Blencowe, Benjamin J.

Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing

Pan, Q., Shai, O., Lee, L. J., Frey, B. J., & Blencowe, B. J. (2008) · Nature Genetics

RNA Research and SplicingGenomics and Phylogenetic Studies

Cited by 3,951

Transcriptomic Analysis of Autistic Brain Reveals Convergent Molecular Pathology

Voineagu, I., Wang, X., Johnston, P., Lowe, J. K., Tian, Y., Horvath, S., Mill, J., Cantor, R. M., Blencowe, B. J., & Geschwind, D. H. (2011) · Nature

Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental Disorders

Cited by 1,874

A compendium of RNA-binding motifs for decoding gene regulation

Ray, D., Kazan, H., Cook, K. B., Weirauch, M. T., Najafabadi, H. S., Li, X., Gueroussov, S., Albu, M., Zheng, H., Yang, A., et al. (2013) · Nature

RNA Research and SplicingRNA and protein synthesis mechanisms

Cited by 1,480

The Evolutionary Landscape of Alternative Splicing in Vertebrate Species

Barbosa-Morais, N. L., Irimia, M., Pan, Q., Xiong, H. Y., Gueroussov, S., Lee, L. J., Slobodeniuc, V., Kutter, C., Watt, S., Çolak, R., et al. (2012) · Science

RNA Research and SplicingRNA and protein synthesis mechanisms

Cited by 1,063

Alternative Splicing Regulatory Networks: Functions, Mechanisms, and Evolution

Ule, J., & Blencowe, B. J. (2019) · Molecular Cell

RNA Research and SplicingRNA regulation and disease

Cited by 780

A Highly Conserved Program of Neuronal Microexons Is Misregulated in Autistic Brains

Irimia, M., Weatheritt, R. J., Ellis, J. D., Parikshak, N. N., Gonatopoulos-Pournatzis, T., Babor, M., Quesnel-Vallières, M., Tapial, J., Raj, B., O’Hanlon, D., et al. (2014) · Cell

RNA Research and SplicingRNA regulation and disease

Cited by 693

Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism

Parikshak, N. N., Swarup, V., Belgard, T. G., Irimia, M., Ramaswami, G., Gandal, M. J., Hartl, C., Leppa, V., Ubieta, L. D. L. T., Huang, J., et al. (2016) · Nature

Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental Disorders

Cited by 685

Widespread intron retention in mammals functionally tunes transcriptomes

Braunschweig, U., Barbosa-Morais, N. L., Pan, Q., Nachman, E. N., Alipanahi, B., Gonatopoulos-Pournatzis, T., Frey, B., Irimia, M., & Blencowe, B. J. (2014) · Genome Research

RNA Research and SplicingCancer-related molecular mechanisms research

Cited by 664

Alternative Splicing in the Mammalian Nervous System: Recent Insights into Mechanisms and Functional Roles

Raj, B., & Blencowe, B. J. (2015) · Neuron

RNA Research and SplicingRNA regulation and disease

Cited by 475

Tissue-specific alternative splicing remodels protein-protein interaction networks

Ellis, J. D., Barrios-Rodiles, M., Çolak, R., Irimia, M., Kim, T., Calarco, J. A., Wang, X., Pan, Q., O'Hanlon, D., Kim, P. M., et al. (2012) · Molecular Cell

RNA Research and SplicingCancer-related molecular mechanisms research

Cited by 431

Dynamic integration of splicing within gene regulatory pathways

Braunschweig, U., Gueroussov, S., Plocik, A. M., Graveley, B. R., & Blencowe, B. J. (2013) · Cell

RNA Research and SplicingRNA regulation and disease

Cited by 406

Probing microRNAs with microarrays: tissue specificity and functional inference

BABAK, T., ZHANG, W., MORRIS, Q., BLENCOWE, B. J., & HUGHES, T. R. (2004) · RNA

MicroRNA in disease regulationPlant Molecular Biology Research

Cited by 385

Revealing global regulatory features of mammalian alternative splicing using a quantitative microarray platform

Pan, Q., Shai, O., Misquitta, C., Zhang, W., Saltzman, A. L., Mohammad, N., Babak, T., Siu, H., Hughes, T. R., Morris, Q. D., et al. (2004) · Molecular Cell

RNA Research and SplicingCancer-related molecular mechanisms research

Cited by 323

Regulation of vertebrate nervous system alternative splicing and development by an SR-related protein

Calarco, J. A., Superina, S., O'Hanlon, D., Gabut, M., Raj, B., Pan, Q., Skalska, U., Clarke, L., Gelinas, D., van der Kooy, D., et al. (2009) · Cell

RNA Research and SplicingRNA regulation and disease

Cited by 225

The Relationship between Alternative Splicing and Proteomic Complexity

Blencowe, B. J. (2017) · Trends in Biochemical Sciences

RNA Research and SplicingRNA and protein synthesis mechanisms

Cited by 178

Misregulation of an Activity-Dependent Splicing Network as a Common Mechanism Underlying Autism Spectrum Disorders

Quesnel-Vallières, M., Dargaei, Z., Irimia, M., Gonatopoulos-Pournatzis, T., Ip, J. Y., Wu, M., Sterne-Weiler, T., Nakagawa, S., Woodin, M. A., Blencowe, B. J., et al. (2016) · Molecular Cell

RNA Research and SplicingGenetics and Neurodevelopmental Disorders

Cited by 178

Alternative splicing: decoding an expansive regulatory layer

Irimia, M., & Blencowe, B. J. (2012) · Current Opinion in Cell Biology

RNA Research and SplicingCancer-related molecular mechanisms research

Cited by 177

Current-generation high-throughput sequencing: deepening insights into mammalian transcriptomes

Blencowe, B. J., Ahmad, S., & Lee, L. J. (2009) · Genes & Development

Genomics and Phylogenetic StudiesRNA Research and Splicing

Cited by 168

Brain-expressed exons under purifying selection are enriched for de novo mutations in autism spectrum disorder

Uddin, M., Tammimies, K., Pellecchia, G., Alipanahi, B., Hu, P., Wang, Z., Pinto, D., Lau, L., Nalpathamkalam, T., Marshall, C. R., et al. (2014) · Nature Genetics

Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental Disorders

Cited by 163

The ribosome-engaged landscape of alternative splicing

Weatheritt, R. J., Sterne-Weiler, T., & Blencowe, B. J. (2016) · Nature Structural & Molecular Biology

RNA Research and SplicingRNA and protein synthesis mechanisms

Cited by 162

Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development

Quesnel-Vallières, M., Irimia, M., Cordes, S. P., & Blencowe, B. J. (2015) · Genes & Development

RNA Research and SplicingGenetics and Neurodevelopmental Disorders

Cited by 155

An alternative splicing event amplifies evolutionary differences between vertebrates

Gueroussov, S., Gonatopoulos-Pournatzis, T., Irimia, M., Raj, B., Lin, Z.-Y., Gingras, A.-C., & Blencowe, B. J. (2015) · Science

RNA Research and SplicingRNA regulation and disease

Cited by 148

Cross-Regulation between an Alternative Splicing Activator and a Transcription Repressor Controls Neurogenesis

Raj, B., O'Hanlon, D., Vessey, J. P., Pan, Q., Ray, D., Buckley, N. J., Miller, F. D., & Blencowe, B. J. (2011) · Molecular Cell

Neurogenesis and neuroplasticity mechanismsRNA Research and Splicing

Cited by 143

Genetic interaction mapping and exon-resolution functional genomics with a hybrid Cas9–Cas12a platform

Gonatopoulos-Pournatzis, T., Aregger, M., Brown, K. R., Farhangmehr, S., Braunschweig, U., Ward, H. N., Ha, K. C. H., Weiss, A., Billmann, M., Durbic, T., et al. (2020) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 142