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A practical review of functional neurological disorder (FND) for the general physician
Open accessAbstract
We present a practical overview of functional neurological disorder (FND), its epidemiology, assessment and diagnosis, diagnostic pitfalls, treatment, aetiology and mechanism. We present an update on functional limb weakness, tremor, dystonia and other abnormal movements, dissociative seizures, functional cognitive symptoms and urinary retention, and 'scan-negative' cauda equina syndrome. The diagnosis of FND should rest on clear positive evidence, typically from a combination of physical signs on examination or the nature of seizures. In treatment of FND, clear communication of the diagnosis and the involvement of the multidisciplinary team is beneficial. We recommend that patients with FND are referred to specialists with expertise in neurological diagnosis. FND is a common presentation in emergency and acute medical settings and there are many practical elements to making a positive diagnosis and communication which are useful for all physicians to be familiar with.
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“The past decades have seen significant efforts by clinicians and academics involved in the assessment and treatment of FND generally to assist colleagues in primary and secondary care to identify and manage patients with these conditions (34, 35, 36).”
From A qualitative analysis of patients' day-to-day living with functional cognitive disorder (FCD). (2025) · cites this paper as [34]
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“Contemporary diagnostic criteria for FCD imply that neuropsychological testing is unnecessary because a diagnosis can be made on the basis of internal inconsistencies identified through clinical interview (Ball et al., 2020; Bennett et al., 2021; McWhirter & Carson, 2022).”
Background
Metadata
- Authors
- Bennett, K., Diamond, C., Hoeritzauer, I., Gardiner, P., McWhirter, L., Carson, A., & Stone, J.
- Affiliations
- Edinburgh Royal Infirmary (GB)
- University of Edinburgh (GB)
- Venue
- Clinical Medicine
- Publisher
- Elsevier BV
- Published
- 2021-01
- Volume
- 21
- Issue
- 1
- Pages
- 28-36
- ISSN
- 1470-2118 (ISSN-L)
- PMC
- PMC7850207
- OpenAlex
- W3123764886
- Cited by
- 169
- References
- 52
- Citations by year
- 2026: 40 · 2025: 37 · 2024: 43 · 2023: 27 · 2022: 14 · 2021: 8
- FWCI
- 4.10
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Clinical Medicine (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Keywords
- conversion disorder, functional tremor, functional dystonia, psychogenic non-epileptic seizures, urinary retention, cauda equina syndrome, diagnostic pitfalls, etiology, multidisciplinary management, emergency medicine
- MeSH terms
- Conversion Disorder, Emergency Service, Hospital, Humans, Nervous System Diseases, Seizures, Tremor, General Practitioners
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