B cells and aging: molecules and mechanisms

Cancro, Michael P.; Hao, Yi; Scholz, Jean L.; Riley, Richard L.; Frasca, Daniela; Dunn-Walters, Deborah K.; Blomberg, Bonnie B.

doi:10.1016/j.it.2009.04.005

Cited by 198T-cell and B-cell ImmunologyImmune responses and vaccinationsGenetics, Aging, and Longevity in Model Organisms

B cells and aging: molecules and mechanisms

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Cancro, Michael P., Hao, Yi, Scholz, Jean L., Riley, Richard L., Frasca, Daniela, Dunn-Walters, Deborah K., Blomberg, Bonnie B.·2009·Trends in Immunology

DOI 10.1016/j.it.2009.04.005PMC PMC2766868

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Abstract

Recent advances allow aging-associated changes in B-cell function to be approached at a mechanistic level. Reduced expression of genes crucial to lineage commitment and differentiation yield diminished B-cell production. Moreover, intrinsic differences in the repertoire generated by B-cell precursors in aged individuals, coupled with falling B-cell generation rates and life-long homeostatic competition, result in narrowed clonotypic diversity. Similarly, reductions in gene products crucial for immunoglobulin class switch recombination and somatic hypermutation impact the efficacy of humoral immune responses. Together, these findings set the stage for integrated analyses of how age-related changes at the molecular, cellular and population levels interact to yield the overall aging phenotype.

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During ageing, remodelling of peripheral B cell subsets occurs with a decline in B cell production in the bone marrow and expansion of atypical B cell subsets such as ABCs and DN B cells.
“During ageing, a remodelling of peripheral B cell subsets occurs with a decline in B cell production in the bone marrow and the expansion of atypical B cell subsets, such as age-associated B cells (ABCs) and double-negative (DN) B cells.”
From Is there a role for B cells in Alzheimer's disease? (2026) · cites this paper as [65]
The sections “B-cell production wanes with age” and “Homeostatic relationships shift with age” report reduced bone-marrow B-cell output and age-related changes in mature B-cell subsets. They discuss B1 and marginal-zone B cells, but do not identify an expansion of age-associated B cells (ABCs) or double-negative (DN) B cells. Page numbers are unavailable in our copy. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Advancing age is accompanied by profound qualitative changes in the peripheral B cell repertoire with reduced clonotypic diversity and a shift towards autoreactive specificities.
“Advancing age is accompanied by profound qualitative changes in the peripheral B cell repertoire with reduced clonotypic diversity and a shift towards autoreactive specificities [65 -68].”
From Is there a role for B cells in Alzheimer's disease? (2026) · cites this paper as [65]
The “BCR diversity truncates with age” section reports a significant loss of peripheral-blood B-cell diversity in some older subjects, not all older people. “Homeostatic relationships shift with age” says autoreactive cells might enter the primary repertoire and notes age-associated autoreactive antibodies in mouse strains, but it does not establish a general shift of the peripheral B-cell repertoire toward autoreactive specificities. (LLM, conf=0.86)
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Understanding immunosenescence to improve responses to vaccines
Goronzy, J. J., & Weyand, C. M. (2013) · Nature Immunology · doi:10.1038/ni.2588 · Cited by 827 · see citing works
A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice
Hao, Y., O'Neill, P., Naradikian, M. S., Scholz, J. L., & Cancro, M. P. (2011) · Blood · doi:10.1182/blood-2011-01-330530 · Cited by 622 · see citing works
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The ageing haematopoietic stem cell compartment
Geiger, H., de Haan, G., & Florian, M. C. (2013) · Nature Reviews Immunology · doi:10.1038/nri3433 · Cited by 604 · see citing works
Immunosenescence: a key player in cancer development
Lian, J., Yue, Y., Yu, W., & Zhang, Y. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00986-z · Cited by 510 · see citing works
Can physical activity ameliorate immunosenescence and thereby reduce age-related multi-morbidity?
Duggal, N. A., Niemiro, G., Harridge, S. D. R., Simpson, R. J., & Lord, J. M. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0177-9 · Cited by 436 · see citing works
Anti-Aging Implications of Astragalus Membranaceus (Huangqi): A Well-Known Chinese Tonic
Liu, P., Zhao, H., & Luo, Y. (2017) · Aging and Disease · doi:10.14336/ad.2017.0816 · Cited by 348 · see citing works
Aging and Immune Function: Molecular Mechanisms to Interventions
Ponnappan, S., & Ponnappan, U. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3228 · Cited by 339 · see citing works
Interconnections between Inflammageing and Immunosenescence during Ageing
Teissier, T., Boulanger, É., & Cox, L. S. (2022) · Cells · doi:10.3390/cells11030359 · Cited by 310 · see citing works
Limited efficacy of inactivated influenza vaccine in elderly individuals is associated with decreased production of vaccine-specific antibodies
Sasaki, S., Sullivan, M., Narvaez, C. F., Holmes, T. H., Furman, D., Zheng, N.-Y., Nishtala, M., Wrammert, J., Smith, K., James, J. A., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57834 · Cited by 300 · see citing works
The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of “inflame-aging”
Meftahi, G. H., Jangravi, Z., Sahraei, H., & Bahari, Z. (2020) · Inflammation Research · doi:10.1007/s00011-020-01372-8 · Cited by 289 · see citing works
Aging, inflammation, immunity and periodontal disease
Ebersole, J. L., Graves, C. L., González, O. A., Dawson, D. R., Morford, L. A., Emecen‐Huja, P., Hartsfield, J. K., Huja, S. S., Pandruvada, S. N. M., & Wallet, S. M. (2016) · Periodontology 2000 · doi:10.1111/prd.12135 · Cited by 308 · see citing works
Advanced Age Impairs Macrophage Polarization
Mahbub, S., Deburghgraeve, C. R., & Kovacs, E. J. (2012) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2011.0058 · Cited by 222 · see citing works
B cells lacking the tumor suppressor TNFAIP3/A20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice
Chu, Y., Vahl, J. C., Kumar, D., Heger, K., Bertossi, A., Wojtowicz, E. E., Soberon, V., Schenten, D., Mack, B., Reutelshöfer, M., et al. (2010) · Blood · doi:10.1182/blood-2010-09-306019 · Cited by 191 · see citing works
In senescence, age‐associated B cells secrete TNF α and inhibit survival of B‐cell precursors*
Ratliff, M., Alter, S., Frasca, D., Blomberg, B. B., & Riley, R. L. (2013) · Aging Cell · doi:10.1111/acel.12055 · Cited by 183 · see citing works
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Influenza Virus Vaccination Elicits Poorly Adapted B Cell Responses in Elderly Individuals
Henry, C., Zheng, N., Huang, M., Cabanov, A., Rojas, K. T., Kaur, K., Andrews, S. F., Palm, A.-K. E., Chen, Y.-Q., Li, Y., et al. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.01.002 · Cited by 142 · see citing works
Immunosenescence: the potential role of myeloid-derived suppressor cells (MDSC) in age-related immune deficiency
Salminen, A., Kaarniranta, K., & Kauppinen, A. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03048-x · Cited by 156 · see citing works
Vaccination‐induced changes in human B‐cell repertoire and pneumococcal IgM and IgA antibody at different ages
Ademokun, A., Wu, Y., Martin, V., Mitra, R., Sack, U., Baxendale, H., Kipling, D., & Dunn‐Walters, D. K. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00732.x · Cited by 139 · see citing works
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Leukocyte function in the aging immune system
Desai, A., Grolleau‐Julius, A., & Yung, R. L. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.0809542 · Cited by 141 · see citing works
Immunosenescence: A systems-level overview of immune cell biology and strategies for improving vaccine responses
Crooke, S. N., Ovsyannikova, I. G., Poland, G. A., & Kennedy, R. B. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110632 · Cited by 143 · see citing works
Role of inflammation in the aging bones
Abdelmagid, S. M., Barbe, M. F., & Safadi, F. F. (2015) · Life Sciences · doi:10.1016/j.lfs.2014.11.011 · Cited by 134 · see citing works
Heterogeneity and longevity of antibody memory to viruses and vaccines
Antia, A., Ahmed, H., Handel, A., Carlson, N. E., Amanna, I. J., Antia, R., & Slifka, M. (2018) · PLOS Biology · doi:10.1371/journal.pbio.2006601 · Cited by 123 · see citing works
B cells and immunosenescence: A focus on IgG+IgD−CD27− (DN) B cells in aged humans
Bulati, M., Buffa, S., Candore, G., Caruso, C., Dunn‐Walters, D. K., Pellicanò, M., Wu, Y.-C. B., & Romano, G. C. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.12.002 · Cited by 121 · see citing works
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Cytomegalovirus (CMV) seropositivity decreases B cell responses to the influenza vaccine
Frasca, D., Diaz, A., Romero, M., Landin, A. M., & Blomberg, B. B. (2015) · Vaccine · doi:10.1016/j.vaccine.2015.01.071 · Cited by 116 · see citing works
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From lymphopoiesis to plasma cells differentiation, the age-related modifications of B cell compartment are influenced by “inflamm-ageing”
Bulati, M., Caruso, C., & Colonna‐Romano, G. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.04.001 · Cited by 113 · see citing works
B cell immunosenescence: different features of naive and memory B cells in elderly
Buffa, S., Bulati, M., Pellicanò, M., Dunn‐Walters, D. K., Wu, Y.-C. B., Candore, G., Vitello, S., Caruso, C., & Colonna‐Romano, G. (2011) · Biogerontology · doi:10.1007/s10522-011-9353-4 · Cited by 104 · see citing works
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Signal inhibition by the dual-specific phosphatase 4 impairs T cell-dependent B-cell responses with age
Yu, M., Li, G., Lee, W.-W., Yuan, M., Cui, D., Weyand, C. M., & Goronzy, J. J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1109797109 · Cited by 102 · see citing works
An age-related numerical and functional deficit in CD19+CD24hiCD38hi B cells is associated with an increase in systemic autoimmunity
Duggal, N. A., Upton, J., Phillips, A. C., Sapey, E., & Lord, J. (2013) · Aging Cell · doi:10.1111/acel.12114 · Cited by 110 · see citing works
Vaccinomics and a New Paradigm for the Development of Preventive Vaccines Against Viral Infections
Poland, G. A., Ovsyannikova, I. G., Kennedy, R. B., Haralambieva, I. H., & Jacobson, R. M. (2011) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2011.0032 · Cited by 95 · see citing works
Immunosenescence of Polymorphonuclear Neutrophils
Weßels, I., Jansen, J., Rink, L., & Uciechowski, P. (2010) · The Scientific World JOURNAL · doi:10.1100/tsw.2010.14 · Cited by 89 · see citing works
Age Affects Quantity but Not Quality of Antibody Responses after Vaccination with an Inactivated Flavivirus Vaccine against Tick-Borne Encephalitis
Stiasny, K., Aberle, J. H., Keller, M., Grubeck‐Loebenstein, B., & Heinz, F. X. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034145 · Cited by 88 · see citing works
Increased cardiovascular and atherosclerosis markers in blood of older patients with atopic dermatitis
He, H., Li, R., Choi, S., Zhou, L., Pavel, A. B., Estrada, Y. D., Krueger, J. G., & Guttman‐Yassky, E. (2019) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2019.10.013 · Cited by 87 · see citing works
Aging affects B‐cell antigen receptor repertoire diversity in primary and secondary lymphoid tissues
Tabibian‐Keissar, H., Hazanov, L., Schiby, G., Rosenthal, N., Rakovsky, A., Michaeli, M., Shahaf, G. L., Pickman, Y., Rosenblatt, K., Melamed, D., et al. (2016) · European Journal of Immunology · doi:10.1002/eji.201545586 · Cited by 84 · see citing works
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Plasma Cells, the Next Generation: Beyond Antibody Secretion
Pioli, P. D. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02768 · Cited by 87 · see citing works
Enteric pathogens through life stages
Kolling, G. L., Wu, M., & Guerrant, R. L. (2012) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2012.00114 · Cited by 80 · see citing works
Age‐related differences in the immune response could contribute to determine the spectrum of severity of COVID‐19
Costagliola, G., Spada, E., & Consolini, R. (2021) · Immunity, Inflammation and Disease · doi:10.1002/iid3.404 · Cited by 81 · see citing works
A novel B cell population revealed by a CD38/CD24 gating strategy: CD38−CD24− B cells in centenarian offspring and elderly people
Buffa, S., Pellicanò, M., Bulati, M., Martorana, A., Goldeck, D., Caruso, C., Pawelec, G., & Colonna‐Romano, G. (2012) · AGE · doi:10.1007/s11357-012-9488-5 · Cited by 83 · see citing works
The Impact of Immunosenescence on Humoral Immune Response Variation after Influenza A/H1N1 Vaccination in Older Subjects
Haralambieva, I. H., Painter, S. D., Kennedy, R. B., Ovsyannikova, I. G., Lambert, N. D., Goergen, K. M., Oberg, A. L., & Poland, G. A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122282 · Cited by 75 · see citing works
Hind limb unloading, a model of spaceflight conditions, leads to decreased B lymphopoiesis similar to aging
Lescale, C., Schenten, V., Djeghloul, D., Bennabi, M., Gaignier, F., Vandamme, K., Strazielle, C., Kuzniak, I., Petite, H., Dosquet, C., et al. (2014) · The FASEB Journal · doi:10.1096/fj.14-259770 · Cited by 73 · see citing works
Role of Peripheral Immune Cells-Mediated Inflammation on the Process of Neurodegenerative Diseases
Yang, Q., Wang, G., & Zhang, F. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.582825 · Cited by 71 · see citing works
The aging bone marrow and its impact on immune responses in old age
Pritz, T., Weinberger, B., & Grubeck‐Loebenstein, B. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.06.016 · Cited by 71 · see citing works
Donkey and Goat Milk Intake and Modulation of the Human Aged Immune Response
Amati, L., Marzulli, G., Martulli, M., Tafaro, A., Jirillo, F., Pugliese, V., Martemucci, G., D‘Alessandro, A. G., & Jirillo, E. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210790883651 · Cited by 66 · see citing works
Immunosenescence, Aging, and Systemic Lupus Erythematous
Montoya-Ortiz, G. (2013) · Autoimmune Diseases · doi:10.1155/2013/267078 · Cited by 65 · see citing works
Ageing and immunity
Boraschi, D., Giudice, G. D., Dutel, C., Ivanoff, B., Rappuoli, R., & Grubeck‐Loebenstein, B. (2010) · Vaccine · doi:10.1016/j.vaccine.2010.03.035 · Cited by 64 · see citing works
Immunosenescence and organ transplantation
Heinbokel, T., Elkhal, A., Liu, G., Edtinger, K., & Tullius, S. G. (2013) · Transplantation Reviews · doi:10.1016/j.trre.2013.03.001 · Cited by 63 · see citing works
Immune senescence: significance of the stromal microenvironment
Masters, A. R., Haynes, L., Su, D.-M., & Palmer, D. B. (2016) · Clinical & Experimental Immunology · doi:10.1111/cei.12851 · Cited by 63 · see citing works
Kidney transplantation and the ageing immune system
McKay, D. B., & Jameson, J. (2012) · Nature Reviews Nephrology · doi:10.1038/nrneph.2012.242 · Cited by 61 · see citing works
Aging impacts isolated lymphoid follicle development and function
McDonald, K. G., Leach, M. R., Huang, C. C., Wang, C., & Newberry, R. D. (2011) · Immunity & Ageing · doi:10.1186/1742-4933-8-1 · Cited by 60 · see citing works
Disorganization of the splenic microanatomy in ageing mice
Aw, D., Hilliard, L., Nishikawa, Y., Cadman, E. T., Lawrence, R. A., & Palmer, D. B. (2016) · Immunology · doi:10.1111/imm.12590 · Cited by 58 · see citing works
Age-associated B cells (ABC) inhibit B lymphopoiesis and alter antibody repertoires in old age
Riley, R. L., Khomtchouk, K. M., & Blomberg, B. B. (2017) · Cellular Immunology · doi:10.1016/j.cellimm.2017.04.008 · Cited by 56 · see citing works
Self-citation
Genetics of longevity. Data from the studies on Sicilian centenarians
Balistreri, C. R., Candore, G., Accardi, G., Bova, M., Buffa, S., Bulati, M., Forte, G. I., Listı̀, F., Martorana, A., Palmeri, M., et al. (2012) · Immunity & Ageing · doi:10.1186/1742-4933-9-8 · Cited by 56 · see citing works
Immunosenescence and Altered Vaccine Efficiency in Older Subjects: A Myth Difficult to Change
Fülöp, T., Larbi, A., Pawelec, G., Cohen, A. A., Provost, G., Khalil, A., Lacombe, G., Rodrigues, S., Desroches, M., Hirokawa, K., et al. (2022) · Vaccines · doi:10.3390/vaccines10040607 · Cited by 56 · see citing works
Impact of age and comorbidities on SARS-CoV-2 vaccine-induced T cell immunity
Dietz, L. L., Juhl, A. K., Søgaard, O. S., Reekie, J., Nielsen, H., Johansen, I. S., Benfield, T., Wiese, L., Stærke, N. B., Jensen, T. Ø., et al. (2023) · Communications Medicine · doi:10.1038/s43856-023-00277-x · Cited by 55 · see citing works
Do natural antibodies compensate for humoral immunosenescence in tropical pythons?
Újvári, B., & Madsen, T. R. L. (2011) · Functional Ecology · doi:10.1111/j.1365-2435.2011.01860.x · Cited by 53 · see citing works
Dysregulated TGF-β Production Underlies the Age-Related Vulnerability to Chikungunya Virus
Uhrlaub, J. L., Pulko, V., DeFilippis, V. R., Broeckel, R. M., Streblow, D. N., Coleman, G. D., Park, B. S., Lindo, J., Vickers, I. E., Anzinger, J. J., et al. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005891 · Cited by 54 · see citing works
Impact of immunosenescence on transplant outcome
Heinbokel, T., Hock, K., Liu, G., Edtinger, K., Elkhal, A., & Tullius, S. G. (2012) · Transplant International · doi:10.1111/tri.12013 · Cited by 49 · see citing works
Trafficking phenotype and production of granzyme B by double negative B cells (IgG+IgD−CD27−) in the elderly
Bulati, M., Buffa, S., Martorana, A., Candore, G., Lio, D., Caruso, C., & Colonna‐Romano, G. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2013.12.011 · Cited by 50 · see citing works
Mechanistic insights into the impairment of memory B cells and antibody production in the elderly
Aberle, J. H., Stiasny, K., Kundi, M., & Heinz, F. X. (2012) · AGE · doi:10.1007/s11357-011-9371-9 · Cited by 50 · see citing works
CD4 T cell defects in the aged: Causes, consequences and strategies to circumvent
Zhang, W., Brahmakshatriya, V., & Swain, S. L. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.01.002 · Cited by 49 · see citing works
Impaired B lymphopoiesis in old age: a role for inflammatory B cells?
Riley, R. L. (2013) · Immunologic Research · doi:10.1007/s12026-013-8444-5 · Cited by 48 · see citing works
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Double negative (CD19+IgG+IgD−CD27−) B lymphocytes: A new insight from telomerase in healthy elderly, in centenarian offspring and in Alzheimer's disease patients
Martorana, A., Balistreri, C. R., Bulati, M., Buffa, S., Azzarello, D. M., Camarda, C., Monastero, R., Caruso, C., & Colonna‐Romano, G. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.06.003 · Cited by 47 · see citing works
Immune senescence in aged nonhuman primates☆
Haberthur, K., Engelmann, F., Barron, A., & Messaoudi, I. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.06.001 · Cited by 44 · see citing works
Inflammaging: triggers, molecular mechanisms, immunological consequences, sex differences, and cutaneous manifestations
Karpuzoglu, E., Holladay, S. D., & Gogal, R. M. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1704203 · Cited by 43 · see citing works
Genome organization and chromatin analysis identify transcriptional downregulation of insulin-like growth factor signaling as a hallmark of aging in developing B cells
Koohy, H., Bolland, D. J., Matheson, L. S., Schoenfelder, S., Stellato, C., Dimond, A., Várnai, C., Chovanec, P., Chessa, T. A. M., Denizot, J., et al. (2018) · Genome biology · doi:10.1186/s13059-018-1489-y · Cited by 38 · see citing works
Effects of spaceflight on the immunoglobulin repertoire of unimmunized C57BL/6 mice
Ward, C., Rettig, T. A., Hlavacek, S., Bye, B. A., Pecaut, M. J., & Chapes, S. K. (2017) · Life Sciences in Space Research · doi:10.1016/j.lssr.2017.11.003 · Cited by 42 · see citing works
The Impact of the Microbiome on Immunosenescence
Amsterdam, D., & Ostrov, B. E. (2018) · Immunological Investigations · doi:10.1080/08820139.2018.1537570 · Cited by 40 · see citing works
Seropositivity in blood donors and pregnant women during the first year of SARS‐CoV‐2 transmission in Stockholm, Sweden
Dopico, X. C., Muschiol, S., Christian, M., Hanke, L., Sheward, D. J., Grinberg, N. F., Rorbach, J., Bogdanović, G., McInerney, G. M., Allander, T., et al. (2021) · Journal of Internal Medicine · doi:10.1111/joim.13304 · Cited by 36 · see citing works
Booster vaccination against tetanus and diphtheria: insufficient protection against diphtheria in young and elderly adults
Grasse, M., Meryk, A., Schirmer, M., Grubeck‐Loebenstein, B., & Weinberger, B. (2016) · Immunity & Ageing · doi:10.1186/s12979-016-0081-0 · Cited by 39 · see citing works
Immunoporosis: The hidden link between aging immune cells and bone fragility
Cheng, X., Chen, Y., Zhou, X.-C., Gu, Q.-L., Zhao, H., Wan, C., Chen, M.-M., Yang, H.-L., & Shi, Q. (2025) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2025.06.015 · Cited by 44 · see citing works
Increased IL-21 secretion by aged CD4+T cells is associated with prolonged STAT-4 activation and CMV seropositivity
Agrawal, A., Su, H., Chen, J., Osann, K., Agrawal, S., & Gupta, S. (2012) · Aging · doi:10.18632/aging.100490 · Cited by 35 · see citing works
The role of DNA methylation and hydroxymethylation in immunosenescence
Johnson, N. D., & Conneely, K. N. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.01.011 · Cited by 35 · see citing works
Immunosuppression Considerations for Older Kidney Transplant Recipients
Cheungpasitporn, W., Lentine, K. L., Tan, J. C., Kaufmann, M., Çalışkan, Y., Bunnapradist, S., Lam, N. N., Schnitzler, M. A., & Axelrod, D. A. (2021) · Current Transplantation Reports · doi:10.1007/s40472-021-00321-6 · Cited by 35 · see citing works
Immunoglobulin G glycans – Biomarkers and molecular effectors of aging
Krištić, J., Lauc, G., & Pezer, M. (2022) · Clinica Chimica Acta · doi:10.1016/j.cca.2022.08.006 · Cited by 34 · see citing works
Immune risk phenotype is associated with nosocomial lung infections in elderly in-patients
Plonquet, A., Bastuji‐Garin, S., Tahmasebi, F., Brisacier, C., Dudal, K. L., Farcet, J., & Paillaud, É. (2011) · Immunity & Ageing · doi:10.1186/1742-4933-8-8 · Cited by 33 · see citing works
The presence of CLL-associated stereotypic B cell receptors in the normal BCR repertoire from healthy individuals increases with age
Muggen, A. F., de Jong, M. M. E., Wolvers-Tettero, I. L. M., Kallemeijn, M. J., Teodósio, C., Darzentas, N., Stadhouders, R., IJspeert, H., van der Burg, M., van IJcken, W. F. J., et al. (2019) · Immunity & Ageing · doi:10.1186/s12979-019-0163-x · Cited by 32 · see citing works
Phenotype and functions of conventional dendritic cells are not compromised in aged mice
Tan, S., Cavanagh, L. L., d'Advigor, W., Shackel, N. A., Groth, B. F. D. S., & Weninger, W. (2012) · Immunology and Cell Biology · doi:10.1038/icb.2011.104 · Cited by 32 · see citing works
Cooperation between inhibitory immune checkpoints of senescent cells with immunosuppressive network to promote immunosenescence and the aging process
Salminen, A. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102694 · Cited by 33 · see citing works
Aging impairs murine B cell differentiation and function in primary and secondary lymphoid tissues.
Frasca, D., & Blomberg, B. B. (2011) · Europe PMC (PubMed Central) · Cited by 31 · see citing works
Self-citation
What’s new in asthma pathophysiology and immunopathology?
Orihara, K., Dil, N., Anaparti, V., & Moqbel, R. (2010) · Expert Review of Respiratory Medicine · doi:10.1586/ers.10.57 · Cited by 31 · see citing works
Clinical vaccine development for H5N1 influenza
Clegg, C. H., Rininger, J. A., & Baldwin, S. L. (2013) · Expert Review of Vaccines · doi:10.1586/14760584.2013.811178 · Cited by 31 · see citing works
Immune aging and infectious diseases
Chen, R., Zou, J., Chen, J., Wang, L., Kang, R., & Tang, D. (2024) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003410 · Cited by 33 · see citing works
Organoid Polymer Functionality and Mode of Klebsiella pneumoniae Membrane Antigen Presentation Regulates Ex Vivo Germinal Center Epigenetics in Young and Aged B Cells
Graney, P. L., Lai, K., Post, S. E., Brito, I., Cyster, J. G., & Singh, A. K. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202001232 · Cited by 30 · see citing works
Age-related epigenome-wide DNA methylation and hydroxymethylation in longitudinal mouse blood
Kochmanski, J. J., Marchlewicz, E. H., Cavalcante, R. G., Sartor, M. A., & Dolinoy, D. C. (2018) · Epigenetics · doi:10.1080/15592294.2018.1507198 · Cited by 29 · see citing works
Combination of the Probiotics Lacticaseibacillus rhamnosus GG and Bifidobacterium animalis subsp. lactis, BB-12 Has Limited Effect on Biomarkers of Immunity and Inflammation in Older People Resident in Care Homes: Results From the Probiotics to Reduce Infections iN CarE home reSidentS Randomized, Controlled Trial
Herrera, V. M. C., Fisk, H. L., Wootton, M., Lown, M. T., Owen-Jones, E., Lau, M., Lowe, R., Hood, K., Gillespie, D., Hobbs, R. F., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.643321 · Cited by 30 · see citing works
Immunosenescence and gender: a study in healthy Cubans
Verdecia, B. G., Hernández, D. S., Lorenzo-Luaces, P., Badia, T., Rupalé, I. L., Mazorra, Z., Crombet, T., & Dávila, A. L. (2013) · Immunity & Ageing · doi:10.1186/1742-4933-10-16 · Cited by 27 · see citing works
Let-7 as a Promising Target in Aging and Aging-Related Diseases: A Promise or a Pledge
Wang, Y., Zhao, J., Chen, S., Li, D., Yang, J., Zhao, X., Qin, M., Guo, M., Chen, C., He, Z., et al. (2022) · Biomolecules · doi:10.3390/biom12081070 · Cited by 35 · see citing works
Immunopathology and Immunosenescence, the Immunological Key Words of Severe COVID-19. Is There a Role for Stem Cell Transplantation?
Ligotti, M. E., Pojero, F., Accardi, G., Aiello, A., Caruso, C., Duro, G., & Candore, G. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.725606 · Cited by 25 · see citing works
Efficacy of Disease Modifying Therapies in Progressive MS and How Immune Senescence May Explain Their Failure
Manouchehri, N., Salinas, V. H., Yeganeh, N. R., Pitt, D., Hussain, R. Z., & Stüve, O. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.854390 · Cited by 26 · see citing works
T Cell–Expressed microRNA-155 Reduces Lifespan in a Mouse Model of Age-Related Chronic Inflammation
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Authors: Cancro, M. P., Hao, Y., Scholz, J. L., Riley, R. L., Frasca, D., Dunn-Walters, D. K., & Blomberg, B. B.
Affiliations: University of Pennsylvania (US)
University of Miami (US)
Corresponding author: Cancro, Michael P.
ORCID: Cancro, Michael P.
Hao, Yi
Scholz, Jean L.
Frasca, Daniela
Blomberg, Bonnie B.
Venue: Trends in Immunology
Publisher: Elsevier BV
Published: 2009-07
Volume: 30
Issue: 7
Pages: 313-318
ISSN: 1471-4906 (ISSN-L)
DOI: 10.1016/j.it.2009.04.005
PMC: PMC2766868
OpenAlex: W2013273227
Cited by: 198
References: 79
Citations by year: 2026: 10 · 2025: 10 · 2024: 6 · 2023: 7 · 2022: 8 · 2021: 18 · 2020: 13 · 2019: 20 · 2018: 8 · 2017: 10 · 2016: 11 · 2015: 9 · 2014: 10 · 2013: 14 · 2012: 14
FWCI: 1.18
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Research Portal (King's College London) (submittedVersion)
Funders: National Institute on Aging (R37AG023717, R01AG016841)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords: B cells, aging, B cell function, B cell differentiation, B cell lineage commitment, B cell homeostasis, immunoglobulin class switch recombination, somatic hypermutation, humoral immune response, B cell precursors, gene expression changes
MeSH terms: Aging, Animals, B-Lymphocytes, Bone Marrow, Homeostasis, Humans, Receptors, Antigen, B-Cell, Precursor Cells, B-Lymphoid

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