Locomotor hyperactivity induced by blockade of prefrontal cortical α2-adrenoceptors in monkeys
Abstract
Background Stimulation of alpha(2)-adrenergic receptors (alpha(2)-ARs) in the prefrontal cortex (PFC) has a beneficial effect on working memory and attentional regulation in monkeys. alpha(2)-adrenergic agonists like clonidine and guanfacine have been used experimentally and clinically for the treatment of attention deficit and hyperactivity disorder (ADHD). However, it is unknown if alpha(2)-ARs in the PFC are involved in the neural mechanisms underlying regulation of locomotor activity. Methods The alpha(2)-adrenergic antagonist yohimbine was infused bilaterally and chronically into the dorsolateral PFC (dlPFC) in two monkeys, using mini-osmotic pumps. Spontaneous locomotor activity was measured continuously before, during and after drug administration, using an activity monitor. Results The monkeys exhibited a dramatic increase in motoric activity during infusion of yohimbine into the dlPFC. Similar treatment with saline was without effect. Thus, the locomotor hyperactivity was due to blockade of alpha(2)-ARs, not because of nonspecific factors such as cortical damage by drug administration. Conclusions The present study suggests that alpha(2)-ARs in the dlPFC are involved in inhibitory control of locomotor activity.
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Blockade of α2 receptors selectively within the monkey PFC can recreate many of the key symptoms of ADHD.
“Importantly, blockade of α2 receptors selectively within the monkey PFC can recreate many of the key symptoms of ADHD.”
From Catecholamine Influences on Dorsolateral Prefrontal Cortical Networks (2011) · cites this paper as [68]
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The Cellular Mechanisms of Executive Functions and Working Memory
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- Authors
- Ma, C.-L., Arnsten, A. F. T., & Li, B.-M.
- Affiliations
- Yale University (US)
- Fudan University (CN)
- Corresponding author
- Li, Bao-Ming
- ORCID
- Arnsten, Amy F.T.
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2005-01
- Volume
- 57
- Issue
- 2
- Pages
- 192-195
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W1967694983
- Cited by
- 96
- References
- 28
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 2 · 2022: 5 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 4 · 2017: 6 · 2016: 4 · 2015: 7 · 2014: 4 · 2013: 4 · 2012: 4
- FWCI
- 3.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- alpha2-adrenoceptors, prefrontal cortex, dorsolateral prefrontal cortex, yohimbine, locomotor hyperactivity, locomotor inhibition, attention deficit hyperactivity disorder, clonidine, guanfacine, spontaneous motor activity, non-human primates
- MeSH terms
- Adrenergic alpha-Antagonists, Animals, Drug Administration Schedule, Female, Hyperkinesis, Macaca mulatta, Microinjections, Motor Activity, Yohimbine, Prefrontal Cortex, Receptors, Adrenergic, alpha-2, Adrenergic alpha-2 Receptor Antagonists
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