Epigenetic Epidemiology of Common Complex Disease: Prospects for Prediction, Prevention, and Treatment

Translating the Histone Code

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Epigenetic programming by maternal behavior

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‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?*

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Lanthanum Chloride Inhibits LPS Mediated Expressions of Pro-Inflammatory Cytokines and Adhesion Molecules in HUVECs: Involvement of NF-κB-Jmjd3 Signaling

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Human DNA methylomes at base resolution show widespread epigenomic differences

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Epigenetic differences arise during the lifetime of monozygotic twins

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Biological, clinical and population relevance of 95 loci for blood lipids

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Persistent epigenetic differences associated with prenatal exposure to famine in humans

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Epigenetic Reprogramming in Mammalian Development

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Perceptions of epigenetics

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Epigenetics in cancer

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Elective induction versus spontaneous labor after sonographic diagnosis of fetal macrosomia.

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The power and the promise of DNA methylation markers

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Genetics of gene expression and its effect on disease

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Epigenetics and the biological definition of gene×environment interactions

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DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific

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Molecular mechanisms of alcohol-mediated carcinogenesis

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Transcriptional control of the inflammatory response

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Genetically elevated C-reactive protein and ischemic vascular disease

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Intra-individual Change Over Time in DNA Methylation With Familial Clustering

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Rapid DNA methylation changes after exposure to traffic particles

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Epigenetic interplay between histone modifications and DNA methylation in gene silencing

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Changes in DNA Methylation Patterns in Subjects Exposed to Low-Dose Benzene

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Prenatal Tobacco Smoke Exposure Affects Global and Gene-specific DNA Methylation

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Environmental epigenetics

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Clustered environments and randomized genes: a fundamental distinction between conventional and genetic epidemiology

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Parental origin of sequence variants associated with complex diseases

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Ecological developmental biology: integrating epigenetics, medicine, and evolution

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Epigenetic mechanisms in mammals

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Genomic Medicine — An Updated Primer

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MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium

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Genetic Control of Individual Differences in Gene-Specific Methylation in Human Brain

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Mendelian Randomisation and Causal Inference in Observational Epidemiology

Sheehan, N. A., Didelez, V., Burton, P. R., & Tobin, M. D. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050177 · Cited by 373 · see citing works

The Relationship of DNA Methylation with Age, Gender and Genotype in Twins and Healthy Controls

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Effects of Particulate Matter on Genomic DNA Methylation Content and iNOS Promoter Methylation

Tarantini, L., Bonzini, M., Apostoli, P., Pegoraro, V., Bollati, V., Marinelli, B., Cantone, L., Rizzo, G., Hou, L., Schwartz, J. D., et al. (2008) · Environmental Health Perspectives · doi:10.1289/ehp.11898 · Cited by 349 · see citing works

C-reactive protein and its role in metabolic syndrome: mendelian randomisation study

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The role of epigenetics in aging and age-related diseases

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A longitudinal study of epigenetic variation in twins

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Repeated alcohol administration during adolescence causes changes in the mesolimbic dopaminergic and glutamatergic systems and promotes alcohol intake in the adult rat

Pascual, M., Boix, J., Felipo, V., & Guerri, C. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05835.x · Cited by 318 · see citing works

The Epstein–Barr virus oncogene product, latent membrane protein 1, induces the downregulation of E-cadherin gene expression via activation of DNA methyltransferases

Tsai, C., Tsai, C.-L., Tse, K., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152059399 · Cited by 316 · see citing works

Alcohol Intake and Blood Pressure: A Systematic Review Implementing a Mendelian Randomization Approach

Chen, L., Davey Smith, G., Harbord, R. M., & Lewis, S. J. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050052 · Cited by 314 · see citing works

Common Variation in the FTO Gene Alters Diabetes-Related Metabolic Traits to the Extent Expected Given Its Effect on BMI

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Variation, patterns, and temporal stability of DNA methylation: considerations for epigenetic epidemiology

Talens, R. P., Boomsma, D. I., Tobi, E. W., Kremer, D., Jukema, J. W., Willemsen, G. A. H. M., Putter, H., Slagboom, P. E., & Heijmans, B. T. (2010) · The FASEB Journal · doi:10.1096/fj.09-150490 · Cited by 312 · see citing works

Exercise-induced histone modifications in human skeletal muscle

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Assessing the Effects of High Methionine Intake on DNA Methylation

Waterland, R. A. (2006) · Journal of Nutrition · doi:10.1093/jn/136.6.1706s · Cited by 296 · see citing works

Global DNA Methylation Level in Whole Blood as a Biomarker in Head and Neck Squamous Cell Carcinoma

Hsiung, D. T., Marsit, C. J., Houseman, E. A., Eddy, K., Furniss, C. S., McClean, M. D., & Kelsey, K. T. (2007) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-06-0636 · Cited by 293 · see citing works

The methylome: approaches for global DNA methylation profiling

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Individuality and epigenetics in obesity

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Epigenetic profiling of somatic tissues from human autopsy specimens identifies tissue- and individual-specific DNA methylation patterns

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Epigenetics and environment: a complex relationship.

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Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus

Heijmans, B. T., Kremer, D., Tobi, E. W., Boomsma, D. I., & Slagboom, P. E. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm010 · Cited by 238 · see citing works

Alcohol, ALDH2, and Esophageal Cancer: A Meta-analysis Which Illustrates the Potentials and Limitations of a Mendelian Randomization Approach

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Tissue-specific dysregulation of DNA methylation in aging

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DNA methylation, an epigenetic mechanism connecting folate to healthy embryonic development and aging

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Global DNA hypomethylation is associated with in utero exposure to cotinine and perfluorinated alkyl compounds

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Mendelian Randomization for Strengthening Causal Inference in Observational Studies

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Does Greater Adiposity Increase Blood Pressure and Hypertension Risk?

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MicroRNAs: Master Regulators of Ethanol Abuse and Toxicity?

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Weismann Rules! OK? Epigenetics and the Lamarckian temptation

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MicroRNA: an Emerging Therapeutic Target and Intervention Tool

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Lifelong Reduction of LDL-Cholesterol Related to a Common Variant in the LDL-Receptor Gene Decreases the Risk of Coronary Artery Disease—A Mendelian Randomisation Study

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Tobacco Smoke Induces Polycomb-Mediated Repression of Dickkopf-1 in Lung Cancer Cells

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Histone Deacetylases as Targets for Dietary Cancer Preventive Agents: Lessons Learned with Butyrate, Diallyl Disulfide, and Sulforaphane

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Dietary Manipulation of Histone Structure and Function

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Evidence for microRNA involvement in exercise-associated neutrophil gene expression changes

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Epigenetic Modifiers: Basic Understanding and Clinical Development

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Smoking Induces Long-Lasting Effects through a Monoamine-Oxidase Epigenetic Regulation

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Inflammatory signalling as mediator of epigenetic modulation in tissue-specific chronic inflammation

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Aldehyde Dehydrogenase 2 and Head and Neck Cancer: A Meta-analysis Implementing a Mendelian Randomization Approach

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Genome-scale approaches to the epigenetics of common human disease

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Essential Amino Acids Increase MicroRNA-499, −208b, and −23a and Downregulate Myostatin and Myocyte Enhancer Factor 2C mRNA Expression in Human Skeletal Muscle

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High-fat diet leads to a decreased methylation of theMc4r gene in the obese BFMI and the lean B6 mouse lines

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The impact of genomic imprinting for neurobehavioral and developmental disorders

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Cigarette smoke induces demethylation of prometastatic oncogene synuclein-γ in lung cancer cells by downregulation of DNMT3B

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Modulation of microRNA expression by budesonide, phenethyl isothiocyanate and cigarette smoke in mouse liver and lung

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How Does Body Fat Influence Bone Mass in Childhood? A Mendelian Randomization Approach

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Inferring gene transcriptional modulatory relations: a genetical genomics approach

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Black Carbon Exposures, Blood Pressure, and Interactions with Single Nucleotide Polymorphisms in MicroRNA Processing Genes

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Role of Helicobacter pylori infection in aberrant DNA methylation along multistep gastric carcinogenesis

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Allele-Specific Chromatin Immunoprecipitation Studies Show Genetic Influence on Chromatin State in Human Genome

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Promoter hypermethylation in Indian primary oral squamous cell carcinoma

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Project set to map marks on genome

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Ageing, chronic alcohol consumption and folate are determinants of genomic DNA methylation,p16promoter methylation and the expression ofp16in the mouse colon

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Inhalation of cigarette smoke induces regions of altered DNA methylation (RAMs) in SENCAR mouse lung

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Methods of Epigenetic Analysis

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Variations in blood lipids

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Genetic variation of regulatory systems

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Epigenetic Variation and Customising Nutritional Intervention

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Interindividual variation in epigenomic phenomena in humans

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Cohort Profile: The ‘Children of the 90s’—the index offspring of the Avon Longitudinal Study of Parents and Children

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Mendelian Randomization: Concepts and Scope

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Two-step epigenetic Mendelian randomization: a strategy for establishing the causal role of epigenetic processes in pathways to disease

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Network Mendelian randomization: using genetic variants as instrumental variables to investigate mediation in causal pathways.

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