Lauffenburger, Douglas A.

Cell Migration: A Physically Integrated Molecular Process

Lauffenburger, D. A., & Horwitz, A. F. (1996) · Cell

Cellular Mechanics and InteractionsCell Adhesion Molecules Research

Cited by 3,915

Correlates of Protection Against SARS-CoV-2 in Rhesus Macaques

McMahan, K., Yu, J., Mercado, N. B., Loos, C., Tostanoski, L. H., Chandrashekar, A., Liu, J., Peter, L., Atyeo, C., Zhu, A., et al. (2021) · Nature

SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections Studies

Cited by 1,068

Single-Shot Ad26 Vaccine Protects Against SARS-CoV-2 in Rhesus Macaques

Mercado, N. B., Zahn, R., Wegmann, F., Loos, C., Chandrashekar, A., Yu, J., Liu, J., Peter, L., McMahan, K., Tostanoski, L. H., et al. (2020) · Nature

SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections Studies

Cited by 789

Physicochemical modelling of cell signalling pathways

Aldridge, B. B., Burke, J. M., Lauffenburger, D. A., & Sorger, P. K. (2006) · Nature Cell Biology

Gene Regulatory Network AnalysisBioinformatics and Genomic Networks

Cited by 592

Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies

Edington, C. D., Chen, W. L. K., Geishecker, E., Kassis, T., Soenksen, L. R., Bhushan, B. M., Freake, D., Kirschner, J., Maass, C., Tsamandouras, N., et al. (2018) · Scientific Reports

3D Printing in Biomedical ResearchMicrofluidic and Capillary Electrophoresis Applications

Cited by 487

Input–output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data

Chen, W. W., Schoeberl, B., Jasper, P. J., Niepel, M., Nielsen, U. B., Lauffenburger, D. A., & Sorger, P. K. (2009) · Molecular Systems Biology

HER2/EGFR in Cancer ResearchGene Regulatory Network Analysis

Cited by 391

Regulation of Cell Migration by the Calcium-dependent Protease Calpain

Huttenlocher, A., Palecek, S. P., Lu, Q., Zhang, W., Mellgren, R. L., Lauffenburger, D. A., Ginsberg, M. H., & Horwitz, A. F. (1997) · Journal of Biological Chemistry

Calpain Protease Function and RegulationCell Adhesion Molecules Research

Cited by 390

Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation

Tape, C. J., Ling, S., Dimitriadi, M., McMahon, K. M., Worboys, J. D., Leong, H. S., Norrie, I. C., Miller, C. J., Poulogiannis, G., Lauffenburger, D. A., et al. (2016) · Cell

Protein Kinase Regulation and GTPase SignalingPancreatic and Hepatic Oncology Research

Cited by 369

Distinct Early Serological Signatures Track with SARS-CoV-2 Survival

Atyeo, C., Fischinger, S., Zohar, T., Slein, M. D., Burke, J., Loos, C., McCulloch, D. J., Newman, K. L., Wolf, C., Yu, J., et al. (2020) · Immunity

SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studies

Cited by 349

Robustness and applicability of transcription factor and pathway analysis tools on single-cell RNA-seq data

Holland, C. H., Tanevski, J., Perales-Patón, J., Gleixner, J., Kumar, M. P., Mereu, E., Joughin, B. A., Stegle, O., Lauffenburger, D. A., Heyn, H., et al. (2020) · Genome Biology

Single-cell and spatial transcriptomicsBioinformatics and Genomic Networks

Cited by 323

Compromised Humoral Functional Evolution Tracks with SARS-CoV-2 Mortality

Zohar, T., Loos, C., Fischinger, S., Atyeo, C., Wang, C., Slein, M. D., Burke, J., Yu, J., Feldman, J., Hauser, B. M., et al. (2020) · Cell

SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studies

Cited by 297

Tissue-Specific Oncogenic Activity of KRASA146T

Poulin, E. J., Bera, A. K., Lu, J., Lin, Y.-J., Strasser, S. D., Paulo, J. A., Huang, T. Q., Morales, C., Yan, W., Cook, J., et al. (2019) · Cancer Discovery

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 197

Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases

Trapecar, M., Wogram, E., Svoboda, D., Communal, C., Omer, A., Lungjangwa, T., Sphabmixay, P., Velazquez, J., Schneider, K., Wright, C. W., et al. (2021) · Science Advances

3D Printing in Biomedical ResearchPluripotent Stem Cells Research

Cited by 176

Integrated gut/liver microphysiological systems elucidates inflammatory inter‐tissue crosstalk

Chen, W. L. K., Edington, C., Suter, E., Yu, J., Velazquez, J. J., Velazquez, J. G., Shockley, M., Large, E. M., Venkataramanan, R., Hughes, D. J., et al. (2017) · Biotechnology and Bioengineering

3D Printing in Biomedical ResearchGut microbiota and health

Cited by 172

Deoxycytidine release from pancreatic stellate cells promotes gemcitabine resistance

Dalin, S., Sullivan, M. R., Lau, A. N., Grauman-Boss, B., Mueller, H. S., Kreidl, E., Fenoglio, S., Luengo, A., Lees, J. A., Vander Heiden, M. G., et al. (2019) · Cancer Research

Pancreatic and Hepatic Oncology ResearchPancreatitis Pathology and Treatment

Cited by 156

Mapping functional humoral correlates of protection against malaria challenge following RTS,S/AS01 vaccination

Suscovich, T. J., Fallon, J. K., Das, J., Demas, A. R., Crain, J., Linde, C. H., Michell, A., Natarajan, H., Arevalo, C., Broge, T., et al. (2020) · Science Translational Medicine

Malaria Research and ControlMonoclonal and Polyclonal Antibodies Research

Cited by 142

Applying computational modeling to drug discovery and development

Kumar, N., Hendriks, B. S., Janes, K. A., de Graaf, D., & Lauffenburger, D. A. (2006) · Drug Discovery Today

Computational Drug Discovery MethodsScience, Research, and Medicine

Cited by 131

Multiplexed relative and absolute quantitative immunopeptidomics reveals MHC I repertoire alterations induced by CDK4/6 inhibition

Stopfer, L. E., Mesfin, J. M., Joughin, B. A., Lauffenburger, D. A., & White, F. M. (2020) · Nature Communications

vaccines and immunoinformatics approachesAdvanced Proteomics Techniques and Applications

Cited by 109

Macrophage-Secreted TNFα and TGFβ1 Influence Migration Speed and Persistence of Cancer Cells in 3D Tissue Culture via Independent Pathways

Li, R., Hebert, J. D., Lee, T. A., Xing, H., Boussommier-Calleja, A., Hynes, R. O., Lauffenburger, D. A., & Kamm, R. D. (2017) · Cancer Research

Immune cells in cancerProtease and Inhibitor Mechanisms

Cited by 100

Discrete SARS-CoV-2 antibody titers track with functional humoral stability

Bartsch, Y. C., Fischinger, S., Siddiqui, S. M., Chen, Z., Yu, J., Gebre, M., Atyeo, C., Gorman, M. J., Zhu, A. L., Kang, J., et al. (2021) · Nature Communications

SARS-CoV-2 and COVID-19 ResearchSARS-CoV-2 detection and testing

Cited by 82

Quantitative phosphoproteomics uncovers dysregulated kinase networks in Alzheimer’s disease

Morshed, N., Lee, M. J., Rodriguez, F. H., Lauffenburger, D. A., Mastroeni, D., & White, F. M. (2021) · Nature Aging

Alzheimer's disease research and treatmentsAdvanced Proteomics Techniques and Applications

Cited by 58

Proteogenomic Network Analysis of Context-Specific KRAS Signaling in Mouse-to-Human Cross-Species Translation

Brubaker, D. K., Paulo, J. A., Sheth, S., Poulin, E. J., Popow, O., Joughin, B. A., Strasser, S. D., Starchenko, A., Gygi, S. P., Lauffenburger, D. A., et al. (2019) · Cell Systems

Protein Kinase Regulation and GTPase SignalingBioinformatics and Genomic Networks

Cited by 57

PTMScout, a Web Resource for Analysis of High Throughput Post-translational Proteomics Studies

Naegle, K. M., Gymrek, M., Joughin, B. A., Wagner, J. P., Welsch, R. E., Yaffe, M. B., Lauffenburger, D. A., & White, F. M. (2010) · Molecular & Cellular Proteomics

Advanced Proteomics Techniques and ApplicationsBioinformatics and Genomic Networks

Cited by 41

Analysis of the Diverse Antigenic Landscape of the Malaria Invasion Protein RH5 Identifies a Potent Vaccine-Induced Human Public Antibody Clonotype

Barrett, J. R., Pipini, D., Wright, N. D., Cooper, A. J. R., Gorini, G., Quinkert, D., Lias, A. M., Davies, H., Rigby, C., Aleshnick, M., et al. (2023) · Cell

Malaria Research and ControlMonoclonal and Polyclonal Antibodies Research

Cited by 31