Betenbaugh, Michael J.

The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line

Xu, X., Nagarajan, H., Lewis, N. E., Pan, S., Cai, Z., Liu, X., Chen, W., Xie, M., Wang, W., Hammond, S., et al. (2011) · Nature Biotechnology

Viral Infectious Diseases and Gene Expression in InsectsFungal and yeast genetics research

Cited by 785

A green light for engineered algae: redirecting metabolism to fuel a biotechnology revolution

Rosenberg, J. N., Oyler, G. A., Wilkinson, L., & Betenbaugh, M. J. (2008) · Current Opinion in Biotechnology

Algal biology and biofuel productionMicrobial Metabolic Engineering and Bioproduction

Cited by 631

Genomic landscapes of Chinese hamster ovary cell lines as revealed by the Cricetulus griseus draft genome

Lewis, N. E., Liu, X., Li, Y., Nagarajan, H., Yerganian, G., O'Brien, E., Bordbar, A., Roth, A. M., Rosenbloom, J., Bian, C., et al. (2013) · Nature Biotechnology

Viral Infectious Diseases and Gene Expression in InsectsGenomics and Phylogenetic Studies

Cited by 380

The effect of mixotrophy on microalgal growth, lipid content, and expression levels of three pathway genes in Chlorella sorokiniana

Wan, M., Liu, P., Xia, J., Rosenberg, J. N., Oyler, G. A., Betenbaugh, M. J., Nie, Z., & Qiu, G. (2011) · Applied Microbiology and Biotechnology

Algal biology and biofuel productionMicrobial Metabolic Engineering and Bioproduction

Cited by 300

Determination of nucleotides and sugar nucleotides involved in protein glycosylation by high-performance anion-exchange chromatography: Sugar nucleotide contents in cultured insect cells and mammalian cells

Tomiya, N., Ailor, E., Lawrence, S. M., Betenbaugh, M. J., & Lee, Y. C. (2001) · Analytical Biochemistry

Glycosylation and Glycoproteins ResearchViral Infectious Diseases and Gene Expression in Insects

Cited by 203

Accelerating genome editing in CHO cells using CRISPR Cas9 and CRISPy, a web-based target finding tool

Ronda, C., Pedersen, L. E., Hansen, H. G., Kallehauge, T. B., Betenbaugh, M. J., Nielsen, A. T., & Kildegaard, H. F. (2014) · Biotechnology and Bioengineering

CRISPR and Genetic EngineeringViral Infectious Diseases and Gene Expression in Insects

Cited by 195

Proteomic analysis of Chinese hamster ovary cells

Baycin-Hizal, D., Tabb, D. L., Chaerkady, R., Chen, L., Lewis, N. E., Nagarajan, H., Sarkaria, V., Kumar, A., Wolozny, D., Colao, J., et al. (2012) · Journal of Proteome Research

Viral Infectious Diseases and Gene Expression in InsectsAdvanced Proteomics Techniques and Applications

Cited by 178

A mathematical model of N-linked glycosylation

Krambeck, F. J., & Betenbaugh, M. J. (2005) · Biotechnology and Bioengineering

Glycosylation and Glycoproteins ResearchViral Infectious Diseases and Gene Expression in Insects

Cited by 171

The emerging CHO systems biology era: harnessing the ‘omics revolution for biotechnology

Kildegaard, H. F., Baycin-Hizal, D., Lewis, N. E., & Betenbaugh, M. J. (2013) · Current Opinion in Biotechnology

Viral Infectious Diseases and Gene Expression in InsectsMicrobial Metabolic Engineering and Bioproduction

Cited by 165

A reference genome of the Chinese hamster based on a hybrid assembly strategy

Rupp, O., MacDonald, M. L., Li, S., Dhiman, H., Polson, S., Griep, S., Heffner, K., Hernandez, I., Brinkrolf, K., Jadhav, V., et al. (2018) · Biotechnology and Bioengineering

Genomics and Phylogenetic StudiesGenomic variations and chromosomal abnormalities

Cited by 107

Antibody glycoengineering strategies in mammalian cells

Wang, Q., Chung, C., Chough, S., & Betenbaugh, M. J. (2018) · Biotechnology and Bioengineering

Viral Infectious Diseases and Gene Expression in InsectsGlycosylation and Glycoproteins Research

Cited by 95

A novel microRNA mmu-miR-466h affects apoptosis regulation in mammalian cells

Druz, A., Chu, C., Majors, B., Santuary, R., Betenbaugh, M., & Shiloach, J. (2011) · Biotechnology and Bioengineering

MicroRNA in disease regulationCell death mechanisms and regulation

Cited by 92

Stable inhibition of mmu-miR-466h-5p improves apoptosis resistance and protein production in CHO cells

Druz, A., Son, Y., Betenbaugh, M., & Shiloach, J. (2013) · Metabolic Engineering

Viral Infectious Diseases and Gene Expression in InsectsMicroRNA in disease regulation

Cited by 73

Bcl-2 family in inter-organelle modulation of calcium signaling; roles in bioenergetics and cell survival

Lewis, A., Hayashi, T., Su, T.-P., & Betenbaugh, M. J. (2014) · Journal of Bioenergetics and Biomembranes

Cell death mechanisms and regulationMitochondrial Function and Pathology

Cited by 66

Enhancement of cell proliferation in various mammalian cell lines by gene insertion of a cyclin-dependent kinase homolog

Jaluria, P., Betenbaugh, M., Konstantopoulos, K., & Shiloach, J. (2007) · BMC Biotechnology

Viral Infectious Diseases and Gene Expression in InsectsCancer-related Molecular Pathways

Cited by 58

Top-down and bottom-up microbiome engineering approaches to enable biomanufacturing from waste biomass

Lyu, X., Nuhu, M., Candry, P., Wolfanger, J., Betenbaugh, M., Saldivar, A., Zuniga, C., Wang, Y., & Shrestha, S. (2024) · Journal of Industrial Microbiology and Biotechnology

Microbial Metabolic Engineering and BioproductionMicrobial bioremediation and biosurfactants

Cited by 53

Production of lipid-containing algal-bacterial polyculture in wastewater and biomethanation of lipid extracted residues: Enhancing methane yield through hydrothermal pretreatment and relieving solvent toxicity through co-digestion

Bohutskyi, P., Phan, D., Spierling, R. E., Kopachevsky, A. M., Bouwer, E. J., Lundquist, T. J., & Betenbaugh, M. J. (2019) · Science of The Total Environment

Anaerobic Digestion and Biogas ProductionAlgal biology and biofuel production

Cited by 45

Anti-apoptotic genes Aven and E1B-19K enhance performance of BHK cells engineered to express recombinant factor VIII in batch and low perfusion cell culture

Nivitchanyong, T., Martinez, A., Ishaque, A., Murphy, J. E., Konstantinov, K., Betenbaugh, M. J., & Thrift, J. (2007) · Biotechnology and Bioengineering

Viral Infectious Diseases and Gene Expression in InsectsProtein purification and stability

Cited by 40

Metabolic analysis of the asparagine and glutamine dynamics in an industrial Chinese hamster ovary fed-batch process

Kirsch, B. J., Bennun, S. V., Mendez, A., Johnson, A. S., Wang, H., Qiu, H., Li, N., Lawrence, S. M., Bak, H., & Betenbaugh, M. J. (2022) · Biotechnology and Bioengineering

Viral Infectious Diseases and Gene Expression in InsectsMicrobial Metabolic Engineering and Bioproduction

Cited by 39

E2F-1 overexpression increases viable cell density in batch cultures of Chinese hamster ovary cells

Majors, B. S., Arden, N., Oyler, G. A., Chiang, G. G., Pederson, N. E., & Betenbaugh, M. J. (2008) · Journal of Biotechnology

Viral Infectious Diseases and Gene Expression in InsectsMonoclonal and Polyclonal Antibodies Research

Cited by 36

Combinatorial genome and protein engineering yields monoclonal antibodies with hypergalactosylation from CHO cells

Chung, C., Wang, Q., Yang, S., Ponce, S. A., Kirsch, B. J., Zhang, H., & Betenbaugh, M. J. (2017) · Biotechnology and Bioengineering

Viral Infectious Diseases and Gene Expression in InsectsGlycosylation and Glycoproteins Research

Cited by 32

Comparison of biomass and lipid production under ambient carbon dioxide vigorous aeration and 3% carbon dioxide condition among the lead candidate Chlorella strains screened by various photobioreactor scales

Kobayashi, N., Barnes, A., Jensen, T., Noel, E., Andlay, G., Rosenberg, J. N., Betenbaugh, M. J., Guarnieri, M. T., & Oyler, G. A. (2015) · Bioresource Technology

Algal biology and biofuel productionMicrobial Metabolic Engineering and Bioproduction

Cited by 12