Genetics of circadian rhythms
Open accessAbstract
In mammals, genetic influences of circadian rhythms occur at many levels. A set of core "clock genes" have been identified that form a feedback loop of gene transcription and translation. The core genetic clockwork generates circadian rhythms in cells throughout the body. Polymorphisms in both core clock genes and interacting genes contribute to individual differences in the expression and properties of circadian rhythms. The circadian clock profoundly influences the patterns of gene expression and cellular functions, providing a mechanistic basis for the impact of the genetic circadian system on normal physiological processes as well as the development of diseases.
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“Polymorphisms within core clock genes such as PER, CRY, BMAL1, and CLOCK may lead to individual differences in their expression (144).”
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Republication de : La santé circadienne à la croisée de la physiologie et des comportements
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Phylogeny of Core Molecular Components of Metazoan Circadian Clocks
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La santé circadienne à la croisée de la physiologie et des comportements
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Daily feeding rhythms may play a role in the genetic variability of feed efficiency in growing pigsPreprint
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Circadian Biology and Phase Response: Fundamental Mechanisms and Clinical Applications
Fedele, M. L. M., & Cardinali, D. P. (2026) · Clocks & Sleep · doi:10.3390/clockssleep8030048
- Authors
- Vitaterna, M. H., Shimomura, K., & Jiang, P.
- Affiliations
- Northwestern University (US)
- Corresponding author
- Vitaterna, Martha Hotz
- Venue
- Neurologic Clinics
- Publisher
- Elsevier BV
- Published
- 2019-08
- Volume
- 37
- Issue
- 3
- Pages
- 487-504
- ISSN
- 0733-8619 (ISSN-L)
- PMC
- PMC7202232
- OpenAlex
- W2947961383
- Cited by
- 36
- References
- 128
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 15 · 2023: 3 · 2022: 4 · 2021: 3
- FWCI
- 0.21
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neurologic Clinics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (PO1 AG 11412)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- circadian rhythm, clock genes, circadian clock, genetic polymorphism, gene expression rhythms
- MeSH terms
- Animals, Circadian Rhythm, Humans, Circadian Clocks
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