Watt, Fiona M.

A framework for advancing our understanding of cancer-associated fibroblasts

Sahai, E., Astsaturov, I., Cukierman, E., DeNardo, D. G., Egeblad, M., Evans, R. M., Fearon, D., Greten, F. R., Hingorani, S. R., Hunter, T., et al. (2020) · Nature Reviews Cancer

Cancer Cells and MetastasisTGF-β signaling in diseases

Cited by 3,863

The human cell atlas

Regev, A., Teichmann, S. A., Lander, E. S., Amit, I., Benoist, C., Birney, E., Bodenmiller, B., Campbell, P., Carninci, P., Clatworthy, M., et al. (2017) · eLife

Single-cell and spatial transcriptomicsGene Regulatory Network Analysis

Cited by 2,232

Distinct fibroblast lineages determine dermal architecture in skin development and repair

Driskell, R. R., Lichtenberger, B. M., Hoste, E., Kretzschmar, K., Simons, B. D., Charalambous, M., Ferron, S. R., Herault, Y., Pavlovic, G., Ferguson-Smith, A. C., et al. (2013) · Nature

Hair Growth and DisordersWound Healing and Treatments

Cited by 1,291

Autophagy mediates the mitotic senescence transition

Young, A. R. J., Narita, M., Ferreira, M., Kirschner, K., Sadaie, M., Darot, J. F. J., Tavaré, S., Arakawa, S., Shimizu, S., Watt, F. M., et al. (2009) · Genes & Development

Autophagy in Disease and TherapyTelomeres, Telomerase, and Senescence

Cited by 1,078

Role of the extracellular matrix in regulating stem cell fate

Watt, F. M., & Huck, W. T. S. (2013) · Nature Reviews Molecular Cell Biology

Cellular Mechanics and InteractionsTissue Engineering and Regenerative Medicine

Cited by 861

Role of integrins in regulating epidermal adhesion, growth and differentiation

Watt, F. M. (2002) · The EMBO Journal

Cell Adhesion Molecules ResearchSkin and Cellular Biology Research

Cited by 647

Common genetic variation drives molecular heterogeneity in human iPSCs

Kilpinen, H., Goncalves, A., Leha, A., Afzal, V., Alasoo, K., Ashford, S., Bala, S., Bensaddek, D., Casale, F. P., Culley, O. J., et al. (2017) · Nature

Pluripotent Stem Cells ResearchGenetic Associations and Epidemiology

Cited by 586

Developmental cell programs are co-opted in inflammatory skin disease

Reynolds, G., Vegh, P., Fletcher, J., Poyner, E. F. M., Stephenson, E., Goh, I., Botting, R. A., Huang, N., Olabi, B., Dubois, A., et al. (2021) · Science

Dermatology and Skin DiseasesPsoriasis: Treatment and Pathogenesis

Cited by 529

Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.

White, J. K., Gerdin, A.-K., Karp, N. A., Ryder, E., Buljan, M., Bussell, J. N., Salisbury, J., Clare, S., Ingham, N. J., Podrini, C., et al. (2013) · Cell

Genomics and Rare DiseasesAnimal Genetics and Reproduction

Cited by 509

Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations

Philippeos, C., Telerman, S. B., Oulès, B., Pisco, A. O., Shaw, T. J., Elgueta, R., Lombardi, G., Driskell, R. R., Soldin, M., Lynch, M. D., et al. (2018) · Journal of Investigative Dermatology

Wound Healing and TreatmentsSingle-cell and spatial transcriptomics

Cited by 454

Manipulation of stem cell proliferation and lineage commitment:visualisation of label-retaining cells in wholemounts of mouse epidermis

Braun, K. M., Niemann, C., Jensen, U. B., Sundberg, J. P., Silva-Vargas, V., & Watt, F. M. (2003) · Development

Hair Growth and DisordersSkin and Cellular Biology Research

Cited by 425

Cell-Extracellular Matrix Interactions in Normal and Diseased Skin

Watt, F. M., & Fujiwara, H. (2011) · Cold Spring Harbor Perspectives in Biology

Cell Adhesion Molecules ResearchCellular Mechanics and Interactions

Cited by 384

What is AI? Applications of artificial intelligence to dermatology

Du‐Harpur, X., Watt, F. M., Luscombe, N. M., & Lynch, M. D. (2020) · British Journal of Dermatology

Cutaneous Melanoma Detection and ManagementAI in cancer detection

Cited by 355

c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny

Arnold, I., & Watt, F. M. (2001) · Current Biology

Hair Growth and DisordersSkin and Cellular Biology Research

Cited by 341

Transient activation of β-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours

Celso, C. L., Prowse, D. M., & Watt, F. M. (2004) · Development

Hair Growth and DisordersWnt/β-catenin signaling in development and cancer

Cited by 339

Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression

Cuomo, A. S. E., Seaton, D. D., McCarthy, D. J., Martinez, I., Bonder, M. J., Garcia-Bernardo, J., Amatya, S., Madrigal, P., Isaacson, A., Buettner, F., et al. (2020) · Nature Communications

Pluripotent Stem Cells ResearchSingle-cell and spatial transcriptomics

Cited by 331

Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis

Driskell, R. R., Giangreco, A., Jensen, K. B., Mulder, K. W., & Watt, F. M. (2009) · Development

Hair Growth and DisordersSkin and Cellular Biology Research

Cited by 331

c-Myc promotes differentiation of human epidermal stem cells

Gandarillas, A., & Watt, F. M. (1997) · Genes & Development

Hair Growth and DisordersSkin and Cellular Biology Research

Cited by 326

The EGF Receptor Provides an Essential Survival Signal for SOS-Dependent Skin Tumor Development

Sibilia, M., Fleischmann, A., Behrens, A., Stingl, L., Carroll, J., Watt, F. M., Schlessinger, J., & Wagner, E. F. (2000) · Cell

HER2/EGFR in Cancer ResearchProtein Kinase Regulation and GTPase Signaling

Cited by 304

Assaying proliferation and differentiation capacity of stem cells using disaggregated adult mouse epidermis

Jensen, K. B., Driskell, R. R., & Watt, F. M. (2010) · Nature Protocols

Hair Growth and DisordersSkin and Cellular Biology Research

Cited by 178

Diverse mechanisms for endogenous regeneration and repair in mammalian organs

Wells, J. M., & Watt, F. M. (2018) · Nature

Liver physiology and pathologyTissue Engineering and Regenerative Medicine

Cited by 169

MYC in mammalian epidermis: how can an oncogene stimulate differentiation?

Watt, F. M., Frye, M., & Benitah, S. A. (2008) · Nature Reviews Cancer

Cancer-related Molecular PathwaysHair Growth and Disorders

Cited by 157

Applications and future directions for optical coherence tomography in dermatology*

Wan, B., Ganier, C., Du‐Harpur, X., Harun, N., Watt, F. M., Patalay, R., & Lynch, M. D. (2021) · British Journal of Dermatology

Optical Coherence Tomography ApplicationsCutaneous Melanoma Detection and Management

Cited by 148

Myc regulates keratinocyte adhesion and differentiation via complex formation with Miz1

Gebhardt, A., Frye, M., Herold, S., Benitah, S. A., Braun, K., Samans, B., Watt, F. M., Elsässer, H.-P., & Eilers, M. (2006) · The Journal of Cell Biology

Skin and Cellular Biology ResearchCell Adhesion Molecules Research

Cited by 118