Arnsten, Amy F.T.

Hypothesis: Tau pathology is an initiating factor in sporadic Alzheimer's disease

Arnsten, A. F. T., Datta, D., Del Tredici, K., & Braak, H. (2021) · Alzheimer's & Dementia

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 361

The biology of being frazzled

Arnsten, A. F. T. (1998) · Science

Stress Responses and CortisolNeural and Behavioral Psychology Studies

Cited by 341

Selective prefrontal cortical projections to the region of the locus coeruleus and raphe nuclei in the rhesus monkey

Arnsten, A. F. T., & Goldman-Rakic, P. S. (1984) · Brain Research

Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Cited by 333

Protein kinase C overactivity impairs prefrontal cortical regulation of working memory

Birnbaum, S. G., Yuan, P. X., Wang, M., Vijayraghavan, S., Bloom, A. K., Davis, D. J., Gobeske, K. T., Sweatt, J. D., Manji, H. K., & Arnsten, A. F. T. (2004) · Science

Neural and Behavioral Psychology StudiesNeuroscience and Neuropharmacology Research

Cited by 318

An Open Trial of Guanfacine in the Treatment of Attention-Deficit Hyperactivity Disorder

Hunt, R. D., Arnsten, A. F. T., & Asbell, M. D. (1995) · Journal of the American Academy of Child & Adolescent Psychiatry

Attention Deficit Hyperactivity DisorderBehavioral and Psychological Studies

Cited by 308

In vivo measurement of widespread synaptic loss in Alzheimer’s disease with SV2A PET

Mecca, A. P., Chen, M., O'Dell, R. S., Naganawa, M., Toyonaga, T., Godek, T. A., Harris, J. E., Bartlett, H. H., Zhao, W., Nabulsi, N. B., et al. (2020) · Alzheimer's & Dementia

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 288

Dose-Dependent Effects of the Dopamine D1 Receptor Agonists A77636 or SKF81297 On Spatial Working Memory in Aged Monkeys

Cai, J. X., & Arnsten, A. F. T. (1997) · The Journal of Pharmacology and Experimental Therapeutics

Neurotransmitter Receptor Influence on BehaviorSchizophrenia research and treatment

Cited by 285

A role for norepinephrine in stress-induced cognitive deficits: α-1-adrenoceptor mediation in the prefrontal cortex

Birnbaum, S., Gobeske, K. T., Auerbach, J., Taylor, J. R., & Arnsten, A. F. T. (1999) · Biological Psychiatry

Neurotransmitter Receptor Influence on BehaviorStress Responses and Cortisol

Cited by 281

Neuronal Mechanisms Underlying Attention Deficit Hyperactivity Disorder: The Influence of Arousal on Prefrontal Cortical Function

Brennan, A. R., & Arnsten, A. F. T. (2008) · Annals of the New York Academy of Sciences

Attention Deficit Hyperactivity DisorderNeurotransmitter Receptor Influence on Behavior

Cited by 267

Guanfacine treatment of comorbid attention-deficit hyperactivity disorder and Tourette's syndrome: preliminary clinical experience

CHAPPELL, P. B., RIDDLE, M. A., SCAHILL, L., LYNCH, K. A., SCHULTZ, R., ARNSTEN, A., LECKMAN, J. F., & COHEN, D. J. (1995) · Journal of the American Academy of Child & Adolescent Psychiatry

Obsessive-Compulsive Spectrum DisordersAttention Deficit Hyperactivity Disorder

Cited by 250

α-1 noradrenergic receptor stimulation impairs prefrontal cortical cognitive function

Arnsten, A. F. T., Mathew, R., Ubriani, R., Taylor, J. R., & Li, B.-M. (1999) · Biological Psychiatry

Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Cited by 245

Inhibition of protein kinase C signaling protects prefrontal cortex dendritic spines and cognition from the effects of chronic stress

Hains, A. B., Vu, M. A. T., Maciejewski, P. K., van Dyck, C. H., Gottron, M., & Arnsten, A. F. T. (2009) · Proceedings of the National Academy of Sciences

Neuroscience and Neuropharmacology ResearchStress Responses and Cortisol

Cited by 234

Methylphenidate and Atomoxetine Enhance Prefrontal Function Through α2-Adrenergic and Dopamine D1 Receptors

Gamo, N. J., Wang, M., & Arnsten, A. F. T. (2010) · Journal of the American Academy of Child & Adolescent Psychiatry

Attention Deficit Hyperactivity DisorderNeurotransmitter Receptor Influence on Behavior

Cited by 232

Through the looking glass: Differential noradenergic modulation of prefrontal cortical function

Arnsten, A. F. T. (2000) · Neural Plasticity

Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Cited by 229

ADHD and the Prefrontal Cortex

Arnsten, A. F. T. (2009) · The Journal of Pediatrics

Attention Deficit Hyperactivity DisorderNeurotransmitter Receptor Influence on Behavior

Cited by 220

Dysregulation of Protein Kinase A Signaling in the Aged Prefrontal Cortex

Ramos, B. P., Birnbaum, S. G., Lindenmayer, I., Newton, S. S., Duman, R. S., & Arnsten, A. F. T. (2003) · Neuron

Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Cited by 218

Estrogen mediates sex differences in stress-induced prefrontal cortex dysfunction

Shansky, R. M., Glavis-Bloom, C., Lerman, D., McRae, P., Benson, C., Miller, K., Cosand, L., Horvath, T. L., & Arnsten, A. F. T. (2004) · Molecular Psychiatry

Stress Responses and CortisolNeurotransmitter Receptor Influence on Behavior

Cited by 200

Catecholamine and second messenger influences on prefrontal cortical networks of “representational knowledge”: a rational bridge between genetics and the symptoms of mental illness

Arnsten, A. F. T. (2007) · Cerebral Cortex

Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Cited by 200

Nicotinic α7 receptors enhance NMDA cognitive circuits in dorsolateral prefrontal cortex

Yang, Y., Paspalas, C. D., Jin, L. E., Picciotto, M. R., Arnsten, A. F. T., & Wang, M. (2013) · Proceedings of the National Academy of Sciences

Nicotinic Acetylcholine Receptors StudyNeuroscience and Neuropharmacology Research

Cited by 188

Synaptic density and cognitive performance in Alzheimer's disease: A PET imaging study with [ 11 C]UCB‐J

Mecca, A. P., O'Dell, R. S., Sharp, E. S., Banks, E. R., Bartlett, H. H., Zhao, W., Lipior, S., Diepenbrock, N. G., Chen, M., Naganawa, M., et al. (2022) · Alzheimer's & Dementia

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 186

Mutation of the α2A-Adrenoceptor Impairs Working Memory Performance and Annuls Cognitive Enhancement by Guanfacine

Franowicz, J. S., Kessler, L. E., Borja, C. M. D., Kobilka, B. K., Limbird, L. E., & Arnsten, A. F. T. (2002) · The Journal of Neuroscience

Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Cited by 185

Alpha-2 adrenergic agonists decrease distractibility in aged monkeys performing the delayed response task

Arnsten, A. F. T., & Contant, T. A. (1992) · Psychopharmacology

Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Cited by 168

Dynamic network connectivity: a new form of neuroplasticity

Arnsten, A. F. T., Paspalas, C. D., Gamo, N. J., Yang, Y., & Wang, M. (2010) · Trends in Cognitive Sciences

Neuroscience and Neuropharmacology ResearchNeural dynamics and brain function

Cited by 160

Chronic Stress Weakens Connectivity in the Prefrontal Cortex: Architectural and Molecular Changes.

Woo, E., Sansing, L. H., Arnsten, A. F. T., & Datta, D. (2021) · Chronic Stress

Neuroscience and Neuropharmacology ResearchStress Responses and Cortisol

Cited by 159