Arnsten, Amy F.T.

Local infusion of an α-1 adrenergic agonist into the prefrontal cortex impairs spatial working memory performance in monkeys

Mao, Z.-M., Arnsten, A. F. T., & Li, B.-M. (1999) · Biological Psychiatry

Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology Studies

Cited by 156

Dopamine’s Actions in Primate Prefrontal Cortex: Challenges for Treating Cognitive Disorders

Arnsten, A. F. T., Wang, M., & Paspalas, C. D. (2015) · Pharmacological Reviews

Neurotransmitter Receptor Influence on BehaviorSchizophrenia research and treatment

Cited by 149

The beta-1 adrenergic antagonist, betaxolol, improves working memory performance in rats and monkeys

Ramos, B. P., Colgan, L., Nou, E., Ovadia, S., Wilson, S. R., & Arnsten, A. F. T. (2005) · Biological Psychiatry

Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology Studies

Cited by 147

The aged rhesus macaque manifests Braak stage III/IV Alzheimer's‐like pathology

Paspalas, C. D., Carlyle, B. C., Leslie, S., Preuss, T. M., Crimins, J. L., Huttner, A. J., van Dyck, C. H., Rosene, D. L., Nairn, A. C., & Arnsten, A. F. T. (2018) · Alzheimer's & Dementia

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 140

cAMP-PKA phosphorylation of tau confers risk for degeneration in aging association cortex

Carlyle, B. C., Nairn, A. C., Wang, M., Yang, Y., Jin, L. E., Simen, A. A., Ramos, B. P., Bordner, K. A., Craft, G. E., Davies, P., et al. (2014) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 139

Constellation of HCN Channels and cAMP Regulating Proteins in Dendritic Spines of the Primate Prefrontal Cortex: Potential Substrate for Working Memory Deficits in Schizophrenia

Paspalas, C. D., Wang, M., & Arnsten, A. F. T. (2013) · Cerebral Cortex

Neuroscience and Neuropharmacology ResearchSchizophrenia research and treatment

Cited by 136

Molecular mechanisms of stress-induced prefrontal cortical impairment: Implications for mental illness

Hains, A. B., & Arnsten, A. F. T. (2008) · Learning & Memory

Neurotransmitter Receptor Influence on BehaviorSchizophrenia research and treatment

Cited by 127

α2A-adrenoceptor stimulation improves prefrontal cortical regulation of behavior through inhibition of cAMP signaling in aging animals

Ramos, B. P., Stark, D., Verduzco, L., van Dyck, C. H., & Arnsten, A. F. T. (2006) · Learning & Memory

Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Cited by 124

Activation of cAMP-Dependent Protein Kinase A in Prefrontal Cortex Impairs Working Memory Performance

Taylor, J. R., Birnbaum, S., Ubriani, R., & Arnsten, A. F. T. (1999) · The Journal of Neuroscience

Memory and Neural MechanismsNeuroscience and Neuropharmacology Research

Cited by 120

The effects of sex and hormonal status on restraint-stress-induced working memory impairment

Shansky, R. M., Rubinow, K., Brennan, A., & Arnsten, A. F. (2006) · Behavioral and Brain Functions

Stress Responses and CortisolNeurotransmitter Receptor Influence on Behavior

Cited by 107

Genetic Variants of Nogo-66 Receptor with Possible Association to Schizophrenia Block Myelin Inhibition of Axon Growth

Budel, S., Padukkavidana, T., Liu, B. P., Feng, Z., Hu, F., Johnson, S., Lauren, J., Park, J. H., McGee, A. W., Liao, J., et al. (2008) · The Journal of Neuroscience

Schizophrenia research and treatmentNeurotransmitter Receptor Influence on Behavior

Cited by 107

Psychostimulants and motivated behavior: Arousal and cognition

Berridge, C. W., & Arnsten, A. F. T. (2013) · Neuroscience & Biobehavioral Reviews

Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology Studies

Cited by 104

Stress Impairs Prefrontal Cortical Function via D1 Dopamine Receptor Interactions With Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels

Gamo, N. J., Lur, G., Higley, M. J., Wang, M., Paspalas, C. D., Vijayraghavan, S., Yang, Y., Ramos, B. P., Peng, K., Kata, A., et al. (2015) · Biological Psychiatry

Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Cited by 97

Locomotor hyperactivity induced by blockade of prefrontal cortical α2-adrenoceptors in monkeys

Ma, C.-L., Arnsten, A. F. T., & Li, B.-M. (2005) · Biological Psychiatry

Neurotransmitter Receptor Influence on BehaviorAttention Deficit Hyperactivity Disorder

Cited by 96

The α-2A noradrenergic receptor agonist guanfacine improves visual object discrimination reversal performance in aged rhesus monkeys.

Steere, J. C., & Arnsten, A. F. T. (1997) · Behavioral Neuroscience

Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology Studies

Cited by 94

The Neurobiology of Thought: The Groundbreaking Discoveries of Patricia Goldman-Rakic 1937-2003

Arnsten, A. F. T. (2013) · Cerebral Cortex

Neural and Behavioral Psychology StudiesNeurology and Historical Studies

Cited by 94

Analysis of alpha-2 adrenergic agonist effects on the delayed nonmatch-to-sample performance of aged rhesus monkeys

Arnsten, A. F. T., & Goldman-Rakic, P. S. (1990) · Neurobiology of Aging

Neurotransmitter Receptor Influence on BehaviorCognitive Abilities and Testing

Cited by 88

The alpha-1 adrenergic agonist, cirazoline, impairs spatial working memory performance in aged monkeys

Arnsten, A. F. T., & Jentsch, J. D. (1997) · Pharmacology Biochemistry and Behavior

Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Cited by 85

Noradrenergic alpha-2 receptor agonists reverse working memory deficits induced by the anxiogenic drug, FG7142, in rats

Birnbaum, S. G., Podell, D. M., & Arnsten, A. F. T. (2000) · Pharmacology Biochemistry and Behavior

Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Cited by 81

Muscarinic M1 Receptors Modulate Working Memory Performance and Activity via KCNQ Potassium Channels in the Primate Prefrontal Cortex

Galvin, V. C., Yang, S. T., Paspalas, C. D., Yang, Y., Jin, L. E., Datta, D., Morozov, Y. M., Lightbourne, T. C., Lowet, A. S., Rakic, P., et al. (2020) · Neuron

Neuroscience and Neuropharmacology ResearchIon channel regulation and function

Cited by 79

Loss of prefrontal cortical higher cognition with uncontrollable stress: molecular mechanisms, changes with age, and relevance to treatment

Datta, D., & Arnsten, A. (2019) · Brain Sciences

Stress Responses and CortisolNeurotransmitter Receptor Influence on Behavior

Cited by 78

Classical complement cascade initiating C1q protein within neurons in the aged rhesus macaque dorsolateral prefrontal cortex

Datta, D., Leslie, S. N., Morozov, Y. M., Duque, A., Rakic, P., van Dyck, C. H., Nairn, A. C., & Arnsten, A. F. T. (2020) · Journal of Neuroinflammation

Complement system in diseasesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 76

A translational investigation targeting stress-reactivity and prefrontal cognitive control with guanfacine for smoking cessation

McKee, S. A., Potenza, M. N., Kober, H., Sofuoglu, M., Arnsten, A. F., Picciotto, M. R., Weinberger, A. H., Ashare, R., & Sinha, R. (2015) · Journal of Psychopharmacology

Smoking Behavior and CessationSubstance Abuse Treatment and Outcomes

Cited by 75

Guanfacine’s mechanism of action in treating prefrontal cortical disorders: Successful translation across species

Arnsten, A. F. T. (2020) · Neurobiology of Learning and Memory

Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Cited by 75