The neuropeptide complement of the marine annelid Platynereis dumerilii
Open accessAbstract
BACKGROUND: The marine annelid Platynereis dumerilii is emerging as a powerful lophotrochozoan experimental model for evolutionary developmental biology (evo-devo) and neurobiology. Recent studies revealed the presence of conserved neuropeptidergic signaling in Platynereis, including vasotocin/neurophysin, myoinhibitory peptide and opioid peptidergic systems. Despite these advances, comprehensive peptidome resources have yet to be reported. RESULTS: The present work describes the neuropeptidome of Platynereis. We established a large transcriptome resource, consisting of stage-specific next-generation sequencing datasets and 77,419 expressed sequence tags. Using this information and a combination of bioinformatic searches and mass spectrometry analyses, we increased the known proneuropeptide (pNP) complement of Platynereis to 98. Based on sequence homology to metazoan pNPs, Platynereis pNPs were grouped into ancient eumetazoan, bilaterian, protostome, lophotrochozoan, and annelid families, and pNPs only found in Platynereis. Compared to the planarian Schmidtea mediterranea, the only other lophotrochozoan with a large-scale pNP resource, Platynereis has a remarkably full complement of conserved pNPs, with 53 pNPs belonging to ancient eumetazoan or bilaterian families. Our comprehensive search strategy, combined with analyses of sequence conservation, also allowed us to define several novel lophotrochozoan and annelid pNP families. The stage-specific transcriptome datasets also allowed us to map changes in pNP expression throughout the Platynereis life cycle. CONCLUSION: The large repertoire of conserved pNPs in Platynereis highlights the usefulness of annelids in comparative neuroendocrinology. This work establishes a reference dataset for comparative peptidomics in lophotrochozoans and provides the basis for future studies of Platynereis peptidergic signaling.
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Four preprohormones of the GnRH superfamily were identified in Platynereis by transcriptomics, bioinformatics, and mass spectrometry.
“Four preprohormones of the gnrh superfamily were identified in Platynereis by a combination of transcriptomics, bioinformatics, and mass spectrometry analyses (refs. 53 and 54 and this study).”
From Corazonin signaling integrates energy homeostasis and lunar phase to regulate aspects of growth and sexual maturation in <i>Platynereis</i> (2020) · cites this paper as [53]
Two tobi-like α-glucosidases (tobi-like 1 and 2), as well as homologs of phosphoenolpyruvate carboxykinase (pepck) and glycogen synthase, were identified in Platynereis published transcriptomes.
“Using sequence-similarity and molecular phylogenetic approaches (SI Appendix, Fig. S7), we identified 2 tobi-like α-glucosidases (called hereafter tobi-like 1 and 2), as well as homologs of phosphoenolpyruvate carboxykinase (pepck, one of the key enzymes contributing to gluconeogenesis) and glycogen synthase in Platynereis published transcriptomes (53, 57).”
From Corazonin signaling integrates energy homeostasis and lunar phase to regulate aspects of growth and sexual maturation in <i>Platynereis</i> (2020) · cites this paper as [53]
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Synaptic and peptidergic connectome of a neurosecretory center in the annelid brain
Williams, E. A., Verasztó, C., Jasek, S., Conzelmann, M., Shahidi, R., Bauknecht, P., Mirabeau, O., & Jékely, G. (2017) · eLife · doi:10.7554/elife.26349 · Cited by 119 · see citing works
Self-citationThe evolution and nomenclature of GnRH-type and corazonin-type neuropeptide signaling systems
Zandawala, M., Tian, S., & Elphick, M. R. (2018) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2017.06.007 · Cited by 105 · see citing works
Andreatta, G., Broyart, C., Borghgraef, C., Vadiwala, K., Kozin, V., Polo, A., Bileck, A., Beets, I., Schoofs, L., Gerner, C., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1910262116 · Cited by 61 · see citing works
Schenk, S., Bannister, S. C., Sedlazeck, F. J., Anrather, D., Minh, B. Q., Bileck, A., Hartl, M., von Haeseler, A., Gerner, C., Raible, F., et al. (2019) · eLife · doi:10.7554/elife.41556 · Cited by 59 · see citing works
Sponge Behavior and the Chemical Basis of Responses: A Post-Genomic View
Leys, S. P., Mah, J. L., McGill, P. R., Hamonic, L., De Leo, F. C., & Kahn, A. S. (2019) · Integrative and Comparative Biology · doi:10.1093/icb/icz122 · Cited by 46 · see citing works
- Authors
- Conzelmann, M., Williams, E. A., Krug, K., Franz-Wachtel, M., Macek, B., & Jékely, G.
- Affiliations
- Max Planck Institute for Developmental Biology (DE)
- University of Tübingen (DE)
- Corresponding author
- Conzelmann, Markus
- Jékely, Gáspár
- Venue
- BMC Genomics
- Published
- 2013
- Volume
- 14
- Issue
- 1
- Pages
- 906
- ISSN
- 1471-2164 (ISSN-L)
- PMC
- PMC3890597
- OpenAlex
- W2067804517
- Cited by
- 165
- References
- 97
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 16 · 2023: 15 · 2022: 10 · 2021: 20 · 2020: 13 · 2019: 17 · 2018: 21 · 2017: 14 · 2016: 9 · 2015: 12 · 2014: 3
- FWCI
- 3.92
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- BMC Genomics (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Figshare (submittedVersion)
- Open Research Exeter (University of Exeter) (submittedVersion, cc-by)
- Funders
- European Commission (2007–2013, FP7 2007-2013, 260821, FP7/2007)
- Max-Planck-Gesellschaft
- FP7 Ideas: European Research Council (260821)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Physical Sciences › Earth and Planetary Sciences › Paleontology › Marine Invertebrate Physiology and Ecology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- Platynereis dumerilii, neuropeptidome, neuropeptide families, lophotrochozoans, Annelida, Schmidtea mediterranea, neuroendocrinology, neuropeptide evolution
- MeSH terms
- Amino Acid Sequence, Animals, Annelida, Biological Evolution, Life Cycle Stages, Molecular Sequence Data, Neuropeptides, Mass Spectrometry, Computational Biology, Proteome, Transcriptome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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