Lesch, Klaus-Peter

Defeat stress in rodents: from behavior to molecules

Hammels, C., Pishva, E., De Vry, J., van den Hove, D. L. A., Prickaerts, J., van Winkel, R., Selten, J.-P., Lesch, K.-P., Daskalakis, N. P., Steinbusch, H. W. M., et al. (2015) · Neuroscience & Biobehavioral Reviews

Stress Responses and CortisolNeurotransmitter Receptor Influence on Behavior

Cited by 230

Analysis of DRD4 and DAT polymorphisms and behavioral inhibition in healthy adults: implications for impulsivity

Congdon, E., Lesch, K. P., & Canli, T. (2008) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology Studies

Cited by 218

Subcortical brain volume, regional cortical thickness, and cortical surface area across disorders: findings from the ENIGMA ADHD, ASD, and OCD working groups

Boedhoe, P. S. W., van Rooij, D., Hoogman, M., Twisk, J. W. R., Schmaal, L., Abe, Y., Alonso, P., Ameis, S. H., Anikin, A., Anticevic, A., et al. (2020) · American Journal of Psychiatry

Attention Deficit Hyperactivity DisorderAutism Spectrum Disorder Research

Cited by 201

Dopamine and Cognitive Control: The Influence of Spontaneous Eyeblink Rate and Dopamine Gene Polymorphisms on Perseveration and Distractibility.

Dreisbach, G., Müller, J., Goschke, T., Strobel, A., Schulze, K., Lesch, K.-P., & Brocke, B. (2005) · Behavioral Neuroscience

Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology Studies

Cited by 194

Oxytocin receptor gene methylation: converging multilevel evidence for a role in social anxiety

Ziegler, C., Dannlowski, U., Bräuer, D., Stevens, S., Laeger, I., Wittmann, H., Kugel, H., Dobel, C., Hurlemann, R., Reif, A., et al. (2015) · Neuropsychopharmacology

Neuroendocrine regulation and behaviorAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Cited by 193

Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation

Canli, T., Congdon, E., Gutknecht, L., Constable, R. T., & Lesch, K. P. (2005) · Journal of Neural Transmission

Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology Studies

Cited by 188

Stratified medicine for mental disorders

Schumann, G., Binder, E. B., Holte, A., de Kloet, E. R., Oedegaard, K. J., Robbins, T. W., Walker-Tilley, T. R., Bitter, I., Brown, V. J., Buitelaar, J., et al. (2014) · European Neuropsychopharmacology

Mental Health and PsychiatryMental Health Research Topics

Cited by 186

Multicenter Analysis of the SLC6A3/DAT1 VNTR Haplotype in Persistent ADHD Suggests Differential Involvement of the Gene in Childhood and Persistent ADHD

Franke, B., Vasquez, A. A., Johansson, S., Hoogman, M., Romanos, J., Boreatti-Hümmer, A., Heine, M., Jacob, C. P., Lesch, K.-P., Casas, M., et al. (2010) · Neuropsychopharmacology

Attention Deficit Hyperactivity DisorderNeurotransmitter Receptor Influence on Behavior

Cited by 183

MAOA gene hypomethylation in panic disorder-reversibility of an epigenetic risk pattern by psychotherapy

Ziegler, C., Richter, J., Mahr, M., Gajewska, A., Schiele, M. A., Gehrmann, A., Schmidt, B., Lesch, K.-P., Lang, T., Helbig-Lang, S., et al. (2016) · Translational Psychiatry

Epigenetics and DNA MethylationAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Cited by 183

The ADHD-susceptibility gene lphn3.1 modulates dopaminergic neuron formation and locomotor activity during zebrafish development

Lange, M., Norton, W., Coolen, M., Chaminade, M., Merker, S., Proft, F., Schmitt, A., Vernier, P., Lesch, K.-P., & Bally-Cuif, L. (2012) · Molecular Psychiatry

Attention Deficit Hyperactivity DisorderZebrafish Biomedical Research Applications

Cited by 175

Deficiency of brain 5-HT synthesis but serotonergic neuron formation in Tph2 knockout mice

Gutknecht, L., Waider, J., Kraft, S., Kriegebaum, C., Holtmann, B., Reif, A., Schmitt, A., & Lesch, K.-P. (2008) · Journal of Neural Transmission

Neurotransmitter Receptor Influence on BehaviorNeurogenesis and neuroplasticity mechanisms

Cited by 173

Regional brain activation changes and abnormal functional connectivity of the ventrolateral prefrontal cortex during working memory processing in adults with attention‐deficit/hyperactivity disorder

Wolf, R. C., Plichta, M. M., Sambataro, F., Fallgatter, A. J., Jacob, C., Lesch, K., Herrmann, M. J., Schönfeldt‐Lecuona, C., Connemann, B. J., Grön, G., et al. (2009) · Human Brain Mapping

Attention Deficit Hyperactivity DisorderFunctional Brain Connectivity Studies

Cited by 170

Genome-wide copy number variation analysis in attention-deficit/hyperactivity disorder: association with neuropeptide Y gene dosage in an extended pedigree

Lesch, K.-P., Selch, S., Renner, T. J., Jacob, C., Nguyen, T. T., Hahn, T., Romanos, M., Walitza, S., Shoichet, S., Dempfle, A., et al. (2011) · Molecular Psychiatry

Genomic variations and chromosomal abnormalitiesAttention Deficit Hyperactivity Disorder

Cited by 167

Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder

Walitza, S., Renner, T. J., Dempfle, A., Konrad, K., Wewetzer, C., Halbach, A., Herpertz-Dahlmann, B., Remschmidt, H., Smidt, J., Linder, M., et al. (2005) · Molecular Psychiatry

Attention Deficit Hyperactivity DisorderNeurotransmitter Receptor Influence on Behavior

Cited by 158

High Loading of Polygenic Risk for ADHD in Children With Comorbid Aggression

Hamshere, M. L., Langley, K., Martin, J., Agha, S. S., Stergiakouli, E., Anney, R. J. L., Buitelaar, J., Faraone, S. V., Lesch, K.-P., Neale, B. M., et al. (2013) · American Journal of Psychiatry

Attention Deficit Hyperactivity DisorderGenetic Associations and Epidemiology

Cited by 144

Longitudinal analyses of the DNA methylome in deployed military servicemen identify susceptibility loci for post-traumatic stress disorder

Rutten, B. P. F., Vermetten, E., Vinkers, C. H., Ursini, G., Daskalakis, N. P., Pishva, E., de Nijs, L., Houtepen, L. C., Eijssen, L., Jaffe, A. E., et al. (2018) · Molecular Psychiatry

Posttraumatic Stress Disorder ResearchEpigenetics and DNA Methylation

Cited by 142

Neural response to reward anticipation is modulated by Gray's impulsivity

Hahn, T., Dresler, T., Ehlis, A.-C., Plichta, M. M., Heinzel, S., Polak, T., Lesch, K.-P., Breuer, F., Jakob, P. M., & Fallgatter, A. J. (2009) · NeuroImage

Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on Behavior

Cited by 136

Antidepressant Drugs Transactivate TrkB Neurotrophin Receptors in the Adult Rodent Brain Independently of BDNF and Monoamine Transporter Blockade

Rantamäki, T., Vesa, L., Antila, H., Di Lieto, A., Tammela, P., Schmitt, A., Lesch, K.-P., Rios, M., & Castrén, E. (2011) · PLoS ONE

Treatment of Major DepressionNerve injury and regeneration

Cited by 124

Shared genetic background between children and adults with attention deficit/hyperactivity disorder

Rovira, P., Demontis, D., Sánchez-Mora, C., Zayats, T., Klein, M., Mota, N. R., Weber, H., Garcia-Martínez, I., Pagerols, M., Vilar-Ribó, L., et al. (2020) · Neuropsychopharmacology

Attention Deficit Hyperactivity DisorderGenetic Associations and Epidemiology

Cited by 111

A functional dopamine-β-hydroxylase gene promoter polymorphism is associated with impulsive personality styles, but not with affective disorders

Hess, C., Reif, A., Strobel, A., Boreatti-Hümmer, A., Heine, M., Lesch, K.-P., & Jacob, C. P. (2009) · Journal of Neural Transmission

Neurotransmitter Receptor Influence on BehaviorAttention Deficit Hyperactivity Disorder

Cited by 104

Influence of SLC6A3 and COMT variation on neural activation during response inhibition

Congdon, E., Constable, R. T., Lesch, K. P., & Canli, T. (2009) · Biological Psychology

Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology Studies

Cited by 103

Serotonergic gene expression and depression: implications for developing novel antidepressants

Lesch, K. P. (2001) · Journal of Affective Disorders

Neurotransmitter Receptor Influence on BehaviorTreatment of Major Depression

Cited by 93

Additive effects of serotonin transporter and tryptophan hydroxylase-2 gene variation on neural correlates of affective processing

Canli, T., Congdon, E., Todd Constable, R., & Lesch, K. P. (2008) · Biological Psychology

Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology Studies

Cited by 89

Children under stress–COMT genotype and stressful life events predict cortisol increase in an acute social stress paradigm

Armbruster, D., Mueller, A., Strobel, A., Lesch, K.-P., Brocke, B., & Kirschbaum, C. (2012) · The International Journal of Neuropsychopharmacology

Stress Responses and CortisolNeurotransmitter Receptor Influence on Behavior

Cited by 87