Running throughout middle-age improves memory function, hippocampal neurogenesis, and BDNF levels in female C57BL/6J mice

Marlatt, Michael W.; Potter, Michelle C.; Lucassen, Paul J.; van Praag, Henriette

doi:10.1002/dneu.22009

Cited by 314Neurogenesis and neuroplasticity mechanismsMemory and Neural MechanismsNerve injury and regeneration

Running throughout middle-age improves memory function, hippocampal neurogenesis, and BDNF levels in female C57BL/6J mice

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Marlatt, Michael W., Potter, Michelle C., Lucassen, Paul J., van Praag, Henriette·2012·Developmental Neurobiology

DOI 10.1002/dneu.22009PMC PMC3485396

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Abstract

Age‐related memory loss is considered to commence at middle‐age and coincides with reduced adult hippocampal neurogenesis and neurotrophin levels. Consistent physical activity at midlife may preserve brain‐derived neurotrophic factor (BDNF) levels, new cell genesis, and learning. In the present study, 9‐month‐old female C57Bl/6J mice were housed with or without a running wheel and injected with bromodeoxyuridine (BrdU) to label newborn cells. Morris water maze learning, open field activity and rotarod behavior were tested 1 and 6 months after exercise onset. Here we show that long‐term running improved retention of spatial memory and modestly enhanced rotarod performance at 15 months of age. Both hippocampal neurogenesis and mature BDNF peptide levels were elevated after long‐term running. Thus, regular exercise from the onset and during middle‐age may maintain brain function. © 2011 Wiley Periodicals, Inc. Develop Neurobiol 72: 943–952, 2012

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Physical exercise is able to overcome the age-dependent decline of hippocampal neurogenesis.
“In contrast, physical exercise is able to overcome the age-dependent decline of hippocampal neurogenesis; running is indeed effective in 9-20 month-old rodents in restoring neurogenesis of at least 50% of the control level of young animals, and also the morphology of young neurons and BDNF levels, as well as spatial memory (Morris water maze and place recognition tests; van Praag et al., 2005;Siet”
From Depression and adult neurogenesis: Positive effects of the antidepressant fluoxetine and of physical exercise (2018) · cites this paper as Marlatt et al., 2012
The Discussion reports that running increased hippocampal neurogenesis in middle-aged female mice and says age-related decline can be reversed “to some extent.” The Introduction adds that exercise did not restore neurogenesis to the level of younger animals, so “overcome” overstates the degree of reversal. Page numbers are not provided in our copy. (LLM, conf=0.85)
Experimental — accuracy not yet measured
Animal models have shown aerobic exercise to be associated with a region-specific up-regulation of brain-derived neurotrophic factor in the hippocampus.
“Animal models have shown AE to be associated with a region-specific up-regulation of BDNF in the hippocampus (Neeper et al., 1995; Marlatt et al., 2012; Uysal et al., 2015).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Marlatt et al., 2012
Studies in animal models report an increase in brain BDNF levels when aged animals are submitted to protocols such as long-term environmental enrichment or physical activity.
“Studies in animal models report an increase in brain BDNF levels when aged animals are submitted to protocols such as long-term environmental enrichment [47–49] or physical activity [50, 51].”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [50]

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Authors: Marlatt, M. W., Potter, M. C., Lucassen, P. J., & van Praag, H.
Affiliations: National Institute on Aging (US)
University of Amsterdam (NL)
ORCID: Potter, Michelle C.
Lucassen, Paul J.
Venue: Developmental Neurobiology
Publisher: Wiley
Published: 2012-05-14
Volume: 72
Issue: 6
Pages: 943-952
ISSN: 1932-8451 (ISSN-L)
1932-846X
DOI: 10.1002/dneu.22009
PMC: PMC3485396
OpenAlex: W2116852067
Cited by: 314
References: 54
Citations by year: 2026: 8 · 2025: 20 · 2024: 13 · 2023: 12 · 2022: 18 · 2021: 22 · 2020: 17 · 2019: 21 · 2018: 31 · 2017: 32 · 2016: 34 · 2015: 28 · 2014: 23 · 2013: 25 · 2012: 9
FWCI: 9.06
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Developmental Neurobiology (publishedVersion)
PubMed (publishedVersion)
UvA-DARE (University of Amsterdam) (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
UvA-DARE (University of Amsterdam) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Funders: National Institutes of Health
National Institute on Aging (Z01AG000328)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Keywords: running wheel exercise, middle age (human life stage), hippocampal neurogenesis, brain-derived neurotrophic factor, memory function, spatial memory, exercise and cognition, aging, female mice, rotarod performance, open field behavior, neurogenesis
MeSH terms: Aging, Animals, Cell Count, Female, Hippocampus, Memory, Mice, Inbred C57BL, Motor Activity, Neurons, Physical Conditioning, Animal, Running, Maze Learning, Brain-Derived Neurotrophic Factor, Mice, Neurogenesis

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Running throughout middle-age improves memory function, hippocampal neurogenesis, and BDNF levels in female C57BL/6J mice

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