. V., Gerrard, E. J., Schlichting, M., Orel, L., Ćorić, A., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2115725119 · Cited by 38 · see citing works
Self-citationQin, Z., Ge, Q., Wang, J., Li, M., Liu, P., Li, J., & Li, J. (2021) · Frontiers in Marine Science · doi:10.3389/fmars.2021.759923 · Cited by 39 · see citing works
Circadian biology to advance therapeutics for mood disorders
Bhatnagar, A., Murray, G., & Ray, S. (2023) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2023.07.008 · Cited by 40 · see citing works
Vitaterna, M. H., Shimomura, K., & Jiang, P. (2019) · Neurologic Clinics · doi:10.1016/j.ncl.2019.05.002 · Cited by 36 · see citing works
A scalable culturing system for the marine annelid Platynereis dumerilii
Kuehn, E., Stockinger, A. W., Girard, J., Raible, F., & Özpolat, B. D. (2019) · PLoS ONE · doi:10.1371/journal.pone.0226156 · Cited by 36 · see citing works
Self-citationCircalunar clocks—Old experiments for a new era
Kaiser, T. S., & Neumann, J. (2021) · BioEssays · doi:10.1002/bies.202100074 · Cited by 33 · see citing works
Root, L., Campo, A., MacNiven, L. M., Con, P., Cnaani, A., & Kültz, D. (2021) · Genomics · doi:10.1016/j.ygeno.2021.07.016 · Cited by 29 · see citing works
Sharma, S., Sharma, M., Rana, A. K., Joshi, R., Swarnkar, M. K., Acharya, V., & Singh, D. (2020) · Epilepsia · doi:10.1111/epi.16794 · Cited by 25 · see citing works
Transcriptomics in advancing portunid aquaculture: A systematic review
Waiho, K., Ikhwanuddin, M., Afiqah‐Aleng, N., Shu‐Chien, A. C., Wang, Y., Ma, H., & Fazhan, H. (2022) · Reviews in Aquaculture · doi:10.1111/raq.12689 · Cited by 24 · see citing works
Melanopsin elevates locomotor activity during the wake state of the diurnal zebrafish
Dekens, M. P. S., Fontinha, B. M., Gallach, M., Pflügler, S., & Tessmar‐Raible, K. (2022) · EMBO Reports · doi:10.15252/embr.202051528 · Cited by 19 · see citing works
Self-citationConservative and Atypical Ferritins of Sponges
Adameyko, K. I., Burakov, A. V., Finoshin, A. D., Mikhailov, K. V., Кравчук, О. И., Kozlova, O., Горностаев, Н. Г., Cherkasov, A. V., Erokhov, P. A., Indeykina, M. I., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168635 · Cited by 19 · see citing works
A multi-omic landscape of steatosis-to-NASH progression
Xiang, L., Li, X., Luo, Y., Zhou, B., Liu, Y., Li, Y., Wu, D., Jia, L., Zhu, P., Zheng, M., et al. (2022) · Life Metabolism · doi:10.1093/lifemeta/loac034 · Cited by 18 · see citing works
McKetney, J., Jenkins, C. C., Minogue, C. E., Mach, P. M., Hussey, E. K., Glaros, T., Coon, J. J., & Dhummakupt, E. S. (2021) · Molecular Omics · doi:10.1039/d1mo00271f · Cited by 18 · see citing works
Molecular circadian rhythms are robust in marine annelids lacking rhythmic behavior
Häfker, N. S., Holcik, L., Mat, A. M., Ćorić, A., Vadiwala, K., Beets, I., Stockinger, A. W., Atria, C. E., Hammer, S., Revilla‐i‐Domingo, R., et al. (2024) · PLoS Biology · doi:10.1371/journal.pbio.3002572 · Cited by 13 · see citing works
Self-citationTranscriptomic landscape of posterior regeneration in the annelid Platynereis dumerilii
Paré, L., Bideau, L., Baduel, L., Dalle, C., Benchouaia, M., Schneider, S., Laplane, L., Clément, Y., Vervoort, M., & Gazave, E. (2023) · BMC Genomics · doi:10.1186/s12864-023-09602-z · Cited by 14 · see citing works
Differential Impacts of the Head on Platynereis dumerilii Peripheral Circadian Rhythms
Arboleda, E., Zurl, M., Waldherr, M., & Tessmar‐Raible, K. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00900 · Cited by 14 · see citing works
Self-citationFunctionally diverse front-end desaturases are widespread in the phylum Annelida
Ramos-Llorens, M., Hontoria, F., Navarro, J. C., Ferrier, D. E. K., & Monroig, Ó. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2023.159377 · Cited by 12 · see citing works
Annelids as models of germ cell and gonad regeneration
Özpolat, B. D. (2023) · Journal of Experimental Zoology Part B Molecular and Developmental Evolution · doi:10.1002/jez.b.23233 · Cited by 11 · see citing works
Utilization of—Omic technologies in cold climate hydrocarbon bioremediation: a text-mining approach
Abdullah, K., Wilkins, D., & Ferrari, B. C. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1113102 · Cited by 9 · see citing works
Timely Questions Emerging in Chronobiology: The Circadian Clock Keeps on Ticking
Chawla, S., O'Neill, J. S., Knight, M. I., He, Y., Wang, L., Maronde, E., Rodríguez, S. G., van Ooijen, G., Garbarino‐Pico, E., Wolf, E., et al. (2024) · Journal of Circadian Rhythms · doi:10.5334/jcr.237 · Cited by 9 · see citing works
Yan, X.-M., Wang, J., HongBo, L., Gao, L., Geng, J., Ma, Z., Liu, J., Zhang, J.-S., Xie, P.-G., & Chen, L. (2021) · Animal Bioscience · doi:10.5713/ab.20.0751 · Cited by 9 · see citing works
Mohamed, A. R., Naval-Sánchez, M., Menzies, M., Evans, B., King, H., Reverter, A., & Kijas, J. (2022) · BMC Genomics · doi:10.1186/s12864-022-08514-8 · Cited by 8 · see citing works
Rankawat, S., Kundal, K., Chakraborty, S., Kumar, R., & Ray, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1210299 · Cited by 7 · see citing works
The Annelid Platynereis dumerilii as an Experimental Model for Evo-Devo and Regeneration Studies
Schenkelaars, Q., & Gazave, E. (2021) · CRC Press eBooks · doi:10.1201/9781003217503-13 · Cited by 7 · see citing works
Wilkens, M., Zimbelmann, S., Roth, F., Cartano, J., Sayols, S., Dejung, M., Levin, M., & Butter, F. (2025) · Communications Biology · doi:10.1038/s42003-025-08414-z · Cited by 8 · see citing works
Integrated bioinformatics and interaction analysis to advance chronotherapies for mental disorders
Bhatnagar, A., Raj, G., Das, S., Kannihalli, A., Rajakumara, E., Murray, G., & Ray, S. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1444342 · Cited by 7 · see citing works
Single-cell RNA-Sequencing in Neuroscience
Mayer, S., Khakipoor, S., Droemer, M. A., & Cozetto, D. A. (2019) · e-Neuroforum · doi:10.1515/nf-2019-0021 · Cited by 6 · see citing works
Wang, R., Wen, L., Ma, H., Yang, H., Lv, M., Chen, Z., Du, X., Zeng, L., Lin, Y., Huang, L., et al. (2020) · Comparative Biochemistry and Physiology Part D Genomics and Proteomics · doi:10.1016/j.cbd.2020.100780 · Cited by 6 · see citing works
Sex-biased gene expression precedes sexual dimorphism in the agonadal annelid Platynereis dumerilii
Ribeiro, R. P., Null, R. W., & Özpolat, B. D. (2025) · Development · doi:10.1242/dev.204513 · Cited by 5 · see citing works
Metzger, B. M., & Özpolat, B. D. (2024) · Developmental Biology · doi:10.1016/j.ydbio.2024.05.013 · Cited by 4 · see citing works
Wang, Y., Liu, L., Zhao, Y., Ren, Y., Miao, X., Dong, Y., Liu, L., & Li, X. (2024) · iScience · doi:10.1016/j.isci.2024.111571 · Cited by 3 · see citing works
Light-modulated stem cells in the camera-type eye of an annelid model for adult brain plasticity
Milivojev, N., Scaramuzza, F., Brum, P. O., Gamboa, C. L. V., Andreatta, G., Raible, F., & Tessmar‐Raible, K. (2025) · Nature Communications · doi:10.1038/s41467-025-65631-0 · Cited by 3 · see citing works
Self-citationAssessment of Circalunar (~Monthly) Rhythms
Poehn, B., & Tessmar‐Raible, K. (2022) · Neuromethods · doi:10.1007/978-1-0716-2577-4_10 · Cited by 3 · see citing works
Self-citationNew techniques for studying neurodevelopment
Escalante, A., González-Martínez, R., & Herrera, E. (2020) · Faculty Reviews · doi:10.12703/r/9-17 · Cited by 3 · see citing works
Biological rhythms: Hormones under moon control
Andreatta, G., Raible, F., & Tessmar‐Raible, K. (2022) · Current Biology · doi:10.1016/j.cub.2022.10.018 · Cited by 2 · see citing works
Self-citationSchneck, D. T., & Barreto, F. S. (2020) · Biological Bulletin · doi:10.1086/708678 · Cited by 2 · see citing works
Mohamed, A. R., Naval-Sánchez, M., Menzies, M., Evans, B., King, H., Reverter, A., & Kijas, J. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.28.272286 · Cited by 2 · see citing works
The cost and payout of age on germline regeneration and sexual maturation in Platynereis dumeriliiPreprint
Metzger, B. M., & Özpolat, B. D. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.22.576726 · Cited by 2 · see citing works
Milivojev, N., Gamboa, C. L. V., Andreatta, G., Raible, F., & Tessmar‐Raible, K. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.19.608633 · Cited by 2 · see citing works
Self-citationAdults of the marine annelid Platynereis dumerilii chemically stunt the growth of juveniles
Moris, V. C., Schirrmacher, P., Potter, S., Tickle, M., Squire, R., & Hardege, J. D. (2026) · Journal of Experimental Biology · doi:10.1242/jeb.252116 · Cited by 1 · see citing works
Santamarina, J. B., Astier, C., Garrido, M., Daage, L. C., Roumeliotis, T. I., Anthony, E., Pardo, M., Chasseriaud, M., Gestraud, P., Duong-Ngo, C., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.16.603530 · Cited by 1 · see citing works
Andreatta, G., Scaramuzza, F., Ćorić, A., Orel, L., & Tessmar‐Raible, K. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.12.642703 · Cited by 1 · see citing works
Self-citationBehavioral rhythms are bad predictors of general organismal rhythmicityPreprint
Häfker, N. S., Holcik, L., Vadiwala, K., Beets, I., Mat, A. M., Stockinger, A. W., Hammer, S., Schoofs, L., Raible, F., & Tessmar‐Raible, K. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.07.16.500291
Self-citationWang, Y., Liu, L., Zhao, Y., Ren, Y., Miao, X., Dong, Y., Liu, L., & Li, X. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4886466
Mohamed, A. R., Naval-Sánchez, M., Menzies, M., Evans, B., King, H., Reverter, A., & Kijas, J. (2022) · Figshare · doi:10.6084/m9.figshare.19959586
Andreatta, G., Scaramuzza, F., Ćorić, A., Orel, L., Mat, A. M., Takekata, H., Poehn, B., Milivojev, N., & Tessmar‐Raible, K. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2514719123 · Cited by 1 · see citing works
Self-citationChakraborty, S., & Srivastava, V. (2026) · Chronobiology International · doi:10.1080/07420528.2026.2648750
Evolutionary principles underlying neuron subtype encoding and diversification in animalsPreprint
Hehmeyer, J., Harris, D., Lowe, C. J., & Marlow, H. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.13.718258 · Cited by 1 · see citing works
Adult Marine Annelid Platynereis dumerilii Chemically Stunt the Growth of JuvenilesPreprint
Moris, V. C., Schirrmacher, P., Potter, S., Tickle, M., Squire, R., & Hardege, J. D. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.30.721953
- Authors
- Schenk, S., Bannister, S. C., Sedlazeck, F. J., Anrather, D., Minh, B. Q., Bileck, A., Hartl, M., von Haeseler, A., Gerner, C., Raible, F., & Tessmar-Raible, K.
- Affiliations
- University of Vienna (AT)
- Center of Integrative Bioinformatics Vienna, Max F Perutz Laboratories, University of Vienna, Medical University of Vienna, Vienna BioCenter, Vienna, Austria
- Research Platform 'Rhythms of Life', University of Vienna, Vienna BioCenter, Vienna, Austria
- Corresponding author
- Schenk, Sven
- Bannister, Stephanie C
- Raible, Florian
- ORCID
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2019-02-15
- Volume
- 8
- ISSN
- 2050-084X (ISSN-L)
- PMC
- PMC6377233
- OpenAlex
- W2911985263
- Cited by
- 59
- References
- 111
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 9 · 2023: 6 · 2022: 10 · 2021: 12 · 2020: 6 · 2019: 7
- FWCI
- 4.83
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- eLife (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- European Research Council ((FP7/2007-2013)/ERC Grant Agreement 260304, (FP7/2007-2013)/ERC Grant Agreement 337011)
- University of Vienna (Research Platform Rhythms of Life)
- Austrian Science Fund (#AY0041321, #P28970, #I2972, #M1478)
- Vienna International PostDoctoral Program for Molecular Life Sciences (#GM100402)
- European Molecular Biology Organization (YIP #2893)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Reproductive biology and impacts on aquatic species
- Physical Sciences › Earth and Planetary Sciences › Paleontology › Marine Invertebrate Physiology and Ecology
- Keywords
- circadian clock, Platynereis dumerilii, sexual differentiation, sexual maturation, gene expression profiling, proteomic profiling, ependymin
- MeSH terms
- Animals, Annelida, Brain, Female, Male, Phylogeny, Sexual Maturation, Signal Transduction, Proteome, Proteomics, Circadian Clocks, Transcriptome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review