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Bioinformatic Identification of Chinese Hamster Ovary (CHO) Cold‐Shock Genes and Biological Evidence of their Cold‐Inducible Promoters

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Structural analysis of random transgene integration in CHO manufacturing cell lines by targeted sequencing

Stadermann, A., Gamer, M., Fieder, J., Lindner, B., Fehrmann, S., Schmidt, M. J., Schulz, P., & Gorr, I. H. (2021) · Biotechnology and Bioengineering · doi:10.1002/bit.28012 · Cited by 22 · see citing works

Glutamine synthetase (GS) knockout (KO) using CRISPR/Cpf1 diversely enhances selection efficiency of CHO cells expressing therapeutic antibodies

Srila, W., Baumann, M., Riedl, M., Rangnoi, K., Borth, N., & Yamabhai, M. (2023) · Scientific Reports · doi:10.1038/s41598-023-37288-6 · Cited by 22 · see citing works

A cross-species whole genome siRNA screen in suspension-cultured Chinese hamster ovary cells identifies novel engineering targets

Klanert, G., Fernández, D. J., Weinguny, M., Eisenhut, P., Buehler, E. C., Melcher, M., Titus, S. A., Diendorfer, A. B., Gludovacz, E., Jadhav, V., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-45159-2 · Cited by 22 · see citing works

Random epigenetic modulation of CHO cells by repeated knockdown of DNA methyltransferases increases population diversity and enables sorting of cells with higher production capacities

Weinguny, M., Eisenhut, P., Klanert, G., Virgolini, N., Marx, N., Jonsson, A., Ivansson, D., Lövgren, A., & Borth, N. (2020) · Biotechnology and Bioengineering · doi:10.1002/bit.27493 · Cited by 21 · see citing works

Restoration of DNA repair mitigates genome instability and increases productivity of Chinese hamster ovary cells

Spahn, P. N., Zhang, X., Hu, Q., Lu, H., Hamaker, N. K., Hefzi, H., Li, S., Kuo, C., Huang, Y., Lee, J. C., et al. (2021) · Biotechnology and Bioengineering · doi:10.1002/bit.28016 · Cited by 21 · see citing works

Compartmentalized Proteomic Profiling Outlines the Crucial Role of the Classical Secretory Pathway during Recombinant Protein Production in Chinese Hamster Ovary Cells

Rodriguez, S. P., Wulff, T., Voldborg, B. G. R., Altamirano, C., Trujillo‐Roldán, M. A., & Valdez‐Cruz, N. A. (2021) · ACS Omega · doi:10.1021/acsomega.0c06030 · Cited by 20 · see citing works

Nanopore Cas9‐targeted sequencing enables accurate and simultaneous identification of transgene integration sites, their structure and epigenetic status in recombinant Chinese hamster ovary cells

Leitner, K., Motheramgari, K., Borth, N., & Marx, N. (2023) · Biotechnology and Bioengineering · doi:10.1002/bit.28382 · Cited by 18 · see citing works

Proteogenomic Annotation of Chinese Hamsters Reveals Extensive Novel Translation Events and Endogenous Retroviral Elements

Li, S., Cha, S. W., Heffner, K., Hızal, D. B., Bowen, M. A., Chaerkady, R., Cole, R. N., Tejwani, V., Kaushik, P., Henry, M. A., et al. (2019) · Journal of Proteome Research · doi:10.1021/acs.jproteome.8b00935 · Cited by 18 · see citing works

Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains

Wang, J. Y., Khmelinskaia, A., Sheffler, W., Miranda, M. C., Antanasijevic, A., Borst, A. J., Torres, S. V., Shu, C., Hsia, Y., Nattermann, U., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2214556120 · Cited by 17 · see citing works

Proteomic Profiling of IgG1 Producing CHO Cells Using LC/LC-SPS-MS3: The Effects of Bioprocessing Conditions on Productivity and Product Quality

Strasser, L., Farrell, A., Ho, J. T. C., Scheffler, K., Cook, K., Pankert, P., Mowlds, P., Viner, R., Karger, B. L., & Bones, J. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.569045 · Cited by 17 · see citing works

A reflection on the improvement of Chinese hamster ovary cell-based bioprocesses through advances in proteomic techniques

Nguyen, M., & Zimmer, A. (2023) · Biotechnology Advances · doi:10.1016/j.biotechadv.2023.108141 · Cited by 17 · see citing works

Multi-omic characterization of antibody-producing CHO cell lines elucidates metabolic reprogramming and nutrient uptake bottlenecks

Gopalakrishnan, S., Johnson, W., Valderrama-Gómez, M. Á., Içten, E., Tat, J., Lay, F. D., Diep, J., Gomez, N. V., Stevens, J. L., Schlegel, F., et al. (2024) · Metabolic Engineering · doi:10.1016/j.ymben.2024.07.009 · Cited by 17 · see citing works

Expanded Chinese hamster organ and cell line proteomics profiling reveals tissue-specific functionalities

Heffner, K. M., Hızal, D. B., Majewska, N. I., Kumar, S., Dhara, V. G., Zhu, J., Bowen, M. A., Hatton, D., Yerganian, G., Yerganian, A., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-72959-8 · Cited by 17 · see citing works

De novo assembly and annotation of the CHOZN® GS −/− genome supports high‐throughput genome‐scale screening

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A Chinese hamster transcription start site atlas that enables targeted editing of CHO cells

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Expanding the Chinese hamster ovary cell long noncoding RNA transcriptome using RNASeq

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CHOmics: A web-based tool for multi-omics data analysis and interactive visualization in CHO cell lines

Lin, D., Yalamanchili, H. B., Zhang, X., Lewis, N. E., Alves, C. S., de Groot, J. C. W., Arnsdorf, J., Bjørn, S. P., Wulff, T., Voldborg, B. G. R., et al. (2020) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1008498 · Cited by 15 · see citing works

Epigenetic comparison of CHO hosts and clones reveals divergent methylation and transcription patterns across lineages

Chang, M., Kumar, A., Kumar, S., Huhn, S. C., Timp, W., Betenbaugh, M. J., & Du, Z. (2022) · Biotechnology and Bioengineering · doi:10.1002/bit.28036 · Cited by 15 · see citing works

CHOK1SV GS‐KO SSI expression system: A combination of the Fer1L4 locus and glutamine synthetase selection

Feary, M., Moffat, M. A., Casperson, G. F., Allen, M. J., & Young, R. J. (2021) · Biotechnology Progress · doi:10.1002/btpr.3137 · Cited by 15 · see citing works

The potential of emerging sub-omics technologies for CHO cell engineering

Jerabek, T., Keysberg, C., & Otte, K. (2022) · Biotechnology Advances · doi:10.1016/j.biotechadv.2022.107978 · Cited by 14 · see citing works

Removal of host cell proteins from cell culture fluids by weak partitioning chromatography using peptide-based adsorbents

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Key Challenges in Designing CHO Chassis Platforms

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Adaptive DNA amplification of synthetic gene circuit opens a way to overcome cancer chemoresistance

Wan, Y., Mu, Q., Krzysztoń, R., Cohen, J., Coraci, D., Helenek, C., Tompkins, C., Lin, A. J., Farquhar, K. S., Cross, E., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2303114120 · Cited by 13 · see citing works

RNASeq highlights ATF6 pathway regulators for CHO cell engineering with different impacts of ATF6β and WFS1 knockdown on fed-batch production of IgG1

Rives, D., Peak, C., & Blenner, M. (2024) · Scientific Reports · doi:10.1038/s41598-024-64767-1 · Cited by 13 · see citing works

Identification of RNA content of CHO-derived extracellular vesicles from a production process

Busch, D. J., Zhang, Y., Kumar, A., Huhn, S. C., Du, Z., & Liu, R. (2022) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2022.03.004 · Cited by 12 · see citing works

LncRNA analysis of mAb producing CHO clones reveals marker and engineering potential

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Age of Laboratory Hamster and Human: Drawing the Connexion

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k -mer-Based Metagenomics Tools Provide a Fast and Sensitive Approach for the Detection of Viral Contaminants in Biopharmaceutical and Vaccine Manufacturing Applications Using Next-Generation Sequencing

MacDonald, M. L., Polson, S. W., & Lee, K. H. (2021) · mSphere · doi:10.1128/msphere.01336-20 · Cited by 11 · see citing works

Development and Characterization of the NISTCHO Reference Cell Line

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Whole Transcriptome Analysis Revealed a Stress Response to Deep Underground Environment Conditions in Chinese Hamster V79 Lung Fibroblast Cells

Duan, L., Jiang, H., Liu, J., Liu, Y., Ma, T., Xie, Y., Wang, L., Cheng, J., Zou, J., Wu, J., et al. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.698046 · Cited by 11 · see citing works

Subphysiological temperature induces pervasive alternative splicing in Chinese hamster ovary cells

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Bioinformatic analysis of Chinese hamster ovary host cell protein lipases

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A pooled CRISPR/AsCpf1 screen using paired gRNAs to induce genomic deletions in Chinese hamster ovary cells

Schmieder, V., Novak, N., Dhiman, H., Ly, N. N., Serafimova, E., Klanert, G., Baumann, M., Kildegaard, H. F., & Borth, N. (2021) · Biotechnology Reports · doi:10.1016/j.btre.2021.e00649 · Cited by 10 · see citing works

From omics to cellular mechanisms in mammalian cell factory development

Samoudi, M., Masson, H. O., Kuo, C., Robinson, C. M., & Lewis, N. E. (2021) · Current Opinion in Chemical Engineering · doi:10.1016/j.coche.2021.100688 · Cited by 10 · see citing works

A genome-scale CRISPR deletion screen in Chinese hamster ovary cells reveals essential regions of the coding and non-coding genome

Marco, F. D., Sebastian, I. R., Napoleone, A., Molin, A., Riedl, M., Bydlinski, N., Motheramgari, K., Hussein, M. K., Kramer, L., Kelly, T. J., et al. (2025) · Metabolic Engineering · doi:10.1016/j.ymben.2025.08.007 · Cited by 9 · see citing works

High‐resolution three‐dimensional chromatin profiling of the Chinese hamster ovary cell genome

Bevan, S., Schoenfelder, S., Young, R. J., Zhang, L., Andrews, S. R., Fraser, P., & O'Callaghan, P. M. (2020) · Biotechnology and Bioengineering · doi:10.1002/bit.27607 · Cited by 9 · see citing works

Modulating tyrosine sulfation of recombinant antibodies in CHO cell culture by host selection and sodium chlorate supplementation

Liu, R., Zhang, Y., Kumar, A., Huhn, S. C., Hullinger, L., & Du, Z. (2021) · Biotechnology Journal · doi:10.1002/biot.202100142 · Cited by 9 · see citing works

A high‐fidelity, dual site‐specific integration system in CHO cells by a Bxb1 recombinase

Xu, Y., Crowe, K. B., Lieske, P. L., Barnes, M. R., Bandara, K., Chu, J., Wei, W., Scarcelli, J. J., & Zhang, L. (2024) · Biotechnology Journal · doi:10.1002/biot.202300410 · Cited by 8 · see citing works

Large-scale transcriptomics analysis reveals a novel stress biomarker in CHO cells producing difficult to express mAbs

Papadaki, S., Tournaviti, S., Borth, N., Großkopf, T., Popp, O., Chung, S.-H., & Quaiser, T. (2025) · Scientific Reports · doi:10.1038/s41598-025-89667-w · Cited by 8 · see citing works

Glycoengineering of the hepatitis C virus E2 glycoprotein improves biochemical properties and enhances immunogenicity

Kulakova, L., Li, K. H., Chiang, A. W. T., Schwoerer, M. P., Suzuki, S., Schoffelen, S., Elkholy, K. H., Chao, K. L., Shahid, S., Kumar, B., et al. (2025) · npj Vaccines · doi:10.1038/s41541-025-01161-6 · Cited by 8 · see citing works

Endogenous p21-Dependent Transgene Control for CHO Cell Engineering

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Next-generation sequencing: A powerful multi-purpose tool in cell line development for biologics production

Grassi, L., Harris, C. L., Zhu, J., Hatton, D., & Dunn, S. (2025) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2025.04.006 · Cited by 7 · see citing works

Multiplexed clonality verification of cell lines for protein biologic production

O’Brien, S. A., Ojha, J., Wu, P. Y. K., & Hu, W. (2020) · Biotechnology Progress · doi:10.1002/btpr.2978 · Cited by 7 · see citing works

The microRNomes of Chinese hamster ovary (CHO) cells and their extracellular vesicles, and how they respond to osmotic and ammonia stress

Belliveau, J., & Papoutsakis, E. T. (2023) · Biotechnology and Bioengineering · doi:10.1002/bit.28356 · Cited by 6 · see citing works

Molecular biomarkers identification and applications in CHO bioprocessing

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Fantastic genes and where to find them expressed in CHO

Riedl, M., Ruggeri, C., Marx, N., & Borth, N. (2025) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2025.03.050 · Cited by 5 · see citing works

Genome sequence comparison between Chinese hamster ovary (CHO) DG44 cells and mouse using end sequences of CHO BAC clones based on BAC-FISH results

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Recent developments in miRNA based recombinant protein expression in CHO

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Quantitative proteomics reveals cellular responses to individual mAb expression and tunicamycin in CHO cells

Sulaj, E., Schwaigerlehner, L., Sandell, F. L., Dohm, J. C., Marzban, G., & Kunert, R. (2024) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-024-13223-1 · Cited by 4 · see citing works

Rapid Antibody Glycoengineering in CHO Cells Via RNA Interference and CGE-LIF N-Glycomics

Kotidis, P., Marbiah, M. M., Donini, R., Gómez, I. A., del Val, I. J., Haslam, S. M., Polizzi, K. M., & Kontoravdi, C. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1685-7_7 · Cited by 4 · see citing works

An Omic’s Data-Driven Approach Towards Engineering Mammalian Cell Factories and Bioprocesses for Biopharmaceutical Production

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La bioproduction des anticorps monoclonaux

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Pooled analysis of radiation hybrids identifies loci for growth and drug action in mammalian cellsPreprint

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Deciphering the determinants of recombinant protein yield across the human secretomePreprint

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EvalDNA: a machine learning-based tool for the comprehensive evaluation of mammalian genome assembly quality

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Cost-Effective Mapping of Genetic Interactions in Mammalian Cells

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Understanding the transcriptional response to ER stress in Chinese hamster ovary cells using multiplexed single cell RNA-seqPreprint

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Enhancing CHO by Systems Biotechnology

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Pyro: A Comprehensive Pipeline for Eukaryotic Genome AssemblyPreprint

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The ‘Omics Revolution in CHO Biology: Roadmap to Improved CHO Productivity

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MemorySeq identifies heritable epigenetic phenotypes that initiate cell culture stress tolerance in CHO cells

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Restoration of deficient DNA Repair Genes Mitigates Genome Instability and Increases Productivity of Chinese Hamster Ovary CellsPreprint

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AI-Driven Insights into the complexities of Chinese hamster ovary cells death in order to optimize production processesPreprint

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Genomic Analysis And Engineering Of Chinese Hamster Ovary Cells For Improved Therapeutic Protein Production

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Heritable non-genetic phenotypes are enriched for stress responses as a form of bet hedgingPreprint

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Quantifying structural variants in chromosomes using landmark-based disparityPreprint

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Database Chemistry for Genomics-Based Safety and Quality Evaluation of BiologicsPreprint

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Glycoengineering of the hepatitis C virus E2 glycoprotein leads to improved biochemical properties and enhanced immunogenicityPreprint

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Endogenous Retrovirus‐Like Particle‐Deficient CHO Cells Can be Generated by CRISPR or shRNA and Enriched Based on Cell‐Surface Expression of Retroviral Envelope Protein

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Additional file 1 of EvalDNA: a machine learning-based tool for the comprehensive evaluation of mammalian genome assembly quality

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Genome-Scale Big Data boostet die Produktion von Biotherapeutika

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Chinese hamster genome sequenced from sorted chromosomes

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