Chandel, Navdeep S.

Bcl-xL Prevents Cell Death following Growth Factor Withdrawal by Facilitating Mitochondrial ATP/ADP Exchange

Heiden, M. G. V., Chandel, N. S., Schumacker, P. T., & Thompson, C. B. (1999) · Molecular Cell

Cell death mechanisms and regulationMitochondrial Function and Pathology

Cited by 505

Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair

Zhang, S., Weinberg, S., DeBerge, M., Gainullina, A., Schipma, M., Kinchen, J. M., Ben-Sahra, I., Gius, D. R., Yvan-Charvet, L., Chandel, N. S., et al. (2019) · Cell Metabolism

Phagocytosis and Immune RegulationSirtuins and Resveratrol in Medicine

Cited by 485

Glycolysis

Chandel, N. S. (2021) · Cold Spring Harbor Perspectives in Biology

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 437

Mitochondrial complex III regulates hypoxic activation of HIF

Klimova, T., & Chandel, N. S. (2008) · Cell Death & Differentiation

Cancer, Hypoxia, and MetabolismMitochondrial Function and Pathology

Cited by 433

Loss of the SdhB, but Not the SdhA, Subunit of Complex II Triggers Reactive Oxygen Species-Dependent Hypoxia-Inducible Factor Activation and Tumorigenesis

Guzy, R. D., Sharma, B., Bell, E., Chandel, N. S., & Schumacker, P. T. (2008) · Molecular and Cellular Biology

Cancer, Hypoxia, and MetabolismCancer and biochemical research

Cited by 427

Hypoxia. 2. Hypoxia regulates cellular metabolism

Wheaton, W. W., & Chandel, N. S. (2011) · American Journal of Physiology-Cell Physiology

Cancer, Hypoxia, and MetabolismHigh Altitude and Hypoxia

Cited by 426

Mitochondrial ROS regulation of proliferating cells

Diebold, L., & Chandel, N. S. (2016) · Free Radical Biology and Medicine

Redox biology and oxidative stressMitochondrial Function and Pathology

Cited by 391

Model for Hypoxic Pulmonary Vasoconstriction Involving Mitochondrial Oxygen Sensing

Waypa, G. B., Chandel, N. S., & Schumacker, P. T. (2001) · Circulation Research

Pulmonary Hypertension Research and TreatmentsMitochondrial Function and Pathology

Cited by 367

Oxidation of Alpha-Ketoglutarate Is Required for Reductive Carboxylation in Cancer Cells with Mitochondrial Defects

Mullen, A. R., Hu, Z., Shi, X., Jiang, L., Boroughs, L. K., Kovacs, Z., Boriack, R., Rakheja, D., Sullivan, L. B., Linehan, W. M., et al. (2014) · Cell Reports

Cancer, Hypoxia, and MetabolismBiochemical Acid Research Studies

Cited by 337

Mitochondrial reactive oxygen species regulate hypoxic signaling

Hamanaka, R. B., & Chandel, N. S. (2009) · Current Opinion in Cell Biology

Redox biology and oxidative stressCancer, Hypoxia, and Metabolism

Cited by 332

Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio

Emerling, B. M., Weinberg, F., Snyder, C., Burgess, Z., Mutlu, G. M., Viollet, B., Budinger, G. R. S., & Chandel, N. S. (2009) · Free Radical Biology and Medicine

Metabolism, Diabetes, and CancerCancer, Hypoxia, and Metabolism

Cited by 330

Metabolic regulation of stem cell function in tissue homeostasis and organismal ageing

Chandel, N. S., Jasper, H., Ho, T. T., & Passegué, E. (2016) · Nature Cell Biology

Genetics, Aging, and Longevity in Model OrganismsMetabolism, Diabetes, and Cancer

Cited by 326

Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development

Hamanaka, R. B., Glasauer, A., Hoover, P., Yang, S., Blatt, H., Mullen, A. R., Getsios, S., Gottardi, C. J., DeBerardinis, R. J., Lavker, R. M., et al. (2013) · Science Signaling

Hair Growth and DisordersSkin and Cellular Biology Research

Cited by 315

Hypoxia-induced endocytosis of Na,K-ATPase in alveolar epithelial cells is mediated by mitochondrial reactive oxygen species and PKC-ζ

Dada, L. A., Chandel, N. S., Ridge, K. M., Pedemonte, C., Bertorello, A. M., & Sznajder, J. I. (2003) · Journal of Clinical Investigation

High Altitude and HypoxiaIon Transport and Channel Regulation

Cited by 314

The Proto-oncometabolite Fumarate Binds Glutathione to Amplify ROS-Dependent Signaling

Sullivan, L. B., Martinez-Garcia, E., Nguyen, H., Mullen, A. R., Dufour, E., Sudarshan, S., Licht, J. D., Deberardinis, R. J., & Chandel, N. S. (2013) · Molecular Cell

Cancer, Hypoxia, and MetabolismRedox biology and oxidative stress

Cited by 304

Hypoxic but not anoxic stabilization of HIF-1α requires mitochondrial reactive oxygen species

Schroedl, C., McClintock, D. S., Budinger, G. R. S., & Chandel, N. S. (2002) · American Journal of Physiology-Lung Cellular and Molecular Physiology

Cancer, Hypoxia, and MetabolismRedox biology and oxidative stress

Cited by 266

Mitochondrial reactive oxygen species trigger hypoxia-inducible factor-dependent extension of the replicative life span during hypoxia

Bell, E. L., Klimova, T. A., Eisenbart, J., Schumacker, P. T., & Chandel, N. S. (2007) · Molecular and Cellular Biology

Telomeres, Telomerase, and SenescenceCancer, Hypoxia, and Metabolism

Cited by 237

Amino Acid Metabolism

Chandel, N. S. (2021) · Cold Spring Harbor Perspectives in Biology

Amino Acid Enzymes and MetabolismMetabolism and Genetic Disorders

Cited by 229

Fumarate is a terminal electron acceptor in the mammalian electron transport chain

Spinelli, J. B., Rosen, P. C., Sprenger, H.-G., Puszynska, A. M., Mann, J. L., Roessler, J. M., Cangelosi, A. L., Henne, A., Condon, K. J., Zhang, T., et al. (2021) · Science

Mitochondrial Function and PathologyCancer, Hypoxia, and Metabolism

Cited by 221

Reactive oxygen species are downstream products of TRAF-mediated signal transduction

Chandel, N. S., Schumacker, P. T., & Arch, R. H. (2001) · Journal of Biological Chemistry

NF-κB Signaling PathwaysRedox biology and oxidative stress

Cited by 203

The lung microenvironment shapes a dysfunctional response of alveolar macrophages in aging

McQuattie-Pimentel, A. C., Ren, Z., Joshi, N., Watanabe, S., Stoeger, T., Chi, M., Lu, Z., Sichizya, L., Aillon, R. P., Chen, C.-I., et al. (2021) · Journal of Clinical Investigation

Genetics, Aging, and Longevity in Model OrganismsImmune responses and vaccinations

Cited by 177

Are Metformin Doses Used in Murine Cancer Models Clinically Relevant

Chandel, N. S., Avizonis, D., Reczek, C. R., Weinberg, S. E., Menz, S., Neuhaus, R., Christian, S., Haegebarth, A., Algire, C., & Pollak, M. (2016) · Cell Metabolism

Metabolism, Diabetes, and CancerCancer, Hypoxia, and Metabolism

Cited by 176

Transforming Growth Factor (TGF)-β Promotes de Novo Serine Synthesis for Collagen Production

Nigdelioglu, R., Hamanaka, R. B., Meliton, A. Y., O'Leary, E., Witt, L. J., Cho, T., Sun, K., Bonham, C., Wu, D., Woods, P. S., et al. (2016) · Journal of Biological Chemistry

TGF-β signaling in diseasesInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Cited by 169

Metformin targets mitochondrial electron transport to reduce air-pollution-induced thrombosis

Soberanes, S., Misharin, A. V., Jairaman, A., Morales-Nebreda, L., McQuattie-Pimentel, A. C., Cho, T., Hamanaka, R. B., Meliton, A. Y., Reyfman, P. A., Walter, J. M., et al. (2019) · Cell Metabolism

Air Quality and Health ImpactsMetabolism, Diabetes, and Cancer

Cited by 131